CPXY - BACSU - GREMLIN Contacts

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CPXY - Cytochrome P450

UniProt:	O08469	Sequences: MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSLGALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPPDHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVISEMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGDLISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQQPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIFPNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQMKWKGNFLMRALEELPISF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	410 (360)
Sequences:	43644 (32066)
Seq/√Len:	1690.0

BACSU - CPXY PKSS BIOI CYPX YJIB CYPC CYPE CYPD
HALSA - Q9HS37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
336_N	339_I	3.750	1.00
336_N	341_D	3.317	1.00
273_K	343_E	3.197	1.00
308_I	313_E	3.097	1.00
132_D	375_T	3.067	1.00
260_M	288_A	3.045	1.00
260_M	373_I	2.923	1.00
315_K	318_D	2.828	1.00
256_L	369_A	2.780	1.00
282_N	370_K	2.676	1.00
55_R	58_D	2.598	1.00
306_P	313_E	2.590	1.00
306_P	316_R	2.573	1.00
212_R	235_T	2.557	1.00
263_A	292_H	2.533	1.00
271_L	275_R	2.512	1.00
272_E	276_Q	2.428	1.00
329_R	338_D	2.339	1.00
270_Q	280_L	2.338	1.00
41_P	49_K	2.329	1.00
274_L	284_A	2.258	1.00
211_K	218_D	2.229	1.00
139_Q	380_C	2.228	1.00
303_T	314_I	2.151	1.00
51_W	318_D	2.129	1.00
126_K	161_E	2.120	1.00
273_K	280_L	2.102	1.00
58_D	310_H	2.083	1.00
209_R	235_T	2.083	1.00
205_E	239_Y	2.078	1.00
128_Q	375_T	2.062	1.00
267_H	270_Q	2.060	1.00
139_Q	379_R	1.982	1.00
31_K	34_R	1.978	1.00
154_L	372_A	1.978	1.00
358_F	362_A	1.974	1.00
263_A	291_F	1.974	1.00
205_E	235_T	1.941	1.00
308_I	311_G	1.921	1.00
262_Y	266_C	1.878	1.00
285_I	369_A	1.856	1.00
39_L	53_I	1.844	1.00
205_E	209_R	1.828	1.00
59_A	327_A	1.797	1.00
286_E	366_R	1.797	1.00
270_Q	273_K	1.792	1.00
376_L	383_I	1.724	1.00
195_H	199_E	1.722	1.00
38_A	55_R	1.715	1.00
69_K	305_E	1.701	1.00
53_I	62_L	1.690	1.00
257_I	372_A	1.671	1.00
271_L	382_N	1.665	1.00
29_F	32_E	1.659	1.00
60_I	64_K	1.655	1.00
272_E	382_N	1.652	1.00
43_S	49_K	1.638	1.00
288_A	340_F	1.634	1.00
151_A	261_T	1.632	1.00
29_F	33_L	1.624	1.00
130_I	133_S	1.622	1.00
130_I	161_E	1.619	1.00
172_K	176_W	1.605	1.00
275_R	382_N	1.601	1.00
272_E	275_R	1.599	1.00
107_L	241_M	1.596	1.00
306_P	315_K	1.592	1.00
206_S	210_K	1.565	1.00
271_L	377_L	1.563	1.00
209_R	213_R	1.552	1.00
126_K	129_H	1.550	1.00
175_V	179_A	1.528	1.00
143_F	386_K	1.527	1.00
325_A	329_R	1.515	1.00
260_M	284_A	1.510	1.00
263_A	267_H	1.509	1.00
151_A	257_I	1.503	1.00
67_K	305_E	1.499	1.00
289_L	351_A	1.498	1.00
147_V	258_T	1.490	1.00
129_H	161_E	1.485	1.00
234_S	237_E	1.482	1.00
70_K	307_F	1.471	1.00
375_T	378_R	1.462	1.00
128_Q	132_D	1.443	1.00
