GREMLIN Database
CYPC - Fatty-acid peroxygenase
UniProt: O31440 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (382)
Sequences: 43898 (32663)
Seq/√Len: 1671.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_H333_E3.8121.00
278_M340_A3.4351.00
330_H335_R3.3401.00
267_W337_E3.2461.00
254_S283_V3.0941.00
302_V307_E3.0841.00
120_K379_F3.0471.00
254_S377_L2.9581.00
309_K312_T2.9071.00
250_F373_M2.8421.00
277_E374_K2.6941.00
202_R230_S2.6841.00
51_G54_A2.6671.00
300_D310_K2.6301.00
257_A287_Y2.5771.00
266_E270_S2.5431.00
265_K269_R2.5351.00
300_D307_E2.5021.00
271_G274_R2.4611.00
323_H332_D2.3791.00
264_Y275_E2.3711.00
268_L279_F2.2851.00
127_E384_I2.2761.00
26_K30_E2.2281.00
297_V308_F2.2151.00
201_A212_T2.1901.00
38_Q45_N2.1811.00
195_E234_A2.1401.00
116_T379_F2.0981.00
114_L148_Y2.0911.00
54_A304_N2.0751.00
47_I312_T2.0711.00
267_W275_E2.0681.00
199_E230_S2.0401.00
261_H264_Y2.0111.00
127_E383_Q1.9961.00
200_D204_G1.9941.00
141_I376_S1.9891.00
195_E230_S1.9661.00
362_R366_E1.9401.00
302_V305_N1.9381.00
257_A286_Y1.9381.00
269_R273_S1.9011.00
195_E199_E1.8861.00
280_V373_M1.8171.00
256_L260_E1.8171.00
36_L49_M1.7781.00
55_A321_T1.7781.00
24_F27_N1.7771.00
129_A137_E1.7771.00
264_Y267_W1.7551.00
283_V334_F1.7261.00
380_L386_Y1.7141.00
281_Q370_I1.7081.00
161_E165_D1.7011.00
266_E385_E1.6991.00
20_E23_L1.6981.00
49_M58_F1.6881.00
185_R189_R1.6861.00
35_D51_G1.6791.00
265_K385_E1.6771.00
56_K60_D1.6711.00
65_Q299_K1.6641.00
251_L376_S1.6491.00
118_E148_Y1.6351.00
40_R45_N1.6261.00
95_R236_E1.6181.00
27_N31_R1.6071.00
196_V200_D1.5941.00
118_E121_A1.5931.00
165_D189_R1.5881.00
269_R385_E1.5521.00
300_D309_K1.5501.00
138_A255_A1.5451.00
229_D232_M1.5351.00
257_A261_H1.5301.00
199_E203_A1.5261.00
114_L117_E1.5261.00
266_E269_R1.5201.00
131_E389_P1.5161.00
319_Y323_H1.5151.00
254_S279_F1.5071.00
284_R351_P1.4991.00
117_E148_Y1.4951.00
265_K381_V1.4891.00
272_N382_H1.4771.00
24_F28_R1.4761.00
268_L381_V1.4711.00
254_S258_L1.4671.00
164_D168_D1.4651.00
135_F252_V1.4571.00
63_R299_K1.4511.00
66_R301_F1.4501.00
125_R129_A1.4381.00
116_T120_K1.4171.00
272_N378_D1.4131.00
379_F382_H1.4101.00
325_P332_D1.4041.00
215_H219_F1.3761.00
107_H110_R1.3751.00
133_V136_E1.3691.00
53_E304_N1.3621.00
212_T215_H1.3621.00
268_L276_R1.3591.00
286_Y323_H1.3581.00
278_M337_E1.3521.00
49_M54_A1.3491.00
64_F299_K1.3451.00
199_E202_R1.3441.00
55_A316_L1.3371.00
