GREMLIN Database
CPXY - Cytochrome P450
UniProt: O08469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (360)
Sequences: 43644 (32066)
Seq/√Len: 1690.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
336_N339_I3.7501.00
336_N341_D3.3171.00
273_K343_E3.1971.00
308_I313_E3.0971.00
132_D375_T3.0671.00
260_M288_A3.0451.00
260_M373_I2.9231.00
315_K318_D2.8281.00
256_L369_A2.7801.00
282_N370_K2.6761.00
55_R58_D2.5981.00
306_P313_E2.5901.00
306_P316_R2.5731.00
212_R235_T2.5571.00
263_A292_H2.5331.00
271_L275_R2.5121.00
272_E276_Q2.4281.00
329_R338_D2.3391.00
270_Q280_L2.3381.00
41_P49_K2.3291.00
274_L284_A2.2581.00
211_K218_D2.2291.00
139_Q380_C2.2281.00
303_T314_I2.1511.00
51_W318_D2.1291.00
126_K161_E2.1201.00
273_K280_L2.1021.00
58_D310_H2.0831.00
209_R235_T2.0831.00
205_E239_Y2.0781.00
128_Q375_T2.0621.00
267_H270_Q2.0601.00
139_Q379_R1.9821.00
31_K34_R1.9781.00
154_L372_A1.9781.00
358_F362_A1.9741.00
263_A291_F1.9741.00
205_E235_T1.9411.00
308_I311_G1.9211.00
262_Y266_C1.8781.00
285_I369_A1.8561.00
39_L53_I1.8441.00
205_E209_R1.8281.00
59_A327_A1.7971.00
286_E366_R1.7971.00
270_Q273_K1.7921.00
376_L383_I1.7241.00
195_H199_E1.7221.00
38_A55_R1.7151.00
69_K305_E1.7011.00
53_I62_L1.6901.00
257_I372_A1.6711.00
271_L382_N1.6651.00
29_F32_E1.6591.00
60_I64_K1.6551.00
272_E382_N1.6521.00
43_S49_K1.6381.00
288_A340_F1.6341.00
151_A261_T1.6321.00
29_F33_L1.6241.00
130_I133_S1.6221.00
130_I161_E1.6191.00
172_K176_W1.6051.00
275_R382_N1.6011.00
272_E275_R1.5991.00
107_L241_M1.5961.00
306_P315_K1.5921.00
206_S210_K1.5651.00
271_L377_L1.5631.00
209_R213_R1.5521.00
126_K129_H1.5501.00
175_V179_A1.5281.00
143_F386_K1.5271.00
325_A329_R1.5151.00
260_M284_A1.5101.00
263_A267_H1.5091.00
151_A257_I1.5031.00
67_K305_E1.4991.00
289_L351_A1.4981.00
147_V258_T1.4901.00
129_H161_E1.4851.00
234_S237_E1.4821.00
70_K307_F1.4711.00
375_T378_R1.4621.00
128_Q132_D1.4431.00
260_M264_L1.4411.00
331_E338_D1.4311.00
57_D310_H1.4261.00
176_W199_E1.4231.00
53_I58_D1.4141.00
119_M122_Q1.3991.00
283_S343_E1.3951.00
59_A322_I1.3881.00
68_L305_E1.3851.00
291_F329_R1.3831.00
274_L377_L1.3731.00
221_S225_Q1.3571.00
136_D379_R1.3381.00
261_T376_L1.3111.00
218_D221_S1.3081.00
65_N68_L1.3041.00
274_L281_M1.3021.00
130_I157_I1.3001.00
172_K175_V1.2871.00
61_H65_N1.2831.00
209_R212_R1.2791.00
280_L343_E1.2791.00
275_R377_L1.2711.00
282_N286_E1.2701.00
124_E370_K1.2621.00
256_L294_P1.2581.00
38_A332_K1.2521.00
31_K338_D1.2461.00
305_E316_R1.2371.00
202_E206_S1.2331.00
270_Q284_A1.2291.00
102_P106_R1.2231.00
32_E35_K1.2221.00
331_E337_A1.2221.00
333_I348_R1.2201.00
32_E36_S1.2191.00
102_P105_N1.2141.00
265_M385_L1.2131.00
50_G321_I1.2051.00
328_N351_A1.2031.00
55_R332_K1.1971.00
281_M377_L1.1971.00
101_P105_N1.1881.00
40_Y52_L1.1861.00
207_L210_K1.1811.00
128_Q371_I1.1741.00
69_K307_F1.1701.00
362_A366_R1.1701.00
132_D136_D1.1681.00