260_M	264_L	1.441	1.00
331_E	338_D	1.431	1.00
57_D	310_H	1.426	1.00
176_W	199_E	1.423	1.00
53_I	58_D	1.414	1.00
119_M	122_Q	1.399	1.00
283_S	343_E	1.395	1.00
59_A	322_I	1.388	1.00
68_L	305_E	1.385	1.00
291_F	329_R	1.383	1.00
274_L	377_L	1.373	1.00
221_S	225_Q	1.357	1.00
136_D	379_R	1.338	1.00
261_T	376_L	1.311	1.00
218_D	221_S	1.308	1.00
65_N	68_L	1.304	1.00
274_L	281_M	1.302	1.00
130_I	157_I	1.300	1.00
172_K	175_V	1.287	1.00
61_H	65_N	1.283	1.00
209_R	212_R	1.279	1.00
280_L	343_E	1.279	1.00
275_R	377_L	1.271	1.00
282_N	286_E	1.270	1.00
124_E	370_K	1.262	1.00
256_L	294_P	1.258	1.00
38_A	332_K	1.252	1.00
31_K	338_D	1.246	1.00
305_E	316_R	1.237	1.00
202_E	206_S	1.233	1.00
270_Q	284_A	1.229	1.00
102_P	106_R	1.223	1.00
32_E	35_K	1.222	1.00
331_E	337_A	1.222	1.00
333_I	348_R	1.220	1.00
32_E	36_S	1.219	1.00
102_P	105_N	1.214	1.00
265_M	385_L	1.213	1.00
50_G	321_I	1.205	1.00
328_N	351_A	1.203	1.00
55_R	332_K	1.197	1.00
281_M	377_L	1.197	1.00
101_P	105_N	1.188	1.00
40_Y	52_L	1.186	1.00
207_L	210_K	1.181	1.00
128_Q	371_I	1.174	1.00
69_K	307_F	1.170	1.00
362_A	366_R	1.170	1.00
132_D	136_D	1.168	1.00
277_Q	280_L	1.168	1.00
99_S	103_D	1.165	1.00
281_M	374_S	1.164	1.00
198_G	202_E	1.159	1.00
335_P	341_D	1.156	1.00
273_K	276_Q	1.153	1.00
302_W	317_K	1.150	1.00
159_I	249_G	1.149	1.00
284_A	288_A	1.144	1.00
286_E	349_H	1.130	1.00
270_Q	342_I	1.124	1.00
284_A	340_F	1.124	1.00
265_M	271_L	1.113	1.00
131_A	154_L	1.107	1.00
135_L	375_T	1.105	1.00
121_L	124_E	1.105	1.00
54_S	323_S	1.105	1.00
161_E	166_P	1.104	1.00
172_K	199_E	1.104	1.00
201_V	239_Y	1.100	1.00
179_A	192_E	1.096	1.00
191_Q	195_H	1.093	1.00
131_A	375_T	1.093	1.00
263_A	288_A	1.089	1.00
201_V	205_E	1.088	1.00
278_P	378_R	1.086	1.00
270_Q	343_E	1.085	1.00
129_H	133_S	1.080	1.00
235_T	239_Y	1.078	1.00
124_E	371_I	1.075	1.00
273_K	277_Q	1.067	1.00
236_E	240_S	1.067	1.00
127_I	158_V	1.064	1.00
51_W	314_I	1.063	1.00
124_E	128_Q	1.061	1.00
136_D	139_Q	1.057	1.00
94_K	103_D	1.054	1.00
267_H	339_I	1.052	1.00
133_S	157_I	1.052	1.00
179_A	196_L	1.047	1.00
127_I	367_L	1.045	1.00
131_A	135_L	1.036	1.00
192_E	196_L	1.032	1.00
128_Q	374_S	1.031	1.00
58_D	61_H	1.027	1.00
135_L	380_C	1.027	1.00
134_L	154_L	1.026	1.00
175_V	178_Q	1.024	1.00
133_S	137_K	1.023	1.00
131_A	371_I	1.016	1.00
265_M	383_I	1.015	1.00
37_Q	40_Y	1.010	1.00
268_H	272_E	1.010	1.00
303_T	318_D	1.005	1.00
156_I	250_H	1.003	1.00
280_L	283_S	1.002	1.00
222_A	225_Q	1.001	1.00
328_N	349_H	1.000	1.00
106_R	237_E	0.995	1.00
199_E	202_E	0.994	1.00
126_K	130_I	0.993	1.00
278_P	374_S	0.987	1.00
56_Y	333_I	0.986	1.00
117_H	121_L	0.983	1.00
187_P	190_L	0.982	1.00
386_K	389_K	0.981	1.00
61_H	310_H	0.979	1.00
105_N	109_T	0.975	1.00
263_A	266_C	0.974	1.00
264_L	274_L	0.969	1.00
