SKFB - BACSU - GREMLIN Contacts

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SKFB - Uncharacterized protein SkfB

UniProt:	O31423	Sequences: MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAFLLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSYLPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEAKLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQLRGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTLSVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAWYIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLPFQKEVKAGIQE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	410 (353)
Sequences:	1985 (1722)
Seq/√Len:	91.7

ECOLI - ASLB YDEM MOAA
BACSU - SKFB ALBA MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XZ2 Q97XA7 Q97XS7 Q97XA6 Q97XS8 Q7LXV3 Q97Y04 MOAA Q97WC3 Q97WK5 Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
216_D	230_K	7.511	1.00
119_L	190_L	6.030	1.00
220_D	227_G	5.127	1.00
194_D	238_K	4.961	1.00
198_E	242_A	4.376	1.00
193_R	196_E	3.825	1.00
118_N	188_N	3.548	1.00
347_Y	360_H	3.534	1.00
140_Q	362_L	3.363	1.00
216_D	220_D	3.312	1.00
137_S	140_Q	3.105	1.00
138_S	171_E	3.060	1.00
229_F	266_Q	2.984	1.00
136_L	140_Q	2.951	1.00
213_D	223_R	2.830	1.00
215_M	218_T	2.798	1.00
237_K	270_A	2.701	1.00
146_Q	175_V	2.636	1.00
347_Y	357_P	2.623	1.00
360_H	363_E	2.622	1.00
222_L	253_N	2.611	1.00
219_H	228_G	2.570	1.00
333_C	351_C	2.468	1.00
142_I	175_V	2.448	1.00
149_A	179_L	2.355	1.00
199_L	203_L	2.301	1.00
189_G	210_I	2.215	1.00
116_A	135_E	2.201	1.00
343_R	347_Y	2.184	1.00
170_K	199_L	2.158	1.00
158_L	183_V	2.113	1.00
143_L	362_L	2.055	1.00
214_G	223_R	2.028	1.00
303_I	306_R	1.976	1.00
136_L	141_W	1.959	1.00
159_T	352_Q	1.955	1.00
197_V	239_L	1.938	1.00
146_Q	179_L	1.925	1.00
141_W	172_L	1.889	1.00
365_S	368_D	1.858	1.00
123_F	213_D	1.856	1.00
211_S	251_T	1.837	1.00
177_S	203_L	1.826	1.00
197_V	238_K	1.823	1.00
134_E	345_D	1.813	1.00
198_E	202_H	1.807	1.00
115_N	344_A	1.787	1.00
113_L	169_F	1.763	1.00
371_S	374_R	1.761	1.00
259_E	262_D	1.760	1.00
306_R	310_H	1.716	1.00
174_V	199_L	1.703	1.00
221_Q	255_S	1.698	1.00
143_L	147_K	1.679	1.00
218_T	259_E	1.674	1.00
118_N	191_N	1.657	1.00
142_I	171_E	1.656	1.00
138_S	142_I	1.648	1.00
233_M	270_A	1.619	1.00
109_C	148_L	1.611	1.00
248_V	267_C	1.589	1.00
74_K	78_S	1.586	1.00
135_E	166_I	1.549	1.00
126_A	251_T	1.543	1.00
164_K	185_V	1.543	1.00
214_G	229_F	1.537	1.00
159_T	186_F	1.505	1.00
293_L	296_D	1.498	1.00
237_K	241_E	1.493	1.00
228_G	232_S	1.486	1.00
375_L	378_L	1.454	1.00
190_L	231_E	1.423	0.99
233_M	237_K	1.415	0.99
174_V	178_S	1.401	0.99
195_E	198_E	1.388	0.99
303_I	307_E	1.384	0.99
238_K	241_E	1.373	0.99
192_W	239_L	1.369	0.99
