GREMLIN Database
CYPD - Probable bifunctional P-450/NADPH-P450 reductase 1
UniProt: O08394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1061 (1040)
Sequences: 429 (339)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
420_I426_L6.9921.00
61_K391_H6.7531.00
29_L438_Q5.5191.00
806_I811_I4.8121.00
96_P250_E4.7141.00
762_L827_F4.5271.00
992_A995_A4.4561.00
958_R962_E4.4501.00
86_D97_N4.3250.99
955_F974_T4.2620.99
69_F73_I4.1870.99
723_V763_S4.1000.99
868_S871_G4.0380.99
336_L398_N4.0140.99
1036_G1039_E3.9250.99
597_D607_R3.8890.99
219_D258_R3.8080.99
777_I816_L3.8070.99
293_A421_L3.7750.98
66_E398_N3.6680.98
43_Q50_T3.5850.98
128_L131_K3.5780.98
275_L413_A3.5640.98
54_V63_V3.5480.98
219_D223_A3.5420.98
950_R986_Y3.5280.98
256_N260_Q3.4840.97
991_M998_L3.4480.97
82_A207_F3.4470.97
23_D30_S3.4190.97
863_R872_E3.3780.97
295_E299_R3.3260.96
280_T449_I3.2750.96
973_H994_Q3.2330.96
36_E362_Q3.2330.96
845_S858_T3.2290.96
725_R818_E3.1700.95
783_F826_P3.1040.95
350_I356_I3.1030.95
42_F53_V3.0980.95
244_E251_K3.0390.94
540_V573_V3.0060.94
181_R210_D2.9740.93
1001_I1006_G2.8990.92
60_V363_L2.8940.92
955_F976_F2.8770.92
83_F182_A2.8770.92
978_R986_Y2.8570.92
428_D447_F2.8560.92
341_D352_T2.7860.91
371_G374_A2.7610.90
279_A417_L2.7460.90
984_K990_L2.7360.90
165_N168_Y2.7240.90
683_E692_S2.7200.90
591_Y595_F2.7140.90
927_L969_I2.7130.90
525_A528_N2.6740.89
151_T330_T2.6580.89
559_V595_F2.6500.88
9_Q18_N2.6470.88
965_E971_T2.5990.87
946_Y998_L2.5720.87
940_L943_A2.5570.86
594_R613_E2.5420.86
373_D378_R2.5410.86
70_D93_T2.5140.86
570_L605_A2.4890.85
80_V83_F2.4670.84
944_H973_H2.4360.84
181_R206_Q2.4070.83
65_D68_R2.4010.83
18_N21_L2.3840.82
304_A310_Q2.3750.82
57_H392_A2.3740.82
200_M203_T2.3680.82
252_L364_H2.3520.81
133_A423_Y2.3500.81
394_K398_N2.3480.81
55_S359_L2.3220.80
62_E812_S2.3210.80
903_L911_I2.3160.80
42_F753_G2.3100.80
275_L330_T2.2930.80
583_H615_D2.2880.79
436_I442_L2.2650.79
336_L350_I2.2560.78
631_M635_A2.2550.78
42_F358_V2.2540.78
152_L330_T2.2530.78
994_Q997_T2.2520.78
321_L413_A2.2410.78
772_A777_I2.2350.78
179_M441_T2.2220.77
311_V414_T2.2170.77
548_N711_H2.2130.77
568_G571_E2.1880.76
973_H997_T2.1840.76
330_T413_A2.1840.76
215_F259_F2.1830.76
589_Y613_E2.1810.76
317_I320_I2.1780.76
63_V358_V2.1400.74
341_D351_T2.1380.74
697_E957_Y2.1330.74
9_Q45_H2.1240.74
590_Q611_R2.1150.74
676_A892_M2.1090.73
977_S986_Y2.1030.73
319_M383_E2.1010.73
973_H990_L2.0970.73
86_D95_E2.0780.72
955_F962_E2.0720.72
186_A207_F2.0660.72
153_D166_S2.0540.71
590_Q613_E2.0490.71
199_L286_H2.0330.70
298_D454_R2.0240.70
779_E829_R2.0210.70
850_V854_Q2.0170.70
85_G259_F2.0150.70
500_D553_S2.0100.70
