AZLC - BACSU - GREMLIN Contacts

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AZLC - Branched-chain amino acid transport protein AzlC

UniProt:	O07942	Sequences: MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFLFLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNARHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNHLYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVASLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (219)
Sequences:	3082 (2283)
Seq/√Len:	154.3

ECOLI - YGAZ
BACSU - AZLC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_Y	151_F	4.854	1.00
60_S	63_Y	4.574	1.00
65_I	168_A	4.395	1.00
128_G	156_T	3.687	1.00
54_M	64_P	3.457	1.00
69_F	164_V	3.321	1.00
29_F	154_F	3.178	1.00
32_A	154_F	3.073	1.00
110_S	134_F	2.963	1.00
61_A	171_G	2.749	1.00
30_R	34_P	2.730	1.00
67_M	80_A	2.727	1.00
83_F	88_F	2.724	1.00
66_I	70_M	2.662	1.00
68_S	167_A	2.584	1.00
47_G	166_G	2.558	1.00
79_V	100_V	2.420	1.00
43_F	130_C	2.348	1.00
29_F	157_L	2.147	1.00
73_A	101_N	2.099	1.00
65_I	164_V	2.021	1.00
211_T	239_V	1.910	1.00
160_H	164_V	1.841	1.00
219_S	231_P	1.822	1.00
215_L	235_A	1.818	1.00
39_I	159_N	1.818	1.00
121_K	149_G	1.802	1.00
67_M	71_I	1.802	1.00
31_S	140_A	1.772	1.00
43_F	159_N	1.756	1.00
36_T	155_V	1.754	1.00
50_Y	167_A	1.744	1.00
79_V	96_L	1.736	1.00
73_A	104_H	1.728	1.00
72_F	130_C	1.720	1.00
57_L	81_A	1.685	1.00
55_H	171_G	1.663	1.00
73_A	76_M	1.661	1.00
35_Y	140_A	1.659	1.00
44_L	169_I	1.650	1.00
50_Y	77_E	1.626	1.00
29_F	158_L	1.580	1.00
44_L	48_I	1.556	1.00
64_P	171_G	1.540	1.00
121_K	153_F	1.529	1.00
73_A	97_T	1.528	1.00
133_S	159_N	1.523	1.00
232_A	236_I	1.514	1.00
80_A	97_T	1.490	1.00
31_S	35_Y	1.477	1.00
26_W	30_R	1.475	1.00
131_D	163_W	1.469	1.00
124_Y	160_H	1.451	1.00
50_Y	81_A	1.441	1.00
72_F	160_H	1.391	1.00
69_F	160_H	1.384	1.00
104_H	129_M	1.372	1.00
133_S	155_V	1.361	1.00
162_Y	166_G	1.348	1.00
40_F	158_L	1.346	1.00
127_F	160_H	1.332	1.00
40_F	162_Y	1.306	1.00
168_A	172_I	1.301	1.00
68_S	77_E	1.289	1.00
28_A	148_K	1.284	1.00
36_T	162_Y	1.283	1.00
111_M	129_M	1.280	1.00
223_F	231_P	1.266	1.00
120_K	123_L	1.246	1.00
104_H	107_Y	1.234	1.00
48_I	169_I	1.228	1.00
194_V	198_E	1.225	1.00
77_E	167_A	1.209	1.00
104_H	132_E	1.202	1.00
132_E	190_A	1.182	1.00
43_F	191_L	1.180	1.00
83_F	96_L	1.174	1.00
211_T	235_A	1.167	1.00
50_Y	78_F	1.159	1.00
236_I	240_L	1.159	1.00
31_S	34_P	1.152	1.00
130_C	159_N	1.138	1.00
76_M	97_T	1.123	1.00
50_Y	54_M	1.115	1.00
29_F	32_A	1.112	0.99
81_A	85_L	1.090	0.99
90_P	94_L	1.089	0.99
129_M	152_M	1.086	0.99
82_N	86_G	1.082	0.99
213_L	217_V	1.079	0.99
27_A	30_R	1.077	0.99
30_R	33_F	1.062	0.99
28_A	150_W	1.056	0.99
242_V	246_P	1.044	0.99
212_G	216_S	1.043	0.99
219_S	232_A	1.038	0.99
57_L	85_L	1.037	0.99
43_F	46_L	1.028	0.99
46_L	159_N	1.027	0.99
133_S	156_T	1.019	0.99
182_E	185_D	1.016	0.99
