GREMLIN Database
YKWD - Uncharacterized protein YkwD
UniProt: O31398 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (246)
Sequences: 455 (440)
Seq/√Len: 28.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_S251_T7.6771.00
137_E167_R4.5181.00
225_E229_K3.7801.00
136_Y214_P3.5191.00
159_D238_H3.2871.00
144_T218_V3.0731.00
183_S187_G2.9481.00
222_M231_I2.8711.00
186_Y192_M2.8181.00
139_K215_E2.8061.00
169_K192_M2.7651.00
217_V250_W2.7551.00
211_Q250_W2.5270.99
169_K183_S2.4300.99
218_V221_W2.4230.99
139_K142_E2.3600.99
147_E222_M2.2600.98
211_Q217_V2.2600.98
140_V214_P2.2390.98
141_V239_I2.2100.98
172_D183_S2.1920.98
190_F203_A2.1910.98
171_Q175_D2.1770.98
140_V250_W2.1650.98
204_G236_F2.1590.98
186_Y196_F2.1460.98
140_V221_W2.1340.98
178_Y183_S2.0640.97
214_P221_W2.0260.97
217_V221_W1.9980.96
133_V158_I1.9970.96
147_E150_K1.9370.96
183_S192_M1.9280.96
141_V158_I1.8330.94
140_V217_V1.8070.94
192_M196_F1.7810.93
169_K172_D1.7790.93
209_K249_I1.7630.93
229_K234_P1.7110.92
187_G192_M1.6670.91
141_V241_V1.6550.90
228_R232_L1.6210.89
140_V218_V1.5990.89
179_F207_I1.5760.88
169_K184_P1.5610.87
210_G217_V1.5570.87
212_K216_E1.5520.87
214_P250_W1.5240.86
140_V252_Q1.5160.86
165_S192_M1.5110.86
149_Q155_P1.4940.85
172_D178_Y1.4930.85
147_E231_I1.4810.84
165_S253_Q1.4730.84
165_S196_F1.4660.84
174_K244_V1.4550.83
168_A196_F1.4330.82
183_S186_Y1.4260.82
221_W250_W1.4190.82
214_P217_V1.4160.82
171_Q244_V1.4130.81
173_M183_S1.3820.80
137_E170_S1.3790.80
165_S186_Y1.3490.78
172_D192_M1.3410.78
169_K173_M1.3390.78
173_M178_Y1.3360.78
144_T239_I1.3280.77
180_D253_Q1.3250.77
192_M253_Q1.3180.77
169_K253_Q1.3180.77
222_M228_R1.2810.74
243_Y248_S1.2650.74
140_V211_Q1.2630.73
244_V249_I1.2630.73
210_G250_W1.2610.73
172_D189_P1.2560.73
147_E151_Q1.2510.73
216_E220_A1.2500.73
211_Q220_A1.2450.72
206_N230_N1.2370.72
151_Q232_L1.2370.72
183_S189_P1.1990.69
189_P192_M1.1800.68
169_K189_P1.1760.68
169_K187_G1.1670.67
172_D191_D1.1670.67
172_D176_K1.1610.67
169_K178_Y1.1610.67
222_M232_L1.1440.66
161_T164_K1.1320.65
170_S242_G1.1270.65
211_Q221_W1.1270.65
169_K186_Y1.1220.64
167_R244_V1.1200.64
215_E219_K1.1150.64
169_K185_T1.1050.63
165_S169_K1.1030.63
14_G25_S1.0780.61
218_V250_W1.0770.61
183_S191_D1.0770.61
167_R170_S1.0770.61
137_E251_T1.0710.60
150_K231_I1.0650.60
200_Y203_A1.0640.60
218_V231_I1.0630.60
230_N252_Q1.0440.58
202_T235_N1.0400.58
189_P222_M1.0350.58
193_M203_A1.0350.58
153_L234_P1.0210.57
140_V239_I1.0130.56
173_M189_P1.0120.56
133_V167_R1.0070.56
167_R242_G1.0050.56
207_I217_V1.0000.55
135_A159_D1.0000.55
188_S191_D0.9970.55
174_K249_I0.9890.54
189_P203_A0.9880.54
190_F193_M0.9870.54
108_A118_A0.9830.54
181_H227_H0.9810.54
