GREMLIN Database
GATB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
UniProt: O30509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (471)
Sequences: 3129 (1708)
Seq/√Len: 78.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
424_T472_E4.2781.00
425_E455_A3.6851.00
54_E57_E3.6801.00
235_V240_F3.5741.00
104_W115_R3.5561.00
106_E115_R3.4831.00
399_G407_E3.4101.00
119_T155_E3.3401.00
198_L233_E3.2771.00
5_T229_E3.2651.00
170_K298_D3.2151.00
72_T283_D3.1081.00
109_V112_K3.0111.00
67_N104_W2.9581.00
154_S167_Y2.9021.00
467_K471_E2.8651.00
25_S38_S2.7641.00
117_G157_D2.7241.00
372_G402_E2.7231.00
295_E303_R2.7091.00
420_L472_E2.6531.00
376_L405_V2.6281.00
420_L471_E2.6271.00
23_S38_S2.5861.00
63_A100_G2.5701.00
283_D287_E2.5611.00
372_G400_D2.4921.00
406_K411_V2.4431.00
422_L456_S2.4421.00
331_T341_A2.4061.00
23_S41_D2.3351.00
4_E199_R2.3181.00
184_K187_E2.2611.00
429_N455_A2.2491.00
182_D189_S2.2151.00
302_K306_E2.1871.00
452_I465_V2.1871.00
162_E222_Q2.1671.00
400_D403_K2.1601.00
393_E408_K2.1361.00
161_P225_L2.1121.00
69_E102_N2.1011.00
421_K425_E2.0791.00
444_A448_L2.0771.00
13_V175_I2.0571.00
3_F237_L2.0561.00
425_E429_N2.0501.00
198_L236_L2.0411.00
25_S41_D2.0401.00
287_E290_K2.0391.00
168_L221_V2.0371.00
235_V242_I2.0351.00
62_A150_V2.0121.00
38_S41_D1.9951.00
161_P226_E1.9721.00
106_E113_T1.9701.00
245_E258_L1.9531.00
55_A123_L1.9241.00
249_Y254_K1.9181.00
300_R326_D1.8851.00
54_E58_F1.8751.00
158_I164_A1.8731.00
114_K163_E1.8511.00
403_K407_E1.8481.00
311_A342_S1.8171.00
11_V171_L1.8091.00
62_A180_V1.8001.00
433_S444_A1.7661.00
51_L56_V1.7641.00
330_E368_E1.7471.00
416_E420_L1.7361.00
88_K125_E1.6951.00
305_I312_A1.6901.00
77_D96_D1.6831.00
433_S436_D1.6751.00
390_V404_I1.6691.00
393_E397_K1.6691.00
71_A101_E1.6541.00
31_A36_Q1.6431.00
424_T428_D1.6381.00
248_R259_M1.6341.00
107_I116_I1.6341.00
21_I55_A1.6251.00
382_I386_I1.6201.00
16_K58_F1.6121.00
13_V181_S1.6051.00
287_E291_A1.5931.00
233_E237_L1.5911.00
117_G155_E1.5901.00
68_C102_N1.5891.00
207_G236_L1.5881.00
436_D444_A1.5841.00
449_V466_N1.5791.00
2_N201_I1.5721.00
231_R247_R1.5540.99
337_E378_E1.5520.99
331_T374_I1.5510.99
69_E101_E1.5310.99
86_N89_A1.5260.99
11_V168_L1.5180.99
159_R206_F1.5170.99
418_V421_K1.5100.99
220_F249_Y1.5100.99
56_V279_L1.5010.99
432_Q436_D1.4860.99
322_K326_D1.4820.99
67_N115_R1.4770.99
288_R292_S1.4720.99
372_G401_A1.4680.99
415_D418_V1.4640.99
68_C100_G1.4630.99
431_P435_E1.4620.99