211_K	221_S	0.969	1.00
133_S	136_D	0.968	1.00
210_K	213_R	0.966	1.00
171_Q	175_V	0.961	1.00
302_W	319_V	0.961	1.00
34_R	331_E	0.960	1.00
331_E	335_P	0.957	1.00
57_D	61_H	0.953	1.00
103_D	106_R	0.943	1.00
215_P	225_Q	0.941	1.00
28_E	31_K	0.938	1.00
190_L	194_D	0.935	1.00
197_L	201_V	0.935	1.00
174_R	178_Q	0.934	1.00
279_D	283_S	0.934	1.00
118_R	122_Q	0.933	1.00
259_N	292_H	0.933	1.00
188_E	192_E	0.932	1.00
274_L	280_L	0.930	1.00
374_S	378_R	0.928	1.00
66_E	69_K	0.928	1.00
116_T	119_M	0.923	1.00
53_I	59_A	0.921	1.00
233_L	237_E	0.916	1.00
264_L	271_L	0.911	1.00
307_F	313_E	0.910	1.00
120_I	367_L	0.908	1.00
264_L	270_Q	0.906	1.00
220_I	242_I	0.905	1.00
39_L	58_D	0.904	1.00
227_E	232_Q	0.904	1.00
124_E	367_L	0.903	1.00
282_N	366_R	0.898	1.00
179_A	182_D	0.896	1.00
375_T	379_R	0.894	1.00
303_T	306_P	0.894	1.00
137_K	153_P	0.893	1.00
57_D	332_K	0.892	1.00
62_L	322_I	0.891	1.00
280_L	342_I	0.890	1.00
284_A	342_I	0.890	1.00
66_E	70_K	0.889	1.00
135_L	379_R	0.888	1.00
345_K	348_R	0.886	1.00
199_E	203_Y	0.883	1.00
257_I	369_A	0.879	1.00
269_D	273_K	0.878	1.00
268_H	382_N	0.878	1.00
188_E	191_Q	0.877	1.00
39_L	312_Q	0.877	1.00
196_L	199_E	0.876	1.00
41_P	51_W	0.870	1.00
66_E	307_F	0.870	1.00
299_T	324_L	0.869	1.00
365_A	369_A	0.866	1.00
103_D	107_L	0.863	1.00
187_P	191_Q	0.862	1.00
103_D	237_E	0.857	1.00
171_Q	174_R	0.855	1.00
33_L	40_Y	0.854	1.00
266_C	385_L	0.852	1.00
132_D	379_R	0.849	1.00
287_E	290_R	0.846	1.00
217_G	221_S	0.846	1.00
71_N	74_N	0.841	1.00
146_L	261_T	0.838	1.00
49_K	318_D	0.838	1.00
366_R	370_K	0.838	1.00
194_D	198_G	0.837	1.00
256_L	288_A	0.836	1.00
56_Y	60_I	0.834	1.00
207_L	211_K	0.831	1.00
61_H	307_F	0.825	1.00
111_V	360_L	0.823	1.00
125_D	129_H	0.823	1.00
59_A	350_I	0.814	1.00
48_G	319_V	0.810	1.00
261_T	377_L	0.809	1.00
206_S	209_R	0.808	1.00
251_E	255_N	0.808	1.00
136_D	140_P	0.807	1.00
210_K	214_E	0.807	1.00
149_D	153_P	0.806	1.00
181_I	184_S	0.804	1.00
268_H	271_L	0.803	1.00
95_H	244_L	0.801	1.00
69_K	304_A	0.798	1.00
137_K	140_P	0.797	1.00
198_G	201_V	0.796	1.00
57_D	60_I	0.796	1.00
165_I	210_K	0.794	1.00
202_E	205_E	0.792	1.00
130_I	166_P	0.791	1.00
178_Q	182_D	0.791	1.00
173_F	176_W	0.790	1.00
50_G	319_V	0.787	1.00
115_F	360_L	0.786	1.00
129_H	166_P	0.786	1.00
52_L	323_S	0.784	1.00
153_P	157_I	0.782	1.00
192_E	195_H	0.781	1.00
38_A	330_D	0.781	1.00
37_Q	312_Q	0.781	1.00
201_V	243_M	0.781	1.00
72_Y	304_A	0.780	1.00
281_M	370_K	0.780	1.00
55_R	310_H	0.779	1.00
303_T	315_K	0.778	1.00
179_A	183_F	0.777	1.00
262_Y	385_L	0.775	1.00
314_I	320_I	0.772	1.00
269_D	272_E	0.772	1.00
95_H	99_S	0.767	1.00
370_K	374_S	0.766	1.00
158_V	368_E	0.760	1.00
64_K	354_H	0.758	1.00
111_V	245_L	0.758	1.00
253_T	368_E	0.750	1.00
201_V	236_E	0.746	1.00
