GREMLIN Database
SKFB - Uncharacterized protein SkfB
UniProt: O31423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (353)
Sequences: 1985 (1722)
Seq/√Len: 91.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_D230_K7.5111.00
119_L190_L6.0301.00
220_D227_G5.1271.00
194_D238_K4.9611.00
198_E242_A4.3761.00
193_R196_E3.8251.00
118_N188_N3.5481.00
347_Y360_H3.5341.00
140_Q362_L3.3631.00
216_D220_D3.3121.00
137_S140_Q3.1051.00
138_S171_E3.0601.00
229_F266_Q2.9841.00
136_L140_Q2.9511.00
213_D223_R2.8301.00
215_M218_T2.7981.00
237_K270_A2.7011.00
146_Q175_V2.6361.00
347_Y357_P2.6231.00
360_H363_E2.6221.00
222_L253_N2.6111.00
219_H228_G2.5701.00
333_C351_C2.4681.00
142_I175_V2.4481.00
149_A179_L2.3551.00
199_L203_L2.3011.00
189_G210_I2.2151.00
116_A135_E2.2011.00
343_R347_Y2.1841.00
170_K199_L2.1581.00
158_L183_V2.1131.00
143_L362_L2.0551.00
214_G223_R2.0281.00
303_I306_R1.9761.00
136_L141_W1.9591.00
159_T352_Q1.9551.00
197_V239_L1.9381.00
146_Q179_L1.9251.00
141_W172_L1.8891.00
365_S368_D1.8581.00
123_F213_D1.8561.00
211_S251_T1.8371.00
177_S203_L1.8261.00
197_V238_K1.8231.00
134_E345_D1.8131.00
198_E202_H1.8071.00
115_N344_A1.7871.00
113_L169_F1.7631.00
371_S374_R1.7611.00
259_E262_D1.7601.00
306_R310_H1.7161.00
174_V199_L1.7031.00
221_Q255_S1.6981.00
143_L147_K1.6791.00
218_T259_E1.6741.00
118_N191_N1.6571.00
142_I171_E1.6561.00
138_S142_I1.6481.00
233_M270_A1.6191.00
109_C148_L1.6111.00
248_V267_C1.5891.00
74_K78_S1.5861.00
135_E166_I1.5491.00
126_A251_T1.5431.00
164_K185_V1.5431.00
214_G229_F1.5371.00
159_T186_F1.5051.00
293_L296_D1.4981.00
237_K241_E1.4931.00
228_G232_S1.4861.00
375_L378_L1.4541.00
190_L231_E1.4230.99
233_M237_K1.4150.99
174_V178_S1.4010.99
195_E198_E1.3880.99
303_I307_E1.3840.99
238_K241_E1.3730.99
192_W239_L1.3690.99
126_A211_S1.3630.99
343_R349_T1.3560.99
196_E200_L1.3530.99
123_F159_T1.3500.99
46_L49_K1.3430.99
385_C389_G1.3410.99
148_L156_I1.3400.99
208_V239_L1.3310.99
234_N238_K1.3230.99
194_D242_A1.3190.99
177_S202_H1.3160.99
175_V179_L1.3110.99
72_Q76_E1.3030.99
197_V208_V1.3000.99
171_E174_V1.2840.99
376_L380_C1.2760.99
164_K196_E1.2760.99
153_V180_F1.2690.99
60_W68_M1.2620.99
378_L381_E1.2610.99
45_F48_S1.2560.99
232_S235_T1.2420.98
123_F222_L1.2360.98
142_I146_Q1.2350.98
199_L202_H1.2270.98
385_C388_I1.2260.98
118_N162_E1.2220.98
141_W166_I1.2090.98
60_W63_M1.2060.98
173_V176_A1.2050.98
59_I62_I1.2010.98
77_L80_H1.2000.98
383_K386_K1.1970.98
186_F352_Q1.1960.98
63_M67_E1.1950.98
189_G236_I1.1940.98
60_W64_K1.1930.98
292_A296_D1.1920.98
159_T249_A1.1860.98
123_F186_F1.1860.98
209_Q249_A1.1790.98
359_G364_D1.1760.98
215_M259_E1.1640.98
194_D198_E1.1570.97
168_G171_E1.1520.97
220_D223_R1.1470.97
43_L47_L1.1320.97
60_W65_K1.1070.97
236_I248_V1.1000.97
173_V199_L1.0990.97
385_C394_S1.0980.97
