GREMLIN Database
YISQ - Uncharacterized transporter YisQ
UniProt: O07940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (423)
Sequences: 17914 (13409)
Seq/√Len: 652.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_Q93_E4.7041.00
150_I212_V3.9131.00
139_V201_A3.3671.00
83_S308_G3.1061.00
58_G283_V3.0961.00
349_I362_A3.0851.00
121_V138_K3.0281.00
344_F347_D3.0161.00
244_R248_K2.8701.00
166_Y169_D2.7741.00
121_V125_H2.7101.00
119_A122_P2.6991.00
315_Q318_A2.6941.00
143_V201_A2.5371.00
187_V192_L2.5191.00
180_L213_I2.5121.00
78_T101_S2.4871.00
240_K244_R2.4781.00
45_M189_I2.4071.00
138_K142_Q2.3861.00
85_F93_E2.3441.00
45_M186_F2.3251.00
391_D443_R2.3151.00
56_A136_D2.2891.00
52_N132_A2.2891.00
19_F23_S2.1681.00
177_M214_G2.1651.00
136_D139_V2.1111.00
173_V217_A2.0931.00
153_L215_L2.0921.00
50_S53_S2.0711.00
324_M328_Y2.0281.00
96_E239_H1.9991.00
303_T326_S1.9981.00
364_L423_A1.9841.00
143_V204_A1.9841.00
281_T361_T1.9641.00
201_A205_M1.9591.00
130_S276_A1.9511.00
421_G424_G1.9431.00
356_P360_A1.9411.00
198_L205_M1.9241.00
345_S367_A1.9181.00
42_D207_T1.9151.00
135_P139_V1.9141.00
46_L203_V1.9131.00
147_L208_S1.8981.00
189_I203_V1.8901.00
187_V191_G1.8751.00
29_F298_A1.8571.00
105_N156_T1.8431.00
310_Y318_A1.8281.00
51_D355_S1.8251.00
357_D360_A1.8141.00
26_W30_I1.8021.00
45_M185_N1.8011.00
346_K363_S1.7971.00
85_F90_Q1.7721.00
125_H134_M1.7531.00
168_K172_F1.7201.00
192_L197_V1.7071.00
120_A138_K1.6911.00
85_F88_S1.6761.00
191_G197_V1.6691.00
146_G149_F1.6661.00
143_V205_M1.6571.00
173_V218_M1.6531.00
311_I389_A1.6531.00
345_S363_S1.6531.00
216_I220_V1.6481.00
306_L322_R1.6461.00
375_G434_W1.6411.00
150_I215_L1.6371.00
25_T302_G1.6361.00
321_E324_M1.6301.00
342_T367_A1.6171.00
179_I183_A1.6091.00
239_H242_H1.5961.00
122_P125_H1.5881.00
323_C382_I1.5801.00
81_I97_V1.5711.00
330_A377_S1.5711.00
186_F190_F1.5581.00
185_N203_V1.5571.00
41_A182_I1.5531.00
320_Y324_M1.5491.00
311_I319_A1.5301.00
186_F192_L1.5281.00
143_V208_S1.5231.00
134_M138_K1.5221.00
346_K350_G1.5101.00
321_E325_K1.5011.00
184_G206_S1.4901.00
338_S342_T1.4591.00
391_D394_F1.4551.00
120_A142_Q1.4531.00
347_D350_G1.4491.00
157_F218_M1.4461.00
113_S149_F1.4441.00
188_V192_L1.4421.00
183_A187_V1.4411.00
180_L184_G1.4371.00
350_G359_I1.4261.00
116_V145_G1.4241.00
60_S141_L1.4211.00
317_D321_E1.4191.00
121_V135_P1.4151.00
131_D135_P1.4101.00
125_H131_D1.4011.00
277_Q357_D1.4001.00
438_I442_R1.3941.00
323_C385_S1.3911.00
46_L57_V1.3901.00
310_Y315_Q1.3821.00
420_F424_G1.3781.00
18_T325_K1.3761.00
368_M427_I1.3721.00
132_A135_P1.3721.00
42_D181_N1.3711.00
124_L134_M1.3701.00
183_A186_F1.3681.00
85_F97_V1.3671.00
17_K306_L1.3521.00