270_Q	341_D	0.746	1.00
69_K	72_Y	0.746	1.00
71_N	304_A	0.746	1.00
133_S	166_P	0.745	1.00
62_L	309_L	0.745	1.00
31_K	326_S	0.741	1.00
114_A	222_A	0.741	1.00
127_I	364_L	0.740	1.00
145_N	149_D	0.740	1.00
186_A	190_L	0.739	1.00
42_L	52_L	0.739	1.00
310_H	313_E	0.736	1.00
227_E	230_G	0.734	1.00
179_A	199_E	0.734	1.00
154_L	158_V	0.731	1.00
63_L	322_I	0.725	1.00
176_W	179_A	0.725	1.00
371_I	375_T	0.725	1.00
204_L	242_I	0.725	1.00
71_N	75_V	0.722	1.00
155_P	253_T	0.719	1.00
313_E	316_R	0.718	1.00
99_S	107_L	0.718	1.00
208_V	212_R	0.713	1.00
256_L	289_L	0.712	1.00
338_D	341_D	0.711	1.00
150_Y	372_A	0.710	1.00
38_A	310_H	0.709	1.00
44_L	50_G	0.704	1.00
108_R	112_Q	0.702	1.00
264_L	284_A	0.700	1.00
169_D	172_K	0.692	1.00
303_T	317_K	0.692	1.00
324_L	350_I	0.690	1.00
111_V	241_M	0.687	1.00
118_R	121_L	0.687	1.00
60_I	347_N	0.686	1.00
194_D	197_L	0.685	1.00
138_V	144_M	0.682	1.00
227_E	235_T	0.682	1.00
336_N	344_R	0.682	1.00
177_S	181_I	0.680	1.00
189_R	193_N	0.680	1.00
174_R	177_S	0.679	1.00
138_V	150_Y	0.679	1.00
106_R	231_T	0.676	1.00
190_L	193_N	0.675	1.00
260_M	340_F	0.674	1.00
117_H	363_Q	0.673	1.00
122_Q	217_G	0.672	1.00
309_L	314_I	0.671	1.00
293_S	328_N	0.669	1.00
42_L	50_G	0.668	1.00
261_T	383_I	0.667	1.00
125_D	128_Q	0.667	1.00
281_M	373_I	0.667	1.00
330_D	333_I	0.664	1.00
304_A	316_R	0.663	1.00
141_N	149_D	0.661	1.00
216_A	221_S	0.660	1.00
260_M	285_I	0.659	1.00
31_K	35_K	0.657	1.00
323_S	326_S	0.656	1.00
387_G	391_Q	0.655	1.00
291_F	338_D	0.655	1.00
283_S	342_I	0.655	1.00
41_P	318_D	0.652	1.00
341_D	344_R	0.652	1.00
289_L	349_H	0.652	1.00
391_Q	394_W	0.651	1.00
131_A	372_A	0.646	1.00
89_E	94_K	0.646	1.00
151_A	258_T	0.646	1.00
205_E	236_E	0.646	1.00
104_H	108_R	0.645	1.00
181_I	185_D	0.644	1.00
96_M	244_L	0.643	1.00
303_T	307_F	0.638	1.00
203_Y	206_S	0.638	1.00
268_H	384_Q	0.638	1.00
212_R	227_E	0.635	1.00
131_A	134_L	0.634	1.00
285_I	366_R	0.634	1.00
280_L	284_A	0.633	1.00
164_G	218_D	0.633	1.00
264_L	377_L	0.632	1.00
182_D	185_D	0.631	1.00
61_H	66_E	0.630	1.00
28_E	32_E	0.629	1.00
226_A	229_E	0.626	1.00
30_Y	33_L	0.626	1.00
352_F	366_R	0.625	1.00
354_H	358_F	0.624	1.00
70_K	73_E	0.623	1.00
364_L	368_E	0.621	1.00
38_A	41_P	0.617	1.00
160_S	167_L	0.617	1.00
261_T	373_I	0.616	1.00
61_H	309_L	0.615	1.00
119_M	123_L	0.615	1.00
285_I	370_K	0.614	1.00
134_L	138_V	0.613	1.00
217_G	222_A	0.612	1.00
215_P	221_S	0.612	1.00
165_I	207_L	0.610	1.00
72_Y	99_S	0.610	1.00
300_I	321_I	0.609	1.00
259_N	394_W	0.607	1.00
191_Q	194_D	0.607	1.00
249_G	252_T	0.607	1.00
63_L	324_L	0.606	1.00
248_A	252_T	0.605	1.00
101_P	356_N	0.605	1.00
303_T	320_I	0.602	1.00
203_Y	207_L	0.601	1.00
54_S	330_D	0.601	1.00
155_P	368_E	0.600	1.00
167_L	170_R	0.596	1.00
186_A	189_R	0.596	1.00