164_K191_N1.0920.96
201_S242_A1.0900.96
117_C124_C1.0900.96
370_G379_K1.0870.96
111_L141_W1.0730.96
374_R378_L1.0700.96
377_Q380_C1.0700.96
117_C121_C1.0690.96
57_A61_E1.0680.96
375_L379_K1.0680.96
62_I65_K1.0680.96
162_E188_N1.0640.96
201_S243_N1.0600.96
219_H223_R1.0580.96
173_V203_L1.0540.96
233_M266_Q1.0530.96
383_K387_C1.0490.96
121_C124_C1.0460.95
385_C390_K1.0440.95
197_V235_T1.0430.95
354_E357_P1.0360.95
197_V242_A1.0280.95
45_F49_K1.0280.95
147_K151_H1.0270.95
114_T135_E1.0270.95
194_D197_V1.0250.95
298_E302_Q1.0220.95
118_N190_L1.0220.95
74_K77_L1.0200.95
248_V275_F1.0180.95
212_I248_V1.0170.95
220_D228_G1.0160.95
76_E80_H1.0140.95
112_Q159_T1.0070.94
45_F52_N1.0070.94
215_M262_D1.0040.94
119_L228_G0.9990.94
48_S51_K0.9950.94
109_C342_I0.9910.94
376_L379_K0.9890.94
173_V183_V0.9870.94
144_V342_I0.9850.94
304_Q308_A0.9720.93
44_A47_L0.9700.93
296_D299_E0.9680.93
145_M179_L0.9550.93
373_A376_L0.9540.93
216_D229_F0.9530.93
266_Q270_A0.9520.93
56_T63_M0.9510.93
350_P356_L0.9500.92
249_A352_Q0.9470.92
76_E83_T0.9460.92
113_L158_L0.9450.92
169_F185_V0.9350.92
47_L50_N0.9330.92
73_L76_E0.9300.92
190_L227_G0.9270.92
59_I68_M0.9190.91
254_E293_L0.9160.91
62_I69_S0.9150.91
175_V178_S0.9140.91
145_M158_L0.9110.91
147_K348_V0.9100.91
53_L60_W0.9100.91
110_T157_T0.9100.91
57_A60_W0.9100.91
375_L381_E0.9090.91
223_R227_G0.9080.91
113_L166_I0.9060.91
265_E268_A0.9040.91
192_W196_E0.9020.90
231_E234_N0.9000.90
136_L144_V0.8980.90
140_Q143_L0.8970.90
251_T352_Q0.8960.90
123_F228_G0.8960.90
314_D318_I0.8960.90
292_A295_I0.8950.90
211_S352_Q0.8920.90
250_M267_C0.8920.90
158_L173_V0.8890.90
63_M68_M0.8880.90
304_Q314_D0.8880.90
125_Y353_L0.8870.90
125_Y398_L0.8860.90
126_A159_T0.8860.90
290_F294_D0.8850.90
186_F249_A0.8850.90
186_F353_L0.8840.90
234_N237_K0.8820.89
212_I229_F0.8800.89
46_L50_N0.8800.89
262_D265_E0.8750.89
157_T352_Q0.8740.89
164_K235_T0.8720.89
119_L223_R0.8680.89
185_V208_V0.8670.89
340_W348_V0.8660.89
174_V203_L0.8660.89
197_V201_S0.8660.89
113_L141_W0.8660.89
385_C391_I0.8630.88
114_T166_I0.8620.88
118_N227_G0.8610.88
250_M275_F0.8570.88
76_E82_F0.8570.88
388_I394_S0.8530.88
342_I348_V0.8520.88
283_V286_A0.8460.87
80_H89_G0.8450.87
56_T60_W0.8440.87
302_Q306_R0.8390.87
59_I63_M0.8350.87
223_R228_G0.8350.87
43_L46_L0.8280.86
231_E235_T0.8220.86
123_F249_A0.8210.86
291_K294_D0.8190.86
264_V268_A0.8180.86
147_K152_G0.8170.85
219_H359_G0.8160.85
158_L172_L0.8120.85
112_Q115_N0.8070.85
59_I67_E0.8050.85
57_A63_M0.8010.84
265_E269_N0.7970.84
238_K242_A0.7960.84
43_L51_K0.7930.84
112_Q341_Y0.7930.84
64_K68_M0.7930.84
48_S52_N0.7910.84
128_S285_R0.7910.84
208_V244_I0.7900.83
108_S157_T0.7880.83
186_F209_Q0.7840.83
194_D241_E0.7800.83
126_A253_N0.7800.83
50_N57_A0.7800.83
164_K229_F0.7790.83
212_I266_Q0.7770.82
212_I219_H0.7740.82