277_Q280_L1.1681.00
99_S103_D1.1651.00
281_M374_S1.1641.00
198_G202_E1.1591.00
335_P341_D1.1561.00
273_K276_Q1.1531.00
302_W317_K1.1501.00
159_I249_G1.1491.00
284_A288_A1.1441.00
286_E349_H1.1301.00
270_Q342_I1.1241.00
284_A340_F1.1241.00
265_M271_L1.1131.00
131_A154_L1.1071.00
135_L375_T1.1051.00
121_L124_E1.1051.00
54_S323_S1.1051.00
161_E166_P1.1041.00
172_K199_E1.1041.00
201_V239_Y1.1001.00
179_A192_E1.0961.00
191_Q195_H1.0931.00
131_A375_T1.0931.00
263_A288_A1.0891.00
201_V205_E1.0881.00
278_P378_R1.0861.00
270_Q343_E1.0851.00
129_H133_S1.0801.00
235_T239_Y1.0781.00
124_E371_I1.0751.00
273_K277_Q1.0671.00
236_E240_S1.0671.00
127_I158_V1.0641.00
51_W314_I1.0631.00
124_E128_Q1.0611.00
136_D139_Q1.0571.00
94_K103_D1.0541.00
267_H339_I1.0521.00
133_S157_I1.0521.00
179_A196_L1.0471.00
127_I367_L1.0451.00
131_A135_L1.0361.00
192_E196_L1.0321.00
128_Q374_S1.0311.00
58_D61_H1.0271.00
135_L380_C1.0271.00
134_L154_L1.0261.00
175_V178_Q1.0241.00
133_S137_K1.0231.00
131_A371_I1.0161.00
265_M383_I1.0151.00
37_Q40_Y1.0101.00
268_H272_E1.0101.00
303_T318_D1.0051.00
156_I250_H1.0031.00
280_L283_S1.0021.00
222_A225_Q1.0011.00
328_N349_H1.0001.00
106_R237_E0.9951.00
199_E202_E0.9941.00
126_K130_I0.9931.00
278_P374_S0.9871.00
56_Y333_I0.9861.00
117_H121_L0.9831.00
187_P190_L0.9821.00
386_K389_K0.9811.00
61_H310_H0.9791.00
105_N109_T0.9751.00
263_A266_C0.9741.00
264_L274_L0.9691.00
211_K221_S0.9691.00
133_S136_D0.9681.00
210_K213_R0.9661.00
171_Q175_V0.9611.00
302_W319_V0.9611.00
34_R331_E0.9601.00
331_E335_P0.9571.00
57_D61_H0.9531.00
103_D106_R0.9431.00
215_P225_Q0.9411.00
28_E31_K0.9381.00
190_L194_D0.9351.00
197_L201_V0.9351.00
174_R178_Q0.9341.00
279_D283_S0.9341.00
118_R122_Q0.9331.00
259_N292_H0.9331.00
188_E192_E0.9321.00
274_L280_L0.9301.00
374_S378_R0.9281.00
66_E69_K0.9281.00
116_T119_M0.9231.00
53_I59_A0.9211.00
233_L237_E0.9161.00
264_L271_L0.9111.00
307_F313_E0.9101.00
120_I367_L0.9081.00
264_L270_Q0.9061.00
220_I242_I0.9051.00
39_L58_D0.9041.00
227_E232_Q0.9041.00
124_E367_L0.9031.00
282_N366_R0.8981.00
179_A182_D0.8961.00
375_T379_R0.8941.00
303_T306_P0.8941.00
137_K153_P0.8931.00
57_D332_K0.8921.00
62_L322_I0.8911.00
280_L342_I0.8901.00
284_A342_I0.8901.00
66_E70_K0.8891.00
135_L379_R0.8881.00
345_K348_R0.8861.00
199_E203_Y0.8831.00
257_I369_A0.8791.00
269_D273_K0.8781.00
268_H382_N0.8781.00
188_E191_Q0.8771.00
39_L312_Q0.8771.00
196_L199_E0.8761.00
41_P51_W0.8701.00
66_E307_F0.8701.00
299_T324_L0.8691.00
365_A369_A0.8661.00
103_D107_L0.8631.00
187_P191_Q0.8621.00
103_D237_E0.8571.00
171_Q174_R0.8551.00
33_L40_Y0.8541.00
266_C385_L0.8521.00
132_D379_R0.8491.00
287_E290_R0.8461.00
217_G221_S0.8461.00
71_N74_N0.8411.00
146_L261_T0.8381.00
49_K318_D0.8381.00
366_R370_K0.8381.00
194_D198_G0.8371.00
256_L288_A0.8361.00
56_Y60_I0.8341.00
207_L211_K0.8311.00
61_H307_F0.8251.00
