GREMLIN Database
BSCR - HTH-type transcriptional repressor BscR
UniProt: O08335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (178)
Sequences: 45069 (35769)
Seq/√Len: 2681.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_P41_T3.9531.00
23_R32_M3.9211.00
18_S36_R3.8151.00
49_D53_T2.7701.00
20_F28_T2.4281.00
129_D147_N2.2421.00
34_A44_I2.2371.00
10_D61_E2.1981.00
50_S53_T2.0941.00
22_E36_R2.0911.00
8_K11_M2.0801.00
19_L28_T2.0271.00
82_G134_K1.9961.00
40_G43_T1.9271.00
78_P81_E1.8851.00
129_D133_N1.8761.00
133_N137_A1.8011.00
9_Y57_V1.7961.00
10_D14_K1.7821.00
19_L36_R1.7741.00
11_M15_A1.7351.00
31_P35_E1.7271.00
17_V61_E1.7151.00
19_L32_M1.6971.00
30_I41_T1.6661.00
16_S20_F1.6621.00
15_A36_R1.6471.00
133_N146_S1.6141.00
13_M57_V1.5441.00
57_V60_Q1.5391.00
19_L23_R1.5321.00
30_I45_Y1.5311.00
84_H177_T1.4571.00
88_C177_T1.4511.00
133_N136_K1.4441.00
18_S22_E1.4301.00
15_A18_S1.4301.00
30_I44_I1.4271.00
32_M35_E1.4111.00
29_T32_M1.4051.00
135_G141_I1.4001.00
60_Q116_T1.3841.00
7_S11_M1.3671.00
152_I156_A1.3641.00
14_K61_E1.3621.00
71_K127_M1.3421.00
148_V178_E1.3401.00
24_G27_A1.3381.00
28_T33_I1.3361.00
43_T46_R1.3281.00
134_K138_E1.3191.00
32_M36_R1.3111.00
48_F57_V1.2971.00
17_V58_L1.2951.00
20_F25_F1.2891.00
56_N60_Q1.2791.00
24_G28_T1.2641.00
17_V62_S1.2531.00
136_K143_S1.2451.00
135_G140_V1.2351.00
16_S54_L1.2171.00
61_E65_R1.2171.00
53_T57_V1.2111.00
125_T151_A1.1911.00
88_C173_T1.1731.00
56_N116_T1.1621.00
81_E85_H1.1611.00
39_V43_T1.1551.00
13_M58_L1.1531.00
136_K144_L1.1491.00
78_P140_V1.1331.00
44_I54_L1.1121.00
23_R27_A1.1111.00
80_R84_H1.1111.00
9_Y47_Y1.1101.00
8_K47_Y1.1101.00
15_A19_L1.1101.00
69_K89_C1.1081.00
131_Y135_G1.1061.00
145_P148_V1.1021.00
15_A37_A1.1001.00
43_T47_Y1.0991.00
105_E109_D1.0981.00
40_G46_R1.0961.00
25_F55_V1.0891.00
155_G159_K1.0811.00
7_S10_D1.0721.00
93_F97_S1.0701.00
84_H88_C1.0671.00
45_Y50_S1.0651.00
60_Q64_Q1.0621.00
52_E110_A1.0561.00
33_I54_L1.0541.00
41_T45_Y1.0451.00
42_G46_R1.0341.00
14_K18_S1.0151.00
84_H181_Q0.9951.00
79_V138_E0.9861.00
13_M48_F0.9831.00
125_T129_D0.9811.00
122_E126_Q0.9701.00
136_K146_S0.9641.00
130_D134_K0.9531.00
129_D146_S0.9521.00
85_H88_C0.9481.00
52_E112_Y0.9441.00
17_V21_T0.9391.00
126_Q130_D0.9381.00
130_D133_N0.9361.00
53_T56_N0.9361.00
6_S10_D0.9331.00
52_E56_N0.9311.00
116_T119_K0.9311.00
68_E72_Q0.9271.00
101_L104_L0.9261.00
173_T177_T0.9251.00
71_K75_S0.9211.00
127_M130_D0.9191.00
77_L85_H0.9171.00
64_Q68_E0.9131.00
67_T123_N0.9081.00
82_G131_Y0.9061.00
23_R36_R0.9031.00
81_E84_H0.9021.00
61_E64_Q0.9011.00
144_L149_L0.9011.00
177_T181_Q0.8991.00
136_K139_G0.8951.00
16_S58_L0.8901.00
25_F51_K0.8871.00
41_T46_R0.8791.00
69_K72_Q0.8761.00
23_R28_T0.8751.00
178_E181_Q0.8711.00
115_H119_K0.8701.00
106_T110_A0.8681.00
119_K123_N0.8641.00
106_T109_D0.8621.00
76_E82_G0.8541.00
73_D89_C0.8491.00
57_V61_E0.8451.00
88_C176_I0.8381.00