56_T306_R0.7720.82
191_N197_V0.7720.82
373_A379_K0.7710.82
46_L51_K0.7700.82
373_A378_L0.7700.82
156_I176_A0.7700.82
212_I233_M0.7680.82
301_V305_L0.7680.82
56_T59_I0.7660.82
397_D400_F0.7650.81
112_Q251_T0.7600.81
50_N53_L0.7560.81
229_F267_C0.7500.80
299_E302_Q0.7490.80
125_Y209_Q0.7490.80
157_T186_F0.7490.80
63_M66_E0.7480.80
257_A296_D0.7450.80
211_S336_G0.7430.80
212_I275_F0.7410.79
260_V277_A0.7390.79
75_E79_A0.7350.79
295_I298_E0.7320.79
59_I64_K0.7300.78
176_A183_V0.7300.78
125_Y251_T0.7300.78
184_N209_Q0.7280.78
93_Q97_V0.7270.78
263_V267_C0.7270.78
46_L56_T0.7260.78
375_L380_C0.7240.78
71_D74_K0.7230.78
53_L59_I0.7210.78
339_A352_Q0.7200.77
334_T352_Q0.7200.77
384_N387_C0.7190.77
47_L52_N0.7180.77
298_E309_R0.7170.77
46_L52_N0.7160.77
335_P399_P0.7140.77
214_G224_G0.7140.77
185_V206_V0.7130.77
145_M176_A0.7070.76
276_R280_T0.7010.76
351_C398_L0.7010.76
75_E78_S0.6960.75
51_K56_T0.6950.75
138_S168_G0.6950.75
109_C340_W0.6940.75
185_V200_L0.6920.75
110_T352_Q0.6910.74
49_K52_N0.6910.74
352_Q397_D0.6900.74
373_A377_Q0.6890.74
341_Y352_Q0.6870.74
203_L206_V0.6850.74
158_L176_A0.6820.74
110_T123_F0.6790.73
123_F223_R0.6790.73
364_D368_D0.6780.73
372_P376_L0.6760.73
110_T159_T0.6760.73
112_Q125_Y0.6740.73
112_Q344_A0.6710.72
370_G373_A0.6700.72
249_A335_P0.6680.72
364_D369_I0.6680.72
173_V205_N0.6680.72
60_W66_E0.6670.72
170_K195_E0.6660.72
112_Q123_F0.6640.72
239_L242_A0.6620.71
212_I236_I0.6620.71
214_G232_S0.6600.71
177_S204_G0.6600.71
216_D219_H0.6580.71
96_H100_S0.6580.71
70_A76_E0.6570.71
266_Q269_N0.6570.71
254_E296_D0.6550.71
119_L158_L0.6540.70
123_F126_A0.6540.70
109_C348_V0.6520.70
125_Y352_Q0.6510.70
141_W145_M0.6490.70
217_N221_Q0.6480.70
298_E301_V0.6460.69
122_S222_L0.6460.69
47_L51_K0.6460.69
158_L206_V0.6440.69
366_M370_G0.6420.69
76_E89_G0.6420.69
62_I67_E0.6410.69
219_H227_G0.6410.69
299_E303_I0.6380.69
155_D184_N0.6350.68
372_P375_L0.6330.68
210_I236_I0.6320.68
43_L53_L0.6320.68
123_F352_Q0.6310.68
76_E79_A0.6310.68
116_A133_P0.6300.68
164_K219_H0.6290.67
159_T251_T0.6290.67
192_W208_V0.6270.67
126_A350_P0.6260.67
219_H232_S0.6260.67
336_G350_P0.6240.67
267_C272_A0.6240.67
251_T339_A0.6220.67
47_L56_T0.6210.66
239_L244_I0.6210.66
374_R379_K0.6180.66
274_I315_R0.6180.66
278_G281_L0.6150.66
56_T64_K0.6150.66
134_E344_A0.6140.66
268_A314_D0.6140.66
59_I69_S0.6140.66
50_N59_I0.6130.65
52_N58_R0.6100.65
358_L375_L0.6100.65
210_I232_S0.6100.65
112_Q353_L0.6090.65
65_K68_M0.6090.65
50_N58_R0.6090.65
81_P89_G0.6050.64
368_D371_S0.6050.64
141_W175_V0.6010.64
346_G360_H0.6000.64
43_L49_K0.5970.63
166_I172_L0.5960.63
56_T68_M0.5930.63
213_D251_T0.5930.63
224_G227_G0.5920.63
46_L58_R0.5920.63
158_L209_Q0.5910.63
191_N235_T0.5910.63
198_E238_K0.5890.62
209_Q278_G0.5880.62
125_Y159_T0.5860.62
261_S264_V0.5860.62