72_T286_K1.4600.99
61_K292_S1.4600.99
356_E396_E1.4440.99
394_L401_A1.4360.99
21_I51_L1.4350.99
172_K176_Q1.4280.99
349_V363_V1.4260.99
92_I273_E1.4260.99
324_M350_S1.4250.99
330_E333_Q1.4230.99
53_K285_W1.4200.99
102_N118_I1.4190.99
165_Y222_Q1.4130.99
130_L140_V1.4080.99
200_P205_E1.4020.99
90_Y273_E1.4010.99
433_S448_L1.3950.99
194_A221_V1.3950.99
420_L468_I1.3870.99
165_Y169_E1.3760.99
423_V468_I1.3740.99
416_E464_M1.3690.99
373_M394_L1.3660.99
412_Q461_N1.3550.99
464_M467_K1.3510.98
102_N155_E1.3470.98
426_A452_I1.3340.98
15_L150_V1.3330.98
420_L424_T1.3320.98
62_A66_L1.3320.98
381_T411_V1.3310.98
419_L456_S1.3310.98
305_I315_A1.3210.98
445_I470_L1.3160.98
423_V472_E1.3150.98
57_E285_W1.3130.98
57_E288_R1.2800.98
435_E439_N1.2790.98
442_D470_L1.2780.98
75_K96_D1.2730.98
227_H256_T1.2680.98
14_E184_K1.2640.98
227_H255_K1.2630.98
335_G341_A1.2610.98
229_E233_E1.2610.98
317_V346_M1.2580.98
62_A175_I1.2380.97
466_N470_L1.2380.97
110_G162_E1.2360.97
402_E406_K1.2310.97
249_Y253_T1.2180.97
37_T42_L1.2160.97
358_K362_D1.2160.97
448_L469_L1.2120.97
222_Q226_E1.2090.97
460_A465_V1.2070.97
282_D285_W1.1980.97
154_S158_I1.1940.97
399_G403_K1.1930.97
308_L332_V1.1920.97
376_L401_A1.1920.97
11_V154_S1.1840.96
352_Y392_K1.1640.96
175_I183_C1.1630.96
73_D280_Y1.1530.96
332_V335_G1.1440.96
220_F251_E1.1440.96
392_K396_E1.1410.96
366_T369_G1.1390.96
344_W387_A1.1360.96
121_L150_V1.1350.96
243_Q258_L1.1270.95
16_K179_G1.1250.95
60_M289_V1.1250.95
304_Y308_L1.1210.95
303_R329_E1.1180.95
197_S207_G1.1160.95
311_A346_M1.1140.95
422_L426_A1.1140.95
105_I118_I1.1100.95
427_L434_I1.1090.95
17_T55_A1.1080.95
445_I469_L1.1000.95
375_K379_K1.0990.95
6_V159_R1.0970.95
102_N119_T1.0970.95
426_A451_Q1.0950.95
340_Q378_E1.0950.95
63_A70_I1.0930.95
64_M290_K1.0900.94
172_K190_L1.0900.94
208_T244_Q1.0870.94
352_Y395_I1.0870.94
427_L431_P1.0860.94
463_P467_K1.0840.94
62_A178_T1.0740.94
80_N271_F1.0700.94
313_Y317_V1.0680.94
100_G121_L1.0610.94
359_E362_D1.0600.94
356_E395_I1.0570.93
300_R329_E1.0540.93
17_T148_P1.0530.93
4_E159_R1.0500.93
444_A447_F1.0490.93
403_K406_K1.0430.93
331_T367_P1.0410.93
250_D257_I1.0370.93
380_G414_S1.0370.93
250_D253_T1.0360.93
220_F223_K1.0320.93
59_A99_I1.0240.92
168_L192_C1.0230.92
184_K189_S1.0230.92
426_A448_L1.0190.92
283_D286_K1.0140.92
27_T36_Q1.0140.92
295_E300_R1.0120.92
323_E361_A1.0070.92
93_S273_E1.0050.92
18_K54_E1.0030.92
313_Y346_M1.0030.92
376_L402_E0.9980.91
60_M285_W0.9960.91
