YIST - BACSU - GREMLIN Contacts

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YIST - Uncharacterized protein YisT

UniProt:	O07939	Sequences: MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDVLLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQTDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYYLYEKRESKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	169 (150)
Sequences:	1346 (1067)
Seq/√Len:	87.1

BACSU - YIST DINB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_A	42_S	4.500	1.00
23_E	85_K	3.736	1.00
132_N	135_T	3.617	1.00
110_T	120_E	3.538	1.00
41_V	141_V	3.519	1.00
31_Y	42_S	2.634	1.00
80_N	83_A	2.625	1.00
36_S	144_M	2.527	1.00
59_L	126_T	2.487	1.00
29_T	32_Q	2.239	1.00
95_Y	130_V	2.222	1.00
26_P	29_T	2.140	1.00
34_V	148_L	2.057	1.00
6_Q	157_Y	2.005	1.00
85_K	89_A	1.985	1.00
15_N	92_E	1.968	1.00
93_S	97_D	1.950	1.00
59_L	123_Y	1.941	1.00
5_K	100_S	1.872	1.00
107_Q	123_Y	1.869	1.00
58_V	111_M	1.764	1.00
108_T	120_E	1.665	1.00
8_Y	131_V	1.629	1.00
27_E	31_Y	1.616	1.00
11_H	134_G	1.589	1.00
49_C	87_H	1.560	1.00
112_Q	118_T	1.535	1.00
28_E	32_Q	1.521	1.00
37_V	136_Y	1.480	0.99
21_H	150_H	1.467	0.99
110_T	118_T	1.466	0.99
22_I	45_L	1.454	0.99
24_N	150_H	1.438	0.99
14_A	155_T	1.420	0.99
10_Y	132_N	1.417	0.99
88_A	92_E	1.411	0.99
45_L	141_V	1.401	0.99
9_D	96_H	1.383	0.99
143_A	147_Q	1.372	0.99
104_D	107_Q	1.368	0.99
142_T	152_G	1.357	0.99
12_S	96_H	1.345	0.99
15_N	88_A	1.341	0.99
56_L	91_L	1.324	0.99
144_M	147_Q	1.303	0.99
23_E	82_A	1.281	0.98
88_A	134_G	1.280	0.98
96_H	100_S	1.257	0.98
27_E	42_S	1.250	0.98
29_T	34_V	1.227	0.98
30_A	81_M	1.209	0.98
113_H	119_L	1.208	0.98
58_V	114_P	1.182	0.97
111_M	114_P	1.180	0.97
11_H	15_N	1.156	0.97
16_K	20_T	1.151	0.97
142_T	153_V	1.118	0.96
113_H	116_L	1.114	0.96
109_F	123_Y	1.088	0.96
79_G	83_A	1.085	0.96
6_Q	125_D	1.084	0.96
39_P	43_D	1.081	0.96
25_L	145_L	1.077	0.96
20_T	85_K	1.057	0.95
18_I	45_L	1.054	0.95
34_V	147_Q	1.046	0.95
12_S	93_S	1.008	0.94
111_M	158_M	1.008	0.94
106_E	124_A	1.002	0.93
8_Y	92_E	0.997	0.93
22_I	41_V	0.996	0.93
16_K	89_A	0.990	0.93
133_H	137_H	0.984	0.93
126_T	158_M	0.978	0.93
131_V	134_G	0.969	0.92
87_H	90_E	0.965	0.92
13_W	160_Y	0.962	0.92
86_Q	90_E	0.953	0.92
20_T	23_E	0.952	0.92
23_E	26_P	0.950	0.91
140_N	156_D	0.947	0.91
115_K	158_M	0.942	0.91
83_A	86_Q	0.930	0.91
42_S	81_M	0.929	0.91
136_Y	155_T	0.926	0.90
53_Y	91_L	0.916	0.90
78_Q	87_H	0.915	0.90
14_A	160_Y	0.914	0.90
125_D	157_Y	0.912	0.90
121_S	158_M	0.912	0.90
29_T	148_L	0.900	0.89
19_F	84_I	0.895	0.89
52_D	88_A	0.889	0.89
52_D	134_G	0.887	0.88
29_T	150_H	0.881	0.88
88_A	95_Y	0.881	0.88
98_F	127_I	0.877	0.88
60_S	94_Q	0.877	0.88
144_M	151_S	0.876	0.88
97_D	101_R	0.870	0.87
22_I	136_Y	0.867	0.87
15_N	134_G	0.856	0.87
36_S	143_A	0.851	0.86
49_C	91_L	0.850	0.86
14_A	153_V	0.848	0.86
11_H	95_Y	0.846	0.86
55_W	129_H	0.841	0.86
145_L	150_H	0.834	0.85
20_T	24_N	0.830	0.85
146_R	152_G	0.829	0.85
60_S	63_A	0.822	0.84
14_A	17_K	0.821	0.84
24_N	101_R	0.820	0.84