125_R137_E1.3321.00
61_T64_F1.3231.00
188_P192_E1.2991.00
275_E337_E1.2911.00
27_N30_E1.2881.00
124_T383_Q1.2851.00
255_A380_L1.2841.00
277_E281_Q1.2671.00
35_D326_R1.2621.00
112_A374_K1.2621.00
131_E409_V1.2571.00
264_Y279_F1.2571.00
89_G93_I1.2541.00
118_E144_R1.2451.00
192_E196_V1.2391.00
250_F289_F1.2341.00
57_V61_T1.2331.00
126_W137_E1.2281.00
299_K310_K1.2131.00
325_P331_P1.2111.00
197_M200_D1.2081.00
327_L348_D1.2051.00
322_N351_P1.2041.00
87_M91_A1.2031.00
65_Q301_F1.1951.00
146_A244_I1.1941.00
26_K332_D1.1891.00
90_S93_I1.1831.00
279_F334_F1.1751.00
269_R381_V1.1671.00
279_F283_V1.1631.00
276_R381_V1.1601.00
267_W270_S1.1591.00
329_D335_R1.1571.00
259_H388_V1.1541.00
90_S94_H1.1511.00
116_T375_A1.1451.00
138_A251_L1.1301.00
257_A283_V1.1301.00
296_L311_G1.1301.00
281_Q349_M1.1271.00
120_K124_T1.1251.00
264_Y336_P1.1201.00
191_E195_E1.1191.00
366_E370_I1.1151.00
205_L219_F1.1141.00
276_R378_D1.1091.00
51_G326_R1.1061.00
123_V384_I1.1051.00
168_D186_A1.1011.00
259_H265_K1.0951.00
46_F315_L1.0941.00
109_K112_A1.0941.00
112_A116_T1.0891.00
37_F48_C1.0881.00
191_E234_A1.0831.00
181_W185_R1.0811.00
117_E121_A1.0801.00
123_V379_F1.0791.00
119_W141_I1.0771.00
230_S234_A1.0721.00
161_E189_R1.0711.00
83_A87_M1.0711.00
168_D182_K1.0681.00
394_H397_L1.0671.00
182_K186_A1.0631.00
50_T317_D1.0581.00
267_W271_G1.0571.00
47_I308_F1.0541.00
119_W379_F1.0541.00
200_D203_A1.0531.00
148_Y153_P1.0531.00
271_G275_E1.0511.00
231_R235_I1.0421.00
297_V312_T1.0371.00
264_Y337_E1.0371.00
115_M145_V1.0341.00
30_E325_P1.0331.00
112_A375_A1.0321.00
119_W123_V1.0301.00
262_P266_E1.0281.00
273_S382_H1.0271.00
187_R191_E1.0251.00
149_W368_I1.0251.00
161_E164_D1.0201.00
115_M371_E1.0181.00
268_L275_E1.0161.00
119_W375_A1.0131.00
261_H333_E1.0061.00
62_D65_Q1.0041.00
122_A141_I1.0031.00
54_A57_V0.9981.00
272_N276_R0.9981.00
189_R192_E0.9981.00
216_E219_F0.9941.00
62_D66_R0.9931.00
116_T378_D0.9921.00
322_N349_M0.9921.00
121_A144_R0.9901.00
57_V304_N0.9861.00
178_P182_K0.9861.00
160_K164_D0.9861.00
94_H232_M0.9851.00
124_T127_E0.9841.00
177_G180_H0.9841.00
121_A125_R0.9801.00
258_L268_L0.9781.00
121_A124_T0.9771.00
168_D171_D0.9731.00
259_H386_Y0.9711.00
296_L313_S0.9681.00
23_L26_K0.9681.00
160_K163_A0.9631.00
201_A215_H0.9631.00
143_C245_V0.9591.00
275_E278_M0.9561.00
53_E57_V0.9531.00
168_D172_A0.9501.00
138_A376_S0.9481.00
257_A260_E0.9481.00
114_L118_E0.9471.00
