GREMLIN Database
CYPE - Probable bifunctional P-450/NADPH-P450 reductase 2
UniProt: O08336 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1054 (1036)
Sequences: 429 (333)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_K75_K13.1451.00
420_V426_L6.8451.00
61_A391_H6.4771.00
29_Q438_E5.2761.00
96_P250_E4.5551.00
798_V803_L4.4221.00
753_L819_F4.3840.99
985_K988_T4.3410.99
951_R955_D4.2010.99
948_D967_R4.1810.99
86_D97_N4.1600.99
715_V754_S4.0450.99
1029_S1032_E3.9750.99
336_L398_N3.8430.99
71_K76_G3.8320.99
219_D258_R3.7660.98
860_S863_G3.6100.98
293_A421_L3.6100.98
590_D600_R3.6070.98
768_L808_F3.6000.98
66_E398_N3.5700.98
275_L413_A3.5380.97
128_L131_K3.4520.97
219_D223_A3.4440.97
43_R50_S3.4310.97
942_R979_Y3.4280.97
256_N260_Q3.3520.96
54_V63_V3.3250.96
984_L991_L3.3070.96
23_E30_S3.2570.96
71_K74_G3.2480.96
295_E299_R3.2460.96
966_R987_D3.2270.96
855_K864_E3.2110.95
36_D362_K3.1980.95
73_L76_G3.0980.94
837_S850_T3.0670.94
82_E207_F3.0430.94
774_Y818_P2.9810.93
717_R810_E2.9760.93
280_I449_I2.9580.93
341_D352_K2.9550.93
42_F53_F2.9370.93
350_I356_V2.8850.92
971_R979_Y2.8770.92
244_K251_T2.8750.92
428_N447_F2.8690.92
83_F182_A2.8390.91
533_V566_V2.8230.91
948_D969_Y2.7860.90
181_R210_D2.7670.90
977_K983_L2.7460.90
151_T330_T2.7330.90
60_V363_L2.7110.89
371_G374_A2.6920.89
994_L999_A2.6240.87
279_A417_L2.6160.87
584_R588_L2.5950.87
919_I962_L2.5640.86
552_V588_L2.5460.86
932_L935_A2.5420.86
65_D68_R2.5420.86
563_L598_A2.5170.85
675_E684_S2.5070.85
9_Q18_N2.4890.84
938_Y991_L2.4380.83
304_D310_Q2.4190.83
958_E964_T2.4100.82
587_R606_E2.3880.82
936_L966_R2.3720.81
165_N168_Y2.3700.81
541_N703_H2.3530.81
559_E562_Q2.3180.80
944_P972_V2.3160.80
373_D378_R2.3130.80
133_S423_H2.3130.80
18_N21_H2.3050.79
200_M203_T2.2900.79
394_K398_N2.2730.78
763_A768_L2.2730.78
152_L330_T2.2700.78
970_S979_Y2.2650.78
275_L330_T2.2640.78
55_S359_L2.2630.78
895_M903_M2.2390.77
518_A521_D2.2260.77
181_R206_Q2.2160.77
576_R608_D2.2120.76
252_L364_H2.2080.76
57_H392_A2.2070.76
321_L413_A2.2060.76
436_I442_I2.1860.76
80_V83_F2.1790.75
966_R990_K2.1740.75
179_M441_T2.1720.75
42_F744_D2.1700.75
624_F628_T2.1700.75
582_Y606_E2.1630.75
561_G564_K2.1620.75
330_T413_A2.1610.75
583_Q604_I2.1530.74
62_E804_T2.1360.74
966_R983_L2.1320.74
987_D990_K2.1310.74
311_I414_T2.1110.73
317_I320_V2.1080.73
583_Q606_E2.1070.73
942_R971_R2.1050.73
319_M383_E2.0740.71
127_Q165_N2.0590.71
186_A207_F2.0580.71
180_L331_A2.0510.71
842_V846_I2.0370.70
42_F358_V2.0340.70
948_D955_D2.0270.70
153_D166_S2.0170.69
687_H950_Y2.0060.69
34_I624_F2.0020.69
215_N259_Y2.0000.69
668_G884_C1.9950.68
9_Q45_D1.9910.68
493_N546_D1.9830.68
358_V589_I1.9820.68
79_K189_Q1.9750.68
63_V358_V1.9490.66
336_L350_I1.9440.66
942_R970_S1.9250.65
252_L256_N1.9250.65
689_E950_Y1.9220.65
392_A568_Y1.9170.65
293_A317_I1.9050.65
433_E450_T1.8910.64
127_Q163_R1.8690.63
770_E821_R1.8620.63
117_Y541_N1.8550.62
133_S453_P1.8530.62
537_T589_I1.8470.62
849_M888_T1.8400.62
331_A365_R1.8370.62
330_T416_V1.8260.61