93_S	96_H	0.817	0.84
10_Y	135_T	0.816	0.84
54_I	114_P	0.813	0.84
50_R	54_I	0.808	0.83
126_T	130_V	0.796	0.82
21_H	145_L	0.794	0.82
122_T	125_D	0.791	0.82
55_W	158_M	0.790	0.82
90_E	93_S	0.785	0.81
115_K	119_L	0.782	0.81
142_T	155_T	0.781	0.81
50_R	69_D	0.775	0.81
136_Y	140_N	0.770	0.80
82_A	86_Q	0.768	0.80
19_F	88_A	0.754	0.79
25_L	29_T	0.753	0.79
59_L	130_V	0.752	0.79
59_L	98_F	0.752	0.79
124_A	128_L	0.749	0.78
92_E	95_Y	0.747	0.78
80_N	86_Q	0.746	0.78
129_H	157_Y	0.741	0.78
57_N	65_Q	0.741	0.78
99_F	127_I	0.737	0.77
11_H	52_D	0.717	0.75
154_P	159_Y	0.711	0.75
98_F	123_Y	0.710	0.75
92_E	134_G	0.708	0.74
58_V	116_L	0.708	0.74
49_C	140_N	0.706	0.74
8_Y	11_H	0.700	0.74
12_S	92_E	0.686	0.72
104_D	123_Y	0.684	0.72
18_I	141_V	0.681	0.71
136_Y	142_T	0.681	0.71
89_A	100_S	0.676	0.71
41_V	148_L	0.669	0.70
13_W	138_R	0.661	0.69
51_A	126_T	0.661	0.69
52_D	92_E	0.656	0.69
57_N	67_I	0.653	0.68
19_F	45_L	0.651	0.68
53_Y	87_H	0.644	0.67
47_H	137_H	0.640	0.67
19_F	85_K	0.640	0.67
37_V	92_E	0.636	0.66
62_V	94_Q	0.633	0.66
37_V	143_A	0.624	0.65
139_G	144_M	0.619	0.64
51_A	59_L	0.618	0.64
111_M	119_L	0.615	0.64
46_L	84_I	0.614	0.64
29_T	41_V	0.612	0.63
14_A	144_M	0.609	0.63
140_N	143_A	0.608	0.63
142_T	146_R	0.602	0.62
126_T	129_H	0.602	0.62
37_V	140_N	0.602	0.62
59_L	95_Y	0.598	0.61
58_V	113_H	0.595	0.61
24_N	106_E	0.593	0.61
54_I	158_M	0.592	0.61
86_Q	89_A	0.590	0.60
19_F	22_I	0.583	0.60
144_M	152_G	0.583	0.60
38_F	138_R	0.581	0.59
44_V	140_N	0.577	0.59
134_G	140_N	0.572	0.58
116_L	119_L	0.571	0.58
49_C	77_A	0.570	0.58
5_K	20_T	0.569	0.58
115_K	118_T	0.568	0.58
31_Y	101_R	0.568	0.58
44_V	153_V	0.567	0.57
22_I	81_M	0.557	0.56
34_V	39_P	0.556	0.56
7_F	29_T	0.554	0.56
16_K	103_T	0.552	0.55
5_K	107_Q	0.552	0.55
8_Y	99_F	0.545	0.55
55_W	154_P	0.544	0.54
26_P	30_A	0.543	0.54
109_F	121_S	0.543	0.54
141_V	144_M	0.543	0.54
8_Y	134_G	0.543	0.54
11_H	21_H	0.540	0.54
138_R	145_L	0.539	0.54
109_F	115_K	0.537	0.53
38_F	139_G	0.536	0.53
6_Q	81_M	0.534	0.53
60_S	109_F	0.528	0.52
95_Y	134_G	0.525	0.52
31_Y	80_N	0.524	0.52
89_A	97_D	0.521	0.51
144_M	148_L	0.519	0.51
108_T	122_T	0.518	0.51
134_G	142_T	0.517	0.51
15_N	56_L	0.517	0.51
16_K	85_K	0.517	0.51
46_L	52_D	0.515	0.50
103_T	106_E	0.515	0.50
6_Q	93_S	0.514	0.50
45_L	129_H	0.510	0.50
89_A	110_T	0.508	0.50
8_Y	88_A	0.504	0.49
20_T	89_A	0.504	0.49
43_D	50_R	0.503	0.49
35_K	44_V	0.502	0.49
83_A	103_T	0.502	0.49
54_I	157_Y	0.501	0.49
6_Q	128_L	0.501	0.49
56_L	94_Q	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qe9A	2	0.9467	99.9	0.479	Contact Map
2rd9A	4	0.9408	99.8	0.598	Contact Map
2ou6A	2	0.8402	99.8	0.601	Contact Map
2p1aA	2	0.8284	99.8	0.602	Contact Map
3gorA	2	0.8994	99.8	0.606	Contact Map
3di5A	1	0.8639	99.8	0.606	Contact Map
2hkvA	2	0.8521	99.8	0.611	Contact Map
3dkaA	2	0.8698	99.8	0.612	Contact Map
2f22A	2	0.8462	99.8	0.621	Contact Map
3cexA	2	0.8698	99.7	0.633	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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