GREMLIN Database
YRAK - Uncharacterized hydrolase YraK
UniProt: O07937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (252)
Sequences: 61135 (50567)
Seq/√Len: 3185.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V51_T4.9101.00
94_Y118_V4.2951.00
58_R80_D3.6721.00
42_V256_S3.1921.00
82_H108_L2.9101.00
251_Y254_E2.7941.00
216_S242_P2.7651.00
211_L262_M2.6921.00
239_V258_R2.6791.00
92_P117_H2.6201.00
94_Y117_H2.5931.00
123_E218_S2.5841.00
122_H255_F2.4291.00
241_F258_R2.4131.00
14_N64_N2.2581.00
18_Q36_A2.2151.00
82_H115_Q2.1171.00
108_L112_H2.0861.00
216_S240_E2.0811.00
85_L93_A2.0701.00
82_H112_H2.0271.00
82_H86_A2.0221.00
95_V105_G1.9801.00
49_W260_H1.9641.00
86_A115_Q1.9501.00
102_A124_P1.9441.00
16_H62_R1.9231.00
230_L236_T1.9221.00
17_Y84_L1.9201.00
45_H256_S1.8921.00
25_I53_V1.8371.00
94_Y263_L1.8181.00
19_V53_V1.7941.00
107_D111_R1.7921.00
109_C119_M1.7671.00
24_P94_Y1.7591.00
20_R54_T1.7411.00
79_D111_R1.7251.00
25_I51_T1.7211.00
94_Y120_I1.7191.00
25_I90_N1.7181.00
223_P240_E1.7101.00
16_H36_A1.6941.00
24_P117_H1.6901.00
30_H60_H1.6711.00
211_L239_V1.6121.00
50_Y94_Y1.6071.00
30_H57_R1.5991.00
258_R261_D1.5971.00
105_G119_M1.5831.00
75_E111_R1.5541.00
34_G38_K1.5311.00
228_N232_E1.5271.00
11_P83_R1.5221.00
57_R104_I1.5201.00
55_Y81_A1.5061.00
78_S107_D1.5041.00
29_V57_R1.4901.00
29_V81_A1.4741.00
257_E261_D1.4631.00
81_A108_L1.4541.00
112_H115_Q1.4281.00
108_L116_V1.4261.00
210_I233_Q1.3911.00
16_H56_D1.3781.00
45_H260_H1.3721.00
90_N93_A1.3681.00
36_A56_D1.3531.00
107_D110_I1.3321.00
73_R76_T1.3261.00
53_V84_L1.3181.00
86_A112_H1.3161.00
29_V105_G1.3141.00
28_L96_F1.3131.00
45_H48_N1.3071.00
98_S248_Y1.3041.00
120_I259_L1.3031.00
254_E258_R1.2901.00
108_L115_Q1.2741.00
243_G251_Y1.2731.00
106_L121_P1.2691.00
20_R43_A1.2521.00
43_A54_T1.2421.00
33_G60_H1.2411.00
15_I80_D1.2411.00
227_A231_A1.2281.00
254_E257_E1.2261.00
121_P124_P1.2231.00
13_A58_R1.2061.00
96_F122_H1.2001.00
84_L88_I1.1751.00
163_D166_S1.1701.00
36_A62_R1.1661.00
214_G226_C1.1631.00
99_S245_H1.1581.00
28_L52_V1.1581.00
120_I211_L1.1371.00
26_I50_Y1.1261.00
202_V205_S1.1211.00
38_K248_Y1.1161.00
23_G51_T1.1151.00
27_L85_L1.0981.00
214_G238_W1.0981.00
33_G99_S1.0971.00
45_H253_K1.0961.00
213_A241_F1.0871.00
223_P227_A1.0851.00
93_A116_V1.0671.00
237_E258_R1.0501.00
36_A54_T1.0501.00
214_G240_E1.0491.00
49_W264_E1.0471.00
186_I189_I1.0431.00
255_F259_L1.0321.00
24_P50_Y1.0321.00
233_Q236_T1.0311.00
211_L237_E1.0291.00
31_G99_S1.0271.00
96_F259_L1.0251.00
118_V209_K1.0241.00
17_Y88_I1.0101.00
173_R176_G1.0081.00
55_Y84_L1.0041.00
182_T185_E1.0031.00
185_E188_G1.0011.00
214_G223_P1.0001.00
24_P92_P0.9991.00
50_Y263_L0.9961.00