300_R304_Y0.9950.91
446_G466_N0.9950.91
421_K424_T0.9940.91
419_L459_Q0.9870.91
201_I205_E0.9850.91
23_S39_V0.9790.91
199_R206_F0.9750.90
2_N237_L0.9710.90
401_A405_V0.9700.90
281_I285_W0.9640.90
441_K444_A0.9630.90
40_I47_V0.9590.90
114_K159_R0.9580.90
170_K173_S0.9570.90
159_R199_R0.9570.90
405_V411_V0.9560.89
304_Y325_A0.9530.89
416_E467_K0.9520.89
339_K343_N0.9400.89
183_C189_S0.9380.89
451_Q454_K0.9380.89
11_V167_Y0.9380.89
172_K183_C0.9370.89
40_I50_V0.9370.89
393_E396_E0.9360.88
383_S412_Q0.9310.88
353_L363_V0.9250.88
447_F451_Q0.9230.88
369_G398_G0.9220.88
413_I456_S0.9180.87
295_E329_E0.9160.87
334_K368_E0.9150.87
432_Q435_E0.9150.87
75_K97_K0.9150.87
89_A145_Q0.9150.87
336_A375_K0.9120.87
426_A455_A0.9070.87
301_R305_I0.9060.87
177_Y300_R0.9040.87
468_I471_E0.9020.87
185_M190_L0.9020.87
4_E201_I0.9010.87
168_L218_F0.8990.86
4_E202_G0.8990.86
212_L215_L0.8980.86
314_D339_K0.8950.86
442_D445_I0.8950.86
2_N200_P0.8940.86
324_M345_L0.8920.86
26_P36_Q0.8880.86
385_K389_K0.8880.86
332_V336_A0.8830.85
393_E398_G0.8820.85
198_L229_E0.8790.85
231_R245_E0.8730.85
116_I158_I0.8730.85
212_L256_T0.8730.85
223_K254_K0.8720.85
29_F187_E0.8720.85
436_D441_K0.8710.85
248_R257_I0.8700.85
107_I114_K0.8660.84
44_Y47_V0.8650.84
304_Y329_E0.8650.84
176_Q323_E0.8640.84
334_K371_A0.8620.84
437_F442_D0.8620.84
404_I408_K0.8560.84
7_I158_I0.8550.83
348_E388_K0.8550.83
383_S386_I0.8520.83
335_G374_I0.8520.83
430_N451_Q0.8510.83
285_W289_V0.8490.83
332_V338_A0.8470.83
345_L349_V0.8470.83
42_L142_F0.8450.83
67_N299_E0.8450.83
435_E438_K0.8410.82
288_R291_A0.8390.82
426_A456_S0.8380.82
210_T247_R0.8370.82
76_F123_L0.8360.82
423_V452_I0.8360.82
219_A223_K0.8350.82
336_A341_A0.8320.82
57_E60_M0.8320.82
417_G420_L0.8270.81
434_I473_I0.8250.81
347_G350_S0.8230.81
59_A150_V0.8210.81
285_W288_R0.8200.81
389_K408_K0.8200.81
414_S419_L0.8200.81
394_L397_K0.8180.81
453_M458_G0.8170.81
62_A68_C0.8170.81
108_E113_T0.8160.81
172_K218_F0.8140.80
93_S96_D0.8140.80
452_I469_L0.8130.80
348_E352_Y0.8120.80
446_G449_V0.8100.80
28_P31_A0.8090.80
376_L381_T0.8060.80
64_M286_K0.8060.80
231_R235_V0.8050.80
289_V292_S0.8050.80
198_L237_L0.8040.80
436_D448_L0.8020.79
196_I229_E0.8020.79
419_L468_I0.8010.79
244_Q265_S0.8010.79
351_A355_A0.8000.79
53_K57_E0.7990.79
32_E35_T0.7970.79
247_R256_T0.7890.78
434_I438_K0.7890.78
130_L138_S0.7890.78
165_Y218_F0.7860.78
399_G404_I0.7860.78
352_Y356_E0.7850.78
468_I472_E0.7840.78