328_Y332_G1.3401.00
220_V224_K1.3391.00
91_K95_M1.3381.00
172_F176_G1.3311.00
30_I171_M1.3311.00
188_V198_L1.3281.00
53_S136_D1.3211.00
92_K96_E1.3201.00
347_D351_L1.3191.00
132_A276_A1.3151.00
93_E96_E1.3141.00
201_A204_A1.3141.00
342_T370_I1.3101.00
413_L417_H1.3061.00
330_A381_I1.3031.00
84_Q308_G1.2981.00
87_G312_G1.2971.00
442_R445_R1.2941.00
55_A280_T1.2831.00
360_A364_L1.2831.00
49_Y190_F1.2831.00
121_V134_M1.2821.00
86_L309_R1.2811.00
363_S367_A1.2801.00
34_L175_I1.2771.00
84_Q88_S1.2751.00
441_Y445_R1.2601.00
184_G209_I1.2571.00
394_F443_R1.2531.00
412_Y416_I1.2501.00
122_P126_M1.2501.00
86_L94_A1.2441.00
349_I359_I1.2381.00
406_I435_V1.2311.00
288_I348_L1.2271.00
173_V221_I1.2241.00
93_E242_H1.2171.00
393_K397_Y1.2101.00
18_T329_W1.2031.00
339_V343_I1.1981.00
181_N207_T1.1871.00
401_I405_G1.1861.00
43_T287_N1.1861.00
241_E244_R1.1811.00
185_N206_S1.1751.00
176_G217_A1.1641.00
316_F320_Y1.1641.00
188_V209_I1.1641.00
251_I255_G1.1591.00
420_F427_I1.1571.00
186_F189_I1.1511.00
117_F142_Q1.1511.00
43_T54_V1.1511.00
56_A133_L1.1391.00
124_L137_A1.1361.00
231_S234_K1.1341.00
84_Q390_G1.1331.00
100_V238_M1.1241.00
52_N136_D1.1201.00
113_S117_F1.1141.00
238_M243_L1.1111.00
300_S384_N1.1101.00
48_Q190_F1.1091.00
51_D277_Q1.1091.00
307_I319_A1.1051.00
57_V200_V1.0961.00
186_F191_G1.0951.00
98_A160_I1.0901.00
21_L326_S1.0901.00
100_V243_L1.0871.00
82_I163_S1.0841.00
48_Q354_Q1.0831.00
359_I362_A1.0801.00
424_G428_S1.0791.00
166_Y170_T1.0781.00
361_T364_L1.0671.00
409_P413_L1.0651.00
188_V191_G1.0601.00
278_A422_L1.0541.00
104_A243_L1.0531.00
323_C444_W1.0511.00
379_N433_E1.0491.00
398_M440_M1.0471.00
180_L210_A1.0461.00
285_T365_L1.0421.00
42_D185_N1.0411.00
191_G198_L1.0381.00
397_Y401_I1.0291.00
417_H420_F1.0271.00
386_L443_R1.0261.00
105_N152_A1.0191.00
16_D19_F1.0131.00
353_T358_I1.0111.00
332_G336_A1.0031.00
169_D221_I1.0031.00
382_I444_W1.0021.00
142_Q146_G1.0011.00
405_G409_P1.0011.00
113_S146_G1.0001.00
270_F274_M0.9961.00
95_M234_K0.9931.00
96_E242_H0.9911.00
118_F122_P0.9901.00
106_F153_L0.9891.00
165_G309_R0.9861.00
87_G313_G0.9831.00
22_F26_W0.9801.00
97_V242_H0.9791.00
245_K248_K0.9781.00
269_Y273_I0.9781.00
192_L198_L0.9761.00
325_K329_W0.9751.00
101_S246_L0.9681.00
175_I179_I0.9581.00
205_M208_S0.9561.00
360_A363_S0.9521.00
103_G238_M0.9521.00
346_K360_A0.9511.00
310_Y322_R0.9491.00
39_G61_N0.9471.00
86_L164_Y0.9451.00
365_L422_L0.9451.00
99_Y235_V0.9401.00
185_N207_T0.9381.00
414_F420_F0.9341.00
71_F152_A0.9311.00
298_A302_G0.9301.00
284_Y352_F0.9291.00
86_L91_K0.9281.00
288_I341_M0.9261.00
368_M423_A0.9251.00
120_A141_L0.9241.00
335_A339_V0.9191.00
59_V129_L0.9151.00