695_H957_Y2.0070.69
566_K569_E1.9990.69
180_V331_A1.9950.69
252_L256_N1.9940.69
950_R978_R1.9930.69
565_I570_L1.9910.69
358_V596_I1.9830.69
293_A317_I1.9710.68
433_E450_S1.9610.68
279_A324_S1.9520.67
34_L631_M1.9360.67
544_T596_I1.9250.66
392_A575_Y1.9220.66
127_Q165_N1.9180.66
857_I896_T1.9160.66
142_D145_G1.9100.65
71_K77_L1.9040.65
738_V758_L1.8930.65
133_A453_S1.8850.64
79_K189_Q1.8840.64
117_Y548_N1.8790.64
911_I943_A1.8680.64
192_R200_M1.8670.64
212_Q216_S1.8600.63
637_K696_I1.8570.63
589_Y600_L1.8490.63
330_T416_V1.8400.62
331_A365_R1.8210.62
845_S856_S1.8140.61
937_G940_L1.8040.61
81_R86_D1.8020.61
714_V729_R1.7800.60
280_T417_L1.7640.59
350_I426_L1.7640.59
950_R977_S1.7510.58
38_Q740_L1.7470.58
293_A320_I1.7460.58
592_V704_V1.7270.57
81_R95_E1.7260.57
536_K572_G1.7150.57
134_R168_Y1.7090.57
897_P902_Q1.7070.56
64_C334_F1.7010.56
793_L816_L1.6980.56
711_H964_F1.6840.55
66_E446_D1.6830.55
337_Y353_N1.6700.55
43_Q354_D1.6600.54
127_Q163_R1.6590.54
992_A1024_A1.6520.54
282_F330_T1.6470.54
944_H998_L1.6460.54
719_S723_V1.6440.53
151_T293_A1.6400.53
96_P100_K1.6380.53
110_S114_M1.6300.53
100_K253_D1.6300.53
311_V418_G1.6270.53
125_A419_M1.6230.53
681_N694_R1.6150.52
934_K969_I1.6060.52
576_A608_F1.6010.51
1030_Q1037_E1.6000.51
123_D163_R1.5940.51
888_D956_I1.5930.51
766_V834_L1.5900.51
99_R103_N1.5870.51
66_E394_K1.5770.50
825_M925_G1.5660.50
789_H822_A1.5570.49
911_I941_G1.5560.49
281_Y447_F1.5550.49
61_K390_H1.5500.49
583_H617_S1.5480.49
104_I816_L1.5460.49
322_N393_Y1.5460.49
697_E928_Q1.5360.48
806_I810_R1.5270.48
41_I54_V1.5230.48
730_F830_F1.5220.48
656_L762_L1.5150.47
284_L442_L1.5100.47
113_A407_Q1.5090.47
160_F260_Q1.5080.47
56_G366_D1.5040.47
100_K260_Q1.4960.47
8_P17_G1.4950.46
340_E352_T1.4940.46
117_Y159_G1.4930.46
608_F631_M1.4920.46
903_L943_A1.4770.46
214_M217_L1.4660.45
68_R71_K1.4630.45
809_K866_A1.4620.45
825_M970_V1.4590.45
179_M183_L1.4530.45
22_I30_S1.4530.45
1013_D1019_P1.4520.44
78_E92_W1.4520.44
621_E693_T1.4520.44
575_Y605_A1.4500.44
163_R168_Y1.4500.44
971_T997_T1.4480.44
291_K295_E1.4470.44
221_I426_L1.4460.44
106_M179_M1.4440.44
282_F331_A1.4430.44
596_I856_S1.4400.44
143_V330_T1.4400.44
507_V624_L1.4390.44
282_F328_W1.4380.44
727_L734_G1.4360.44
605_A779_E1.4350.44
294_Y425_T1.4280.43
592_V595_F1.4210.43
189_Q711_H1.4150.43
336_L358_V1.4130.43
566_K602_E1.4120.43
256_N259_F1.4110.43
388_V392_A1.4110.43
207_F223_A1.4080.42
495_V702_P1.4060.42
309_K631_M1.4050.42
784_T822_A1.4010.42
536_K573_V1.4000.42
338_P350_I1.3970.42
541_V631_M1.3950.42
631_M991_M1.3950.42
218_V261_I1.3690.41
713_G841_Y1.3630.40
351_T946_Y1.3610.40
293_A330_T1.3610.40