75_K93_S0.7830.78
372_G375_K0.7800.77
63_A121_L0.7780.77
6_V199_R0.7780.77
177_Y322_K0.7760.77
6_V206_F0.7750.77
176_Q183_C0.7740.77
3_F200_P0.7710.77
430_N447_F0.7690.76
434_I437_F0.7670.76
197_S209_K0.7670.76
431_P445_I0.7650.76
452_I456_S0.7640.76
331_T371_A0.7640.76
344_W374_I0.7630.76
330_E334_K0.7620.76
39_V44_Y0.7610.76
247_R258_L0.7600.76
5_T160_T0.7580.75
430_N433_S0.7570.75
25_S39_V0.7570.75
170_K301_R0.7550.75
210_T242_I0.7540.75
232_Q242_I0.7540.75
386_I410_L0.7530.75
384_S388_K0.7490.75
390_V405_V0.7490.75
14_E248_R0.7490.75
335_G378_E0.7460.74
437_F445_I0.7450.74
321_T324_M0.7450.74
162_E166_A0.7440.74
51_L55_A0.7420.74
261_V266_D0.7390.74
369_G394_L0.7380.73
192_C221_V0.7350.73
60_M70_I0.7350.73
425_E428_D0.7340.73
175_I178_T0.7320.73
327_F331_T0.7320.73
212_L224_G0.7310.73
352_Y391_F0.7310.73
5_T198_L0.7300.73
194_A225_L0.7290.73
60_M281_I0.7280.72
336_A371_A0.7270.72
198_L235_V0.7270.72
210_T235_V0.7260.72
394_L404_I0.7230.72
437_F470_L0.7220.72
402_E405_V0.7190.72
64_M293_I0.7170.71
117_G156_P0.7160.71
9_L194_A0.7140.71
96_D120_R0.7130.71
108_E301_R0.7130.71
348_E351_A0.7120.71
373_M390_V0.7110.71
132_H138_S0.7110.71
437_F473_I0.7100.71
369_G400_D0.7090.70
420_L467_K0.7070.70
419_L460_A0.7070.70
341_A374_I0.7070.70
327_F360_L0.7050.70
344_W377_I0.7050.70
284_E288_R0.7030.70
382_I390_V0.7030.70
300_R303_R0.7030.70
207_G242_I0.7020.70
66_L118_I0.7020.70
243_Q261_V0.7020.70
249_Y255_K0.7010.70
68_C121_L0.7000.70
74_T279_L0.6950.69
161_P222_Q0.6920.69
127_A130_L0.6910.69
433_S447_F0.6900.68
26_P31_A0.6890.68
340_Q377_I0.6880.68
414_S461_N0.6860.68
109_V162_E0.6860.68
7_I229_E0.6860.68
427_L445_I0.6850.68
109_V166_A0.6820.68
363_V395_I0.6800.67
150_V180_V0.6800.67
175_I179_G0.6800.67
331_T370_L0.6790.67
369_G372_G0.6780.67
331_T345_L0.6760.67
364_A398_G0.6760.67
95_F120_R0.6730.66
314_D346_M0.6720.66
57_E61_K0.6720.66
199_R205_E0.6700.66
15_L148_P0.6690.66
304_Y328_F0.6680.66
337_E340_Q0.6640.65
150_V187_E0.6630.65
374_I377_I0.6630.65
372_G403_K0.6630.65
73_D97_K0.6620.65
437_F448_L0.6600.65
308_L333_Q0.6590.65
51_L276_L0.6590.65
324_M360_L0.6590.65
434_I448_L0.6570.65
235_V247_R0.6570.65
342_S346_M0.6550.64
177_Y325_A0.6550.64
418_V422_L0.6540.64
95_F265_S0.6530.64
215_L220_F0.6510.64
209_K242_I0.6500.64
417_G421_K0.6500.64
386_I408_K0.6490.64
452_I460_A0.6480.64
347_G351_A0.6480.64
28_P36_Q0.6480.64
66_L121_L0.6470.63
197_S208_T0.6460.63
60_M286_K0.6450.63
27_T147_T0.6430.63
