GREMLIN Database
ACOA - Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha
UniProt: O31404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (314)
Sequences: 5243 (2924)
Seq/√Len: 165.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_Q297_R4.0891.00
162_H206_Y3.5461.00
287_D290_K3.4391.00
176_V232_A3.1051.00
229_I233_R2.9931.00
151_F179_A2.7351.00
211_V227_E2.7291.00
230_E234_N2.7181.00
288_A292_S2.6911.00
59_V150_F2.5431.00
87_D308_F2.5181.00
212_T244_M2.5151.00
146_V229_I2.5041.00
283_L288_A2.4571.00
172_N195_A2.4491.00
70_T134_S2.3791.00
26_I77_G2.3511.00
41_V310_E2.3341.00
25_E301_S2.3221.00
132_C164_G2.3061.00
279_K283_L2.3051.00
231_R236_G2.2581.00
138_A147_S2.1921.00
231_R239_S2.1831.00
319_E322_T2.1831.00
12_T15_K2.1401.00
87_D304_K2.1151.00
307_S311_D2.0801.00
64_H144_K1.9731.00
138_A143_T1.9701.00
279_K295_E1.9661.00
59_V225_A1.9461.00
128_F161_F1.9431.00
280_N284_K1.9241.00
293_D297_R1.9041.00
267_E271_E1.8991.00
300_E304_K1.8821.00
279_K291_L1.8771.00
161_F165_L1.8741.00
217_D220_A1.8721.00
203_A210_G1.8221.00
232_A239_S1.8001.00
179_A199_I1.7721.00
132_C177_F1.7691.00
66_G145_N1.7651.00
18_W22_K1.7431.00
138_A145_N1.7041.00
216_K248_N1.6901.00
59_V148_V1.6871.00
154_G185_G1.6741.00
213_V224_A1.6741.00
178_V243_C1.6611.00
283_L291_L1.6531.00
98_T312_S1.6501.00
209_P231_R1.6311.00
13_E290_K1.6121.00
211_V224_A1.6061.00
135_A175_V1.5481.00
290_K293_D1.5471.00
59_V178_V1.5151.00
128_F164_G1.5141.00
268_H271_E1.5101.00
209_P237_G1.5071.00
201_D204_A1.5011.00
308_F312_S1.4881.00
104_K323_D1.4831.00
16_A282_L1.4821.00
181_N242_E1.4811.00
136_L140_Y1.4631.00
19_M218_I1.4571.00
228_A239_S1.4571.00
102_K323_D1.4541.00
19_M61_A1.4411.00
151_F155_A1.4381.00
304_K308_F1.4261.00
297_R301_S1.4251.00
281_Y285_E1.4201.00
13_E17_L1.4081.00
85_D88_G1.3971.00
24_L298_V1.3951.00
17_L290_K1.3911.00
216_K245_T1.3891.00
226_E230_E1.3881.00
296_Q300_E1.3861.00
276_Q280_N1.3601.00
165_L208_M1.3461.00
224_A241_I1.3421.00
267_E270_E1.3351.00
305_A309_S1.3121.00
79_C117_M1.3081.00
148_V176_V1.3061.00
15_K18_W1.3051.00
159_G163_E1.2951.00
31_D50_A1.2911.00
200_A212_T1.2871.00
266_V270_E1.2771.00
112_D115_K1.2691.00
68_S138_A1.2691.00
179_A240_L1.2661.00
225_A241_I1.2551.00
198_S201_D1.2531.00
58_G221_V1.2461.00
213_V220_A1.2401.00
55_V243_C1.2341.00
183_G244_M1.2301.00
178_V225_A1.2241.00
146_V232_A1.2191.00
289_N292_S1.2091.00
289_N293_D1.2041.00
222_Y226_E1.1941.00
91_A98_T1.1851.00
292_S296_Q1.1811.00
22_K61_A1.1791.00
28_G299_S1.1751.00