167_K170_K0.5850.62
117_C161_G0.5820.61
158_L166_I0.5820.61
183_V205_N0.5810.61
125_Y397_D0.5800.61
126_A249_A0.5800.61
237_K240_S0.5770.61
295_I299_E0.5750.61
126_A353_L0.5750.61
251_T334_T0.5750.61
214_G228_G0.5740.60
83_T88_E0.5730.60
116_A166_I0.5730.60
321_W325_E0.5730.60
167_K171_E0.5730.60
43_L50_N0.5710.60
45_F50_N0.5710.60
367_A371_S0.5680.60
211_S249_A0.5680.60
349_T357_P0.5670.59
96_H99_G0.5650.59
141_W158_L0.5650.59
265_E314_D0.5640.59
198_E201_S0.5630.59
52_N65_K0.5630.59
188_N191_N0.5630.59
140_Q144_V0.5630.59
332_F353_L0.5620.59
245_P354_E0.5620.59
249_A397_D0.5610.59
211_S232_S0.5600.59
115_N343_R0.5590.58
357_P360_H0.5570.58
188_N227_G0.5560.58
138_S174_V0.5550.58
121_C161_G0.5540.58
146_Q149_A0.5530.58
252_I320_D0.5530.58
51_K64_K0.5490.57
67_E70_A0.5490.57
107_I110_T0.5440.56
374_R381_E0.5430.56
48_S60_W0.5430.56
371_S375_L0.5420.56
95_L98_S0.5410.56
159_T209_Q0.5410.56
115_N126_A0.5390.56
159_T166_I0.5390.56
45_F64_K0.5380.56
157_T184_N0.5370.55
124_C161_G0.5370.55
264_V267_C0.5370.55
332_F339_A0.5370.55
46_L53_L0.5360.55
43_L69_S0.5350.55
79_A145_M0.5350.55
138_S146_Q0.5340.55
162_E333_C0.5330.55
72_Q81_P0.5320.55
188_N351_C0.5310.55
46_L60_W0.5310.55
97_V100_S0.5300.54
224_G228_G0.5300.54
249_A278_G0.5290.54
162_E165_L0.5270.54
136_L147_K0.5270.54
337_Y371_S0.5270.54
43_L306_R0.5260.54
103_S355_D0.5260.54
214_G336_G0.5250.54
157_T353_L0.5250.54
94_P98_S0.5250.54
78_S85_A0.5240.54
189_G396_P0.5240.54
278_G284_G0.5230.53
119_L227_G0.5220.53
49_K56_T0.5220.53
47_L58_R0.5220.53
85_A88_E0.5210.53
48_S77_L0.5210.53
140_Q147_K0.5200.53
177_S183_V0.5200.53
58_R61_E0.5170.53
280_T284_G0.5170.53
74_K80_H0.5170.53
188_N256_N0.5160.52
56_T66_E0.5160.52
74_K85_A0.5160.52
116_A120_S0.5150.52
249_A341_Y0.5150.52
62_I66_E0.5150.52
260_V263_V0.5140.52
74_K230_K0.5110.52
156_I183_V0.5110.52
275_F280_T0.5100.52
230_K234_N0.5090.52
197_V204_G0.5090.52
88_E93_Q0.5090.52
56_T61_E0.5090.52
224_G284_G0.5080.51
123_F394_S0.5080.51
348_V366_M0.5080.51
372_P377_Q0.5080.51
111_L172_L0.5060.51
201_S244_I0.5060.51
261_S265_E0.5060.51
374_R377_Q0.5040.51
196_E199_L0.5040.51
253_N256_N0.5030.51
323_H327_S0.5020.51
108_S155_D0.5020.51
320_D324_E0.5010.50
308_A313_G0.5010.50
45_F53_L0.5010.50
119_L213_D0.5000.50
248_V266_Q0.5000.50
162_E187_S0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.7439 100 0.42 Contact Map
4m7tA 1 0.561 100 0.538 Contact Map
1tv8A 2 0.6951 100 0.562 Contact Map
4rtbA 2 0.8488 100 0.628 Contact Map
3c8fA 1 0.5512 100 0.652 Contact Map
4wcxA 1 0.8951 100 0.659 Contact Map
2yx0A 1 0.6707 100 0.671 Contact Map
2qgqA 1 0.5902 100 0.685 Contact Map
2z2uA 1 0.6049 99.9 0.69 Contact Map
2a5hA 4 0.8512 99.9 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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