111_V360_L0.8231.00
125_D129_H0.8231.00
59_A350_I0.8141.00
48_G319_V0.8101.00
261_T377_L0.8091.00
206_S209_R0.8081.00
251_E255_N0.8081.00
136_D140_P0.8071.00
210_K214_E0.8071.00
149_D153_P0.8061.00
181_I184_S0.8041.00
268_H271_L0.8031.00
95_H244_L0.8011.00
69_K304_A0.7981.00
137_K140_P0.7971.00
198_G201_V0.7961.00
57_D60_I0.7961.00
165_I210_K0.7941.00
202_E205_E0.7921.00
130_I166_P0.7911.00
178_Q182_D0.7911.00
173_F176_W0.7901.00
50_G319_V0.7871.00
115_F360_L0.7861.00
129_H166_P0.7861.00
52_L323_S0.7841.00
153_P157_I0.7821.00
192_E195_H0.7811.00
38_A330_D0.7811.00
37_Q312_Q0.7811.00
201_V243_M0.7811.00
72_Y304_A0.7801.00
281_M370_K0.7801.00
55_R310_H0.7791.00
303_T315_K0.7781.00
179_A183_F0.7771.00
262_Y385_L0.7751.00
314_I320_I0.7721.00
269_D272_E0.7721.00
95_H99_S0.7671.00
370_K374_S0.7661.00
158_V368_E0.7601.00
64_K354_H0.7581.00
111_V245_L0.7581.00
253_T368_E0.7501.00
201_V236_E0.7461.00
270_Q341_D0.7461.00
69_K72_Y0.7461.00
71_N304_A0.7461.00
133_S166_P0.7451.00
62_L309_L0.7451.00
31_K326_S0.7411.00
114_A222_A0.7411.00
127_I364_L0.7401.00
145_N149_D0.7401.00
186_A190_L0.7391.00
42_L52_L0.7391.00
310_H313_E0.7361.00
227_E230_G0.7341.00
179_A199_E0.7341.00
154_L158_V0.7311.00
63_L322_I0.7251.00
176_W179_A0.7251.00
371_I375_T0.7251.00
204_L242_I0.7251.00
71_N75_V0.7221.00
155_P253_T0.7191.00
313_E316_R0.7181.00
99_S107_L0.7181.00
208_V212_R0.7131.00
256_L289_L0.7121.00
338_D341_D0.7111.00
150_Y372_A0.7101.00
38_A310_H0.7091.00
44_L50_G0.7041.00
108_R112_Q0.7021.00
264_L284_A0.7001.00
169_D172_K0.6921.00
303_T317_K0.6921.00
324_L350_I0.6901.00
111_V241_M0.6871.00
118_R121_L0.6871.00
60_I347_N0.6861.00
194_D197_L0.6851.00
138_V144_M0.6821.00
227_E235_T0.6821.00
336_N344_R0.6821.00
177_S181_I0.6801.00
189_R193_N0.6801.00
174_R177_S0.6791.00
138_V150_Y0.6791.00
106_R231_T0.6761.00
190_L193_N0.6751.00
260_M340_F0.6741.00
117_H363_Q0.6731.00
122_Q217_G0.6721.00
309_L314_I0.6711.00
293_S328_N0.6691.00
42_L50_G0.6681.00
261_T383_I0.6671.00
125_D128_Q0.6671.00
281_M373_I0.6671.00
330_D333_I0.6641.00
304_A316_R0.6631.00
141_N149_D0.6611.00
216_A221_S0.6601.00
260_M285_I0.6591.00
31_K35_K0.6571.00
323_S326_S0.6561.00
387_G391_Q0.6551.00
291_F338_D0.6551.00
283_S342_I0.6551.00
41_P318_D0.6521.00
341_D344_R0.6521.00
289_L349_H0.6521.00
391_Q394_W0.6511.00
131_A372_A0.6461.00
89_E94_K0.6461.00
151_A258_T0.6461.00
205_E236_E0.6461.00
104_H108_R0.6451.00
181_I185_D0.6441.00
96_M244_L0.6431.00
303_T307_F0.6381.00
203_Y206_S0.6381.00
268_H384_Q0.6381.00
212_R227_E0.6351.00
131_A134_L0.6341.00
285_I366_R0.6341.00
280_L284_A0.6331.00
164_G218_D0.6331.00
264_L377_L0.6321.00
182_D185_D0.6311.00
61_H66_E0.6301.00
28_E32_E0.6291.00
226_A229_E0.6261.00
30_Y33_L0.6261.00
352_F366_R0.6251.00
354_H358_F0.6241.00
70_K73_E0.6231.00
364_L368_E0.6211.00
38_A41_P0.6171.00
160_S167_L0.6171.00
261_T373_I0.6161.00
