GREMLIN Database
YOSP - SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
UniProt: O30601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (300)
Sequences: 2184 (804)
Seq/√Len: 46.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_K241_E5.8301.00
244_E257_K4.7131.00
49_K52_Q4.2261.00
265_N278_E4.1101.00
240_L261_R4.0721.00
35_I104_S3.9721.00
132_Q136_R3.4901.00
155_K227_W3.4251.00
56_M117_Q3.3801.00
53_D57_K3.2481.00
229_L276_W2.9921.00
233_Q276_W2.9671.00
162_F232_L2.9241.00
48_G51_E2.8281.00
236_Y277_F2.7871.00
229_L268_L2.6061.00
240_L257_K2.4151.00
157_M208_L2.3891.00
229_L273_F2.3021.00
229_L274_D2.3021.00
164_E198_E2.2951.00
236_Y264_A2.2911.00
158_V228_A2.1681.00
129_R133_K2.0981.00
230_N234_E2.0951.00
226_A230_N2.0721.00
44_W52_Q2.0711.00
66_D105_Y2.0541.00
43_T46_Y2.0030.99
228_A273_F1.9890.99
233_Q277_F1.9700.99
41_L45_K1.9570.99
69_Q142_Y1.9210.99
261_R279_E1.9150.99
97_E164_E1.9140.99
10_W88_A1.8840.99
56_M113_A1.8520.99
198_E201_H1.8430.99
209_A216_Q1.8300.99
237_E241_E1.8270.99
26_V31_L1.8130.99
222_K226_A1.7790.99
229_L233_Q1.7500.98
37_L107_N1.7340.98
283_N286_V1.7300.98
25_N96_M1.7160.98
222_K225_Y1.7070.98
32_P104_S1.7070.98
97_E198_E1.6860.98
91_N94_A1.6820.98
286_V289_G1.6730.98
23_N33_E1.6530.98
227_W230_N1.6480.98
89_V204_Y1.6000.97
17_F211_E1.5960.97
178_F184_L1.5800.97
50_N249_Q1.5740.97
104_S190_I1.5480.96
287_I290_L1.5470.96
151_I227_W1.5470.96
193_L196_R1.5470.96
15_D83_G1.5370.96
91_N99_A1.5320.96
255_D258_K1.5120.96
286_V290_L1.4930.96
140_S234_E1.4920.96
269_N275_H1.4630.95
209_A273_F1.4600.95
172_F307_Y1.4540.95
149_D152_S1.4500.95
285_I289_G1.4450.95
44_W56_M1.4350.95
168_F194_I1.4340.95
134_K239_E1.4200.94
25_N93_M1.4120.94
92_F95_M1.4020.94
92_F96_M1.4000.94
51_E183_K1.3940.94
244_E254_P1.3830.93
144_T155_K1.3750.93
154_F209_A1.3600.93
218_P274_D1.3600.93
166_F232_L1.3590.93
26_V32_P1.3480.92
168_F198_E1.3450.92
101_H201_H1.3270.92
52_Q56_M1.3260.92
257_K261_R1.3200.92
7_A12_K1.2970.91
233_Q237_E1.2930.91
47_L184_L1.2830.90
133_K234_E1.2760.90
136_R140_S1.2650.90
189_E305_N1.2640.90
225_Y274_D1.2380.89
45_K114_P1.2360.89
32_P35_I1.2300.88
297_H302_T1.2290.88
173_Y243_T1.2260.88
136_R274_D1.2230.88
70_G99_A1.2090.88
298_D301_S1.2020.87
241_E244_E1.1860.87
108_I187_S1.1840.87
258_K279_E1.1670.86
23_N103_K1.1610.85
158_V271_L1.1610.85
173_Y287_I1.1540.85
62_L69_Q1.1530.85
61_G242_Y1.1430.84
