GREMLIN Database
AZLC - Branched-chain amino acid transport protein AzlC
UniProt: O07942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (219)
Sequences: 3082 (2283)
Seq/√Len: 154.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y151_F4.8541.00
60_S63_Y4.5741.00
65_I168_A4.3951.00
128_G156_T3.6871.00
54_M64_P3.4571.00
69_F164_V3.3211.00
29_F154_F3.1781.00
32_A154_F3.0731.00
110_S134_F2.9631.00
61_A171_G2.7491.00
30_R34_P2.7301.00
67_M80_A2.7271.00
83_F88_F2.7241.00
66_I70_M2.6621.00
68_S167_A2.5841.00
47_G166_G2.5581.00
79_V100_V2.4201.00
43_F130_C2.3481.00
29_F157_L2.1471.00
73_A101_N2.0991.00
65_I164_V2.0211.00
211_T239_V1.9101.00
160_H164_V1.8411.00
219_S231_P1.8221.00
215_L235_A1.8181.00
39_I159_N1.8181.00
121_K149_G1.8021.00
67_M71_I1.8021.00
31_S140_A1.7721.00
43_F159_N1.7561.00
36_T155_V1.7541.00
50_Y167_A1.7441.00
79_V96_L1.7361.00
73_A104_H1.7281.00
72_F130_C1.7201.00
57_L81_A1.6851.00
55_H171_G1.6631.00
73_A76_M1.6611.00
35_Y140_A1.6591.00
44_L169_I1.6501.00
50_Y77_E1.6261.00
29_F158_L1.5801.00
44_L48_I1.5561.00
64_P171_G1.5401.00
121_K153_F1.5291.00
73_A97_T1.5281.00
133_S159_N1.5231.00
232_A236_I1.5141.00
80_A97_T1.4901.00
31_S35_Y1.4771.00
26_W30_R1.4751.00
131_D163_W1.4691.00
124_Y160_H1.4511.00
50_Y81_A1.4411.00
72_F160_H1.3911.00
69_F160_H1.3841.00
104_H129_M1.3721.00
133_S155_V1.3611.00
162_Y166_G1.3481.00
40_F158_L1.3461.00
127_F160_H1.3321.00
40_F162_Y1.3061.00
168_A172_I1.3011.00
68_S77_E1.2891.00
28_A148_K1.2841.00
36_T162_Y1.2831.00
111_M129_M1.2801.00
223_F231_P1.2661.00
120_K123_L1.2461.00
104_H107_Y1.2341.00
48_I169_I1.2281.00
194_V198_E1.2251.00
77_E167_A1.2091.00
104_H132_E1.2021.00
132_E190_A1.1821.00
43_F191_L1.1801.00
83_F96_L1.1741.00
211_T235_A1.1671.00
50_Y78_F1.1591.00
236_I240_L1.1591.00
31_S34_P1.1521.00
130_C159_N1.1381.00
76_M97_T1.1231.00
50_Y54_M1.1151.00
29_F32_A1.1120.99
81_A85_L1.0900.99
90_P94_L1.0890.99
129_M152_M1.0860.99
82_N86_G1.0820.99
213_L217_V1.0790.99
27_A30_R1.0770.99
30_R33_F1.0620.99
28_A150_W1.0560.99
242_V246_P1.0440.99
212_G216_S1.0430.99
219_S232_A1.0380.99
57_L85_L1.0370.99
43_F46_L1.0280.99
46_L159_N1.0270.99
133_S156_T1.0190.99
182_E185_D1.0160.99
137_N152_M1.0060.99
33_F158_L0.9880.99
150_W154_F0.9870.99
118_T125_L0.9830.99
211_T214_G0.9820.99
78_F188_M0.9790.99
36_T39_I0.9760.99
93_A97_T0.9680.99
207_Y243_L0.9670.99
211_T215_L0.9570.98