86_D95_E1.8200.61
123_D163_R1.8200.61
582_Y593_M1.8200.61
279_A324_T1.8150.61
72_N75_K1.8130.61
134_R168_Y1.7900.60
630_D688_I1.7830.59
784_L808_F1.7770.59
298_D454_R1.7720.59
212_E216_S1.7700.59
81_R95_E1.7610.58
199_M286_H1.7540.58
903_M935_A1.7540.58
192_R200_M1.7530.58
350_I426_L1.7520.58
142_D145_D1.7500.58
337_Y353_G1.7460.58
85_G259_Y1.7430.57
706_I721_R1.7410.57
837_S848_S1.7340.57
703_H957_A1.7130.56
529_E566_V1.7040.56
568_Y598_A1.6970.55
280_I417_L1.6840.55
151_T293_A1.6830.55
293_A320_V1.6770.54
936_L991_L1.6390.53
110_S114_M1.6340.52
8_P17_K1.6340.52
43_R354_Q1.6330.52
585_I696_K1.6290.52
711_S715_V1.6260.52
926_K962_L1.6120.51
531_G613_F1.6050.51
282_C330_T1.5940.51
66_E446_D1.5860.50
189_Q703_H1.5830.50
780_H814_A1.5610.49
817_M917_G1.5600.49
106_L179_M1.5590.49
160_F260_Q1.5560.49
558_L563_L1.5560.49
96_P100_K1.5510.49
284_L442_I1.5420.48
99_Q103_R1.5380.48
689_E920_Q1.5380.48
104_I808_F1.5370.48
614_E685_T1.5370.48
221_M426_L1.5330.48
117_Y159_G1.5310.48
151_T331_A1.5300.48
214_M217_L1.5290.48
61_A390_H1.5270.47
322_N393_Y1.5240.47
757_V826_L1.5230.47
985_K1017_T1.5180.47
66_E394_K1.5170.47
798_V802_R1.5110.47
125_A419_L1.5100.47
880_D949_L1.5080.47
903_M933_G1.5070.46
529_E565_G1.5060.46
341_D351_S1.4960.46
100_K253_D1.4900.46
71_K77_L1.4790.45
281_Y447_F1.4750.45
311_I418_G1.4740.45
1006_D1012_P1.4700.45
293_A330_T1.4680.45
673_N686_R1.4630.44
282_C331_A1.4620.44
256_N259_Y1.4580.44
722_F822_F1.4540.44
576_R610_A1.4530.44
589_I848_S1.4530.44
569_A601_L1.4530.44
889_P894_Q1.4520.44
113_A407_Q1.4500.44
56_G366_D1.4500.44
143_V330_T1.4490.44
151_T155_I1.4470.44
895_M935_A1.4470.44
127_Q168_Y1.4420.43
601_L624_F1.4370.43
62_E68_R1.4320.43
22_L30_S1.4250.43
351_S938_Y1.4140.42
656_E660_A1.4130.42
1023_E1030_Q1.4090.42
132_W146_D1.4080.42
535_I589_I1.3990.42
123_D127_Q1.3990.42
106_L924_V1.3980.41
48_G609_A1.3900.41
500_I617_R1.3880.41
163_R168_Y1.3880.41
118_H411_Q1.3820.41
311_I318_R1.3820.41
100_K260_Q1.3810.41
388_I392_A1.3800.41
805_M825_L1.3790.41
976_P983_L1.3760.40
321_L402_A1.3720.40
944_P949_L1.3690.40
282_C328_Y1.3680.40
64_C334_F1.3640.40
160_F382_F1.3630.40
488_V694_A1.3630.40
141_I451_V1.3610.40
41_I54_V1.3600.40
598_A770_E1.3590.40
449_I882_A1.3590.40
291_K295_E1.3590.40
338_A350_I1.3580.40
534_V624_F1.3570.40
775_T814_A1.3550.40
179_M183_L1.3530.39
47_P344_L1.3500.39
541_N957_A1.3490.39
964_T990_K1.3440.39
104_I437_K1.3410.39
801_K858_A1.3390.39
487_L531_G1.3370.39
690_L884_C1.3340.39
238_S261_I1.3330.39
853_V871_N1.3320.39
842_V848_S1.3300.38
705_G833_Y1.3280.38
719_L726_S1.3270.38
585_I588_L1.3200.38
78_Q92_W1.3180.38
138_N847_V1.3160.38
294_Q425_E1.3120.38
293_A394_K1.3090.38
151_T186_A1.2990.37
279_A320_V1.2960.37
148_T441_T1.2910.37
730_I819_F1.2890.37
274_G330_T1.2880.37
703_H833_Y1.2800.36
26_Q29_Q1.2770.36
499_G730_I1.2750.36
730_I749_V1.2740.36
995_I1001_I1.2730.36
624_F825_L1.2730.36
113_A193_L1.2670.36
519_P522_D1.2670.36
295_E751_D1.2660.36
923_S957_A1.2660.36
747_I752_L1.2610.35
138_N220_R1.2580.35