61_H309_L0.6151.00
119_M123_L0.6151.00
285_I370_K0.6141.00
134_L138_V0.6131.00
217_G222_A0.6121.00
215_P221_S0.6121.00
165_I207_L0.6101.00
72_Y99_S0.6101.00
300_I321_I0.6091.00
259_N394_W0.6071.00
191_Q194_D0.6071.00
249_G252_T0.6071.00
63_L324_L0.6061.00
248_A252_T0.6051.00
101_P356_N0.6051.00
303_T320_I0.6021.00
203_Y207_L0.6011.00
54_S330_D0.6011.00
155_P368_E0.6001.00
167_L170_R0.5961.00
186_A189_R0.5961.00
264_L267_H0.5941.00
173_F177_S0.5941.00
120_I364_L0.5901.00
56_Y330_D0.5841.00
241_M244_L0.5831.00
60_I354_H0.5831.00
263_A340_F0.5801.00
178_Q181_I0.5791.00
155_P254_V0.5791.00
119_M222_A0.5751.00
43_S47_L0.5751.00
40_Y54_S0.5751.00
283_S341_D0.5741.00
303_T316_R0.5741.00
281_M284_A0.5721.00
347_N354_H0.5701.00
172_K206_S0.5701.00
201_V240_S0.5701.00
256_L285_I0.5681.00
159_I162_M0.5681.00
157_I170_R0.5671.00
137_K157_I0.5661.00
58_D309_L0.5651.00
35_K332_K0.5641.00
38_A54_S0.5641.00
61_H308_I0.5631.00
223_L238_L0.5621.00
137_K149_D0.5611.00
27_Y31_K0.5591.00
377_L383_I0.5591.00
279_D282_N0.5571.00
107_L237_E0.5551.00
127_I368_E0.5541.00
87_K90_E0.5541.00
110_L226_A0.5541.00
51_W312_Q0.5531.00
68_L307_F0.5531.00
193_N197_L0.5521.00
281_M285_I0.5511.00
212_R224_I0.5501.00
175_V199_E0.5501.00
217_G225_Q0.5471.00
273_K342_I0.5471.00
27_Y325_A0.5461.00
129_H132_D0.5461.00
34_R54_S0.5451.00
153_P174_R0.5441.00
52_L321_I0.5421.00
59_A63_L0.5401.00
146_L151_A0.5401.00
127_I371_I0.5401.00
115_F245_L0.5391.00
152_F254_V0.5381.00
371_I374_S0.5371.00
57_D333_I0.5361.00
134_L137_K0.5331.00
72_Y302_W0.5331.00
67_K70_K0.5321.00
269_D339_I0.5301.00
96_M241_M0.5301.00
70_K304_A0.5301.00
189_R192_E0.5291.00
329_R337_A0.5271.00
289_L294_P0.5261.00
62_L68_L0.5261.00
204_L207_L0.5261.00
176_W180_I0.5251.00
152_F178_Q0.5251.00
218_D222_A0.5231.00
109_T112_Q0.5211.00
385_L389_K0.5201.00
200_F204_L0.5191.00
388_E391_Q0.5191.00
186_A191_Q0.5191.00
176_W196_L0.5171.00
90_E93_T0.5161.00
156_I246_I0.5151.00
208_V220_I0.5131.00
113_K226_A0.5121.00
143_F147_V0.5121.00
219_L223_L0.5091.00
193_N196_L0.5091.00
195_H198_G0.5081.00
86_L89_E0.5081.00
260_M369_A0.5081.00
253_T365_A0.5061.00
335_P339_I0.5061.00
71_N100_D0.5061.00
363_Q367_L0.5051.00
334_F347_N0.5051.00
134_L372_A0.5041.00
208_V224_I0.5041.00
63_L354_H0.5041.00
222_A226_A0.5021.00
72_Y75_V0.5021.00
300_I319_V0.5021.00
324_L328_N0.5021.00
177_S250_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uuqA 2 0.9463 100 0.196 Contact Map
3zpiA 1 0.9512 100 0.197 Contact Map
2z3tA 1 0.9171 100 0.199 Contact Map
3ejbB 1 0.9366 100 0.2 Contact Map
3a4gA 1 0.9415 100 0.201 Contact Map
4mm0A 1 0.9561 100 0.201 Contact Map
3nc3A 1 0.9 100 0.205 Contact Map
4ubsA 1 0.9463 100 0.205 Contact Map
2xkrA 1 0.9317 100 0.206 Contact Map
1z8oA 1 0.9463 100 0.206 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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