GREMLIN Database
YIST - Uncharacterized protein YisT
UniProt: O07939 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (150)
Sequences: 1346 (1067)
Seq/√Len: 87.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A42_S4.5001.00
23_E85_K3.7361.00
132_N135_T3.6171.00
110_T120_E3.5381.00
41_V141_V3.5191.00
31_Y42_S2.6341.00
80_N83_A2.6251.00
36_S144_M2.5271.00
59_L126_T2.4871.00
29_T32_Q2.2391.00
95_Y130_V2.2221.00
26_P29_T2.1401.00
34_V148_L2.0571.00
6_Q157_Y2.0051.00
85_K89_A1.9851.00
15_N92_E1.9681.00
93_S97_D1.9501.00
59_L123_Y1.9411.00
5_K100_S1.8721.00
107_Q123_Y1.8691.00
58_V111_M1.7641.00
108_T120_E1.6651.00
8_Y131_V1.6291.00
27_E31_Y1.6161.00
11_H134_G1.5891.00
49_C87_H1.5601.00
112_Q118_T1.5351.00
28_E32_Q1.5211.00
37_V136_Y1.4800.99
21_H150_H1.4670.99
110_T118_T1.4660.99
22_I45_L1.4540.99
24_N150_H1.4380.99
14_A155_T1.4200.99
10_Y132_N1.4170.99
88_A92_E1.4110.99
45_L141_V1.4010.99
9_D96_H1.3830.99
143_A147_Q1.3720.99
104_D107_Q1.3680.99
142_T152_G1.3570.99
12_S96_H1.3450.99
15_N88_A1.3410.99
56_L91_L1.3240.99
144_M147_Q1.3030.99
23_E82_A1.2810.98
88_A134_G1.2800.98
96_H100_S1.2570.98
27_E42_S1.2500.98
29_T34_V1.2270.98
30_A81_M1.2090.98
113_H119_L1.2080.98
58_V114_P1.1820.97
111_M114_P1.1800.97
11_H15_N1.1560.97
16_K20_T1.1510.97
142_T153_V1.1180.96
113_H116_L1.1140.96
109_F123_Y1.0880.96
79_G83_A1.0850.96
6_Q125_D1.0840.96
39_P43_D1.0810.96
25_L145_L1.0770.96
20_T85_K1.0570.95
18_I45_L1.0540.95
34_V147_Q1.0460.95
12_S93_S1.0080.94
111_M158_M1.0080.94
106_E124_A1.0020.93
8_Y92_E0.9970.93
22_I41_V0.9960.93
16_K89_A0.9900.93
133_H137_H0.9840.93
126_T158_M0.9780.93
131_V134_G0.9690.92
87_H90_E0.9650.92
13_W160_Y0.9620.92
86_Q90_E0.9530.92
20_T23_E0.9520.92
23_E26_P0.9500.91
140_N156_D0.9470.91
115_K158_M0.9420.91
83_A86_Q0.9300.91
42_S81_M0.9290.91
136_Y155_T0.9260.90
53_Y91_L0.9160.90
78_Q87_H0.9150.90
14_A160_Y0.9140.90
125_D157_Y0.9120.90
121_S158_M0.9120.90
29_T148_L0.9000.89
19_F84_I0.8950.89
52_D88_A0.8890.89
52_D134_G0.8870.88
29_T150_H0.8810.88
88_A95_Y0.8810.88
98_F127_I0.8770.88
60_S94_Q0.8770.88
144_M151_S0.8760.88
97_D101_R0.8700.87
22_I136_Y0.8670.87
15_N134_G0.8560.87
36_S143_A0.8510.86
49_C91_L0.8500.86
14_A153_V0.8480.86
11_H95_Y0.8460.86
55_W129_H0.8410.86
145_L150_H0.8340.85
20_T24_N0.8300.85
146_R152_G0.8290.85
60_S63_A0.8220.84
14_A17_K0.8210.84
24_N101_R0.8200.84
93_S96_H0.8170.84
10_Y135_T0.8160.84
54_I114_P0.8130.84
50_R54_I0.8080.83
126_T130_V0.7960.82
21_H145_L0.7940.82