281_I286_K0.6410.63
14_E183_C0.6390.62
207_G232_Q0.6380.62
209_K244_Q0.6380.62
18_K28_P0.6360.62
315_A319_T0.6340.62
305_I309_G0.6330.62
210_T231_R0.6330.62
60_M63_A0.6330.62
184_K248_R0.6290.61
170_K174_I0.6290.61
61_K289_V0.6290.61
382_I405_V0.6280.61
335_G375_K0.6280.61
373_M391_F0.6270.61
325_A329_E0.6270.61
426_A447_F0.6260.61
13_V152_I0.6260.61
308_L328_F0.6260.61
101_E119_T0.6250.61
59_A123_L0.6250.61
162_E226_E0.6230.61
422_L452_I0.6220.60
47_V145_Q0.6210.60
456_S460_A0.6210.60
197_S206_F0.6200.60
332_V341_A0.6190.60
210_T245_E0.6190.60
422_L455_A0.6190.60
393_E404_I0.6170.60
369_G401_A0.6160.60
58_F61_K0.6150.60
8_G12_H0.6140.59
313_Y316_M0.6140.59
89_A249_Y0.6130.59
374_I384_S0.6130.59
3_F236_L0.6120.59
107_I166_A0.6110.59
14_E147_T0.6110.59
6_V162_E0.6090.59
199_R204_E0.6080.59
413_I417_G0.6070.59
427_L472_E0.6070.59
23_S40_I0.6070.59
41_D47_V0.6060.58
381_T402_E0.6060.58
74_T281_I0.6040.58
377_I386_I0.6040.58
436_D439_N0.6010.58
171_L175_I0.6010.58
24_S38_S0.5990.58
165_Y221_V0.5980.57
201_I204_E0.5970.57
310_F342_S0.5960.57
186_E190_L0.5960.57
5_T158_I0.5960.57
169_E190_L0.5950.57
165_Y168_L0.5940.57
21_I125_E0.5930.57
210_T243_Q0.5930.57
161_P165_Y0.5920.57
131_T134_G0.5910.57
22_F76_F0.5900.56
42_L88_K0.5890.56
373_M411_V0.5870.56
16_K181_S0.5870.56
60_M150_V0.5850.56
365_L394_L0.5850.56
223_K249_Y0.5850.56
464_M471_E0.5840.56
169_E172_K0.5830.56
329_E333_Q0.5820.55
279_L285_W0.5810.55
17_T150_V0.5800.55
21_I88_K0.5790.55
236_L242_I0.5780.55
98_P122_H0.5780.55
177_Y319_T0.5780.55
217_S220_F0.5770.55
360_L363_V0.5770.55
71_A74_T0.5770.55
61_K179_G0.5760.55
117_G206_F0.5750.55
328_F332_V0.5750.55
173_S320_L0.5750.55
332_V337_E0.5740.54
414_S417_G0.5740.54
269_R275_D0.5730.54
390_V394_L0.5720.54
420_L423_V0.5710.54
333_Q336_A0.5700.54
424_T427_L0.5700.54
65_A178_T0.5690.54
80_N270_Y0.5690.54
372_G376_L0.5690.54
209_K215_L0.5680.54
3_F233_E0.5670.53
58_F180_V0.5660.53
377_I384_S0.5660.53
23_S47_V0.5640.53
424_T471_E0.5630.53
43_G88_K0.5620.53
301_R316_M0.5620.53
346_M350_S0.5610.53
377_I387_A0.5600.53
105_I174_I0.5600.53
300_R325_A0.5580.52
311_A314_D0.5580.52
282_D287_E0.5580.52
387_A391_F0.5580.52
355_A392_K0.5570.52
368_E372_G0.5570.52
263_E269_R0.5570.52
40_I44_Y0.5560.52
77_D95_F0.5560.52
326_D330_E0.5560.52
207_G244_Q0.5540.52
304_Y318_L0.5540.52
282_D288_R0.5530.52
327_F349_V0.5530.52
67_N290_K0.5480.51
175_I180_V0.5470.51
67_N102_N0.5460.51
72_T280_Y0.5450.51
95_F270_Y0.5440.51
