GREMLIN Database
SKFG - Uncharacterized protein SkfG
UniProt: O31429 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (143)
Sequences: 13036 (10336)
Seq/√Len: 864.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_R109_E2.7451.00
47_E51_L2.6411.00
103_V121_C2.5061.00
109_E114_S2.4841.00
17_N22_T2.2021.00
150_A153_A2.1641.00
102_F105_K2.1001.00
73_L91_S2.0651.00
79_S84_T2.0571.00
53_N57_A1.9291.00
144_H149_V1.9031.00
25_Q28_G1.8891.00
14_N22_T1.8691.00
106_I118_A1.8431.00
76_L88_A1.8191.00
54_I57_A1.7791.00
28_G54_I1.6921.00
40_V44_A1.6351.00
23_I47_E1.6351.00
40_V43_E1.6331.00
57_A61_E1.6291.00
14_N29_E1.6261.00
149_V153_A1.5831.00
25_Q29_E1.5811.00
72_E75_C1.5461.00
71_E75_C1.5381.00
24_V28_G1.5331.00
137_C142_H1.5051.00
23_I27_I1.4961.00
21_I24_V1.4851.00
128_S131_E1.4741.00
135_Y139_K1.4531.00
43_E46_K1.4031.00
61_E64_E1.3971.00
144_H150_A1.3741.00
86_M117_W1.3691.00
90_I94_R1.3661.00
86_M90_I1.3501.00
17_N26_A1.3201.00
101_P105_K1.3151.00
14_N17_N1.3011.00
14_N26_A1.2941.00
112_G116_F1.2941.00
146_S150_A1.2851.00
108_Q140_Y1.2831.00
139_K142_H1.2761.00
68_E71_E1.2601.00
76_L79_S1.2461.00
90_I93_M1.2311.00
83_D86_M1.2081.00
93_M96_G1.1991.00
42_V46_K1.1991.00
123_A126_D1.1931.00
56_A60_G1.1821.00
90_I117_W1.1811.00
52_C55_A1.1781.00
41_L58_V1.1771.00
16_A43_E1.1651.00
21_I25_Q1.1541.00
117_W120_W1.1541.00
136_K140_Y1.1531.00
115_C144_H1.1491.00
19_N22_T1.1401.00
93_M120_W1.1401.00
115_C118_A1.1351.00
75_C78_K1.1321.00
148_I151_P1.1281.00
102_F106_I1.1191.00
22_T25_Q1.1061.00
105_K108_Q1.0961.00
89_A93_M1.0931.00
20_E24_V1.0891.00
145_P150_A1.0801.00
82_E86_M1.0711.00
147_G150_A1.0631.00
129_C132_P1.0561.00
145_P148_I1.0551.00
139_K143_E1.0541.00
135_Y141_E1.0501.00
121_C125_I1.0461.00
87_A90_I1.0371.00
54_I58_V1.0341.00
135_Y140_Y1.0151.00
106_I109_E1.0141.00
74_S78_K1.0131.00
120_W124_W1.0101.00
36_D39_P1.0031.00
147_G151_P0.9991.00
16_A40_V0.9961.00
33_S36_D0.9961.00
45_L59_L0.9931.00
24_V27_I0.9901.00
100_L103_V0.9801.00
84_T87_A0.9731.00
28_G31_K0.9671.00
11_S29_E0.9641.00
28_G32_K0.9581.00
134_M141_E0.9561.00
106_I114_S0.9551.00
116_F119_S0.9431.00
31_K58_V0.9401.00
107_A118_A0.9361.00
113_Q116_F0.9351.00
78_K105_K0.9321.00
27_I31_K0.9271.00
20_E49_G0.9231.00
58_V61_E0.9021.00
79_S88_A0.8931.00
13_Q16_A0.8861.00
55_A58_V0.8801.00
20_E23_I0.8701.00
134_M142_H0.8671.00
52_C79_S0.8651.00
148_I152_F0.8631.00
57_A87_A0.8531.00