97_E168_F1.1380.84
168_F172_F1.1350.84
244_E248_D1.1330.84
23_N31_L1.1320.84
303_K309_K1.1250.84
179_Y188_G1.1210.83
21_F87_K1.1180.83
210_Q213_Y1.1170.83
152_S155_K1.1060.82
41_L111_T1.1040.82
117_Q120_E1.0980.82
54_T246_V1.0890.81
50_N248_D1.0780.81
55_Y187_S1.0600.80
151_I223_E1.0580.80
301_S304_G1.0560.79
35_I193_L1.0560.79
32_P107_N1.0540.79
172_F198_E1.0520.79
134_K242_Y1.0460.79
16_D20_M1.0260.77
48_G257_K1.0030.76
172_F201_H0.9980.75
213_Y220_K0.9940.75
236_Y261_R0.9930.75
248_D255_D0.9880.75
17_F20_M0.9850.74
240_L244_E0.9820.74
171_G194_I0.9780.74
201_H307_Y0.9760.74
32_P100_V0.9750.74
81_V153_L0.9740.74
144_T151_I0.9730.74
153_L157_M0.9710.73
42_L45_K0.9710.73
237_E240_L0.9660.73
19_Q23_N0.9640.73
206_G270_N0.9540.72
176_L195_I0.9530.72
211_E215_K0.9510.72
230_N237_E0.9500.72
88_A99_A0.9500.72
51_E250_V0.9490.72
17_F207_L0.9440.71
49_K255_D0.9430.71
43_T178_F0.9400.71
76_I79_E0.9390.71
202_G267_A0.9360.71
35_I196_R0.9300.70
225_Y273_F0.9270.70
261_R277_F0.9220.69
66_D187_S0.9190.69
88_A91_N0.9190.69
213_Y225_Y0.9160.69
26_V100_V0.9130.69
18_T211_E0.9110.69
263_N267_A0.9110.69
138_I163_L0.9090.68
294_T306_G0.9030.68
29_F92_F0.9020.68
101_H197_D0.9000.68
15_D211_E0.9000.68
166_F170_S0.8960.67
180_G286_V0.8940.67
225_Y229_L0.8920.67
22_Y103_K0.8910.67
151_I221_Q0.8890.67
262_Y266_K0.8890.67
74_M79_E0.8840.66
227_W231_L0.8790.66
66_D307_Y0.8730.65
173_Y255_D0.8710.65
189_E193_L0.8670.65
45_K230_N0.8660.65
164_E172_F0.8650.64
39_G43_T0.8650.64
204_Y208_L0.8640.64
106_S110_L0.8620.64
164_E201_H0.8600.64
248_D253_A0.8590.64
66_D201_H0.8570.64
87_K91_N0.8560.64
19_Q103_K0.8490.63
14_E84_H0.8480.63
101_H307_Y0.8450.63
265_N279_E0.8440.63
160_S205_V0.8430.62
202_G266_K0.8380.62
107_N110_L0.8270.61
122_F131_L0.8240.61
62_L171_G0.8220.61
243_T260_I0.8210.60
136_R277_F0.8150.60
46_Y183_K0.8080.59
36_A39_G0.8070.59
295_K306_G0.8070.59
49_K244_E0.8000.58
49_K228_A0.7990.58
175_P191_I0.7930.58
165_S267_A0.7900.57
268_L276_W0.7870.57
49_K233_Q0.7840.57
229_L275_H0.7840.57
212_I215_K0.7820.57
283_N287_I0.7810.57
66_D197_D0.7810.57
123_E127_N0.7790.56
248_D254_P0.7770.56
86_R208_L0.7750.56
7_A11_S0.7750.56
136_R230_N0.7750.56
18_T207_L0.7710.56
179_Y192_N0.7680.55
105_Y201_H0.7660.55
37_L190_I0.7660.55
170_S260_I0.7630.55
120_E244_E0.7610.55
93_M168_F0.7590.54
275_H278_E0.7530.54
134_K238_N0.7490.53
265_N275_H0.7480.53
136_R276_W0.7460.53
