GREMLIN Database
YBDM - Probable serine/threonine-protein kinase YbdM
UniProt: O31435 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (223)
Sequences: 94843 (58256)
Seq/√Len: 3901.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_I165_I3.1041.00
41_L50_P3.0961.00
130_I196_L3.0711.00
29_E41_L2.7801.00
30_C38_L2.5351.00
189_F231_L2.4851.00
42_C51_Y2.3721.00
42_C53_L2.3451.00
138_E242_A2.3211.00
230_R239_Q2.3151.00
138_E142_D2.3081.00
123_E221_T2.2671.00
44_D47_A2.2201.00
230_R247_D2.1731.00
81_H87_G2.1231.00
231_L244_I2.1171.00
30_C33_M2.1131.00
111_E153_P2.0991.00
132_Q162_L2.0491.00
26_K45_I2.0341.00
158_N161_R2.0121.00
82_H139_Y2.0101.00
132_Q161_R1.9921.00
134_L192_L1.9241.00
133_L155_I1.9031.00
26_K43_T1.8941.00
137_I192_L1.8901.00
103_Q163_C1.8871.00
155_I162_L1.8861.00
41_L104_F1.8741.00
193_G231_L1.8491.00
122_T125_M1.7651.00
28_E43_T1.7641.00
89_I103_Q1.7531.00
43_T50_P1.7051.00
109_N112_E1.6801.00
158_N163_C1.6591.00
174_T187_D1.6511.00
24_Q44_D1.6481.00
87_G103_Q1.6171.00
30_C40_Y1.5391.00
150_I195_T1.5371.00
137_I241_T1.5191.00
126_A200_L1.4821.00
130_I199_L1.4811.00
137_I150_I1.4611.00
138_E245_R1.4461.00
134_L244_I1.4461.00
189_F241_T1.4311.00
135_E245_R1.4301.00
84_Q136_I1.4281.00
53_L101_V1.4261.00
43_T48_Q1.4221.00
240_H243_S1.4041.00
128_Q132_Q1.4031.00
28_E41_L1.3971.00
130_I192_L1.3921.00
227_L247_D1.3841.00
200_L224_V1.3821.00
226_L247_D1.3811.00
33_M38_L1.3731.00
142_D242_A1.3621.00
84_Q135_E1.3611.00
239_Q247_D1.3571.00
105_I158_N1.3521.00
49_T89_I1.3441.00
145_I170_A1.3331.00
136_I164_L1.3301.00
111_E115_F1.3211.00
131_S135_E1.3031.00
155_I195_T1.2861.00
129_L162_L1.2771.00
239_Q244_I1.2721.00
225_T229_K1.2621.00
55_Q97_Q1.2581.00
227_L239_Q1.2541.00
196_L227_L1.2521.00
148_S183_V1.2471.00
126_A199_L1.2461.00
105_I163_C1.2331.00
114_L198_F1.2221.00
141_H241_T1.2141.00
214_W217_E1.2121.00
134_L245_R1.2101.00
139_Y143_R1.1841.00
51_Y101_V1.1831.00
228_L232_L1.1781.00
39_V52_V1.1761.00
241_T244_I1.1761.00
152_T195_T1.1651.00
131_S245_R1.1581.00
134_L241_T1.1531.00
111_E198_F1.1521.00
79_N172_Q1.1461.00
149_D154_N1.1441.00
50_P104_F1.1431.00
198_F204_Y1.1431.00
55_Q99_Y1.1141.00
27_I40_Y1.1051.00
152_T198_F1.0901.00
53_L99_Y1.0851.00
147_H150_I1.0711.00
227_L231_L1.0671.00
133_L162_L1.0671.00
194_E232_L1.0661.00
51_Y89_I1.0651.00
227_L244_I1.0651.00
177_E187_D1.0561.00
40_Y55_Q1.0551.00
105_I156_I1.0541.00
174_T177_E1.0521.00