102_A105_L0.9560.98
215_L219_S0.9480.98
219_S235_A0.9420.98
61_A64_P0.9400.98
208_S212_G0.9390.98
36_T158_L0.9320.98
29_F33_F0.9310.98
238_G242_V0.9300.98
72_F164_V0.9240.98
152_M156_T0.9240.98
61_A65_I0.9180.98
169_I173_F0.9160.98
71_I76_M0.9130.98
53_F81_A0.9040.98
134_F138_Y0.9030.98
196_F209_A0.8940.98
218_A221_I0.8890.98
233_M236_I0.8850.97
196_F213_L0.8840.97
173_F176_Y0.8800.97
243_L246_P0.8760.97
178_K182_E0.8700.97
59_F63_Y0.8690.97
37_I41_A0.8680.97
28_A31_S0.8670.97
73_A100_V0.8640.97
76_M83_F0.8620.97
80_A84_L0.8580.97
91_M95_F0.8530.97
45_F115_Y0.8530.97
107_Y237_L0.8520.97
32_A151_F0.8440.97
45_F129_M0.8420.97
43_F72_F0.8390.97
124_Y128_G0.8360.96
74_G131_D0.8330.96
200_W206_H0.8320.96
107_Y134_F0.8310.96
45_F49_A0.8250.96
53_F188_M0.8200.96
118_T121_K0.8180.96
75_S79_V0.8180.96
72_F159_N0.8170.96
59_F67_M0.8160.96
47_G131_D0.8070.96
49_A191_L0.8070.96
239_V243_L0.8060.96
82_N85_L0.8020.96
107_Y192_F0.7970.95
212_G236_I0.7940.95
211_T236_I0.7920.95
33_F37_I0.7920.95
203_E206_H0.7920.95
61_A168_A0.7890.95
128_G160_H0.7850.95
108_G111_M0.7770.95
204_K243_L0.7730.95
228_F232_A0.7670.94
32_A178_K0.7620.94
137_N155_V0.7560.94
125_L153_F0.7530.94
132_E191_L0.7520.94
214_G218_A0.7480.93
65_I69_F0.7470.93
188_M191_L0.7460.93
51_G170_G0.7400.93
207_Y211_T0.7370.93
77_E130_C0.7320.93
114_K148_K0.7310.93
49_A53_F0.7310.93
106_F233_M0.7280.93
158_L162_Y0.7260.92
219_S223_F0.7250.92
44_L166_G0.7250.92
110_S113_D0.7180.92
210_L214_G0.7100.92
55_H60_S0.7080.92
42_G132_E0.7070.91
89_N92_N0.7070.91
213_L216_S0.7030.91
46_L191_L0.6980.91
180_N183_G0.6950.91
58_G234_L0.6950.91
49_A152_M0.6870.90
36_T43_F0.6870.90
77_E164_V0.6810.90
39_I43_F0.6800.90
166_G191_L0.6790.90
71_I104_H0.6770.90
46_L188_M0.6720.89
198_E201_M0.6720.89
156_T159_N0.6710.89
124_Y153_F0.6700.89
71_I97_T0.6670.89
73_A80_A0.6660.89
50_Y68_S0.6630.89
45_F104_H0.6600.88
36_T40_F0.6580.88
43_F188_M0.6570.88
166_G169_I0.6570.88
74_G163_W0.6530.88
179_F214_G0.6490.88
42_G49_A0.6490.88
47_G163_W0.6460.87
157_L161_L0.6420.87
106_F132_E0.6410.87
146_V150_W0.6400.87
121_K150_W0.6360.87
187_V190_A0.6340.86
48_I165_A0.6230.85
212_G231_P0.6220.85
134_F191_L0.6220.85
133_S160_H0.6210.85
164_V169_I0.6200.85
42_G237_L0.6200.85
192_F233_M0.6140.85
219_S228_F0.6110.84
236_I239_V0.6090.84
45_F184_L0.6090.84
206_H210_L0.6070.84
76_M99_M0.6050.84
46_L187_V0.6050.84