126_A	211_S	1.363	0.99
343_R	349_T	1.356	0.99
196_E	200_L	1.353	0.99
123_F	159_T	1.350	0.99
46_L	49_K	1.343	0.99
385_C	389_G	1.341	0.99
148_L	156_I	1.340	0.99
208_V	239_L	1.331	0.99
234_N	238_K	1.323	0.99
194_D	242_A	1.319	0.99
177_S	202_H	1.316	0.99
175_V	179_L	1.311	0.99
72_Q	76_E	1.303	0.99
197_V	208_V	1.300	0.99
171_E	174_V	1.284	0.99
376_L	380_C	1.276	0.99
164_K	196_E	1.276	0.99
153_V	180_F	1.269	0.99
60_W	68_M	1.262	0.99
378_L	381_E	1.261	0.99
45_F	48_S	1.256	0.99
232_S	235_T	1.242	0.98
123_F	222_L	1.236	0.98
142_I	146_Q	1.235	0.98
199_L	202_H	1.227	0.98
385_C	388_I	1.226	0.98
118_N	162_E	1.222	0.98
141_W	166_I	1.209	0.98
60_W	63_M	1.206	0.98
173_V	176_A	1.205	0.98
59_I	62_I	1.201	0.98
77_L	80_H	1.200	0.98
383_K	386_K	1.197	0.98
186_F	352_Q	1.196	0.98
63_M	67_E	1.195	0.98
189_G	236_I	1.194	0.98
60_W	64_K	1.193	0.98
292_A	296_D	1.192	0.98
159_T	249_A	1.186	0.98
123_F	186_F	1.186	0.98
209_Q	249_A	1.179	0.98
359_G	364_D	1.176	0.98
215_M	259_E	1.164	0.98
194_D	198_E	1.157	0.97
168_G	171_E	1.152	0.97
220_D	223_R	1.147	0.97
43_L	47_L	1.132	0.97
60_W	65_K	1.107	0.97
236_I	248_V	1.100	0.97
173_V	199_L	1.099	0.97
385_C	394_S	1.098	0.97
164_K	191_N	1.092	0.96
201_S	242_A	1.090	0.96
117_C	124_C	1.090	0.96
370_G	379_K	1.087	0.96
111_L	141_W	1.073	0.96
374_R	378_L	1.070	0.96
377_Q	380_C	1.070	0.96
117_C	121_C	1.069	0.96
57_A	61_E	1.068	0.96
375_L	379_K	1.068	0.96
62_I	65_K	1.068	0.96
162_E	188_N	1.064	0.96
201_S	243_N	1.060	0.96
219_H	223_R	1.058	0.96
173_V	203_L	1.054	0.96
233_M	266_Q	1.053	0.96
383_K	387_C	1.049	0.96
121_C	124_C	1.046	0.95
385_C	390_K	1.044	0.95
197_V	235_T	1.043	0.95
354_E	357_P	1.036	0.95
197_V	242_A	1.028	0.95
45_F	49_K	1.028	0.95
147_K	151_H	1.027	0.95
114_T	135_E	1.027	0.95
194_D	197_V	1.025	0.95
298_E	302_Q	1.022	0.95
118_N	190_L	1.022	0.95
74_K	77_L	1.020	0.95
248_V	275_F	1.018	0.95
212_I	248_V	1.017	0.95
220_D	228_G	1.016	0.95
76_E	80_H	1.014	0.95
112_Q	159_T	1.007	0.94
45_F	52_N	1.007	0.94
215_M	262_D	1.004	0.94
119_L	228_G	0.999	0.94
48_S	51_K	0.995	0.94
109_C	342_I	0.991	0.94
376_L	379_K	0.989	0.94
173_V	183_V	0.987	0.94
144_V	342_I	0.985	0.94
304_Q	308_A	0.972	0.93
44_A	47_L	0.970	0.93
296_D	299_E	0.968	0.93
145_M	179_L	0.955	0.93
373_A	376_L	0.954	0.93
216_D	229_F	0.953	0.93
266_Q	270_A	0.952	0.93
56_T	63_M	0.951	0.93
350_P	356_L	0.950	0.92
249_A	352_Q	0.947	0.92
76_E	83_T	0.946	0.92
113_L	158_L	0.945	0.92
169_F	185_V	0.935	0.92
47_L	50_N	0.933	0.92
73_L	76_E	0.930	0.92
190_L	227_G	0.927	0.92
59_I	68_M	0.919	0.91
254_E	293_L	0.916	0.91
62_I	69_S	0.915	0.91
175_V	178_S	0.914	0.91
145_M	158_L	0.911	0.91
147_K	348_V	0.910	0.91
53_L	60_W	0.910	0.91
110_T	157_T	0.910	0.91
57_A	60_W	0.910	0.91
375_L	381_E	0.909	0.91