137_N	152_M	1.006	0.99
33_F	158_L	0.988	0.99
150_W	154_F	0.987	0.99
118_T	125_L	0.983	0.99
211_T	214_G	0.982	0.99
78_F	188_M	0.979	0.99
36_T	39_I	0.976	0.99
93_A	97_T	0.968	0.99
207_Y	243_L	0.967	0.99
211_T	215_L	0.957	0.98
102_A	105_L	0.956	0.98
215_L	219_S	0.948	0.98
219_S	235_A	0.942	0.98
61_A	64_P	0.940	0.98
208_S	212_G	0.939	0.98
36_T	158_L	0.932	0.98
29_F	33_F	0.931	0.98
238_G	242_V	0.930	0.98
72_F	164_V	0.924	0.98
152_M	156_T	0.924	0.98
61_A	65_I	0.918	0.98
169_I	173_F	0.916	0.98
71_I	76_M	0.913	0.98
53_F	81_A	0.904	0.98
134_F	138_Y	0.903	0.98
196_F	209_A	0.894	0.98
218_A	221_I	0.889	0.98
233_M	236_I	0.885	0.97
196_F	213_L	0.884	0.97
173_F	176_Y	0.880	0.97
243_L	246_P	0.876	0.97
178_K	182_E	0.870	0.97
59_F	63_Y	0.869	0.97
37_I	41_A	0.868	0.97
28_A	31_S	0.867	0.97
73_A	100_V	0.864	0.97
76_M	83_F	0.862	0.97
80_A	84_L	0.858	0.97
91_M	95_F	0.853	0.97
45_F	115_Y	0.853	0.97
107_Y	237_L	0.852	0.97
32_A	151_F	0.844	0.97
45_F	129_M	0.842	0.97
43_F	72_F	0.839	0.97
124_Y	128_G	0.836	0.96
74_G	131_D	0.833	0.96
200_W	206_H	0.832	0.96
107_Y	134_F	0.831	0.96
45_F	49_A	0.825	0.96
53_F	188_M	0.820	0.96
118_T	121_K	0.818	0.96
75_S	79_V	0.818	0.96
72_F	159_N	0.817	0.96
59_F	67_M	0.816	0.96
47_G	131_D	0.807	0.96
49_A	191_L	0.807	0.96
239_V	243_L	0.806	0.96
82_N	85_L	0.802	0.96
107_Y	192_F	0.797	0.95
212_G	236_I	0.794	0.95
211_T	236_I	0.792	0.95
33_F	37_I	0.792	0.95
203_E	206_H	0.792	0.95
61_A	168_A	0.789	0.95
128_G	160_H	0.785	0.95
108_G	111_M	0.777	0.95
204_K	243_L	0.773	0.95
228_F	232_A	0.767	0.94
32_A	178_K	0.762	0.94
137_N	155_V	0.756	0.94
125_L	153_F	0.753	0.94
132_E	191_L	0.752	0.94
214_G	218_A	0.748	0.93
65_I	69_F	0.747	0.93
188_M	191_L	0.746	0.93
51_G	170_G	0.740	0.93
207_Y	211_T	0.737	0.93
77_E	130_C	0.732	0.93
114_K	148_K	0.731	0.93
49_A	53_F	0.731	0.93
106_F	233_M	0.728	0.93
158_L	162_Y	0.726	0.92
219_S	223_F	0.725	0.92
44_L	166_G	0.725	0.92
110_S	113_D	0.718	0.92
210_L	214_G	0.710	0.92
55_H	60_S	0.708	0.92
42_G	132_E	0.707	0.91
89_N	92_N	0.707	0.91
213_L	216_S	0.703	0.91
46_L	191_L	0.698	0.91
180_N	183_G	0.695	0.91
58_G	234_L	0.695	0.91
49_A	152_M	0.687	0.90
36_T	43_F	0.687	0.90
77_E	164_V	0.681	0.90
39_I	43_F	0.680	0.90
166_G	191_L	0.679	0.90
71_I	104_H	0.677	0.90
46_L	188_M	0.672	0.89
198_E	201_M	0.672	0.89
156_T	159_N	0.671	0.89
124_Y	153_F	0.670	0.89
71_I	97_T	0.667	0.89
73_A	80_A	0.666	0.89
50_Y	68_S	0.663	0.89
45_F	104_H	0.660	0.88
36_T	40_F	0.658	0.88
43_F	188_M	0.657	0.88
166_G	169_I	0.657	0.88
74_G	163_W	0.653	0.88
179_F	214_G	0.649	0.88
42_G	49_A	0.649	0.88
47_G	163_W	0.646	0.87
157_L	161_L	0.642	0.87
106_F	132_E	0.641	0.87
146_V	150_W	0.640	0.87
121_K	150_W	0.636	0.87
187_V	190_A	0.634	0.86
48_I	165_A	0.623	0.85
212_G	231_P	0.622	0.85
134_F	191_L	0.622	0.85
133_S	160_H	0.621	0.85
164_V	169_I	0.620	0.85
42_G	237_L	0.620	0.85