264_L	267_H	0.594	1.00
173_F	177_S	0.594	1.00
120_I	364_L	0.590	1.00
56_Y	330_D	0.584	1.00
241_M	244_L	0.583	1.00
60_I	354_H	0.583	1.00
263_A	340_F	0.580	1.00
178_Q	181_I	0.579	1.00
155_P	254_V	0.579	1.00
119_M	222_A	0.575	1.00
43_S	47_L	0.575	1.00
40_Y	54_S	0.575	1.00
283_S	341_D	0.574	1.00
303_T	316_R	0.574	1.00
281_M	284_A	0.572	1.00
347_N	354_H	0.570	1.00
172_K	206_S	0.570	1.00
201_V	240_S	0.570	1.00
256_L	285_I	0.568	1.00
159_I	162_M	0.568	1.00
157_I	170_R	0.567	1.00
137_K	157_I	0.566	1.00
58_D	309_L	0.565	1.00
35_K	332_K	0.564	1.00
38_A	54_S	0.564	1.00
61_H	308_I	0.563	1.00
223_L	238_L	0.562	1.00
137_K	149_D	0.561	1.00
27_Y	31_K	0.559	1.00
377_L	383_I	0.559	1.00
279_D	282_N	0.557	1.00
107_L	237_E	0.555	1.00
127_I	368_E	0.554	1.00
87_K	90_E	0.554	1.00
110_L	226_A	0.554	1.00
51_W	312_Q	0.553	1.00
68_L	307_F	0.553	1.00
193_N	197_L	0.552	1.00
281_M	285_I	0.551	1.00
212_R	224_I	0.550	1.00
175_V	199_E	0.550	1.00
217_G	225_Q	0.547	1.00
273_K	342_I	0.547	1.00
27_Y	325_A	0.546	1.00
129_H	132_D	0.546	1.00
34_R	54_S	0.545	1.00
153_P	174_R	0.544	1.00
52_L	321_I	0.542	1.00
59_A	63_L	0.540	1.00
146_L	151_A	0.540	1.00
127_I	371_I	0.540	1.00
115_F	245_L	0.539	1.00
152_F	254_V	0.538	1.00
371_I	374_S	0.537	1.00
57_D	333_I	0.536	1.00
134_L	137_K	0.533	1.00
72_Y	302_W	0.533	1.00
67_K	70_K	0.532	1.00
269_D	339_I	0.530	1.00
96_M	241_M	0.530	1.00
70_K	304_A	0.530	1.00
189_R	192_E	0.529	1.00
329_R	337_A	0.527	1.00
289_L	294_P	0.526	1.00
62_L	68_L	0.526	1.00
204_L	207_L	0.526	1.00
176_W	180_I	0.525	1.00
152_F	178_Q	0.525	1.00
218_D	222_A	0.523	1.00
109_T	112_Q	0.521	1.00
385_L	389_K	0.520	1.00
200_F	204_L	0.519	1.00
388_E	391_Q	0.519	1.00
186_A	191_Q	0.519	1.00
176_W	196_L	0.517	1.00
90_E	93_T	0.516	1.00
156_I	246_I	0.515	1.00
208_V	220_I	0.513	1.00
113_K	226_A	0.512	1.00
143_F	147_V	0.512	1.00
219_L	223_L	0.509	1.00
193_N	196_L	0.509	1.00
195_H	198_G	0.508	1.00
86_L	89_E	0.508	1.00
260_M	369_A	0.508	1.00
253_T	365_A	0.506	1.00
335_P	339_I	0.506	1.00
71_N	100_D	0.506	1.00
363_Q	367_L	0.505	1.00
334_F	347_N	0.505	1.00
134_L	372_A	0.504	1.00
208_V	224_I	0.504	1.00
63_L	354_H	0.504	1.00
222_A	226_A	0.502	1.00
72_Y	75_V	0.502	1.00
300_I	319_V	0.502	1.00
324_L	328_N	0.502	1.00
177_S	250_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2uuqA	2	0.9463	100	0.196	Contact Map
3zpiA	1	0.9512	100	0.197	Contact Map
2z3tA	1	0.9171	100	0.199	Contact Map
3ejbB	1	0.9366	100	0.2	Contact Map
3a4gA	1	0.9415	100	0.201	Contact Map
4mm0A	1	0.9561	100	0.201	Contact Map
3nc3A	1	0.9	100	0.205	Contact Map
4ubsA	1	0.9463	100	0.205	Contact Map
2xkrA	1	0.9317	100	0.206	Contact Map
1z8oA	1	0.9463	100	0.206	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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