GREMLIN Database
YBFA - Putative HTH-type DNA-binding domain-containing acetyltransferase YbfA
UniProt: O31443 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (288)
Sequences: 857 (641)
Seq/√Len: 37.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_L189_L6.4721.00
171_Q185_F4.9851.00
284_V298_E4.7771.00
135_M138_I3.9191.00
170_K231_D3.7941.00
241_T276_K3.5681.00
289_P294_Q3.5581.00
186_L190_Q3.2231.00
218_H224_Q3.1411.00
171_Q229_L3.1171.00
169_E173_Q3.0571.00
156_R204_E2.5401.00
46_I52_C2.3691.00
272_P275_K2.3031.00
248_V259_I2.2480.99
153_I239_L2.2250.99
246_H249_A2.1220.99
47_Y105_Y2.1050.99
208_K233_D2.0820.99
242_Q246_H2.0460.99
54_A95_I2.0300.99
200_I214_G2.0270.99
275_K281_I1.9690.98
213_V228_F1.9630.98
30_I46_I1.9560.98
84_Q96_F1.9330.98
162_E165_Q1.8910.98
38_T75_F1.8890.98
76_E83_K1.8370.98
288_A297_E1.8300.98
250_Y254_M1.8280.98
17_R24_G1.8260.98
248_V279_F1.8250.98
56_A59_D1.7670.97
31_Y112_A1.7610.97
12_F120_L1.7610.97
20_T37_L1.7550.97
212_S229_L1.7410.97
261_L270_A1.7380.97
13_R17_R1.7120.96
172_R176_A1.6900.96
179_H267_M1.6850.96
224_Q260_F1.6790.96
283_E299_R1.6600.96
290_L294_Q1.6600.96
275_K298_E1.6550.96
38_T63_L1.6130.95
221_K257_D1.6100.95
261_L274_Y1.5890.94
170_K174_F1.5740.94
289_P293_Q1.5620.94
246_H253_D1.5410.93
203_A239_L1.5400.93
167_L214_G1.5350.93
264_V297_E1.5250.93
291_W297_E1.4970.92
167_L174_F1.4880.92
67_Y71_I1.4850.92
244_L273_L1.4770.92
270_A274_Y1.4740.92
63_L67_Y1.4590.91
82_Y99_E1.4580.91
13_R20_T1.4510.91
230_V239_L1.4510.91
10_L113_N1.4480.91
201_W250_Y1.4470.91
166_L209_F1.4340.91
153_I242_Q1.4280.90
228_F244_L1.4280.90
64_D70_R1.4230.90
215_L247_L1.4200.90
42_I57_L1.4200.90
13_R24_G1.4090.90
14_K139_E1.4030.90
99_E110_E1.4030.90
264_V288_A1.3840.89
134_A209_F1.3740.89
181_W185_F1.3670.88
281_I298_E1.3660.88
171_Q175_Y1.3590.88
20_T41_R1.3500.88
84_Q126_K1.3410.87
130_K137_E1.3400.87
290_L297_E1.3380.87
123_I141_I1.3310.87
169_E209_F1.3190.87
99_E102_K1.3180.87
43_L75_F1.3130.86
213_V247_L1.3070.86
190_Q195_A1.3040.86
155_I158_Y1.2980.86
158_Y200_I1.2920.85
30_I33_S1.2860.85
139_E146_L1.2690.84
124_N127_E1.2670.84
224_Q227_W1.2660.84
188_Y191_E1.2560.84
166_L170_K1.2540.84
181_W184_T1.2450.83
167_L171_Q1.2390.83
131_L141_I1.2370.83
156_R170_K1.2290.82
172_R185_F1.2220.82
163_D167_L1.2050.81
224_Q299_R1.1980.81
41_R66_G1.1910.80
263_T267_M1.1800.80
171_Q291_W1.1760.79
166_L169_E1.1510.78
49_T56_A1.1490.78
182_D185_F1.1480.78
295_L298_E1.1460.78
198_E217_K1.1450.78
219_D222_T1.1280.77
120_L241_T1.1180.76
15_F19_Y1.1100.75
41_R67_Y1.1090.75
25_F116_V1.1050.75
171_Q174_F1.0970.74
263_T270_A1.0850.74
20_T26_L1.0800.73
54_A72_V1.0780.73
37_L41_R1.0770.73
188_Y192_T1.0760.73
58_Q95_I1.0680.72
83_K93_H1.0610.72
289_P295_L1.0540.71
212_S224_Q1.0450.71
261_L267_M1.0420.71
20_T24_G1.0210.69
17_R45_E1.0140.68
17_R26_L1.0130.68
287_E296_T1.0080.68
264_V290_L1.0060.68
82_Y96_F0.9950.67
131_L138_I0.9890.67
99_E207_G0.9860.66
12_F135_M0.9830.66
245_E277_F0.9740.65
209_F229_L0.9720.65
290_L295_L0.9710.65
109_E113_N0.9700.65
110_E133_E0.9700.65