260_H264_E0.9901.00
82_H111_R0.9871.00
228_N231_A0.9801.00
253_K257_E0.9791.00
75_E107_D0.9771.00
154_I158_S0.9681.00
29_V95_V0.9671.00
230_L238_W0.9651.00
78_S104_I0.9651.00
244_N250_M0.9621.00
20_R47_A0.9611.00
98_S246_T0.9571.00
213_A258_R0.9561.00
44_N47_A0.9521.00
204_T232_E0.9471.00
239_V261_D0.9451.00
146_K149_H0.9421.00
56_D61_S0.9331.00
21_G51_T0.9301.00
85_L108_L0.9301.00
203_F206_S0.9301.00
241_F254_E0.9291.00
122_H248_Y0.9271.00
97_G105_G0.9251.00
93_A115_Q0.9211.00
47_A52_V0.9161.00
50_Y264_E0.9131.00
15_I63_S0.9121.00
41_H44_N0.9111.00
13_A64_N0.9111.00
227_A240_E0.9061.00
27_L93_A0.8981.00
227_A238_W0.8941.00
40_H54_T0.8921.00
155_K158_S0.8841.00
53_V88_I0.8781.00
122_H247_G0.8701.00
227_A230_L0.8681.00
28_L39_F0.8621.00
173_R177_N0.8591.00
26_I52_V0.8571.00
163_D167_K0.8541.00
76_T79_D0.8511.00
239_V254_E0.8441.00
119_M210_I0.8431.00
25_I93_A0.8381.00
71_G76_T0.8281.00
83_R87_K0.8261.00
109_C116_V0.8221.00
29_V55_Y0.8201.00
26_I96_F0.8191.00
154_I157_M0.8191.00
118_V262_M0.8171.00
170_L173_R0.8151.00
24_P118_V0.8131.00
57_R100_S0.8101.00
83_R86_A0.8081.00
174_L177_N0.8031.00
184_Y188_G0.7981.00
183_E187_Q0.7981.00
212_P236_T0.7951.00
97_G102_A0.7951.00
144_D148_N0.7931.00
27_L81_A0.7921.00
25_I50_Y0.7901.00
79_D82_H0.7851.00
241_F251_Y0.7851.00
82_H85_L0.7821.00
78_S111_R0.7751.00
178_S185_E0.7721.00
85_L90_N0.7661.00
181_F184_Y0.7661.00
37_D40_H0.7661.00
157_M160_L0.7661.00
180_Y185_E0.7641.00
77_H100_S0.7621.00
195_D198_A0.7611.00
43_A52_V0.7591.00
110_I202_V0.7561.00
170_L174_L0.7501.00
44_N48_N0.7461.00
95_V116_V0.7451.00
139_E143_E0.7441.00
215_G247_G0.7431.00
162_T167_K0.7421.00
79_D83_R0.7401.00
123_E247_G0.7311.00
18_Q40_H0.7291.00
36_A55_Y0.7281.00
164_E167_K0.7271.00
225_R228_N0.7241.00
141_F145_L0.7231.00
179_T183_E0.7221.00
95_V108_L0.7211.00
162_T166_S0.7201.00
184_Y187_Q0.7141.00
185_E189_I0.7131.00
180_Y184_Y0.7121.00
171_T174_L0.7101.00
164_E168_A0.7091.00
182_T186_I0.7091.00
30_H55_Y0.7071.00
190_L193_T0.7041.00
256_S260_H0.7011.00
22_S51_T0.7001.00
50_Y260_H0.7001.00
143_E147_K0.7001.00
78_S108_L0.6991.00
171_T175_L0.6991.00
107_D202_V0.6961.00
224_Y227_A0.6951.00
166_S169_V0.6941.00
33_G100_S0.6941.00
40_H44_N0.6871.00
43_A47_A0.6851.00
26_I94_Y0.6841.00
181_F185_E0.6831.00
27_L95_V0.6831.00
178_S182_T0.6811.00
120_I262_M0.6801.00
91_K115_Q0.6791.00
179_T182_T0.6781.00
42_V45_H0.6781.00
180_Y183_E0.6771.00
172_K176_G0.6771.00
140_Q143_E0.6741.00
178_S181_F0.6731.00
32_G100_S0.6721.00
168_A171_T0.6721.00
123_E215_G0.6711.00
39_F43_A0.6701.00
116_V208_M0.6641.00
98_S123_E0.6621.00
109_C208_M0.6621.00
20_R44_N0.6601.00
162_T165_Q0.6601.00
153_V160_L0.6601.00
213_A255_F0.6591.00