226_L230_R1.0481.00
157_I162_L1.0421.00
108_E165_I1.0391.00
88_F91_E1.0361.00
186_Q240_H1.0351.00
86_P165_I1.0221.00
76_L170_A1.0191.00
230_R233_G1.0171.00
92_F99_Y1.0151.00
86_P102_M1.0151.00
58_P93_I1.0141.00
79_N143_R1.0001.00
192_L231_L0.9941.00
154_N166_D0.9911.00
52_V104_F0.9891.00
28_E50_P0.9871.00
144_L185_K0.9861.00
67_K71_Q0.9821.00
50_P106_E0.9691.00
86_P105_I0.9661.00
128_Q161_R0.9631.00
194_E204_Y0.9631.00
135_E138_E0.9621.00
113_L121_F0.9611.00
138_E241_T0.9581.00
92_F101_V0.9541.00
233_G239_Q0.9511.00
183_V187_D0.9501.00
113_L157_I0.9421.00
230_R243_S0.9331.00
133_L195_T0.9291.00
31_L104_F0.9281.00
145_I172_Q0.9231.00
85_I140_L0.9161.00
77_L88_F0.9031.00
44_D49_T0.8951.00
71_Q75_K0.8931.00
192_L241_T0.8861.00
81_H139_Y0.8841.00
105_I165_I0.8801.00
243_S246_E0.8751.00
125_M128_Q0.8741.00
25_Y90_D0.8721.00
151_R154_N0.8711.00
150_I164_L0.8701.00
107_G160_G0.8661.00
27_I42_C0.8641.00
88_F100_Y0.8591.00
133_L150_I0.8581.00
177_E183_V0.8561.00
109_N153_P0.8531.00
121_F129_L0.8471.00
194_E198_F0.8411.00
140_L167_F0.8401.00
84_Q161_R0.8371.00
108_E112_E0.8361.00
113_L125_M0.8331.00
197_L201_Y0.8321.00
231_L239_Q0.8321.00
137_I141_H0.8321.00
84_Q132_Q0.8311.00
80_I145_I0.8271.00
193_G232_L0.8261.00
129_L157_I0.8201.00
192_L196_L0.8061.00
200_L220_L0.8001.00
203_Q207_K0.7991.00
114_L199_L0.7981.00
123_E126_A0.7961.00
190_F232_L0.7941.00
214_W225_T0.7821.00
222_K226_L0.7781.00
151_R166_D0.7751.00
38_L57_R0.7741.00
74_I91_E0.7721.00
242_A246_E0.7711.00
186_Q237_E0.7701.00
189_F244_I0.7631.00
108_E113_L0.7631.00
80_I139_Y0.7621.00
133_L192_L0.7621.00
190_F194_E0.7601.00
38_L55_Q0.7591.00
194_E197_L0.7591.00
111_E152_T0.7571.00
139_Y142_D0.7571.00
42_C101_V0.7571.00
140_L145_I0.7561.00
77_L102_M0.7541.00
197_L232_L0.7531.00
125_M160_G0.7491.00
127_L224_V0.7491.00
222_K225_T0.7481.00
34_G37_G0.7441.00
241_T245_R0.7421.00
24_Q46_L0.7401.00
25_Y101_V0.7361.00
213_T217_E0.7341.00
213_T216_E0.7321.00
82_H135_E0.7291.00
32_G39_V0.7291.00
216_E225_T0.7271.00
194_E205_K0.7231.00
176_E187_D0.7201.00
133_L136_I0.7191.00
24_Q90_D0.7181.00
126_A196_L0.7171.00
88_F102_M0.7131.00
80_I140_L0.7121.00
72_Q75_K0.7111.00
189_F239_Q0.7071.00
193_G228_L0.7041.00
108_E117_R0.7001.00
75_K78_K0.6991.00
83_P161_R0.6921.00
33_M57_R0.6891.00
32_G52_V0.6801.00
76_L145_I0.6791.00
239_Q243_S0.6751.00
44_D48_Q0.6721.00
106_E158_N0.6711.00
85_I139_Y0.6711.00
82_H85_I0.6641.00
113_L129_L0.6601.00