258_L264_Y0.9451.00
396_S406_S0.9451.00
52_A327_L0.9441.00
105_P109_K0.9411.00
253_F287_Y0.9411.00
91_A94_H0.9291.00
293_L318_L0.9281.00
104_T107_H0.9241.00
93_I97_M0.9221.00
277_E370_I0.9181.00
389_P392_S0.9161.00
325_P329_D0.9131.00
26_K320_G0.9111.00
301_F307_E0.9051.00
258_L265_K0.9041.00
297_V300_D0.9041.00
36_L54_A0.9031.00
152_V200_D0.9021.00
279_F336_P0.8971.00
108_Q371_E0.8961.00
255_A410_M0.8911.00
123_V383_Q0.8891.00
379_F383_Q0.8891.00
201_A204_G0.8881.00
188_P191_E0.8851.00
49_M55_A0.8851.00
369_T373_M0.8851.00
201_A205_L0.8841.00
91_A95_R0.8821.00
214_L237_L0.8801.00
164_D167_I0.8801.00
178_P181_W0.8771.00
132_V137_E0.8751.00
26_K29_T0.8741.00
53_E326_R0.8721.00
275_E336_P0.8721.00
189_R193_W0.8701.00
125_R140_E0.8691.00
378_D382_H0.8681.00
167_I171_D0.8641.00
28_R37_F0.8621.00
251_L373_M0.8611.00
396_S405_E0.8581.00
120_K383_Q0.8551.00
197_M201_A0.8541.00
165_D168_D0.8491.00
370_I374_K0.8441.00
141_I145_V0.8441.00
58_F316_L0.8421.00
221_T227_Q0.8361.00
163_A167_I0.8361.00
62_D301_F0.8351.00
263_K267_W0.8351.00
282_E285_R0.8331.00
53_E56_K0.8311.00
262_P385_E0.8301.00
29_T50_T0.8291.00
158_E161_E0.8271.00
45_N312_T0.8251.00
36_L306_C0.8241.00
274_R278_M0.8231.00
125_R128_K0.8221.00
250_F283_V0.8201.00
394_H399_R0.8191.00
112_A371_E0.8131.00
103_M364_P0.8111.00
345_N348_D0.8101.00
166_F170_V0.8091.00
38_Q47_I0.8081.00
124_T128_K0.8071.00
106_P110_R0.8031.00
91_A232_M0.8031.00
393_L397_L0.8011.00
228_L232_M0.8011.00
180_H184_R0.8011.00
113_E117_E0.8001.00
57_V301_F0.7981.00
99_F364_P0.7901.00
118_E153_P0.7851.00
73_R76_K0.7851.00
184_R188_P0.7841.00
202_R205_L0.7831.00
52_A56_K0.7781.00
35_D324_D0.7781.00
140_E144_R0.7751.00
55_A350_I0.7731.00
263_K266_E0.7721.00
308_F314_V0.7721.00
191_E231_R0.7711.00
83_A239_N0.7711.00
110_R211_G0.7691.00
177_G181_W0.7671.00
260_E388_V0.7671.00
191_E238_I0.7661.00
46_F313_S0.7651.00
186_A189_R0.7631.00
396_S399_R0.7611.00
44_K313_S0.7601.00
147_C154_L0.7601.00
374_K378_D0.7581.00
102_L216_E0.7561.00
262_P265_K0.7541.00
51_G304_N0.7521.00
134_L255_A0.7511.00
297_V309_K0.7501.00
211_G215_H0.7501.00
307_E310_K0.7471.00
58_F303_W0.7461.00
195_E231_R0.7461.00
136_E140_E0.7431.00
182_K185_R0.7401.00
393_L396_S0.7381.00
276_R374_K0.7381.00
142_L247_I0.7351.00
259_H410_M0.7351.00
255_A381_V0.7341.00
247_I372_V0.7331.00
145_V372_V0.7301.00
256_L388_V0.7261.00
162_R166_F0.7261.00
134_L410_M0.7231.00