223_R	227_G	0.908	0.91
113_L	166_I	0.906	0.91
265_E	268_A	0.904	0.91
192_W	196_E	0.902	0.90
231_E	234_N	0.900	0.90
136_L	144_V	0.898	0.90
140_Q	143_L	0.897	0.90
251_T	352_Q	0.896	0.90
123_F	228_G	0.896	0.90
314_D	318_I	0.896	0.90
292_A	295_I	0.895	0.90
211_S	352_Q	0.892	0.90
250_M	267_C	0.892	0.90
158_L	173_V	0.889	0.90
63_M	68_M	0.888	0.90
304_Q	314_D	0.888	0.90
125_Y	353_L	0.887	0.90
125_Y	398_L	0.886	0.90
126_A	159_T	0.886	0.90
290_F	294_D	0.885	0.90
186_F	249_A	0.885	0.90
186_F	353_L	0.884	0.90
234_N	237_K	0.882	0.89
212_I	229_F	0.880	0.89
46_L	50_N	0.880	0.89
262_D	265_E	0.875	0.89
157_T	352_Q	0.874	0.89
164_K	235_T	0.872	0.89
119_L	223_R	0.868	0.89
185_V	208_V	0.867	0.89
340_W	348_V	0.866	0.89
174_V	203_L	0.866	0.89
197_V	201_S	0.866	0.89
113_L	141_W	0.866	0.89
385_C	391_I	0.863	0.88
114_T	166_I	0.862	0.88
118_N	227_G	0.861	0.88
250_M	275_F	0.857	0.88
76_E	82_F	0.857	0.88
388_I	394_S	0.853	0.88
342_I	348_V	0.852	0.88
283_V	286_A	0.846	0.87
80_H	89_G	0.845	0.87
56_T	60_W	0.844	0.87
302_Q	306_R	0.839	0.87
59_I	63_M	0.835	0.87
223_R	228_G	0.835	0.87
43_L	46_L	0.828	0.86
231_E	235_T	0.822	0.86
123_F	249_A	0.821	0.86
291_K	294_D	0.819	0.86
264_V	268_A	0.818	0.86
147_K	152_G	0.817	0.85
219_H	359_G	0.816	0.85
158_L	172_L	0.812	0.85
112_Q	115_N	0.807	0.85
59_I	67_E	0.805	0.85
57_A	63_M	0.801	0.84
265_E	269_N	0.797	0.84
238_K	242_A	0.796	0.84
43_L	51_K	0.793	0.84
112_Q	341_Y	0.793	0.84
64_K	68_M	0.793	0.84
48_S	52_N	0.791	0.84
128_S	285_R	0.791	0.84
208_V	244_I	0.790	0.83
108_S	157_T	0.788	0.83
186_F	209_Q	0.784	0.83
194_D	241_E	0.780	0.83
126_A	253_N	0.780	0.83
50_N	57_A	0.780	0.83
164_K	229_F	0.779	0.83
212_I	266_Q	0.777	0.82
212_I	219_H	0.774	0.82
56_T	306_R	0.772	0.82
191_N	197_V	0.772	0.82
373_A	379_K	0.771	0.82
46_L	51_K	0.770	0.82
373_A	378_L	0.770	0.82
156_I	176_A	0.770	0.82
212_I	233_M	0.768	0.82
301_V	305_L	0.768	0.82
56_T	59_I	0.766	0.82
397_D	400_F	0.765	0.81
112_Q	251_T	0.760	0.81
50_N	53_L	0.756	0.81
229_F	267_C	0.750	0.80
299_E	302_Q	0.749	0.80
125_Y	209_Q	0.749	0.80
157_T	186_F	0.749	0.80
63_M	66_E	0.748	0.80
257_A	296_D	0.745	0.80
211_S	336_G	0.743	0.80
212_I	275_F	0.741	0.79
260_V	277_A	0.739	0.79
75_E	79_A	0.735	0.79
295_I	298_E	0.732	0.79
59_I	64_K	0.730	0.78
176_A	183_V	0.730	0.78
125_Y	251_T	0.730	0.78
184_N	209_Q	0.728	0.78
93_Q	97_V	0.727	0.78
263_V	267_C	0.727	0.78
46_L	56_T	0.726	0.78
375_L	380_C	0.724	0.78
71_D	74_K	0.723	0.78
53_L	59_I	0.721	0.78
339_A	352_Q	0.720	0.77
334_T	352_Q	0.720	0.77
384_N	387_C	0.719	0.77
47_L	52_N	0.718	0.77
298_E	309_R	0.717	0.77
46_L	52_N	0.716	0.77
335_P	399_P	0.714	0.77
214_G	224_G	0.714	0.77
185_V	206_V	0.713	0.77
145_M	176_A	0.707	0.76
276_R	280_T	0.701	0.76