229_K233_G0.6581.00
123_E127_L0.6571.00
71_Q93_I0.6551.00
190_F233_G0.6521.00
74_I78_K0.6521.00
148_S171_K0.6511.00
134_L189_F0.6511.00
197_L228_L0.6471.00
105_I157_I0.6471.00
220_L224_V0.6451.00
83_P135_E0.6441.00
173_L185_K0.6411.00
28_E42_C0.6351.00
110_I199_L0.6341.00
110_I195_T0.6301.00
118_K125_M0.6221.00
34_G52_V0.6211.00
27_I55_Q0.6211.00
214_W218_L0.6131.00
196_L224_V0.6131.00
22_N25_Y0.6131.00
141_H188_D0.6111.00
122_T126_A0.6111.00
174_T178_M0.6111.00
192_L244_I0.6101.00
94_I97_Q0.6071.00
121_F126_A0.6071.00
197_L206_G0.6071.00
179_E234_I0.6041.00
105_I108_E0.6021.00
87_G163_C0.6011.00
204_Y207_K0.5991.00
68_V71_Q0.5991.00
187_D191_D0.5991.00
141_H185_K0.5961.00
221_T224_V0.5961.00
27_I53_L0.5931.00
132_Q135_E0.5931.00
44_D51_Y0.5901.00
58_P61_A0.5881.00
76_L172_Q0.5881.00
93_I98_A0.5861.00
49_T87_G0.5861.00
25_Y51_Y0.5861.00
107_G158_N0.5831.00
196_L228_L0.5811.00
27_I30_C0.5811.00
74_I88_F0.5801.00
75_K79_N0.5741.00
103_Q158_N0.5641.00
47_A78_K0.5611.00
140_L164_L0.5611.00
66_E69_R0.5591.00
73_E77_L0.5591.00
129_L199_L0.5561.00
67_K93_I0.5561.00
197_L205_K0.5541.00
104_F108_E0.5531.00
220_L225_T0.5501.00
124_L127_L0.5501.00
56_L70_F0.5491.00
54_K73_E0.5481.00
90_D101_V0.5421.00
108_E156_I0.5411.00
123_E200_L0.5391.00
72_Q76_L0.5391.00
243_S247_D0.5381.00
129_L155_I0.5371.00
189_F193_G0.5361.00
129_L133_L0.5351.00
123_E220_L0.5331.00
114_L152_T0.5321.00
244_I247_D0.5321.00
54_K166_D0.5311.00
68_V72_Q0.5301.00
37_G56_L0.5301.00
146_F183_V0.5301.00
226_L229_K0.5291.00
86_P163_C0.5271.00
217_E220_L0.5241.00
130_I137_I0.5231.00
146_F185_K0.5221.00
146_F184_R0.5191.00
149_D166_D0.5181.00
85_I167_F0.5181.00
126_A130_I0.5171.00
127_L131_S0.5171.00
213_T229_K0.5161.00
73_E76_L0.5121.00
215_L218_L0.5061.00
225_T228_L0.5061.00
85_I136_I0.5051.00
24_Q45_I0.5051.00
146_F187_D0.5041.00
65_K68_V0.5031.00
123_E224_V0.5031.00
223_E226_L0.5011.00
57_R60_K0.5001.00
58_P94_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lqsA 1 0.9336 100 0.177 Contact Map
3zonA 1 0.8906 100 0.18 Contact Map
4c0tA 1 0.9219 100 0.187 Contact Map
4oliA 1 0.9062 100 0.19 Contact Map
4e5wA 2 0.9531 100 0.19 Contact Map
4dc2A 1 0.9062 100 0.191 Contact Map
3cblA 1 0.9883 100 0.195 Contact Map
4fl3A 1 0.9688 100 0.195 Contact Map
4qoxA 1 0.9648 100 0.196 Contact Map
4aszA 1 0.9336 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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