375_A379_F0.7221.00
196_V199_E0.7211.00
389_P409_V0.7191.00
134_L138_A0.7181.00
180_H183_G0.7181.00
192_E195_E0.7161.00
99_F240_V0.7161.00
72_K75_Q0.7141.00
258_L279_F0.7131.00
264_Y335_R0.7121.00
297_V311_G0.7101.00
254_S334_F0.7081.00
60_D354_G0.7081.00
117_E153_P0.7071.00
202_R221_T0.7061.00
106_P109_K0.7061.00
65_Q298_K0.7011.00
250_F284_R0.6981.00
48_C317_D0.6961.00
39_A48_C0.6951.00
335_R341_E0.6941.00
275_E279_F0.6901.00
105_P367_G0.6901.00
209_T219_F0.6861.00
198_I202_R0.6841.00
168_D189_R0.6831.00
121_A153_P0.6831.00
194_I237_L0.6821.00
68_N298_K0.6821.00
254_S280_V0.6811.00
304_N307_E0.6811.00
115_M368_I0.6791.00
29_T48_C0.6761.00
41_L46_F0.6751.00
288_P322_N0.6721.00
221_T230_S0.6711.00
119_W376_S0.6711.00
332_D335_R0.6691.00
59_Y316_L0.6681.00
278_M336_P0.6651.00
193_W197_M0.6641.00
335_R338_R0.6641.00
258_L381_V0.6611.00
99_F236_E0.6611.00
340_A343_E0.6591.00
179_R183_G0.6571.00
184_R187_R0.6571.00
324_D327_L0.6571.00
262_P387_D0.6561.00
159_V162_R0.6541.00
354_G362_R0.6541.00
171_D174_G0.6531.00
87_M95_R0.6531.00
35_D304_N0.6511.00
22_Y319_Y0.6501.00
113_E116_T0.6491.00
221_T225_G0.6491.00
33_N37_F0.6471.00
126_W132_V0.6471.00
270_S273_S0.6471.00
96_K100_L0.6461.00
76_K81_V0.6431.00
255_A386_Y0.6431.00
317_D320_G0.6431.00
133_V409_V0.6421.00
57_V62_D0.6411.00
243_P246_A0.6401.00
193_W196_V0.6381.00
276_R377_L0.6381.00
318_L350_I0.6381.00
23_L27_N0.6371.00
159_V163_A0.6371.00
303_W308_F0.6361.00
284_R349_M0.6351.00
210_S215_H0.6331.00
108_Q368_I0.6311.00
92_H96_K0.6301.00
119_W122_A0.6291.00
294_G315_L0.6261.00
63_R66_R0.6261.00
298_K301_F0.6261.00
170_V173_F0.6261.00
28_R32_Y0.6221.00
56_K347_F0.6201.00
368_I372_V0.6191.00
330_H338_R0.6181.00
211_G216_E0.6171.00
170_V174_G0.6151.00
172_A175_A0.6151.00
122_A137_E0.6141.00
181_W184_R0.6131.00
297_V301_F0.6121.00
280_V370_I0.6101.00
21_G25_I0.6091.00
395_Y398_A0.6091.00
25_I29_T0.6071.00
222_Q225_G0.6071.00
255_A377_L0.6061.00
151_G212_T0.6051.00
162_R165_D0.6051.00
169_M172_A0.6051.00
286_Y332_D0.6031.00
39_A46_F0.6011.00
40_R43_G0.6001.00
335_R343_E0.6001.00
276_R279_F0.5991.00
159_V170_V0.5951.00
35_D38_Q0.5951.00
29_T35_D0.5931.00
257_A334_F0.5931.00
280_V374_K0.5901.00
268_L272_N0.5881.00
202_R222_Q0.5881.00
72_K76_K0.5871.00
59_Y318_L0.5861.00
29_T324_D0.5831.00
71_P74_V0.5821.00
236_E239_N0.5791.00
122_A126_W0.5791.00
144_R159_V0.5751.00
70_L73_R0.5721.00
133_V407_G0.5711.00