587_R591_D1.2520.35
100_K252_L1.2520.35
40_P206_Q1.2500.35
763_A805_M1.2470.35
80_V186_A1.2450.35
534_V569_A1.2430.35
559_E595_A1.2420.35
699_K894_Q1.2420.35
500_I609_A1.2390.35
318_R322_N1.2380.34
939_F954_L1.2380.34
389_P392_A1.2340.34
48_G286_H1.2330.34
207_F262_I1.2330.34
316_Y379_P1.2320.34
14_G17_K1.2320.34
817_M963_V1.2310.34
207_F223_A1.2300.34
274_G413_A1.2270.34
333_A438_E1.2270.34
57_H61_A1.2260.34
427_I452_K1.2250.34
327_L331_A1.2230.34
803_L808_F1.2220.34
159_G407_Q1.2210.34
117_Y130_Q1.2210.34
420_V854_V1.2200.34
218_V261_I1.2180.34
609_A613_F1.2150.33
852_G910_T1.2140.33
252_L363_L1.2120.33
100_K256_N1.2090.33
9_Q12_T1.2090.33
96_P152_L1.2090.33
895_M933_G1.2070.33
794_Y798_V1.2060.33
170_D313_Q1.2030.33
365_R375_E1.2020.33
278_F717_R1.2020.33
27_L35_A1.2020.33
276_L293_A1.1980.33
254_D257_I1.1960.33
843_H846_I1.1960.33
664_G690_L1.1950.33
81_R86_D1.1950.33
489_L533_V1.1940.33
854_V954_L1.1890.32
541_N833_Y1.1870.32
437_K445_D1.1860.32
193_L196_Q1.1860.32
352_K1013_D1.1830.32
435_K445_D1.1820.32
809_L817_M1.1790.32
988_T1021_A1.1790.32
520_L589_I1.1790.32
624_F984_L1.1760.32
309_K624_F1.1750.32
121_M154_T1.1700.32
321_L332_P1.1700.32
222_I324_T1.1680.32
393_Y407_Q1.1680.32
519_P1024_A1.1680.32
730_I962_L1.1670.32
730_I771_L1.1670.32
143_V359_L1.1670.32
114_M402_A1.1650.31
123_D168_Y1.1630.31
64_C340_E1.1620.31
797_Q801_K1.1580.31
282_C545_P1.1560.31
79_K82_E1.1550.31
97_N256_N1.1530.31
841_K921_A1.1480.31
274_G331_A1.1480.31
569_A991_L1.1450.31
186_A928_E1.1430.31
777_C1006_D1.1430.31
226_K1038_Q1.1420.31
819_F825_L1.1380.30
563_L593_M1.1350.30
575_N610_A1.1350.30
719_L749_V1.1330.30
257_I494_L1.1310.30
721_R819_F1.1260.30
92_W95_E1.1260.30
364_H788_V1.1230.30
151_T416_V1.1200.30
983_L987_D1.1190.30
82_E186_A1.1190.30
156_G447_F1.1110.29
483_G536_V1.1110.29
115_K282_C1.1110.29
749_V753_L1.1090.29
727_N732_V1.1090.29
187_M508_G1.1050.29
114_M117_Y1.1050.29
635_N798_V1.1050.29
988_T1024_A1.1030.29
131_K135_L1.1030.29
35_A42_F1.0990.29
933_G1003_V1.0980.29
123_D165_N1.0970.29
490_F901_T1.0960.29
703_H1048_K1.0960.29
428_N703_H1.0950.29
674_R1034_A1.0940.29
974_N977_K1.0920.29
340_E352_K1.0900.29
594_K600_R1.0860.28
23_E26_Q1.0850.28
489_L520_L1.0850.28
76_G151_T1.0840.28
369_A389_P1.0830.28
411_Q965_I1.0820.28
185_E203_T1.0820.28
236_L402_A1.0780.28
703_H985_K1.0780.28
293_A297_A1.0770.28
125_A385_P1.0770.28
819_F826_L1.0740.28
8_P14_G1.0710.28
724_L836_I1.0690.28
764_S880_D1.0670.28
286_H478_T1.0660.28
563_L933_G1.0640.28
730_I872_Y1.0630.28
870_S939_F1.0600.27
71_K605_G1.0590.27
648_I706_I1.0590.27
504_L536_V1.0560.27
161_N812_Y1.0560.27
532_A632_F1.0560.27
156_G1051_W1.0540.27
47_P286_H1.0540.27
418_G456_T1.0530.27
438_E1010_M1.0530.27
329_P365_R1.0510.27
700_E921_A1.0510.27
641_E875_E1.0490.27
142_D583_Q1.0470.27
858_A863_G1.0460.27
529_E535_I1.0450.27
185_E869_A1.0430.27
71_K142_D1.0410.27
145_D749_V1.0410.27
252_L606_E1.0400.27
677_Q1013_D1.0400.27
161_N768_L1.0370.27
874_A954_L1.0340.26
601_L1023_E1.0340.26
