GREMLIN Database
MRNC - Mini-ribonuclease 3
UniProt: O31418 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (122)
Sequences: 1131 (817)
Seq/√Len: 74.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_L79_L4.0531.00
59_A101_Y3.2371.00
76_E80_K2.9991.00
34_L49_S2.9201.00
63_F101_Y2.5721.00
94_T98_T2.4971.00
79_L104_A2.4931.00
77_A80_K2.1741.00
17_A35_L2.1121.00
61_I128_A2.0671.00
71_F108_L2.0191.00
66_Q76_E2.0101.00
29_Y121_L1.9771.00
87_S100_R1.9111.00
64_F131_F1.8931.00
109_L124_L1.8371.00
105_F128_A1.8331.00
109_L125_V1.8291.00
70_F127_E1.8101.00
33_H129_I1.7981.00
41_K44_D1.7781.00
48_K51_R1.7621.00
29_Y125_V1.7361.00
90_T96_V1.6961.00
105_F109_L1.6651.00
95_D98_T1.6180.99
24_A27_E1.5800.99
96_V100_R1.5700.99
79_L108_L1.5560.99
20_Y27_E1.5300.99
11_K74_E1.5240.99
43_N47_K1.5210.99
32_H113_F1.5160.99
112_L117_K1.4980.99
79_L101_Y1.4860.99
82_G85_A1.4480.99
71_F79_L1.4390.99
10_S115_E1.4320.99
15_G78_V1.4090.99
26_F111_Y1.4000.99
127_E130_Q1.3590.98
15_G38_G1.3130.98
54_S94_T1.2880.97
30_V129_I1.2300.97
56_K98_T1.2270.97
70_F124_L1.2080.96
25_I109_L1.2030.96
39_F46_H1.1980.96
91_P94_T1.1810.96
93_N98_T1.1740.96
26_F52_I1.1690.95
32_H36_K1.1680.95
82_G107_A1.1120.94
66_Q69_S1.1060.94
97_Q101_Y1.1050.94
62_L104_A1.0530.92
21_I113_F1.0500.92
62_L105_F1.0440.92
17_A45_L1.0430.92
25_I28_V1.0180.91
54_S98_T1.0090.90
91_P95_D0.9970.90
109_L121_L0.9850.89
121_L125_V0.9830.89
65_L124_L0.9820.89
27_E50_S0.9810.89
29_Y122_S0.9580.88
55_A94_T0.9440.87
65_L71_F0.9210.86
27_E31_R0.9070.85
103_T108_L0.8740.83
70_F123_Q0.8700.83
78_V107_A0.8700.83
74_E117_K0.8680.82
75_E120_R0.8610.82
34_L45_L0.8540.81
126_A130_Q0.8520.81
62_L101_Y0.8400.80
50_S91_P0.8380.80
42_P103_T0.8380.80
21_I28_V0.8370.80
16_L87_S0.8310.80
127_E131_F0.8290.79
73_E76_E0.8180.79
94_T102_S0.8070.78
125_V128_A0.8040.77
44_D47_K0.7900.76
12_Q78_V0.7760.75
16_L42_P0.7650.74
20_Y49_S0.7620.73
40_T44_D0.7600.73
61_I131_F0.7520.72
80_K131_F0.7420.71
65_L127_E0.7300.70
38_G107_A0.7240.70
13_L33_H0.7240.70
72_T120_R0.7210.69
59_A98_T0.7190.69
29_Y60_E0.7180.69
29_Y109_L0.7170.69
56_K93_N0.7160.69
26_F71_F0.7150.69
17_A41_K0.7030.67
119_E123_Q0.7030.67
14_N82_G0.6960.67
60_E64_F0.6960.67
11_K115_E0.6930.66
16_L85_A0.6890.66
69_S76_E0.6860.65
51_R57_S0.6800.65
96_V104_A0.6740.64
102_S105_F0.6730.64
46_H49_S0.6720.64
21_I114_L0.6680.63
81_R114_L0.6670.63
15_G40_T0.6670.63
80_K83_R0.6580.62
18_L104_A0.6580.62
72_T117_K0.6540.62
65_L128_A0.6500.61
25_I77_A0.6480.61
26_F50_S0.6430.60
46_H58_Q0.6340.59
46_H50_S0.6310.59
69_S122_S0.6280.59
53_V86_K0.6200.58
125_V129_I0.6190.58
55_A83_R0.6130.57
64_F127_E0.6120.57
14_N39_F0.6120.57
102_S121_L0.6100.56
64_F69_S0.6090.56
25_I125_V0.6080.56
58_Q102_S0.6000.55
63_F69_S0.5970.55
100_R103_T0.5960.55
75_E110_G0.5960.55
39_F102_S0.5960.55
122_S125_V0.5910.54
14_N52_I0.5910.54
34_L91_P0.5850.53
21_I35_L0.5840.53
90_T104_A0.5820.53
17_A20_Y0.5660.51
31_R59_A0.5650.51
101_Y104_A0.5650.51
121_L126_A0.5640.51
97_Q130_Q0.5630.51
17_A42_P0.5630.51
78_V108_L0.5630.51
119_E131_F0.5580.50
30_V125_V0.5560.50
46_H90_T0.5540.49
51_R118_E0.5510.49
13_L41_K0.5480.49
8_K119_E0.5470.49
10_S14_N0.5460.49
28_V49_S0.5450.48
21_I32_H0.5440.48
8_K12_Q0.5420.48
123_Q126_A0.5410.48
33_H37_Q0.5400.48
18_L85_A0.5300.47
61_I91_P0.5290.46
20_Y30_V0.5290.46
36_K64_F0.5290.46
57_S92_K0.5250.46
108_L112_L0.5230.46
16_L96_V0.5220.46
74_E126_A0.5190.45
73_E119_E0.5180.45
20_Y50_S0.5180.45
57_S71_F0.5170.45
65_L123_Q0.5170.45
89_T100_R0.5150.45
123_Q127_E0.5110.44
46_H95_D0.5110.44
44_D119_E0.5090.44
15_G103_T0.5080.44
32_H122_S0.5070.44
65_L70_F0.5050.43
83_R93_N0.5020.43
85_A100_R0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ounA 2 0.8741 100 0.455 Contact Map
2gslA 2 0.9161 100 0.473 Contact Map
1u61A 1 0.8881 100 0.484 Contact Map
3o2rA 2 0.8671 99.6 0.698 Contact Map
2a11A 2 0.9021 99.5 0.716 Contact Map
3n3wA 2 0.8741 99.4 0.728 Contact Map
1vw49 1 0.8462 99.3 0.735 Contact Map
2nugA 2 0.8741 99.3 0.735 Contact Map
1o0wA 2 0.9161 99.3 0.739 Contact Map
3rv1A 2 0.8601 99.3 0.745 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.