242_V245_K0.6040.84
180_N184_L0.6000.83
27_A31_S0.6000.83
223_F228_F0.6000.83
178_K181_T0.5990.83
32_A150_W0.5990.83
75_S131_D0.5930.82
47_G74_G0.5930.82
46_L106_F0.5920.82
64_P167_A0.5920.82
27_A146_V0.5870.82
202_K205_K0.5850.82
136_I155_V0.5850.82
145_N150_W0.5850.82
211_T243_L0.5830.81
31_S214_G0.5820.81
154_F158_L0.5810.81
74_G132_E0.5800.81
48_I88_F0.5790.81
42_G159_N0.5770.81
52_I55_H0.5740.80
69_F73_A0.5740.80
72_F104_H0.5720.80
210_L213_L0.5680.80
75_S187_V0.5680.80
132_E195_I0.5670.80
124_Y168_A0.5650.79
54_M63_Y0.5630.79
156_T160_H0.5620.79
109_I113_D0.5620.79
54_M67_M0.5620.79
208_S236_I0.5610.79
173_F177_V0.5580.79
43_F155_V0.5570.78
240_L244_R0.5560.78
48_I166_G0.5550.78
39_I128_G0.5540.78
104_H188_M0.5530.78
107_Y186_F0.5520.78
132_E188_M0.5510.78
40_F43_F0.5500.78
125_L149_G0.5480.77
102_A227_Q0.5480.77
182_E222_L0.5480.77
83_F129_M0.5470.77
28_A140_A0.5460.77
54_M59_F0.5450.77
187_V233_M0.5440.77
165_A214_G0.5430.77
26_W239_V0.5420.77
112_L116_R0.5410.76
50_Y64_P0.5410.76
88_F216_S0.5400.76
218_A222_L0.5390.76
126_I200_W0.5390.76
102_A230_I0.5380.76
132_E187_V0.5360.76
83_F93_A0.5360.76
42_G187_V0.5340.75
99_M132_E0.5320.75
108_G129_M0.5320.75
55_H234_L0.5320.75
31_S151_F0.5320.75
30_R172_I0.5290.75
30_R37_I0.5260.74
174_G187_V0.5250.74
77_E136_I0.5250.74
234_L238_G0.5250.74
37_I155_V0.5240.74
98_L104_H0.5240.74
175_S210_L0.5220.74
146_V210_L0.5220.74
183_G188_M0.5210.74
209_A212_G0.5200.74
193_I211_T0.5200.74
62_I66_I0.5200.74
207_Y210_L0.5190.73
65_I171_G0.5160.73
34_P37_I0.5160.73
27_A238_G0.5160.73
44_L47_G0.5140.73
159_N188_M0.5120.72
234_L242_V0.5120.72
53_F77_E0.5100.72
209_A232_A0.5090.72
186_F189_T0.5090.72
183_G190_A0.5060.72
32_A63_Y0.5050.71
104_H130_C0.5050.71
124_Y149_G0.5030.71
72_F156_T0.5020.71
94_L120_K0.5010.71
42_G190_A0.5010.71
200_W209_A0.5000.71
124_Y157_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j05A 3 0.7913 35 0.95 Contact Map
4pypA 1 0.8425 27.2 0.953 Contact Map
1pw4A 1 0.8071 19.1 0.956 Contact Map
2cfqA 1 0.8543 18.5 0.956 Contact Map
3wdoA 1 0.7992 17.1 0.957 Contact Map
4cbcA 3 0.3543 13.6 0.959 Contact Map
2kluA 1 0.1693 13.3 0.959 Contact Map
4ltoA 3 0.4055 12.7 0.959 Contact Map
2l2tA 2 0.1732 11.6 0.96 Contact Map
2m20A 2 0.1496 11.1 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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