433_S441_K0.5440.51
194_A215_L0.5440.51
80_N273_E0.5440.51
418_V459_Q0.5430.50
71_A97_K0.5420.50
168_L190_L0.5420.50
340_Q384_S0.5410.50
58_F178_T0.5410.50
416_E472_E0.5410.50
197_S242_I0.5410.50
352_Y355_A0.5400.50
13_V121_L0.5390.50
321_T359_E0.5380.50
169_E218_F0.5380.50
69_E72_T0.5380.50
451_Q455_A0.5370.50
30_G187_E0.5370.50
377_I382_I0.5370.50
305_I311_A0.5370.50
301_R312_A0.5360.49
72_T281_I0.5360.49
67_N106_E0.5340.49
173_S301_R0.5340.49
432_Q444_A0.5340.49
14_E89_A0.5330.49
192_C215_L0.5330.49
263_E271_F0.5320.49
428_D455_A0.5320.49
158_I167_Y0.5320.49
244_Q264_G0.5310.49
202_G205_E0.5300.49
422_L425_E0.5300.49
416_E468_I0.5300.49
117_G154_S0.5300.49
113_T302_K0.5290.49
100_G123_L0.5290.49
77_D181_S0.5290.49
233_E236_L0.5280.48
93_S150_V0.5280.48
431_P436_D0.5280.48
223_K251_E0.5280.48
330_E367_P0.5270.48
25_S37_T0.5260.48
56_V123_L0.5260.48
300_R322_K0.5260.48
119_T154_S0.5250.48
77_D250_D0.5250.48
14_E193_D0.5250.48
175_I181_S0.5250.48
9_L168_L0.5230.48
313_Y339_K0.5230.48
209_K261_V0.5220.48
181_S185_M0.5210.48
87_P142_F0.5200.47
166_A170_K0.5180.47
364_A395_I0.5180.47
370_L374_I0.5170.47
380_G463_P0.5170.47
395_I461_N0.5160.47
77_D248_R0.5160.47
437_F447_F0.5160.47
448_L473_I0.5150.47
102_N117_G0.5150.47
176_Q184_K0.5150.47
312_A316_M0.5140.47
142_F145_Q0.5140.47
81_Y85_D0.5140.47
142_F248_R0.5140.47
118_I194_A0.5140.47
88_K180_V0.5140.47
400_D407_E0.5130.47
382_I387_A0.5130.47
88_K145_Q0.5130.47
84_P275_D0.5120.46
215_L247_R0.5120.46
353_L360_L0.5120.46
310_F343_N0.5120.46
108_E170_K0.5120.46
122_H153_V0.5110.46
71_A277_V0.5110.46
305_I310_F0.5110.46
34_N141_D0.5100.46
210_T232_Q0.5090.46
19_S88_K0.5080.46
365_L370_L0.5080.46
284_E287_E0.5070.46
463_P470_L0.5070.46
314_D317_V0.5060.46
385_K405_V0.5060.46
261_V264_G0.5060.46
301_R319_T0.5060.46
413_I419_L0.5050.46
437_F444_A0.5040.45
236_L239_G0.5030.45
327_F366_T0.5020.45
230_K234_Q0.5020.45
118_I157_D0.5020.45
178_T296_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4B 1 0.9979 100 -0.005 Contact Map
3al0B 1 1 100 -0.003 Contact Map
3h0lB 1 0.8592 100 -0.001 Contact Map
4wj3B 2 0.8361 100 0.067 Contact Map
3kfuF 2 0.8172 100 0.076 Contact Map
2d6fC 1 0.6828 100 0.15 Contact Map
1zq1C 1 0.6933 100 0.153 Contact Map
4n0hB 1 0.5714 100 0.279 Contact Map
2hz7A 1 0.1975 100 0.762 Contact Map
1ng6A 1 0.2941 99.4 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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