189_Q192_R1.0340.26
856_A865_Y1.0320.26
336_L358_V1.0280.26
243_A538_A1.0270.26
1003_V1046_Y1.0270.26
841_K957_A1.0270.26
192_R344_L1.0260.26
485_P917_G1.0260.26
311_I317_I1.0230.26
889_P907_G1.0210.26
275_L293_A1.0210.26
617_R756_Y1.0170.26
430_T541_N1.0150.26
278_F436_I1.0150.26
226_K254_D1.0110.26
60_V358_V1.0100.26
727_N904_I1.0100.26
129_I233_I1.0090.26
285_T428_N1.0080.26
10_P18_N1.0070.25
687_H920_Q1.0060.25
497_A727_N1.0050.25
320_V601_L1.0050.25
140_E429_H1.0000.25
434_L554_W0.9990.25
749_V882_A0.9990.25
539_S585_I0.9980.25
894_Q927_K0.9950.25
294_Q983_L0.9940.25
1032_E1035_V0.9940.25
853_V870_S0.9940.25
364_H527_L0.9940.25
954_L965_I0.9930.25
987_D1033_S0.9930.25
252_L358_V0.9920.25
318_R577_S0.9920.25
176_I180_L0.9910.25
260_Q912_I0.9880.25
42_F688_I0.9870.25
277_S903_M0.9860.25
967_R995_I0.9840.25
860_S865_Y0.9840.25
520_L599_S0.9840.25
333_A579_A0.9830.25
783_E812_Y0.9820.25
55_S485_P0.9820.25
980_V1010_M0.9810.25
983_L991_L0.9810.25
226_K419_L0.9800.25
703_H1051_W0.9780.24
37_E210_D0.9780.24
583_Q851_V0.9780.24
23_E719_L0.9760.24
39_G316_Y0.9750.24
742_P763_A0.9720.24
143_V152_L0.9720.24
294_Q585_I0.9720.24
381_R869_A0.9720.24
359_L932_L0.9700.24
1003_V1014_V0.9680.24
10_P17_K0.9680.24
291_K594_K0.9670.24
200_M673_N0.9660.24
775_T815_C0.9650.24
111_Q393_Y0.9610.24
274_G440_L0.9590.24
44_F690_L0.9570.24
753_L757_V0.9530.24
687_H764_S0.9530.24
730_I934_E0.9510.24
38_L137_P0.9500.24
38_L732_V0.9500.24
124_I153_D0.9490.23
7_I52_V0.9490.23
555_L825_L0.9480.23
601_L628_T0.9480.23
54_V516_E0.9480.23
752_L870_S0.9460.23
981_Q1010_M0.9450.23
81_R97_N0.9450.23
609_A847_V0.9430.23
320_V782_K0.9430.23
802_R859_W0.9430.23
110_S360_I0.9430.23
52_V354_Q0.9420.23
706_I885_F0.9400.23
43_R517_T0.9400.23
351_S718_V0.9390.23
111_Q117_Y0.9360.23
402_A579_A0.9340.23
54_V320_V0.9330.23
93_T400_Q0.9310.23
417_L606_E0.9310.23
104_I253_D0.9300.23
752_L766_L0.9280.23
63_V350_I0.9230.23
182_A266_I0.9230.23
253_D256_N0.9210.23
568_Y749_V0.9190.22
206_Q210_D0.9180.22
850_T918_F0.9160.22
128_L262_I0.9150.22
207_F211_I0.9150.22
351_S798_V0.9140.22
618_E1013_D0.9100.22
35_A359_L0.9100.22
644_P824_A0.9090.22
8_P18_N0.9090.22
531_G582_Y0.9070.22
125_A772_A0.9050.22
354_Q360_I0.9050.22
904_I1014_V0.9050.22
538_A571_F0.9040.22
137_P424_F0.9040.22
536_V860_S0.9040.22
833_Y1051_W0.9040.22
63_V356_V0.9020.22
775_T816_E0.9000.22
222_I238_S0.9000.22
133_S967_R0.8980.22
964_T987_D0.8970.22
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981_Q1013_D0.6180.14
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703_H908_P0.6170.14
1046_Y1049_D0.6160.14
182_A210_D0.6160.14
227_A790_D0.6160.14
446_D973_E0.6160.14
894_Q903_M0.6160.14
899_P933_G0.6160.14
282_C329_P0.6150.14
112_K117_Y0.6150.14
532_A629_M0.6150.14
258_R370_W0.6140.14
628_T632_F0.6140.14
178_S214_M0.6130.14
183_L331_A0.6130.14
144_A875_E0.6130.14
219_D256_N0.6130.14
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222_I321_L0.6100.14
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427_I751_D0.5790.13
