GREMLIN Database
YAZA - UPF0213 protein YazA
UniProt: O31414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 99 (81)
Sequences: 2253 (1721)
Seq/√Len: 191.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_K32_T2.8691.00
20_A69_F2.3681.00
54_E65_A2.3391.00
58_T61_E2.3121.00
10_V20_A2.2251.00
67_Y71_K2.1881.00
6_H22_Y2.1481.00
12_K49_E2.1391.00
22_Y63_M2.0421.00
65_A68_Y1.9901.00
17_S41_Y1.9291.00
26_L53_A1.8781.00
31_K35_D1.8511.00
73_T76_K1.7601.00
60_R64_Q1.6621.00
30_V34_N1.6541.00
11_V30_V1.5671.00
15_D45_R1.5651.00
18_W78_E1.5621.00
12_K51_I1.5511.00
8_F69_F1.4961.00
59_K63_M1.4741.00
39_A43_K1.4451.00
74_R78_E1.4381.00
12_K16_N1.4311.00
6_H59_K1.3181.00
34_N48_V1.2891.00
10_V69_F1.2871.00
72_L76_K1.2341.00
36_G46_R1.2281.00
22_Y59_K1.2111.00
79_L83_E1.2081.00
78_E82_E1.1641.00
64_Q68_Y1.1621.00
30_V50_L1.1381.00
13_C41_Y1.0771.00
56_F65_A1.0681.00
12_K78_E1.0671.00
13_C47_P1.0641.00
42_T47_P1.0431.00
36_G48_V1.0421.00
75_K79_L1.0361.00
76_K79_L1.0241.00
51_I81_I1.0141.00
5_N55_S1.0091.00
26_L50_L0.9950.99
65_A80_Y0.9930.99
8_F20_A0.9910.99
52_F65_A0.9900.99
23_T26_L0.9700.99
60_R63_M0.9260.99
34_N46_R0.9150.99
24_N28_K0.9090.99
56_F61_E0.8770.99
30_V48_V0.8660.99
20_A77_K0.8650.99
13_C42_T0.8450.98
32_T37_K0.8360.98
6_H24_N0.8340.98
69_F80_Y0.8160.98
68_Y72_L0.8110.98
52_F80_Y0.8010.98
10_V52_F0.7830.97
63_M67_Y0.7740.97
25_D28_K0.7600.97
11_V47_P0.7470.96
70_K77_K0.7470.96
13_C17_S0.7420.96
7_F55_S0.7360.96
11_V34_N0.7310.96
15_D41_Y0.7190.96
11_V42_T0.6870.94
17_S45_R0.6830.94
14_K46_R0.6740.94
26_L30_V0.6720.94
32_T46_R0.6640.93
18_W81_I0.6630.93
7_F53_A0.6620.93
24_N32_T0.6610.93
12_K18_W0.6590.93
8_F80_Y0.6520.93
42_T45_R0.6490.92
74_R81_I0.6450.92
57_S61_E0.6440.92
71_K76_K0.6390.92
54_E80_Y0.6380.92
40_K43_K0.6360.92
75_K78_E0.6340.92
82_E85_R0.6340.92
8_F56_F0.6290.91
22_Y32_T0.6260.91
11_V48_V0.6220.91
14_K34_N0.6150.90
73_T79_L0.6040.89
31_K37_K0.6020.89
7_F59_K0.6020.89
38_G43_K0.5980.89
10_V18_W0.5930.89
51_I80_Y0.5930.89
63_M70_K0.5910.88
13_C45_R0.5890.88
6_H63_M0.5890.88
8_F22_Y0.5810.88
20_A72_L0.5730.87
34_N45_R0.5720.87
41_Y44_V0.5620.86
27_H53_A0.5580.85
36_G43_K0.5530.85
42_T48_V0.5530.85
39_A42_T0.5480.84
72_L80_Y0.5420.84
67_Y70_K0.5420.84
27_H84_K0.5410.84
24_N59_K0.5390.83
54_E68_Y0.5360.83
37_K40_K0.5330.83
24_N63_M0.5290.82
14_K45_R0.5210.81
43_K46_R0.5120.80
27_H55_S0.5090.80
68_Y76_K0.5010.79
23_T28_K0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zg2A 1 0.9495 100 0.201 Contact Map
1ywlA 1 0.9394 100 0.228 Contact Map
4xlgA 1 0.7778 99.9 0.358 Contact Map
1mk0A 1 0.8586 97.5 0.796 Contact Map
1yd0A 1 0.7879 97.4 0.798 Contact Map
1yd6A 5 0.8485 96.9 0.815 Contact Map
2wshA 4 0.7879 79 0.885 Contact Map
4zcfA 2 0.7576 16.7 0.926 Contact Map
4gbsA 1 0.3939 9.6 0.934 Contact Map
3u22A 4 0.4242 8.3 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.