202_G262_Y0.7440.53
134_K298_D0.7430.53
120_E127_N0.7420.53
21_F203_V0.7420.53
9_N12_K0.7410.53
25_N204_Y0.7400.53
19_Q22_Y0.7380.52
17_F32_P0.7370.52
18_T86_R0.7370.52
46_Y120_E0.7370.52
198_E307_Y0.7360.52
23_N27_K0.7340.52
91_N227_W0.7340.52
95_M100_V0.7310.52
285_I288_N0.7300.52
101_H172_F0.7300.52
164_E168_F0.7290.51
151_I224_L0.7290.51
295_K302_T0.7290.51
182_G305_N0.7280.51
127_N274_D0.7280.51
38_N41_L0.7280.51
285_I290_L0.7250.51
81_V157_M0.7250.51
37_L186_Q0.7250.51
100_V310_A0.7230.51
25_N28_Q0.7210.51
133_K137_T0.7200.51
39_G42_L0.7200.51
127_N136_R0.7110.50
192_N295_K0.7100.50
209_A271_L0.7100.50
204_Y207_L0.7100.50
42_L241_E0.7030.49
42_L255_D0.7030.49
97_E201_H0.7030.49
237_E244_E0.6940.48
128_N162_F0.6900.48
197_D201_H0.6890.48
45_K50_N0.6880.47
49_K218_P0.6860.47
45_K120_E0.6850.47
25_N89_V0.6840.47
232_L264_A0.6840.47
258_K313_E0.6830.47
74_M78_A0.6830.47
283_N289_G0.6800.47
259_F299_F0.6790.47
55_Y62_L0.6790.47
236_Y240_L0.6790.47
130_F245_D0.6780.46
54_T250_V0.6770.46
243_T257_K0.6770.46
168_F201_H0.6760.46
286_V292_T0.6760.46
105_Y172_F0.6750.46
122_F125_V0.6750.46
285_I293_K0.6720.46
34_E303_K0.6700.46
66_D168_F0.6680.45
80_H156_G0.6680.45
128_N245_D0.6670.45
101_H198_E0.6640.45
25_N200_I0.6640.45
207_L211_E0.6640.45
297_H304_G0.6620.45
106_S309_K0.6610.45
244_E261_R0.6550.44
162_F235_L0.6520.44
31_L100_V0.6470.43
216_Q220_K0.6460.43
289_G292_T0.6460.43
105_Y198_E0.6450.43
46_Y274_D0.6450.43
20_M234_E0.6430.43
214_K273_F0.6390.43
299_F304_G0.6370.42
298_D304_G0.6360.42
70_G94_A0.6350.42
14_E100_V0.6330.42
140_S144_T0.6310.42
261_R265_N0.6310.42
129_R274_D0.6310.42
69_Q163_L0.6270.41
171_G175_P0.6260.41
211_E218_P0.6230.41
75_P78_A0.6220.41
194_I198_E0.6220.41
68_E134_K0.6200.41
54_T174_Y0.6160.40
26_V92_F0.6160.40
257_K260_I0.6130.40
66_D106_S0.6130.40
151_I217_T0.6110.40
57_K260_I0.6110.40
101_H168_F0.6080.40
162_F228_A0.6080.40
123_E226_A0.6070.40
97_E105_Y0.6050.39
36_A186_Q0.6040.39
95_M99_A0.6020.39
100_V246_V0.6010.39
199_A203_V0.5990.39
254_P257_K0.5970.39
289_G293_K0.5960.39
29_F65_L0.5960.39
214_K255_D0.5940.38
52_Q254_P0.5940.38
30_W40_D0.5940.38
274_D278_E0.5920.38
64_L193_L0.5920.38
47_L52_Q0.5910.38
205_V260_I0.5910.38
66_D205_V0.5910.38
137_T141_V0.5880.38
144_T150_E0.5860.38
226_A229_L0.5850.38
14_E17_F0.5840.37
66_D101_H0.5820.37
55_Y184_L0.5810.37
143_K255_D0.5800.37
65_L69_Q0.5790.37