183_S190_F0.9780.53
217_V243_Y0.9710.53
62_K67_A0.9680.53
157_Q238_H0.9630.52
158_I163_S0.9590.52
18_F21_V0.9580.52
10_A13_V0.9530.52
198_I203_A0.9510.51
208_A217_V0.9500.51
178_Y189_P0.9450.51
210_G231_I0.9310.50
214_P218_V0.9220.49
211_Q214_P0.9180.49
107_A113_A0.9150.49
105_K109_D0.9130.49
133_V137_E0.9110.48
241_V249_I0.9050.48
173_M191_D0.9030.48
219_K223_N0.8940.47
139_K176_K0.8910.47
97_K107_A0.8820.46
190_F198_I0.8800.46
189_P231_I0.8770.46
222_M230_N0.8660.45
165_S190_F0.8640.45
19_G24_A0.8630.45
178_Y190_F0.8570.44
226_G233_N0.8520.44
189_P210_G0.8510.44
224_S227_H0.8420.43
219_K235_N0.8390.43
173_M179_F0.8310.42
100_Q105_K0.8300.42
173_M192_M0.8300.42
95_T105_K0.8270.42
186_Y195_S0.8220.42
167_R251_T0.8210.42
246_S249_I0.8200.41
187_G203_A0.8190.41
174_K242_G0.8170.41
141_V157_Q0.8150.41
242_G251_T0.8140.41
135_A139_K0.8110.41
184_P192_M0.8070.40
193_M253_Q0.8050.40
170_S183_S0.8050.40
165_S183_S0.8010.40
226_G230_N0.8010.40
169_K191_D0.7970.40
188_S192_M0.7950.40
228_R231_I0.7940.40
100_Q115_K0.7910.39
185_T192_M0.7900.39
21_V24_A0.7890.39
137_E244_V0.7870.39
203_A217_V0.7810.39
99_A120_A0.7800.39
193_M255_I0.7770.38
241_V250_W0.7620.37
164_K168_A0.7610.37
136_Y213_T0.7570.37
163_S250_W0.7560.37
57_I66_A0.7550.37
145_N227_H0.7540.37
202_T233_N0.7520.36
79_H84_N0.7500.36
188_S203_A0.7500.36
190_F200_Y0.7500.36
113_A121_E0.7440.36
143_L210_G0.7440.36
106_A109_D0.7430.36
210_G220_A0.7380.35
60_N64_L0.7360.35
173_M207_I0.7360.35
24_A28_E0.7310.35
183_S203_A0.7250.35
242_G249_I0.7220.34
186_Y190_F0.7210.34
73_K77_Q0.7200.34
15_L18_F0.7170.34
207_I221_W0.7160.34
92_K103_T0.7150.34
172_D228_R0.7120.34
136_Y241_V0.7090.33
174_K238_H0.7070.33
183_S207_I0.7070.33
152_G254_F0.7060.33
184_P207_I0.7050.33
140_V150_K0.7040.33
98_P103_T0.7040.33
165_S187_G0.6980.33
25_S30_S0.6970.33
96_A113_A0.6970.33
231_I252_Q0.6960.33
178_Y188_S0.6950.33
156_L206_N0.6940.32
218_V248_S0.6880.32
218_V222_M0.6850.32
243_Y250_W0.6840.32
10_A18_F0.6840.32
204_G241_V0.6840.32
208_A230_N0.6720.31
193_M233_N0.6700.31
165_S250_W0.6700.31
183_S253_Q0.6680.31
23_Q27_K0.6670.31
140_V241_V0.6640.30
174_K253_Q0.6610.30
14_G23_Q0.6600.30
25_S28_E0.6590.30
26_A37_V0.6570.30
178_Y187_G0.6540.30
206_N252_Q0.6540.30
165_S189_P0.6540.30
21_V34_V0.6530.30
70_K74_Q0.6510.30
221_W239_I0.6510.30
189_P193_M0.6510.30
190_F210_G0.6490.30
173_M230_N0.6490.30
218_V239_I0.6490.30
187_G190_F0.6470.29
143_L223_N0.6470.29
217_V241_V0.6450.29
206_N226_G0.6430.29
27_K37_V0.6410.29
32_Q38_K0.6400.29
178_Y193_M0.6400.29
165_S193_M0.6390.29
23_Q26_A0.6380.29
206_N232_L0.6380.29
101_K113_A0.6370.29
29_L37_V0.6350.29
147_E250_W0.6350.29
138_K159_D0.6340.29
53_K56_H0.6340.29