118_F142_Q0.9111.00
49_Y197_V0.9101.00
157_F215_L0.9081.00
161_L222_V0.9071.00
52_N276_A0.9041.00
336_A340_L0.9021.00
44_L47_S0.9011.00
184_G188_V0.8991.00
84_Q311_I0.8981.00
432_D436_R0.8951.00
208_S212_V0.8951.00
139_V142_Q0.8911.00
375_G437_G0.8881.00
259_S400_M0.8831.00
319_A323_C0.8821.00
281_T358_I0.8801.00
28_I301_Q0.8781.00
349_I363_S0.8781.00
336_A339_V0.8771.00
342_T346_K0.8771.00
41_A181_N0.8711.00
20_S23_S0.8691.00
136_D200_V0.8661.00
176_G180_L0.8651.00
327_L378_F0.8651.00
410_L431_A0.8631.00
212_V216_I0.8631.00
34_L178_N0.8621.00
319_A389_A0.8571.00
343_I347_D0.8561.00
107_F111_A0.8551.00
131_D134_M0.8531.00
359_I363_S0.8521.00
428_S432_D0.8501.00
357_D361_T0.8491.00
52_N133_L0.8451.00
213_I217_A0.8441.00
55_A133_L0.8411.00
154_I214_G0.8401.00
307_I385_S0.8391.00
114_A118_F0.8391.00
45_M190_F0.8361.00
181_N185_N0.8341.00
255_G396_V0.8331.00
41_A178_N0.8331.00
282_K426_W0.8321.00
64_L144_V0.8291.00
307_I388_A0.8281.00
84_Q245_K0.8271.00
166_Y221_I0.8261.00
410_L414_F0.8261.00
277_Q361_T0.8251.00
281_T362_A0.8251.00
78_T82_I0.8241.00
278_A361_T0.8221.00
310_Y313_G0.8171.00
296_G334_A0.8151.00
111_A115_V0.8141.00
24_L167_T0.8141.00
321_E328_Y0.8121.00
406_I409_P0.8091.00
172_F175_I0.8091.00
146_G208_S0.8051.00
143_V146_G0.8051.00
171_M175_I0.8011.00
205_M209_I0.8011.00
217_A220_V0.8001.00
70_M254_A0.7951.00
271_I422_L0.7951.00
402_S436_R0.7941.00
423_A427_I0.7941.00
157_F222_V0.7931.00
248_K393_K0.7921.00
287_N352_F0.7891.00
115_V119_A0.7871.00
411_A415_G0.7871.00
120_A145_G0.7841.00
117_F121_V0.7841.00
318_A321_E0.7831.00
299_I326_S0.7801.00
332_G335_A0.7771.00
21_L325_K0.7761.00
414_F424_G0.7731.00
101_S156_T0.7721.00
133_L279_L0.7671.00
325_K328_Y0.7671.00
356_P359_I0.7671.00
51_D358_I0.7671.00
82_I160_I0.7671.00
284_Y362_A0.7661.00
80_V84_Q0.7661.00
83_S163_S0.7651.00
99_Y234_K0.7641.00
46_L189_I0.7621.00
161_L218_M0.7591.00
378_F437_G0.7591.00
326_S381_I0.7561.00
20_S309_R0.7551.00
18_T22_F0.7551.00
92_K234_K0.7531.00
52_N55_A0.7491.00
166_Y225_R0.7491.00
139_V200_V0.7471.00
220_V223_N0.7471.00
56_A200_V0.7461.00
274_M278_A0.7451.00
81_I249_I0.7441.00
31_E174_T0.7441.00
128_G131_D0.7441.00
250_G254_A0.7431.00
281_T365_L0.7411.00
38_M207_T0.7411.00
185_N189_I0.7411.00
270_F412_Y0.7401.00
434_W438_I0.7401.00
331_L335_A0.7401.00
103_G107_F0.7401.00
162_K170_T0.7381.00
274_M415_G0.7371.00
47_S54_V0.7361.00
37_F41_A0.7351.00
34_L37_F0.7311.00
161_L169_D0.7311.00
317_D324_M0.7281.00
181_N210_A0.7271.00
81_I85_F0.7271.00
20_S306_L0.7271.00
242_H245_K0.7261.00
335_A374_P0.7261.00
307_I323_C0.7261.00
40_N291_F0.7251.00
135_P138_K0.7251.00
355_S359_I0.7241.00
88_S312_G0.7221.00