24_L295_E1.1751.00
269_L272_K1.1591.00
307_S310_E1.1481.00
20_Y24_L1.1471.00
303_E307_S1.1371.00
121_N126_G1.1361.00
316_K319_E1.1331.00
66_G82_K1.1291.00
301_S305_A1.1261.00
62_H226_E1.1261.00
55_V178_V1.1261.00
194_S199_I1.1141.00
63_L148_V1.1111.00
32_K303_E1.1081.00
134_S147_S1.1071.00
169_A208_M1.1061.00
172_N236_G1.1031.00
262_K267_E1.1031.00
291_L295_E1.0961.00
211_V239_S1.0951.00
25_E86_L1.0931.00
63_L229_I1.0921.00
148_V225_A1.0901.00
157_N193_A1.0871.00
169_A207_N1.0811.00
172_N237_G1.0791.00
132_C175_V1.0771.00
16_A278_F1.0750.99
157_N202_R1.0730.99
65_D115_K1.0720.99
58_G218_I1.0700.99
277_G281_Y1.0700.99
97_A313_P1.0690.99
62_H222_Y1.0650.99
148_V178_V1.0610.99
263_D267_E1.0510.99
24_L275_I1.0510.99
28_G295_E1.0480.99
13_E285_E1.0430.99
146_V176_V1.0420.99
96_K314_Y1.0400.99
227_E230_E1.0390.99
123_I126_G1.0390.99
62_H229_I1.0310.99
28_G302_I1.0290.99
70_T118_L1.0290.99
167_L171_W1.0280.99
16_A219_L1.0270.99
298_V302_I1.0260.99
18_W61_A1.0160.99
219_L278_F1.0150.99
33_V93_I1.0130.99
214_D220_A1.0090.99
104_K319_E1.0020.99
21_Q25_E0.9960.99
278_F282_L0.9950.99
11_L15_K0.9950.99
146_V233_R0.9930.99
210_G240_L0.9910.99
24_L28_G0.9840.99
61_A222_Y0.9830.99
36_L306_V0.9820.99
20_Y294_I0.9760.99
32_K35_E0.9760.99
184_Y264_E0.9710.99
176_V229_I0.9680.99
68_S118_L0.9660.99
23_M275_I0.9610.99
217_D277_G0.9590.99
19_M222_Y0.9540.99
128_F151_F0.9520.99
63_L69_I0.9400.99
22_K57_V0.9380.99
220_A223_Q0.9370.99
20_Y279_K0.9370.99
32_K306_V0.9350.99
280_N283_L0.9330.99
139_K172_N0.9310.99
260_K264_E0.9300.99
211_V241_I0.9250.98
196_C201_D0.9230.98
301_S304_K0.9230.98
300_E303_E0.9180.98
28_G31_D0.9180.98
203_A208_M0.9170.98
223_Q227_E0.9160.98
131_A175_V0.9100.98
25_E298_V0.9080.98
228_A232_A0.9040.98
125_G161_F0.9020.98
151_F156_N0.9010.98
156_N161_F0.9000.98
279_K288_A0.8980.98
23_M54_A0.8980.98
132_C173_L0.8950.98
131_A149_C0.8950.98
304_K307_S0.8840.98
97_A102_K0.8810.98
248_N270_E0.8790.98
144_K234_N0.8750.98
156_N199_I0.8730.98
164_G177_F0.8710.98
224_A228_A0.8660.98
37_F253_E0.8640.98
165_L240_L0.8590.98
54_A58_G0.8540.97
86_L301_S0.8530.97
15_K222_Y0.8530.97
169_A172_N0.8480.97
36_L94_F0.8460.97
87_D312_S0.8450.97
45_F252_F0.8440.97
198_S212_T0.8420.97
169_A195_A0.8390.97
49_Y77_G0.8320.97
135_A174_P0.8310.97
176_V225_A0.8310.97
79_C84_C0.8300.97
18_W21_Q0.8270.97
125_G155_A0.8250.97
221_V243_C0.8230.97
66_G144_K0.8170.97
198_S244_M0.8160.97
214_D277_G0.8070.96
87_D305_A0.8050.96
91_A312_S0.8040.96
21_Q294_I0.8030.96