125_T147_N0.8341.00
84_H180_E0.8321.00
100_A103_F0.8281.00
34_A41_T0.8241.00
92_Q173_T0.8191.00
89_C92_Q0.8141.00
148_V174_D0.8041.00
85_H89_C0.7971.00
116_T120_M0.7951.00
18_S99_Y0.7941.00
146_S150_I0.7931.00
11_M37_A0.7921.00
8_K39_V0.7911.00
136_K141_I0.7891.00
88_C92_Q0.7831.00
134_K137_A0.7771.00
13_M17_V0.7741.00
12_I44_I0.7731.00
174_D178_E0.7721.00
79_V135_G0.7681.00
147_N151_A0.7671.00
11_M14_K0.7641.00
118_K121_I0.7621.00
129_D150_I0.7581.00
131_Y134_K0.7581.00
35_E41_T0.7561.00
77_L81_E0.7561.00
20_F55_V0.7501.00
153_V183_C0.7481.00
60_Q120_M0.7451.00
73_D85_H0.7361.00
19_L22_E0.7351.00
67_T71_K0.7301.00
62_S65_R0.7301.00
132_F153_V0.7211.00
176_I180_E0.7131.00
132_F136_K0.7111.00
31_P45_Y0.7091.00
76_E81_E0.7081.00
12_I37_A0.7071.00
171_M174_D0.7011.00
65_R68_E0.7001.00
68_E71_K0.6991.00
88_C180_E0.6921.00
60_Q119_K0.6871.00
133_N147_N0.6851.00
126_Q129_D0.6841.00
176_I179_L0.6781.00
25_F28_T0.6771.00
67_T127_M0.6741.00
111_H115_H0.6691.00
114_N118_K0.6661.00
12_I47_Y0.6641.00
123_N127_M0.6611.00
132_F146_S0.6601.00
111_H114_N0.6561.00
87_F153_V0.6531.00
164_V167_G0.6511.00
25_F52_E0.6481.00
155_G158_L0.6461.00
8_K43_T0.6431.00
148_V152_I0.6431.00
74_V127_M0.6371.00
30_I34_A0.6361.00
173_T176_I0.6341.00
123_N126_Q0.6291.00
92_Q96_E0.6201.00
37_A40_G0.6151.00
175_L179_L0.6141.00
175_L178_E0.6101.00
84_H87_F0.6091.00
8_K40_G0.6091.00
6_S9_Y0.6061.00
79_V140_V0.6041.00
76_E85_H0.5991.00
178_E182_C0.5981.00
92_Q176_I0.5971.00
105_E108_K0.5941.00
13_M61_E0.5921.00
80_R181_Q0.5911.00
14_K17_V0.5901.00
179_L183_C0.5891.00
72_Q89_C0.5881.00
152_I155_G0.5881.00
177_T180_E0.5801.00
145_P178_E0.5781.00
17_V65_R0.5781.00
174_D177_T0.5771.00
118_K122_E0.5721.00
64_Q120_M0.5691.00
145_P149_L0.5671.00
82_G135_G0.5611.00
8_K12_I0.5591.00
163_L166_T0.5581.00
71_K123_N0.5561.00
20_F24_G0.5551.00
119_K122_E0.5511.00
115_H118_K0.5491.00
109_D112_Y0.5491.00
31_P40_G0.5471.00
78_P82_G0.5471.00
22_E32_M0.5471.00
79_V141_I0.5471.00
112_Y115_H0.5471.00
135_G139_G0.5461.00
97_S100_A0.5461.00
155_G163_L0.5411.00
156_A179_L0.5361.00
46_R49_D0.5331.00
90_L124_L0.5291.00
34_A39_V0.5241.00
132_F149_L0.5211.00
37_A41_T0.5201.00
89_C93_F0.5171.00
30_I51_K0.5161.00
71_K130_D0.5131.00
41_T44_I0.5121.00
19_L29_T0.5091.00
136_K142_R0.5091.00
8_K46_R0.5081.00
79_V82_G0.5041.00
90_L94_T0.5041.00
148_V151_A0.5011.00
39_V47_Y0.5011.00
34_A37_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3colA 2 0.9124 100 0.206 Contact Map
3pasA 2 0.9948 100 0.211 Contact Map
2iaiA 2 0.9536 100 0.212 Contact Map
4jykA 2 0.9794 100 0.217 Contact Map
4udsA 2 0.933 100 0.221 Contact Map
3on2A 1 0.9639 100 0.222 Contact Map
3he0A 2 0.9485 100 0.224 Contact Map
2f07A 2 0.9794 100 0.224 Contact Map
3ppbA 2 0.9536 100 0.226 Contact Map
2ibdA 2 0.9639 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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