992_M1025_E0.5790.13
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546_D576_R0.5790.13
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260_Q496_T0.5470.13
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379_P544_P0.5460.13
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545_P833_Y0.5450.13
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316_Y380_E0.5420.13
466_Q994_L0.5410.13
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898_D987_D0.5410.13
869_A917_G0.5400.13
113_A497_A0.5390.12
674_R763_A0.5390.12
241_L971_R0.5390.12
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159_G995_I0.5390.12
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882_A1042_D0.5380.12
19_L356_V0.5370.12
236_L239_L0.5370.12
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763_A804_T0.5370.12
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125_A154_T0.5360.12
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959_Q1039_K0.5350.12
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561_G951_R0.5210.12
76_G435_K0.5210.12
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1010_M1014_V0.5170.12
456_T462_Q0.5160.12
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136_N833_Y0.5160.12
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555_L594_K0.5150.12
80_V451_V0.5150.12
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55_S363_L0.5140.12
23_E952_E0.5140.12
23_E142_D0.5130.12
564_K585_I0.5130.12
564_K713_E0.5130.12
381_R685_T0.5130.12
71_K84_G0.5120.12
583_Q981_Q0.5110.12
343_V349_P0.5110.12
715_V1001_I0.5110.12
839_S957_A0.5110.12
648_I878_T0.5110.12
198_K372_P0.5110.12
28_S38_L0.5100.12
817_M1024_A0.5100.12
657_T661_K0.5090.12
714_L768_L0.5090.12
893_F908_P0.5090.12
723_G768_L0.5090.12
148_T175_F0.5090.12
811_D854_V0.5090.12
207_F763_A0.5080.12
42_F208_Q0.5080.12
234_K453_P0.5070.12
739_A743_M0.5070.12
257_I764_S0.5070.12
58_N962_L0.5060.12
190_S814_A0.5060.12
171_S355_P0.5050.12
390_H534_V0.5050.12
165_N722_F0.5050.12
138_N226_K0.5050.12
111_Q217_L0.5050.12
665_A668_G0.5040.12
488_V504_L0.5040.12
977_K986_Q0.5040.12
207_F266_I0.5040.12
844_A936_L0.5030.12
255_E982_H0.5030.12
29_Q167_F0.5030.12
137_P988_T0.5030.12
58_N599_S0.5030.12
279_A812_Y0.5020.12
343_V748_K0.5020.12
117_Y494_L0.5020.12
54_V140_E0.5020.12
170_D376_D0.5020.12
347_E631_A0.5020.12
956_Q1016_R0.5020.12
266_I774_Y0.5010.12
534_V993_T0.5010.12
68_R446_D0.5010.12
332_P398_N0.5010.12
269_H441_T0.5010.12
965_I969_Y0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bpoA 1 0.5436 100 0.731 Contact Map
3qe2A 1 0.5417 100 0.735 Contact Map
1tllA 2 0.537 100 0.739 Contact Map
2ij2A 1 0.4345 100 0.787 Contact Map
4dqlA 2 0.3615 100 0.799 Contact Map
1f20A 1 0.3918 100 0.801 Contact Map
3qfsA 1 0.3994 100 0.808 Contact Map
2qtlA 1 0.4051 100 0.809 Contact Map
3dbgA 1 0.3577 100 0.816 Contact Map
1ddgA 1 0.352 100 0.816 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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