141_V451_V1.3600.40
931_D964_F1.3550.40
631_M833_L1.3530.40
1002_L1008_L1.3520.40
151_T155_I1.3520.40
813_M833_L1.3510.40
594_R598_E1.3500.40
138_N855_A1.3500.40
542_I596_I1.3500.40
321_L402_A1.3490.40
861_V879_N1.3450.40
104_I437_K1.3430.40
151_T331_A1.3400.39
118_H411_H1.3380.39
132_W146_D1.3370.39
160_F382_F1.3300.39
538_G620_F1.3300.39
9_Q12_T1.3250.39
127_Q168_Y1.3230.39
698_I892_M1.3180.38
983_P990_L1.3100.38
548_N964_F1.3090.38
389_P392_A1.3080.38
732_L844_I1.3050.38
756_V761_L1.3050.38
123_D127_Q1.3040.38
26_K29_L1.3010.38
138_N220_S1.3000.38
526_P529_D1.3000.38
148_T441_T1.3000.38
541_V576_A1.2960.37
570_L600_L1.2940.37
252_L363_L1.2930.37
151_T186_A1.2930.37
333_A438_Q1.2920.37
96_P152_L1.2850.37
707_Q902_Q1.2840.37
35_A42_F1.2810.37
222_I324_S1.2760.37
100_K256_N1.2710.36
817_L825_M1.2680.36
186_A936_E1.2630.36
47_P344_I1.2600.36
311_V318_R1.2600.36
238_A261_I1.2590.36
316_Y379_P1.2570.36
849_R929_A1.2570.36
97_N256_N1.2560.36
427_I452_Q1.2560.36
40_P206_Q1.2510.35
862_V961_L1.2500.35
170_E313_E1.2490.35
435_D445_G1.2470.35
276_L293_A1.2450.35
772_A813_M1.2440.35
494_L538_G1.2400.35
851_N854_Q1.2400.35
295_E760_D1.2390.35
274_G413_A1.2380.35
106_M932_V1.2350.35
318_R322_N1.2330.35
60_V358_V1.2320.35
100_K252_L1.2280.34
672_E698_I1.2270.34
321_L332_P1.2260.34
418_G456_Q1.2250.34
364_H797_S1.2240.34
278_F725_R1.2230.34
727_L758_L1.2220.34
616_V620_F1.2220.34
437_K445_G1.2200.34
711_H841_Y1.2190.34
449_I890_V1.2180.34
274_G330_T1.2150.34
69_F77_L1.2150.34
193_L196_Q1.2130.34
57_H61_K1.2120.34
143_V359_L1.2090.34
226_R1045_R1.2090.34
159_G407_Q1.2090.34
341_D592_V1.2090.34
279_A320_I1.2070.34
527_L596_I1.2050.33
576_A998_L1.2020.33
365_R375_E1.2010.33
850_V856_S1.2010.33
115_K282_F1.1980.33
117_Y130_Q1.1950.33
327_L331_A1.1940.33
185_E203_T1.1930.33
286_H485_V1.1900.33
27_P35_A1.1830.33
582_D617_S1.1810.33
860_G918_T1.1810.33
827_F833_L1.1790.32
496_L540_V1.1780.32
995_A1028_A1.1780.32
229_G232_D1.1760.32
92_W95_E1.1760.32
811_I816_L1.1750.32
1010_V1053_Y1.1740.32
642_E806_I1.1740.32
70_D337_Y1.1730.32
497_Y909_T1.1690.32
257_I501_T1.1690.32
995_A1031_A1.1660.32
420_I862_V1.1630.32
990_L994_Q1.1620.32
664_E668_A1.1610.32
274_G331_A1.1610.32
735_T912_I1.1500.31
63_V350_I1.1500.31
113_A193_L1.1490.31
14_G17_G1.1490.31
368_D857_I1.1490.31
496_L527_L1.1470.31
570_L941_G1.1420.31
114_M402_A1.1420.31
490_N572_G1.1420.31
729_R827_F1.1400.31
64_C575_Y1.1400.31
254_D257_I1.1380.31
947_F961_L1.1310.30
121_M154_T1.1300.30
54_V320_I1.1290.30
62_E68_R1.1290.30
277_S911_I1.1260.30
897_P915_G1.1260.30
849_R964_F1.1190.30
285_K428_D1.1110.30
293_A394_K1.1110.30
438_Q1017_M1.1080.30