167_L186_L0.9690.65
242_Q248_V0.9650.65
292_G295_L0.9620.64
14_K280_R0.9540.64
32_D35_F0.9510.63
239_L272_P0.9490.63
192_T197_I0.9470.63
173_Q208_K0.9420.63
200_I215_L0.9360.62
163_D204_E0.9350.62
171_Q212_S0.9320.62
157_D199_K0.9310.62
15_F41_R0.9300.62
19_Y138_I0.9240.61
87_K254_M0.9180.61
22_V119_M0.9140.60
39_E204_E0.9130.60
53_T95_I0.9120.60
233_D237_R0.9110.60
102_K239_L0.9100.60
55_K59_D0.9070.60
174_F177_E0.9030.59
156_R163_D0.8950.59
241_T245_E0.8950.59
28_E139_E0.8900.58
154_S239_L0.8870.58
170_K173_Q0.8830.58
100_T104_I0.8800.57
71_I75_F0.8780.57
193_F198_E0.8780.57
250_Y256_F0.8720.57
75_F93_H0.8720.57
50_P126_K0.8720.57
92_H121_K0.8720.57
250_Y253_D0.8700.57
64_D134_A0.8680.56
37_L67_Y0.8680.56
96_F152_E0.8660.56
15_F67_Y0.8650.56
227_W297_E0.8630.56
47_Y109_E0.8630.56
177_E232_A0.8630.56
273_L279_F0.8620.56
37_L68_V0.8600.56
114_E253_D0.8560.55
210_A234_F0.8490.55
179_H295_L0.8490.55
242_Q255_K0.8490.55
12_F27_N0.8480.55
264_V267_M0.8400.54
120_L140_A0.8390.54
271_R298_E0.8390.54
22_V224_Q0.8360.54
139_E142_L0.8360.54
164_L200_I0.8350.53
225_L247_L0.8280.53
28_E100_T0.8250.53
174_F178_A0.8210.52
27_N30_I0.8210.52
36_S66_G0.8200.52
56_A68_V0.8200.52
289_P296_T0.8150.52
222_T258_R0.8150.52
23_L42_I0.8120.51
223_V226_R0.8110.51
165_Q172_R0.8110.51
208_K231_D0.8100.51
73_K121_K0.8070.51
289_P292_G0.7990.50
179_H244_L0.7990.50
192_T195_A0.7980.50
214_G224_Q0.7970.50
9_G117_E0.7970.50
263_T274_Y0.7950.50
84_Q249_A0.7940.50
56_A92_H0.7900.49
215_L234_F0.7900.49
11_K32_D0.7880.49
292_G298_E0.7860.49
65_R69_S0.7860.49
175_Y226_R0.7830.49
178_A182_D0.7820.49
226_R263_T0.7800.49
34_P77_K0.7780.48
162_E201_W0.7760.48
234_F237_R0.7750.48
42_I71_I0.7740.48
16_N19_Y0.7700.48
9_G46_I0.7680.47
236_G270_A0.7680.47
230_V251_C0.7640.47
33_S40_T0.7630.47
291_W300_W0.7630.47
223_V256_F0.7610.47
41_R64_D0.7550.46
215_L259_I0.7550.46
175_Y181_W0.7540.46
265_S268_A0.7510.46
267_M270_A0.7500.46
70_R235_R0.7490.46
24_G45_E0.7480.46
55_K98_T0.7470.46
134_A138_I0.7470.46
170_K229_L0.7450.45
155_I188_Y0.7450.45
185_F227_W0.7440.45
104_I128_Q0.7400.45
54_A58_Q0.7390.45
152_E206_G0.7380.45
124_N207_G0.7380.45
140_A151_S0.7350.45
214_G297_E0.7350.45
41_R138_I0.7330.44
39_E67_Y0.7280.44
113_N241_T0.7260.44
67_Y75_F0.7250.44
43_L80_L0.7170.43
16_N41_R0.7160.43
262_W267_M0.7100.42
185_F247_L0.7090.42
150_A153_I0.7040.42
293_Q298_E0.7040.42
165_Q168_I0.7020.42
189_L227_W0.7010.42
9_G249_A0.6980.41
77_K126_K0.6950.41
259_I264_V0.6910.41
60_K249_A0.6900.41
52_C57_L0.6890.41
34_P87_K0.6880.40
133_E137_E0.6830.40
164_L189_L0.6780.40
155_I197_I0.6760.39
66_G83_K0.6750.39
51_N103_T0.6750.39
211_G243_L0.6750.39
45_E70_R0.6750.39
223_V229_L0.6720.39
35_F111_K0.6700.39
161_S171_Q0.6690.39
185_F226_R0.6690.39
163_D166_L0.6680.39
88_D152_E0.6680.39
154_S157_D0.6660.39
261_L279_F0.6650.38
156_R256_F0.6650.38
87_K124_N0.6650.38
153_I205_S0.6640.38
165_Q171_Q0.6630.38
18_F142_L0.6590.38
132_A150_A0.6560.38
93_H134_A0.6530.37
83_K95_I0.6530.37
58_Q81_I0.6520.37
170_K209_F0.6500.37
262_W271_R0.6490.37
110_E117_E0.6480.37
57_L81_I0.6470.37