351_C	398_L	0.701	0.76
75_E	78_S	0.696	0.75
51_K	56_T	0.695	0.75
138_S	168_G	0.695	0.75
109_C	340_W	0.694	0.75
185_V	200_L	0.692	0.75
110_T	352_Q	0.691	0.74
49_K	52_N	0.691	0.74
352_Q	397_D	0.690	0.74
373_A	377_Q	0.689	0.74
341_Y	352_Q	0.687	0.74
203_L	206_V	0.685	0.74
158_L	176_A	0.682	0.74
110_T	123_F	0.679	0.73
123_F	223_R	0.679	0.73
364_D	368_D	0.678	0.73
372_P	376_L	0.676	0.73
110_T	159_T	0.676	0.73
112_Q	125_Y	0.674	0.73
112_Q	344_A	0.671	0.72
370_G	373_A	0.670	0.72
249_A	335_P	0.668	0.72
364_D	369_I	0.668	0.72
173_V	205_N	0.668	0.72
60_W	66_E	0.667	0.72
170_K	195_E	0.666	0.72
112_Q	123_F	0.664	0.72
239_L	242_A	0.662	0.71
212_I	236_I	0.662	0.71
214_G	232_S	0.660	0.71
177_S	204_G	0.660	0.71
216_D	219_H	0.658	0.71
96_H	100_S	0.658	0.71
70_A	76_E	0.657	0.71
266_Q	269_N	0.657	0.71
254_E	296_D	0.655	0.71
119_L	158_L	0.654	0.70
123_F	126_A	0.654	0.70
109_C	348_V	0.652	0.70
125_Y	352_Q	0.651	0.70
141_W	145_M	0.649	0.70
217_N	221_Q	0.648	0.70
298_E	301_V	0.646	0.69
122_S	222_L	0.646	0.69
47_L	51_K	0.646	0.69
158_L	206_V	0.644	0.69
366_M	370_G	0.642	0.69
76_E	89_G	0.642	0.69
62_I	67_E	0.641	0.69
219_H	227_G	0.641	0.69
299_E	303_I	0.638	0.69
155_D	184_N	0.635	0.68
372_P	375_L	0.633	0.68
210_I	236_I	0.632	0.68
43_L	53_L	0.632	0.68
123_F	352_Q	0.631	0.68
76_E	79_A	0.631	0.68
116_A	133_P	0.630	0.68
164_K	219_H	0.629	0.67
159_T	251_T	0.629	0.67
192_W	208_V	0.627	0.67
126_A	350_P	0.626	0.67
219_H	232_S	0.626	0.67
336_G	350_P	0.624	0.67
267_C	272_A	0.624	0.67
251_T	339_A	0.622	0.67
47_L	56_T	0.621	0.66
239_L	244_I	0.621	0.66
374_R	379_K	0.618	0.66
274_I	315_R	0.618	0.66
278_G	281_L	0.615	0.66
56_T	64_K	0.615	0.66
134_E	344_A	0.614	0.66
268_A	314_D	0.614	0.66
59_I	69_S	0.614	0.66
50_N	59_I	0.613	0.65
52_N	58_R	0.610	0.65
358_L	375_L	0.610	0.65
210_I	232_S	0.610	0.65
112_Q	353_L	0.609	0.65
65_K	68_M	0.609	0.65
50_N	58_R	0.609	0.65
81_P	89_G	0.605	0.64
368_D	371_S	0.605	0.64
141_W	175_V	0.601	0.64
346_G	360_H	0.600	0.64
43_L	49_K	0.597	0.63
166_I	172_L	0.596	0.63
56_T	68_M	0.593	0.63
213_D	251_T	0.593	0.63
224_G	227_G	0.592	0.63
46_L	58_R	0.592	0.63
158_L	209_Q	0.591	0.63
191_N	235_T	0.591	0.63
198_E	238_K	0.589	0.62
209_Q	278_G	0.588	0.62
125_Y	159_T	0.586	0.62
261_S	264_V	0.586	0.62
167_K	170_K	0.585	0.62
117_C	161_G	0.582	0.61
158_L	166_I	0.582	0.61
183_V	205_N	0.581	0.61
125_Y	397_D	0.580	0.61
126_A	249_A	0.580	0.61
237_K	240_S	0.577	0.61
295_I	299_E	0.575	0.61
126_A	353_L	0.575	0.61
251_T	334_T	0.575	0.61
214_G	228_G	0.574	0.60
83_T	88_E	0.573	0.60
116_A	166_I	0.573	0.60
321_W	325_E	0.573	0.60
167_K	171_E	0.573	0.60
43_L	50_N	0.571	0.60
45_F	50_N	0.571	0.60
367_A	371_S	0.568	0.60
211_S	249_A	0.568	0.60
349_T	357_P	0.567	0.59