371_I374_P0.7221.00
197_V201_A0.7221.00
21_L302_G0.7211.00
245_K390_G0.7141.00
345_S366_I0.7091.00
384_N388_A0.7081.00
270_F273_I0.7061.00
25_T298_A0.7051.00
271_I425_I0.7051.00
111_A114_A0.7041.00
18_T328_Y0.7031.00
95_M231_S0.7021.00
44_L351_L0.7021.00
119_A123_L0.6991.00
299_I333_I0.6991.00
331_L377_S0.6981.00
317_D320_Y0.6971.00
56_A137_A0.6971.00
424_G427_I0.6961.00
328_Y331_L0.6951.00
272_A279_L0.6931.00
368_M430_I0.6921.00
204_A208_S0.6911.00
310_Y319_A0.6911.00
140_F185_N0.6901.00
169_D217_A0.6851.00
41_A45_M0.6841.00
109_S149_F0.6831.00
124_L141_L0.6831.00
334_A377_S0.6821.00
394_F398_M0.6821.00
258_L262_L0.6811.00
224_K227_Q0.6801.00
408_L412_Y0.6791.00
344_F348_L0.6771.00
299_I330_A0.6771.00
247_L251_I0.6771.00
303_T307_I0.6751.00
274_M277_Q0.6751.00
219_I223_N0.6731.00
345_S349_I0.6731.00
46_L53_S0.6721.00
93_E97_V0.6711.00
141_L145_G0.6711.00
427_I430_I0.6681.00
249_I392_A0.6651.00
333_I337_T0.6651.00
82_I94_A0.6641.00
209_I212_V0.6631.00
176_G213_I0.6621.00
273_I277_Q0.6621.00
145_G148_S0.6621.00
180_L209_I0.6611.00
198_L201_A0.6601.00
147_L150_I0.6601.00
73_F254_A0.6531.00
114_A117_F0.6521.00
44_L48_Q0.6511.00
316_F319_A0.6511.00
342_T345_S0.6501.00
346_K359_I0.6491.00
415_G424_G0.6471.00
49_Y53_S0.6461.00
353_T356_P0.6441.00
406_I410_L0.6431.00
145_G149_F0.6431.00
121_V142_Q0.6421.00
92_K95_M0.6411.00
132_A136_D0.6401.00
228_L232_L0.6391.00
147_L211_R0.6361.00
270_F411_A0.6351.00
53_S199_G0.6351.00
367_A371_I0.6311.00
146_G150_I0.6311.00
295_F333_I0.6311.00
142_Q201_A0.6271.00
133_L136_D0.6271.00
267_V425_I0.6251.00
252_P396_V0.6251.00
210_A213_I0.6221.00
413_L416_I0.6221.00
96_E99_Y0.6201.00
38_M211_R0.6201.00
38_M177_M0.6191.00
54_V284_Y0.6181.00
80_V249_I0.6181.00
311_I316_F0.6171.00
266_I408_L0.6171.00
88_S314_K0.6161.00
289_T373_E0.6161.00
33_S37_F0.6161.00
46_L200_V0.6161.00
271_I282_K0.6151.00
188_V203_V0.6151.00
157_F219_I0.6131.00
54_V353_T0.6121.00
20_S318_A0.6111.00
175_I178_N0.6101.00
103_G235_V0.6101.00
343_I346_K0.6091.00
340_L344_F0.6081.00
386_L391_D0.6061.00
106_F110_L0.6041.00
223_N226_I0.6031.00
278_A281_T0.6031.00
134_M137_A0.6031.00
37_F178_N0.5991.00
96_E100_V0.5981.00
109_S145_G0.5971.00
181_N206_S0.5961.00
422_L426_W0.5961.00
275_G278_A0.5961.00
223_N229_K0.5961.00
53_S56_A0.5961.00
16_D20_S0.5951.00
92_K233_K0.5941.00
382_I440_M0.5941.00
188_V205_M0.5941.00
398_M439_L0.5931.00
117_F146_G0.5921.00
158_S162_K0.5911.00
385_S389_A0.5911.00
370_I374_P0.5911.00
292_I337_T0.5901.00
55_A58_G0.5881.00
154_I215_L0.5871.00
110_L114_A0.5871.00
309_R313_G0.5861.00
124_L138_K0.5851.00
80_V308_G0.5851.00
273_I416_I0.5831.00
281_T426_W0.5831.00
190_F198_L0.5821.00