297_V310_K0.5711.00
163_A166_F0.5711.00
57_V303_W0.5701.00
89_G356_H0.5691.00
258_L261_H0.5681.00
159_V166_F0.5681.00
386_Y410_M0.5671.00
71_P76_K0.5651.00
297_V314_V0.5631.00
140_E160_K0.5631.00
337_E340_A0.5601.00
183_G186_A0.5591.00
288_P291_P0.5581.00
222_Q226_S0.5571.00
159_V165_D0.5571.00
38_Q312_T0.5561.00
125_R144_R0.5561.00
84_I236_E0.5551.00
171_D175_A0.5551.00
211_G219_F0.5541.00
298_K310_K0.5541.00
194_I197_M0.5531.00
117_E120_K0.5531.00
29_T33_N0.5511.00
83_A86_G0.5511.00
352_Q370_I0.5501.00
400_M404_P0.5491.00
37_F50_T0.5491.00
74_V77_S0.5471.00
138_A252_V0.5451.00
61_T65_Q0.5441.00
152_V197_M0.5441.00
329_D333_E0.5441.00
204_G210_S0.5421.00
142_L372_V0.5421.00
250_F280_V0.5421.00
107_H216_E0.5411.00
28_R31_R0.5401.00
137_E140_E0.5401.00
266_E273_S0.5371.00
84_I239_N0.5371.00
271_G276_R0.5371.00
395_Y399_R0.5361.00
404_P408_F0.5361.00
57_V302_V0.5351.00
29_T32_Y0.5351.00
185_R188_P0.5331.00
35_D50_T0.5321.00
30_E326_R0.5311.00
390_E394_H0.5301.00
68_N87_M0.5291.00
217_M233_A0.5291.00
381_V386_Y0.5281.00
294_G313_S0.5271.00
272_N381_V0.5271.00
328_W339_F0.5261.00
328_W331_P0.5261.00
50_T324_D0.5261.00
98_L220_H0.5261.00
347_F354_G0.5251.00
274_R277_E0.5251.00
139_K167_I0.5241.00
220_H224_D0.5231.00
55_A59_Y0.5231.00
400_M405_E0.5221.00
48_C315_L0.5191.00
119_W138_A0.5191.00
292_F315_L0.5191.00
53_E327_L0.5181.00
142_L146_A0.5171.00
212_T216_E0.5171.00
274_R341_E0.5161.00
216_E220_H0.5161.00
52_A324_D0.5161.00
232_M236_E0.5141.00
375_A378_D0.5141.00
278_M339_F0.5141.00
147_C241_L0.5141.00
191_E235_I0.5141.00
142_L248_S0.5131.00
183_G187_R0.5131.00
28_R39_A0.5111.00
56_K354_G0.5111.00
247_I369_T0.5111.00
54_A303_W0.5091.00
143_C147_C0.5081.00
52_A348_D0.5081.00
328_W347_F0.5081.00
131_E135_F0.5061.00
103_M240_V0.5061.00
21_G24_F0.5051.00
115_M375_A0.5031.00
60_D63_R0.5031.00
107_H111_L0.5021.00
64_F301_F0.5011.00
156_E193_W0.5011.00
257_A264_Y0.5011.00
179_R182_K0.5001.00
143_C241_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1izoA 1 0.9856 100 0.16 Contact Map
4l54A 1 0.9784 100 0.187 Contact Map
3awmA 1 0.9664 100 0.189 Contact Map
4lxjA 1 0.9856 100 0.208 Contact Map
2ve3A 1 0.9688 100 0.209 Contact Map
2cibA 1 0.9113 100 0.216 Contact Map
3dbgA 1 0.8513 100 0.218 Contact Map
4r21A 1 0.9281 100 0.223 Contact Map
3czhA 2 0.9856 100 0.225 Contact Map
4g3jA 1 0.9784 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.