96_H	99_G	0.565	0.59
141_W	158_L	0.565	0.59
265_E	314_D	0.564	0.59
198_E	201_S	0.563	0.59
52_N	65_K	0.563	0.59
188_N	191_N	0.563	0.59
140_Q	144_V	0.563	0.59
332_F	353_L	0.562	0.59
245_P	354_E	0.562	0.59
249_A	397_D	0.561	0.59
211_S	232_S	0.560	0.59
115_N	343_R	0.559	0.58
357_P	360_H	0.557	0.58
188_N	227_G	0.556	0.58
138_S	174_V	0.555	0.58
121_C	161_G	0.554	0.58
146_Q	149_A	0.553	0.58
252_I	320_D	0.553	0.58
51_K	64_K	0.549	0.57
67_E	70_A	0.549	0.57
107_I	110_T	0.544	0.56
374_R	381_E	0.543	0.56
48_S	60_W	0.543	0.56
371_S	375_L	0.542	0.56
95_L	98_S	0.541	0.56
159_T	209_Q	0.541	0.56
115_N	126_A	0.539	0.56
159_T	166_I	0.539	0.56
45_F	64_K	0.538	0.56
157_T	184_N	0.537	0.55
124_C	161_G	0.537	0.55
264_V	267_C	0.537	0.55
332_F	339_A	0.537	0.55
46_L	53_L	0.536	0.55
43_L	69_S	0.535	0.55
79_A	145_M	0.535	0.55
138_S	146_Q	0.534	0.55
162_E	333_C	0.533	0.55
72_Q	81_P	0.532	0.55
188_N	351_C	0.531	0.55
46_L	60_W	0.531	0.55
97_V	100_S	0.530	0.54
224_G	228_G	0.530	0.54
249_A	278_G	0.529	0.54
162_E	165_L	0.527	0.54
136_L	147_K	0.527	0.54
337_Y	371_S	0.527	0.54
43_L	306_R	0.526	0.54
103_S	355_D	0.526	0.54
214_G	336_G	0.525	0.54
157_T	353_L	0.525	0.54
94_P	98_S	0.525	0.54
78_S	85_A	0.524	0.54
189_G	396_P	0.524	0.54
278_G	284_G	0.523	0.53
119_L	227_G	0.522	0.53
49_K	56_T	0.522	0.53
47_L	58_R	0.522	0.53
85_A	88_E	0.521	0.53
48_S	77_L	0.521	0.53
140_Q	147_K	0.520	0.53
177_S	183_V	0.520	0.53
58_R	61_E	0.517	0.53
280_T	284_G	0.517	0.53
74_K	80_H	0.517	0.53
188_N	256_N	0.516	0.52
56_T	66_E	0.516	0.52
74_K	85_A	0.516	0.52
116_A	120_S	0.515	0.52
249_A	341_Y	0.515	0.52
62_I	66_E	0.515	0.52
260_V	263_V	0.514	0.52
74_K	230_K	0.511	0.52
156_I	183_V	0.511	0.52
275_F	280_T	0.510	0.52
230_K	234_N	0.509	0.52
197_V	204_G	0.509	0.52
88_E	93_Q	0.509	0.52
56_T	61_E	0.509	0.52
224_G	284_G	0.508	0.51
123_F	394_S	0.508	0.51
348_V	366_M	0.508	0.51
372_P	377_Q	0.508	0.51
111_L	172_L	0.506	0.51
201_S	244_I	0.506	0.51
261_S	265_E	0.506	0.51
374_R	377_Q	0.504	0.51
196_E	199_L	0.504	0.51
253_N	256_N	0.503	0.51
323_H	327_S	0.502	0.51
108_S	155_D	0.502	0.51
320_D	324_E	0.501	0.50
308_A	313_G	0.501	0.50
45_F	53_L	0.501	0.50
119_L	213_D	0.500	0.50
248_V	266_Q	0.500	0.50
162_E	187_S	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.7439	100	0.42	Contact Map
4m7tA	1	0.561	100	0.538	Contact Map
1tv8A	2	0.6951	100	0.562	Contact Map
4rtbA	2	0.8488	100	0.628	Contact Map
3c8fA	1	0.5512	100	0.652	Contact Map
4wcxA	1	0.8951	100	0.659	Contact Map
2yx0A	1	0.6707	100	0.671	Contact Map
2qgqA	1	0.5902	100	0.685	Contact Map
2z2uA	1	0.6049	99.9	0.69	Contact Map
2a5hA	4	0.8512	99.9	0.693	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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