106_F109_S0.5801.00
17_K321_E0.5801.00
304_Q387_R0.5791.00
331_L378_F0.5791.00
392_A396_V0.5771.00
90_Q96_E0.5771.00
180_L183_A0.5771.00
61_N65_N0.5741.00
217_A221_I0.5741.00
293_L376_R0.5731.00
51_D280_T0.5721.00
378_F441_Y0.5721.00
139_V143_V0.5721.00
427_I431_A0.5711.00
410_L413_L0.5701.00
241_E245_K0.5691.00
412_Y415_G0.5681.00
327_L331_L0.5681.00
79_T159_A0.5671.00
329_W332_G0.5651.00
109_S113_S0.5651.00
176_G179_I0.5641.00
74_I254_A0.5641.00
414_F417_H0.5631.00
49_Y186_F0.5611.00
99_Y103_G0.5611.00
140_F203_V0.5601.00
17_K325_K0.5591.00
110_L113_S0.5591.00
290_M293_L0.5571.00
251_I254_A0.5571.00
410_L428_S0.5551.00
296_G377_S0.5541.00
439_L442_R0.5531.00
407_G432_D0.5531.00
94_A98_A0.5511.00
82_I97_V0.5511.00
270_F415_G0.5491.00
100_V242_H0.5481.00
129_L134_M0.5471.00
74_I108_I0.5461.00
353_T359_I0.5451.00
133_L137_A0.5451.00
154_I158_S0.5441.00
289_T369_T0.5421.00
402_S439_L0.5421.00
358_I362_A0.5401.00
399_A402_S0.5401.00
28_I298_A0.5381.00
379_N436_R0.5381.00
270_F416_I0.5381.00
173_V214_G0.5381.00
285_T366_I0.5371.00
382_I441_Y0.5371.00
21_L25_T0.5351.00
149_F212_V0.5330.99
257_Q297_T0.5330.99
22_F329_W0.5320.99
48_Q353_T0.5320.99
21_L329_W0.5310.99
267_V411_A0.5290.99
215_L219_I0.5290.99
331_L374_P0.5280.99
259_S396_V0.5280.99
150_I208_S0.5280.99
410_L435_V0.5270.99
409_P412_Y0.5250.99
162_K167_T0.5250.99
59_V279_L0.5240.99
274_M421_G0.5240.99
113_S118_F0.5230.99
76_T301_Q0.5230.99
324_M444_W0.5220.99
41_A44_L0.5220.99
182_I186_F0.5220.99
39_G144_V0.5210.99
338_S374_P0.5200.99
115_V118_F0.5200.99
129_L272_A0.5200.99
243_L247_L0.5190.99
304_Q384_N0.5180.99
117_F145_G0.5180.99
303_T381_I0.5180.99
59_V137_A0.5180.99
159_A162_K0.5180.99
28_I167_T0.5180.99
17_K318_A0.5170.99
127_M265_M0.5160.99
17_K322_R0.5160.99
117_F120_A0.5160.99
411_A425_I0.5140.99
89_R313_G0.5130.99
421_G428_S0.5100.99
221_I225_R0.5100.99
263_S403_M0.5100.99
412_Y417_H0.5090.99
65_N261_N0.5080.99
45_M206_S0.5070.99
37_F40_N0.5060.99
364_L367_A0.5060.99
123_L126_M0.5060.99
113_S145_G0.5050.99
284_Y358_I0.5050.99
323_C327_L0.5050.99
401_I439_L0.5030.99
77_G250_G0.5030.99
169_D225_R0.5010.99
110_L149_F0.5000.99
124_L129_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9824 100 0.289 Contact Map
4humA 1 0.989 100 0.302 Contact Map
4lz6A 1 0.9692 100 0.324 Contact Map
3w4tA 1 0.9692 100 0.374 Contact Map
4ikvA 1 0.8901 89.4 0.936 Contact Map
4xnjA 1 0.8659 65.8 0.949 Contact Map
3wdoA 1 0.8527 56.1 0.952 Contact Map
3o7qA 1 0.8308 51.2 0.954 Contact Map
1pw4A 1 0.8879 47.3 0.955 Contact Map
4w6vA 1 0.8747 27.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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