961_L972_V1.1080.30
827_F834_L1.1080.30
252_L613_E1.1070.30
507_V616_V1.1060.29
10_P18_N1.1040.29
912_I1021_V1.1040.29
773_T888_D1.1040.29
903_L941_G1.1030.29
511_L543_V1.1010.29
226_R254_D1.0990.29
393_Y407_Q1.0980.29
548_N841_Y1.0960.29
140_A429_H1.0950.29
73_I76_A1.0900.29
114_M117_Y1.0890.29
187_M515_A1.0890.29
882_A961_L1.0850.29
79_K82_A1.0850.29
320_I608_F1.0800.28
311_V317_I1.0790.28
941_G1010_V1.0770.28
54_V523_K1.0730.28
990_L998_L1.0730.28
156_G447_F1.0710.28
151_T416_V1.0690.28
252_L358_V1.0690.28
526_P1031_A1.0680.28
37_E210_D1.0680.28
428_D711_H1.0670.28
711_H992_A1.0630.28
711_H1055_K1.0620.28
601_A607_R1.0610.28
539_A639_F1.0590.28
52_I354_D1.0580.28
131_K135_L1.0560.28
542_I689_S1.0560.28
278_F436_I1.0520.27
75_G812_S1.0520.27
156_G1058_W1.0460.27
624_L765_S1.0460.27
878_S947_F1.0450.27
608_F1030_Q1.0450.27
790_R794_E1.0440.27
646_N1006_G1.0430.27
994_Q1040_A1.0420.27
317_I645_E1.0400.27
352_T1020_D1.0400.27
124_I913_M1.0390.27
420_I634_D1.0380.27
293_A297_V1.0380.27
111_Q393_Y1.0380.27
123_D389_P1.0350.27
595_F644_N1.0350.27
1010_V1021_V1.0340.27
758_L762_L1.0340.27
80_V402_A1.0310.27
207_F211_I1.0300.27
805_Q809_K1.0300.27
861_V878_S1.0300.27
987_V1017_M1.0290.27
411_H972_V1.0280.27
195_V798_A1.0270.26
44_I698_I1.0270.26
1039_E1042_N1.0260.26
784_T823_C1.0220.26
7_I18_N1.0210.26
125_A385_Q1.0190.26
758_L890_V1.0180.26
786_C1013_D1.0180.26
992_A1027_K1.0150.26
129_I233_E1.0130.26
60_V64_C1.0130.26
192_R402_A1.0090.26
708_E929_A1.0080.26
866_A869_G1.0080.26
229_G238_A1.0080.26
152_L880_D1.0050.26
527_L678_I1.0040.26
810_R867_W0.9980.25
1046_H1050_T0.9980.25
35_A359_L0.9980.25
490_N543_V0.9980.25
196_Q204_K0.9980.25
736_D884_R0.9980.25
145_G758_L0.9980.25
176_I180_V0.9970.25
8_P14_G0.9950.25
291_K601_A0.9930.25
359_L940_L0.9920.25
927_L961_L0.9910.25
318_R584_N0.9900.25
84_S228_N0.9900.25
711_H1058_W0.9900.25
504_A735_T0.9880.25
70_D339_K0.9860.25
282_F552_P0.9860.25
773_T956_I0.9830.25
714_V893_F0.9830.25
402_A586_A0.9820.25
329_P365_R0.9820.25
364_H534_L0.9810.25
994_Q1050_T0.9800.25
207_F262_I0.9800.25
506_G738_V0.9760.25
123_D168_Y0.9760.25
524_T918_T0.9760.25
294_Y990_L0.9730.25
590_Q859_V0.9730.25
275_L293_A0.9730.25
492_P925_G0.9700.24
39_G316_Y0.9700.24
93_T400_Q0.9690.24
695_H928_Q0.9690.24
185_E200_M0.9690.24
589_Y675_H0.9690.24
902_Q935_R0.9670.24
52_I493_L0.9670.24
243_V545_S0.9670.24
110_S360_I0.9630.24
693_T990_L0.9630.24
695_H773_T0.9620.24
275_L387_Q0.9590.24
773_T836_P0.9580.24
733_K736_D0.9550.24
605_A830_F0.9550.24
80_V186_A0.9540.24
142_D590_Q0.9510.24
608_F635_A0.9510.24
685_Q1020_D0.9500.24
864_G873_Y0.9500.24
756_V914_V0.9500.24
543_V682_R0.9500.24