96_F120_I0.6581.00
26_I263_L0.6571.00
216_S223_P0.6571.00
48_N260_H0.6571.00
97_G101_G0.6551.00
147_K151_S0.6511.00
146_K150_R0.6501.00
118_V263_L0.6481.00
58_R77_H0.6461.00
53_V90_N0.6451.00
123_E214_G0.6451.00
39_F42_V0.6391.00
57_R77_H0.6381.00
120_I263_L0.6371.00
56_D62_R0.6361.00
106_L126_L0.6331.00
89_T92_P0.6321.00
153_V157_M0.6311.00
103_V125_I0.6301.00
42_V255_F0.6301.00
257_E260_H0.6301.00
75_E79_D0.6291.00
98_S122_H0.6281.00
156_L159_R0.6271.00
179_T185_E0.6251.00
139_E142_M0.6251.00
226_C238_W0.6241.00
206_S210_I0.6241.00
252_H256_S0.6231.00
143_E146_K0.6201.00
11_P76_T0.6181.00
172_K175_L0.6171.00
51_T90_N0.6141.00
110_I205_S0.6131.00
152_E156_L0.6081.00
165_Q168_A0.6071.00
145_L149_H0.6051.00
134_E138_A0.6021.00
16_H63_S0.6011.00
237_E261_D0.6001.00
142_M146_K0.5991.00
169_V173_R0.5981.00
168_A172_K0.5971.00
152_E155_K0.5961.00
15_I58_R0.5941.00
49_W52_V0.5941.00
156_L160_L0.5921.00
93_A117_H0.5911.00
99_S246_T0.5851.00
142_M145_L0.5841.00
26_I46_L0.5811.00
11_P79_D0.5751.00
19_V88_I0.5741.00
230_L234_L0.5731.00
167_K171_T0.5731.00
28_L54_T0.5681.00
171_T177_N0.5661.00
134_E137_Q0.5621.00
57_R60_H0.5621.00
28_L46_L0.5611.00
154_I160_L0.5611.00
74_V107_D0.5601.00
121_P212_P0.5591.00
188_G191_S0.5571.00
259_L263_L0.5551.00
217_A243_G0.5521.00
153_V156_L0.5501.00
196_F199_L0.5501.00
78_S82_H0.5491.00
18_Q37_D0.5451.00
218_S245_H0.5431.00
229_A233_Q0.5431.00
46_L259_L0.5431.00
93_A108_L0.5431.00
149_H152_E0.5421.00
77_H104_I0.5411.00
57_R81_A0.5401.00
140_Q144_D0.5401.00
109_C206_S0.5381.00
191_S194_L0.5381.00
247_G255_F0.5341.00
84_L87_K0.5331.00
38_K98_S0.5331.00
198_A201_T0.5311.00
141_F149_H0.5291.00
178_S184_Y0.5281.00
207_P234_L0.5271.00
42_V46_L0.5271.00
144_D147_K0.5241.00
213_A239_V0.5231.00
18_Q54_T0.5221.00
224_Y228_N0.5211.00
31_G98_S0.5211.00
187_Q191_S0.5201.00
144_D149_H0.5201.00
68_Q71_G0.5201.00
102_A121_P0.5191.00
34_G246_T0.5181.00
118_V211_L0.5171.00
122_H213_A0.5141.00
111_R202_V0.5131.00
155_K160_L0.5131.00
120_I213_A0.5121.00
155_K159_R0.5101.00
197_E200_K0.5081.00
226_C230_L0.5071.00
212_P238_W0.5061.00
85_L115_Q0.5041.00
248_Y255_F0.5041.00
147_K150_R0.5001.00
106_L124_P0.5001.00
30_H39_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9668 100 0.174 Contact Map
1ehyA 1 0.9299 100 0.186 Contact Map
3oosA 1 0.9594 100 0.189 Contact Map
3om8A 4 0.952 100 0.19 Contact Map
2xuaA 2 0.9225 100 0.2 Contact Map
2pujA 4 0.9779 100 0.207 Contact Map
3r40A 2 0.9483 100 0.213 Contact Map
2wueA 4 0.9742 100 0.22 Contact Map
4opmA 2 0.9852 100 0.221 Contact Map
1iupA 2 0.952 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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