179_F184_P0.6310.28
179_F183_S0.6300.28
214_P239_I0.6270.28
10_A19_G0.6260.28
80_A84_N0.6250.28
221_W249_I0.6230.28
245_E248_S0.6220.28
147_E228_R0.6200.28
169_K193_M0.6190.28
76_L87_V0.6150.27
218_V232_L0.6150.27
165_S203_A0.6140.27
170_S245_E0.6120.27
118_A121_E0.6120.27
187_G198_I0.6100.27
168_A171_Q0.6090.27
115_K125_T0.6080.27
115_K123_T0.6080.27
14_G18_F0.6070.27
52_V55_L0.6000.26
169_K190_F0.5990.26
173_M206_N0.5970.26
165_S176_K0.5950.26
18_F25_S0.5930.26
10_A30_S0.5920.26
79_H83_S0.5920.26
137_E178_Y0.5900.26
222_M252_Q0.5900.26
208_A252_Q0.5880.26
213_T250_W0.5880.26
101_K106_A0.5850.26
191_D223_N0.5840.26
102_T107_A0.5830.25
59_T63_T0.5820.25
212_K250_W0.5820.25
184_P187_G0.5810.25
174_K209_K0.5800.25
172_D187_G0.5790.25
217_V220_A0.5780.25
23_Q31_C0.5770.25
185_T196_F0.5760.25
200_Y255_I0.5750.25
144_T231_I0.5740.25
203_A210_G0.5740.25
170_S192_M0.5730.25
197_G200_Y0.5720.25
31_C44_Q0.5680.25
36_T45_N0.5630.24
85_V88_Q0.5600.24
172_D184_P0.5590.24
144_T147_E0.5590.24
238_H255_I0.5590.24
186_Y253_Q0.5580.24
50_D63_T0.5570.24
213_T243_Y0.5560.24
137_E163_S0.5550.24
190_F255_I0.5520.24
93_T98_P0.5520.24
92_K99_A0.5510.24
217_V239_I0.5510.24
193_M200_Y0.5480.23
169_K203_A0.5470.23
186_Y198_I0.5460.23
228_R251_T0.5450.23
145_N206_N0.5450.23
145_N148_R0.5440.23
169_K200_Y0.5430.23
204_G223_N0.5420.23
136_Y211_Q0.5390.23
59_T66_A0.5390.23
136_Y250_W0.5370.23
185_T203_A0.5370.23
23_Q28_E0.5340.23
148_R205_E0.5330.23
29_L40_G0.5330.23
100_Q103_T0.5330.23
178_Y207_I0.5330.23
211_Q243_Y0.5320.23
162_L193_M0.5300.23
165_S185_T0.5300.23
61_I90_V0.5290.22
169_K177_N0.5280.22
14_G24_A0.5270.22
179_F200_Y0.5270.22
176_K185_T0.5260.22
196_F216_E0.5200.22
174_K246_S0.5180.22
171_Q174_K0.5180.22
172_D197_G0.5160.22
169_K176_K0.5160.22
54_K57_I0.5150.22
145_N181_H0.5140.22
243_Y255_I0.5130.22
144_T250_W0.5130.22
92_K106_A0.5130.22
75_L83_S0.5120.22
20_G23_Q0.5120.22
74_Q82_Q0.5090.21
172_D253_Q0.5060.21
154_K157_Q0.5050.21
134_S214_P0.5050.21
181_H205_E0.5050.21
156_L230_N0.5040.21
159_D215_E0.5040.21
101_K120_A0.5040.21
69_E81_K0.5010.21
250_W255_I0.5010.21
169_K196_F0.5000.21
203_A208_A0.5000.21
211_Q216_E0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ifaA 1 0.9066 100 0.48 Contact Map
4h0aA 1 0.8988 100 0.511 Contact Map
4aiwA 1 0.4436 99.9 0.638 Contact Map
1cfeA 1 0.4086 99.9 0.668 Contact Map
4p27A 1 0.4358 99.7 0.743 Contact Map
3q2uA 1 0.4825 99.7 0.743 Contact Map
2ddbA 2 0.4397 99.6 0.762 Contact Map
1xtaA 2 0.4708 99.5 0.77 Contact Map
4tpvA 2 0.4397 99.3 0.8 Contact Map
1u53A 1 0.4553 99.2 0.809 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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