122_T125_D0.7910.82
55_W158_M0.7900.82
90_E93_S0.7850.81
115_K119_L0.7820.81
142_T155_T0.7810.81
50_R69_D0.7750.81
136_Y140_N0.7700.80
82_A86_Q0.7680.80
19_F88_A0.7540.79
25_L29_T0.7530.79
59_L130_V0.7520.79
59_L98_F0.7520.79
124_A128_L0.7490.78
92_E95_Y0.7470.78
80_N86_Q0.7460.78
129_H157_Y0.7410.78
57_N65_Q0.7410.78
99_F127_I0.7370.77
11_H52_D0.7170.75
154_P159_Y0.7110.75
98_F123_Y0.7100.75
92_E134_G0.7080.74
58_V116_L0.7080.74
49_C140_N0.7060.74
8_Y11_H0.7000.74
12_S92_E0.6860.72
104_D123_Y0.6840.72
18_I141_V0.6810.71
136_Y142_T0.6810.71
89_A100_S0.6760.71
41_V148_L0.6690.70
13_W138_R0.6610.69
51_A126_T0.6610.69
52_D92_E0.6560.69
57_N67_I0.6530.68
19_F45_L0.6510.68
53_Y87_H0.6440.67
47_H137_H0.6400.67
19_F85_K0.6400.67
37_V92_E0.6360.66
62_V94_Q0.6330.66
37_V143_A0.6240.65
139_G144_M0.6190.64
51_A59_L0.6180.64
111_M119_L0.6150.64
46_L84_I0.6140.64
29_T41_V0.6120.63
14_A144_M0.6090.63
140_N143_A0.6080.63
142_T146_R0.6020.62
126_T129_H0.6020.62
37_V140_N0.6020.62
59_L95_Y0.5980.61
58_V113_H0.5950.61
24_N106_E0.5930.61
54_I158_M0.5920.61
86_Q89_A0.5900.60
19_F22_I0.5830.60
144_M152_G0.5830.60
38_F138_R0.5810.59
44_V140_N0.5770.59
134_G140_N0.5720.58
116_L119_L0.5710.58
49_C77_A0.5700.58
5_K20_T0.5690.58
115_K118_T0.5680.58
31_Y101_R0.5680.58
44_V153_V0.5670.57
22_I81_M0.5570.56
34_V39_P0.5560.56
7_F29_T0.5540.56
16_K103_T0.5520.55
5_K107_Q0.5520.55
8_Y99_F0.5450.55
55_W154_P0.5440.54
26_P30_A0.5430.54
109_F121_S0.5430.54
141_V144_M0.5430.54
8_Y134_G0.5430.54
11_H21_H0.5400.54
138_R145_L0.5390.54
109_F115_K0.5370.53
38_F139_G0.5360.53
6_Q81_M0.5340.53
60_S109_F0.5280.52
95_Y134_G0.5250.52
31_Y80_N0.5240.52
89_A97_D0.5210.51
144_M148_L0.5190.51
108_T122_T0.5180.51
134_G142_T0.5170.51
15_N56_L0.5170.51
16_K85_K0.5170.51
46_L52_D0.5150.50
103_T106_E0.5150.50
6_Q93_S0.5140.50
45_L129_H0.5100.50
89_A110_T0.5080.50
8_Y88_A0.5040.49
20_T89_A0.5040.49
43_D50_R0.5030.49
35_K44_V0.5020.49
83_A103_T0.5020.49
54_I157_Y0.5010.49
6_Q128_L0.5010.49
56_L94_Q0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe9A 2 0.9467 99.9 0.479 Contact Map
2rd9A 4 0.9408 99.8 0.598 Contact Map
2ou6A 2 0.8402 99.8 0.601 Contact Map
2p1aA 2 0.8284 99.8 0.602 Contact Map
3gorA 2 0.8994 99.8 0.606 Contact Map
3di5A 1 0.8639 99.8 0.606 Contact Map
2hkvA 2 0.8521 99.8 0.611 Contact Map
3dkaA 2 0.8698 99.8 0.612 Contact Map
2f22A 2 0.8462 99.8 0.621 Contact Map
3cexA 2 0.8698 99.7 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.