192_F	233_M	0.614	0.85
219_S	228_F	0.611	0.84
236_I	239_V	0.609	0.84
45_F	184_L	0.609	0.84
206_H	210_L	0.607	0.84
76_M	99_M	0.605	0.84
46_L	187_V	0.605	0.84
242_V	245_K	0.604	0.84
180_N	184_L	0.600	0.83
27_A	31_S	0.600	0.83
223_F	228_F	0.600	0.83
178_K	181_T	0.599	0.83
32_A	150_W	0.599	0.83
75_S	131_D	0.593	0.82
47_G	74_G	0.593	0.82
46_L	106_F	0.592	0.82
64_P	167_A	0.592	0.82
27_A	146_V	0.587	0.82
202_K	205_K	0.585	0.82
136_I	155_V	0.585	0.82
145_N	150_W	0.585	0.82
211_T	243_L	0.583	0.81
31_S	214_G	0.582	0.81
154_F	158_L	0.581	0.81
74_G	132_E	0.580	0.81
48_I	88_F	0.579	0.81
42_G	159_N	0.577	0.81
52_I	55_H	0.574	0.80
69_F	73_A	0.574	0.80
72_F	104_H	0.572	0.80
210_L	213_L	0.568	0.80
75_S	187_V	0.568	0.80
132_E	195_I	0.567	0.80
124_Y	168_A	0.565	0.79
54_M	63_Y	0.563	0.79
156_T	160_H	0.562	0.79
109_I	113_D	0.562	0.79
54_M	67_M	0.562	0.79
208_S	236_I	0.561	0.79
173_F	177_V	0.558	0.79
43_F	155_V	0.557	0.78
240_L	244_R	0.556	0.78
48_I	166_G	0.555	0.78
39_I	128_G	0.554	0.78
104_H	188_M	0.553	0.78
107_Y	186_F	0.552	0.78
132_E	188_M	0.551	0.78
40_F	43_F	0.550	0.78
125_L	149_G	0.548	0.77
102_A	227_Q	0.548	0.77
182_E	222_L	0.548	0.77
83_F	129_M	0.547	0.77
28_A	140_A	0.546	0.77
54_M	59_F	0.545	0.77
187_V	233_M	0.544	0.77
165_A	214_G	0.543	0.77
26_W	239_V	0.542	0.77
112_L	116_R	0.541	0.76
50_Y	64_P	0.541	0.76
88_F	216_S	0.540	0.76
218_A	222_L	0.539	0.76
126_I	200_W	0.539	0.76
102_A	230_I	0.538	0.76
132_E	187_V	0.536	0.76
83_F	93_A	0.536	0.76
42_G	187_V	0.534	0.75
99_M	132_E	0.532	0.75
108_G	129_M	0.532	0.75
55_H	234_L	0.532	0.75
31_S	151_F	0.532	0.75
30_R	172_I	0.529	0.75
30_R	37_I	0.526	0.74
174_G	187_V	0.525	0.74
77_E	136_I	0.525	0.74
234_L	238_G	0.525	0.74
37_I	155_V	0.524	0.74
98_L	104_H	0.524	0.74
175_S	210_L	0.522	0.74
146_V	210_L	0.522	0.74
183_G	188_M	0.521	0.74
209_A	212_G	0.520	0.74
193_I	211_T	0.520	0.74
62_I	66_I	0.520	0.74
207_Y	210_L	0.519	0.73
65_I	171_G	0.516	0.73
34_P	37_I	0.516	0.73
27_A	238_G	0.516	0.73
44_L	47_G	0.514	0.73
159_N	188_M	0.512	0.72
234_L	242_V	0.512	0.72
53_F	77_E	0.510	0.72
209_A	232_A	0.509	0.72
186_F	189_T	0.509	0.72
183_G	190_A	0.506	0.72
32_A	63_Y	0.505	0.71
104_H	130_C	0.505	0.71
124_Y	149_G	0.503	0.71
72_F	156_T	0.502	0.71
94_L	120_K	0.501	0.71
42_G	190_A	0.501	0.71
200_W	209_A	0.500	0.71
124_Y	157_L	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4j05A	3	0.7913	35	0.95	Contact Map
4pypA	1	0.8425	27.2	0.953	Contact Map
1pw4A	1	0.8071	19.1	0.956	Contact Map
2cfqA	1	0.8543	18.5	0.956	Contact Map
3wdoA	1	0.7992	17.1	0.957	Contact Map
4cbcA	3	0.3543	13.6	0.959	Contact Map
2kluA	1	0.1693	13.3	0.959	Contact Map
4ltoA	3	0.4055	12.7	0.959	Contact Map
2l2tA	2	0.1732	11.6	0.96	Contact Map
2m20A	2	0.1496	11.1	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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