228_A241_I0.8030.96
17_L21_Q0.8020.96
293_D296_Q0.8010.96
278_F281_Y0.8000.96
183_G191_E0.7960.96
131_A147_S0.7960.96
298_V301_S0.7930.96
299_S303_E0.7920.96
228_A231_R0.7890.96
88_G114_D0.7880.96
45_F253_E0.7840.96
20_Y295_E0.7830.96
29_F90_M0.7820.96
266_V269_L0.7800.96
231_R237_G0.7800.96
246_Y264_E0.7780.96
78_H150_F0.7770.96
220_A224_A0.7770.96
231_R235_G0.7710.95
49_Y56_A0.7710.95
58_G62_H0.7700.95
64_H229_I0.7680.95
80_I89_M0.7660.95
116_G145_N0.7610.95
17_L282_L0.7610.95
69_I78_H0.7600.95
55_V245_T0.7590.95
176_V239_S0.7580.95
216_K277_G0.7520.95
22_K81_A0.7520.95
57_V218_I0.7510.95
124_V158_Q0.7460.94
246_Y269_L0.7460.94
213_V241_I0.7450.94
268_H272_K0.7440.94
11_L222_Y0.7430.94
295_E299_S0.7420.94
52_E180_E0.7410.94
15_K226_E0.7370.94
135_A173_L0.7370.94
34_H38_A0.7340.94
225_A229_I0.7320.94
219_L281_Y0.7300.94
292_S295_E0.7300.94
249_Y253_E0.7280.94
294_I298_V0.7270.94
21_Q301_S0.7250.94
185_G193_A0.7210.93
98_T313_P0.7210.93
50_A249_Y0.7210.93
129_T160_T0.7160.93
236_G239_S0.7160.93
14_E18_W0.7150.93
203_A240_L0.7130.93
100_L110_I0.7120.93
199_I240_L0.7100.93
91_A96_K0.7080.93
90_M306_V0.7070.93
262_K266_V0.7060.93
170_V193_A0.7040.93
186_E252_F0.7030.93
34_H253_E0.7020.93
28_G298_V0.7000.92
248_N273_D0.7000.92
64_H145_N0.7000.92
44_G252_F0.6990.92
151_F177_F0.6990.92
291_L294_I0.6970.92
125_G128_F0.6970.92
189_P192_Y0.6960.92
60_C150_F0.6910.92
58_G225_A0.6910.92
313_P316_K0.6900.92
161_F240_L0.6890.92
209_P239_S0.6880.92
157_N194_S0.6850.92
80_I86_L0.6820.91
15_K61_A0.6800.91
297_R300_E0.6790.91
84_C100_L0.6780.91
88_G100_L0.6740.91
32_K36_L0.6710.91
150_F178_V0.6690.91
283_L287_D0.6680.91
135_A147_S0.6650.90
104_K322_T0.6630.90
272_K277_G0.6620.90
102_K319_E0.6620.90
20_Y291_L0.6610.90
70_T131_A0.6570.90
105_G108_M0.6480.89
308_F311_D0.6480.89
19_M57_V0.6470.89
126_G130_L0.6410.89
186_E254_G0.6410.89
22_K25_E0.6400.89
19_M219_L0.6390.89
217_D281_Y0.6390.89
30_E37_F0.6360.88
162_H205_A0.6360.88
200_A210_G0.6360.88
124_V155_A0.6340.88
70_T130_L0.6330.88
21_Q298_V0.6330.88
144_K229_I0.6320.88
49_Y76_H0.6300.88
276_Q279_K0.6280.88
263_D268_H0.6260.88
202_R205_A0.6260.88
125_G158_Q0.6210.87
91_A308_F0.6190.87
70_T127_G0.6180.87
11_L16_A0.6170.87
213_V221_V0.6170.87
212_T242_E0.6170.87
277_G280_N0.6160.87
213_V243_C0.6140.87
250_G257_Q0.6140.87
87_D91_A0.6140.87
97_A319_E0.6130.86
86_L302_I0.6130.86
303_E306_V0.6120.86
196_C199_I0.6120.86
153_D199_I0.6120.86
20_Y275_I0.6120.86
194_S202_R0.6110.86
33_V90_M0.6110.86
24_L294_I0.6100.86