82_E111_E0.8481.00
144_H153_A0.8461.00
119_S123_A0.8361.00
12_V16_A0.8211.00
72_E76_L0.8141.00
57_A60_G0.8131.00
85_R89_A0.8121.00
88_A92_L0.7961.00
53_N87_A0.7941.00
79_S85_R0.7921.00
133_K142_H0.7901.00
22_T29_E0.7831.00
33_S39_P0.7821.00
78_K102_F0.7801.00
80_H84_T0.7791.00
60_G63_G0.7751.00
116_F120_W0.7751.00
61_E65_D0.7651.00
117_W121_C0.7631.00
16_A19_N0.7621.00
148_I153_A0.7541.00
81_A84_T0.7451.00
24_V54_I0.7431.00
20_E25_Q0.7421.00
25_Q32_K0.7371.00
111_E114_S0.7361.00
46_K72_E0.7271.00
133_K136_K0.7251.00
146_S149_V0.7181.00
89_A106_I0.7161.00
29_E32_K0.7161.00
51_L54_I0.7081.00
110_S114_S0.6941.00
115_C119_S0.6931.00
136_K142_H0.6911.00
98_P102_F0.6841.00
100_L106_I0.6821.00
141_E144_H0.6811.00
17_N21_I0.6751.00
36_D48_E0.6731.00
26_A29_E0.6651.00
104_I108_Q0.6651.00
60_G94_R0.6641.00
93_M124_W0.6621.00
70_A74_S0.6611.00
24_V32_K0.6611.00
68_E72_E0.6601.00
126_D129_C0.6591.00
14_N27_I0.6591.00
60_G65_D0.6581.00
103_V118_A0.6551.00
137_C140_Y0.6541.00
89_A103_V0.6521.00
16_A31_K0.6511.00
22_T27_I0.6491.00
15_L19_N0.6471.00
50_S53_N0.6461.00
27_I30_L0.6431.00
87_A91_S0.6251.00
120_W123_A0.6191.00
44_A51_L0.6131.00
60_G90_I0.6111.00
44_A55_A0.6001.00
139_K145_P0.6001.00
20_E27_I0.5921.00
15_L30_L0.5901.00
48_E52_C0.5761.00
136_K144_H0.5671.00
149_V152_F0.5631.00
48_E51_L0.5621.00
114_S117_W0.5601.00
134_M139_K0.5551.00
117_W126_D0.5521.00
109_E115_C0.5481.00
56_A88_A0.5481.00
141_E150_A0.5471.00
140_Y144_H0.5411.00
89_A118_A0.5391.00
126_D130_I0.5391.00
18_T25_Q0.5331.00
23_I26_A0.5301.00
96_G99_S0.5291.00
97_K132_P0.5281.00
135_Y145_P0.5281.00
82_E85_R0.5281.00
16_A20_E0.5261.00
25_Q31_K0.5241.00
142_H145_P0.5231.00
20_E30_L0.5221.00
145_P149_V0.5211.00
46_K75_C0.5161.00
14_N18_T0.5111.00
96_G126_D0.5091.00
18_T21_I0.5071.00
37_A40_V0.5071.00
76_L84_T0.5071.00
19_N25_Q0.5061.00
56_A91_S0.5041.00
44_A58_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lacA 1 0.9825 99.5 0.362 Contact Map
4qmiA 1 0.9942 99.5 0.372 Contact Map
4g3aA 1 0.9942 99.4 0.399 Contact Map
4qmhA 1 0.9942 99.4 0.402 Contact Map
2qk2A 1 0.9942 99.4 0.409 Contact Map
1wa5B 1 0.9649 99.4 0.423 Contact Map
3tpoA 1 0.9942 99.4 0.424 Contact Map
1b3uA 1 0.9942 99.3 0.437 Contact Map
1u6gC 1 0.9532 99.3 0.439 Contact Map
3ltmA 1 0.8889 99.3 0.441 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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