135_A259_F0.5770.37
105_Y202_G0.5750.37
206_G271_L0.5730.36
117_Q122_F0.5730.36
269_N278_E0.5720.36
108_I169_Y0.5720.36
173_Y260_I0.5700.36
259_F267_A0.5690.36
117_Q230_N0.5690.36
226_A278_E0.5680.36
125_V135_A0.5680.36
86_R204_Y0.5680.36
6_D14_E0.5670.36
162_F259_F0.5660.36
180_G189_E0.5630.36
179_Y184_L0.5630.36
152_S240_L0.5630.36
63_T194_I0.5610.35
163_L175_P0.5600.35
66_D262_Y0.5590.35
21_F24_Q0.5580.35
25_N92_F0.5570.35
177_Y181_Q0.5560.35
158_V224_L0.5560.35
87_K304_G0.5550.35
16_D45_K0.5540.35
155_K224_L0.5540.35
221_Q224_L0.5540.35
130_F246_V0.5530.35
62_L298_D0.5530.35
274_D280_E0.5510.34
139_V143_K0.5500.34
53_D58_V0.5470.34
217_T220_K0.5470.34
21_F204_Y0.5460.34
215_K218_P0.5430.34
78_A94_A0.5410.34
165_S186_Q0.5400.33
129_R229_L0.5390.33
160_S202_G0.5390.33
116_E120_E0.5380.33
18_T83_G0.5380.33
233_Q280_E0.5370.33
184_L190_I0.5330.33
247_Y268_L0.5310.33
213_Y272_G0.5300.33
168_F307_Y0.5300.33
142_Y169_Y0.5290.32
60_A121_V0.5290.32
49_K151_I0.5280.32
49_K129_R0.5280.32
133_K139_V0.5280.32
224_L273_F0.5270.32
160_S170_S0.5260.32
165_S202_G0.5260.32
297_H303_K0.5260.32
259_F296_S0.5250.32
157_M213_Y0.5250.32
133_K238_N0.5240.32
12_K85_Q0.5230.32
252_L256_V0.5220.32
66_D172_F0.5200.32
46_Y178_F0.5190.32
30_W101_H0.5190.32
15_D18_T0.5180.32
185_M302_T0.5180.32
68_E108_I0.5180.32
72_T93_M0.5170.31
49_K274_D0.5170.31
273_F276_W0.5160.31
270_N301_S0.5150.31
21_F44_W0.5150.31
22_Y32_P0.5140.31
164_E194_I0.5130.31
155_K231_L0.5120.31
265_N268_L0.5120.31
262_Y284_P0.5120.31
90_L205_V0.5120.31
144_T149_D0.5110.31
150_E218_P0.5110.31
295_K305_N0.5100.31
236_Y260_I0.5080.31
59_L187_S0.5080.31
183_K276_W0.5070.31
97_E172_F0.5060.31
56_M70_G0.5060.31
57_K246_V0.5050.30
251_G283_N0.5050.30
59_L109_F0.5040.30
10_W204_Y0.5040.30
92_F99_A0.5040.30
59_L63_T0.5030.30
105_Y164_E0.5020.30
213_Y216_Q0.5010.30
10_W15_D0.5000.30
310_A314_P0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dr0A 2 0.8815 100 0.112 Contact Map
4bmoA 2 0.8754 100 0.121 Contact Map
4n83A 4 0.8602 100 0.123 Contact Map
3n37A 2 0.8571 100 0.124 Contact Map
3dhzA 2 0.8632 100 0.133 Contact Map
1mxrA 2 0.8693 100 0.153 Contact Map
1jk0A 1 0.8359 100 0.157 Contact Map
2rccA 4 0.8784 100 0.16 Contact Map
1h0oA 2 0.8328 100 0.164 Contact Map
1jk0B 1 0.7508 100 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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