37_F45_F0.6100.86
29_F89_M0.6080.86
224_A227_E0.6070.86
84_C115_K0.6070.86
300_E307_S0.6060.86
223_Q226_E0.6060.86
216_K246_Y0.6050.86
135_A138_A0.6040.86
69_I117_M0.6000.85
60_C82_K0.5990.85
148_V229_I0.5980.85
82_K115_K0.5980.85
128_F165_L0.5970.85
147_S175_V0.5970.85
187_A253_E0.5970.85
107_S119_G0.5960.85
176_V241_I0.5950.85
23_M278_F0.5930.85
94_F310_E0.5930.85
73_H127_G0.5910.84
71_S117_M0.5910.84
34_H50_A0.5900.84
168_A177_F0.5870.84
66_G143_T0.5870.84
214_D272_K0.5840.84
318_S322_T0.5830.84
190_F194_S0.5830.84
25_E80_I0.5830.84
50_A248_N0.5820.83
11_L223_Q0.5820.83
186_E253_E0.5790.83
257_Q266_V0.5780.83
208_M238_P0.5730.83
208_M240_L0.5730.83
181_N190_F0.5720.82
44_G47_H0.5700.82
71_S75_G0.5700.82
305_A308_F0.5690.82
34_H249_Y0.5670.82
90_M309_S0.5660.82
68_S145_N0.5640.82
92_E99_G0.5610.81
287_D293_D0.5610.81
118_L134_S0.5610.81
29_F76_H0.5580.81
73_H186_E0.5570.81
164_G175_V0.5570.81
178_V221_V0.5560.81
26_I57_V0.5560.81
219_L223_Q0.5560.81
155_A179_A0.5540.80
183_G190_F0.5500.80
246_Y266_V0.5490.80
309_S312_S0.5470.80
94_F309_S0.5460.79
108_M124_V0.5450.79
54_A221_V0.5440.79
184_Y248_N0.5420.79
69_I82_K0.5420.79
169_A206_Y0.5410.79
134_S137_T0.5400.79
66_G116_G0.5380.78
209_P227_E0.5380.78
290_K294_I0.5360.78
59_V78_H0.5340.78
92_E122_G0.5320.78
36_L39_Q0.5320.78
72_T127_G0.5310.78
72_T75_G0.5310.78
118_L121_N0.5300.77
68_S116_G0.5290.77
188_T193_A0.5290.77
248_N269_L0.5280.77
78_H148_V0.5280.77
37_F254_G0.5280.77
296_Q299_S0.5270.77
29_F33_V0.5240.77
302_I306_V0.5240.77
315_P323_D0.5230.76
166_N195_A0.5230.76
105_G119_G0.5220.76
253_E257_Q0.5220.76
190_F199_I0.5210.76
47_H105_G0.5200.76
43_P254_G0.5170.76
47_H76_H0.5170.76
73_H252_F0.5170.76
69_I150_F0.5160.76
38_A253_E0.5130.75
52_E163_E0.5130.75
25_E302_I0.5130.75
191_E197_D0.5120.75
52_E72_T0.5110.75
75_G180_E0.5090.75
68_S147_S0.5080.74
231_R234_N0.5070.74
97_A316_K0.5030.74
117_M120_A0.5020.74
197_D201_D0.5010.73
263_D266_V0.5010.73
40_G43_P0.5000.73
136_L173_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qs0A 2 0.994 100 0.258 Contact Map
1umdA 2 0.994 100 0.262 Contact Map
2bfdA 2 0.9279 100 0.27 Contact Map
2ozlA 2 0.985 100 0.281 Contact Map
1w85A 2 0.967 100 0.309 Contact Map
2xt6A 2 0.9099 100 0.393 Contact Map
2yicA 2 0.9159 100 0.395 Contact Map
2jgdA 2 0.8949 100 0.419 Contact Map
1itzA 2 0.9099 100 0.635 Contact Map
3m49A 2 0.8829 100 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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