354_D601_A0.9490.24
536_K542_I0.9490.24
274_G440_L0.9490.24
430_E548_N0.9470.24
124_I153_D0.9470.24
161_N777_I0.9460.24
682_R1041_Q0.9450.24
7_I10_P0.9440.24
16_L863_R0.9440.24
71_K76_A0.9440.24
351_T806_I0.9440.24
43_Q524_T0.9430.24
236_L402_A0.9430.24
206_Q210_D0.9410.23
427_I827_F0.9400.23
704_V790_R0.9400.23
226_R419_M0.9390.23
16_L20_P0.9390.23
287_P611_R0.9380.23
185_E877_A0.9350.23
434_L561_W0.9350.23
762_L766_V0.9320.23
8_P18_N0.9320.23
782_S849_R0.9310.23
417_L613_E0.9290.23
355_R912_I0.9290.23
161_N820_Y0.9260.23
527_L606_T0.9250.23
137_P424_F0.9250.23
988_Q1017_M0.9240.23
82_A186_A0.9230.23
42_F696_I0.9230.23
774_R807_L0.9220.23
929_A957_Y0.9210.23
802_Y806_I0.9170.23
962_E972_V0.9150.23
241_L493_L0.9140.23
250_E253_D0.9130.23
282_F324_S0.9100.22
381_R877_A0.9100.22
182_A266_I0.9090.22
23_D26_K0.9080.22
30_S34_L0.9080.22
222_I238_A0.9070.22
143_V152_L0.9050.22
20_P226_R0.9050.22
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255_E1008_L0.5130.12
189_Q1018_A0.5120.12
261_I1055_K0.5120.12
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957_Y994_Q0.5120.12
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570_L666_P0.5090.12
288_D1027_K0.5090.12
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547_Y1010_V0.5060.12
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780_L900_R0.5060.12
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1003_D1009_Y0.5060.12
841_Y964_F0.5060.12
928_Q950_R0.5060.12
590_Q988_Q0.5050.12
749_H837_L0.5050.12
344_I435_D0.5050.12
711_H995_A0.5050.12
115_K232_D0.5050.12
348_F681_N0.5050.12
212_Q250_E0.5050.12
748_G752_L0.5050.12
308_Y786_C0.5040.12
156_G506_G0.5040.12
296_E949_C0.5040.12
711_H774_R0.5030.12
708_E1031_A0.5030.12
963_R1023_A0.5030.12
562_L601_A0.5030.12
274_G443_K0.5020.12
599_Q761_L0.5020.12
23_D727_L0.5020.12
890_V965_E0.5020.12
931_D967_D0.5010.12
23_D816_L0.5010.12
36_E387_Q0.5010.12
583_H731_G0.5010.12
805_Q1001_I0.5010.12
307_T991_M0.5010.12
311_V616_V0.5010.12
96_P600_L0.5000.12
117_Y501_T0.5000.12
328_W439_T0.5000.12
527_L681_N0.5000.12
661_G855_A0.5000.12
144_P275_L0.5000.12
507_V1022_E0.5000.12
878_S1022_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bpoA 1 0.541 100 0.733 Contact Map
3qe2A 1 0.5382 100 0.735 Contact Map
1tllA 2 0.5335 100 0.739 Contact Map
2ij2A 1 0.4317 100 0.785 Contact Map
4dqlA 2 0.3582 100 0.797 Contact Map
1f20A 1 0.3883 100 0.802 Contact Map
3qfsA 1 0.3949 100 0.809 Contact Map
2qtlA 1 0.4006 100 0.809 Contact Map
3dbgA 1 0.3553 100 0.815 Contact Map
4r21A 1 0.3864 100 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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