200_I224_Q0.6470.37
128_Q142_L0.6430.37
99_E103_T0.6410.36
21_N62_G0.6380.36
189_L192_T0.6350.36
50_P96_F0.6330.36
158_Y192_T0.6320.36
92_H209_F0.6300.36
261_L273_L0.6280.35
131_L134_A0.6270.35
46_I60_K0.6260.35
110_E126_K0.6220.35
58_Q93_H0.6200.35
76_E93_H0.6200.35
172_R175_Y0.6180.35
205_S210_A0.6160.34
267_M288_A0.6130.34
20_T44_F0.6130.34
232_A239_L0.6120.34
42_I244_L0.6120.34
34_P107_K0.6110.34
175_Y262_W0.6090.34
85_R220_E0.6050.34
152_E157_D0.6020.33
17_R23_L0.6020.33
17_R70_R0.6020.33
142_L246_H0.6010.33
158_Y186_L0.6000.33
30_I281_I0.5990.33
242_Q253_D0.5990.33
121_K133_E0.5980.33
19_Y131_L0.5970.33
163_D202_I0.5970.33
220_E258_R0.5950.33
102_K128_Q0.5920.33
210_A233_D0.5910.32
31_Y111_K0.5900.32
290_L293_Q0.5880.32
136_A140_A0.5870.32
134_A137_E0.5850.32
247_L252_Q0.5840.32
109_E177_E0.5830.32
27_N40_T0.5830.32
51_N84_Q0.5830.32
68_V203_A0.5830.32
164_L168_I0.5830.32
9_G240_G0.5820.32
85_R257_D0.5820.32
204_E256_F0.5820.32
197_I254_M0.5800.32
178_A235_R0.5800.32
11_K139_E0.5780.31
214_G291_W0.5770.31
167_L175_Y0.5760.31
81_I95_I0.5750.31
84_Q98_T0.5750.31
107_K123_I0.5730.31
288_A291_W0.5720.31
16_N67_Y0.5710.31
237_R259_I0.5710.31
69_S91_R0.5680.31
66_G69_S0.5670.31
64_D67_Y0.5660.31
15_F37_L0.5660.31
11_K136_A0.5650.30
96_F249_A0.5650.30
163_D172_R0.5640.30
281_I284_V0.5640.30
35_F104_I0.5640.30
172_R178_A0.5620.30
179_H183_D0.5620.30
17_R20_T0.5620.30
293_Q296_T0.5610.30
203_A210_A0.5600.30
180_G292_G0.5570.30
118_L191_E0.5550.30
224_Q270_A0.5550.30
86_S94_Y0.5540.30
224_Q259_I0.5540.30
228_F273_L0.5540.30
58_Q62_G0.5540.30
12_F54_A0.5530.30
19_Y41_R0.5530.30
16_N22_V0.5520.29
193_F197_I0.5500.29
81_I186_L0.5500.29
103_T231_D0.5490.29
262_W285_K0.5470.29
200_I273_L0.5460.29
86_S92_H0.5430.29
43_L104_I0.5420.29
262_W281_I0.5400.29
292_G297_E0.5400.29
66_G71_I0.5370.28
123_I134_A0.5370.28
17_R65_R0.5360.28
200_I227_W0.5360.28
88_D248_V0.5340.28
230_V265_S0.5340.28
9_G120_L0.5330.28
164_L171_Q0.5330.28
265_S296_T0.5330.28
117_E124_N0.5320.28
75_F221_K0.5320.28
191_E210_A0.5320.28
33_S111_K0.5310.28
84_Q136_A0.5310.28
233_D239_L0.5300.28
68_V265_S0.5280.28
13_R202_I0.5270.28
216_V226_R0.5260.28
154_S204_E0.5250.28
214_G227_W0.5240.27
175_Y185_F0.5230.27
147_S255_K0.5210.27
200_I247_L0.5210.27
154_S258_R0.5200.27
180_G225_L0.5170.27
37_L66_G0.5120.27
226_R261_L0.5110.27
155_I163_D0.5100.26
66_G138_I0.5100.26
126_K150_A0.5090.26
50_P88_D0.5070.26
152_E205_S0.5060.26
125_Q293_Q0.5060.26
114_E117_E0.5050.26
58_Q65_R0.5040.26
147_S150_A0.5040.26
21_N75_F0.5010.26
215_L250_Y0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d8pA 1 0.5016 99.9 0.744 Contact Map
3dr6A 2 0.5016 99.8 0.757 Contact Map
1cjwA 1 0.4918 99.8 0.76 Contact Map
3f8kA 1 0.4131 99.8 0.761 Contact Map
2cy2A 1 0.4951 99.8 0.761 Contact Map
2q7bA 2 0.5049 99.8 0.763 Contact Map
1n71A 4 0.482 99.8 0.763 Contact Map
2j8mA 2 0.4984 99.8 0.763 Contact Map
3pp9A 2 0.5049 99.8 0.763 Contact Map
3zj0A 1 0.4754 99.8 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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