GREMLIN Database
AZLD - Branched-chain amino acid transport protein AzlD
UniProt: O07923 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (103)
Sequences: 575 (463)
Seq/√Len: 45.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_M24_F4.3051.00
80_A101_V3.9371.00
60_L78_A3.3481.00
86_L89_K3.1691.00
81_V98_G3.0361.00
85_H94_S2.9291.00
84_L97_G2.7591.00
104_V108_L2.6311.00
83_L87_W2.2361.00
88_K93_L2.1101.00
7_Q11_T2.0390.99
76_V101_V1.8440.99
6_T9_M1.8220.99
42_Y46_V1.7170.98
8_Q11_T1.7140.98
77_G81_V1.7100.98
103_M107_Q1.6740.98
77_G101_V1.5700.97
47_L50_A1.5100.96
18_G22_T1.4730.95
27_F85_H1.4690.95
63_V71_G1.4650.95
22_T95_I1.3150.91
43_L46_V1.2950.90
7_Q25_L1.2870.90
11_T15_V1.2820.90
70_H74_E1.2560.89
14_M18_G1.2490.89
8_Q91_M1.2440.89
48_P98_G1.2210.88
14_M17_L1.2180.88
15_V52_I1.2130.87
36_T54_L1.2000.87
32_S36_T1.1980.87
52_I91_M1.1890.86
10_I76_V1.1800.86
38_K56_V1.1740.86
80_A83_L1.1730.85
71_G74_E1.1580.85
80_A105_L1.1520.84
13_A48_P1.1500.84
12_I16_V1.1470.84
92_L107_Q1.1400.84
13_A80_A1.1270.83
15_V51_V1.1030.82
91_M95_I1.0850.81
15_V18_G1.0710.80
51_V54_L1.0560.79
29_I58_Y1.0480.78
43_L50_A1.0210.76
85_H99_T1.0150.76
30_F61_K1.0080.76
10_I14_M0.9970.75
15_V46_V0.9850.74
75_L97_G0.9620.72
102_Y106_V0.9540.71
38_K89_K0.9410.70
92_L96_A0.9410.70
44_G50_A0.9320.70
22_T25_L0.9310.70
8_Q52_I0.9170.68
41_Q45_K0.9100.68
56_V61_K0.9090.68
17_L21_L0.8990.67
8_Q49_S0.8880.66
44_G57_I0.8730.65
11_T18_G0.8620.64
99_T103_M0.8510.63
24_F28_M0.8480.62
32_S51_V0.8450.62
53_G57_I0.8400.61
46_V91_M0.8270.60
74_E102_Y0.8270.60
31_P53_G0.8260.60
21_L25_L0.8250.60
18_G24_F0.8210.60
69_S74_E0.8190.60
38_K41_Q0.8170.59
79_A97_G0.8130.59
29_I62_D0.7920.57
43_L102_Y0.7900.57
56_V85_H0.7730.55
33_G50_A0.7500.53
34_K87_W0.7390.52
9_M13_A0.7360.52
101_V104_V0.7310.51
49_S59_C0.7160.50
77_G80_A0.7120.49
40_V76_V0.7040.48
36_T96_A0.6890.47
36_T47_L0.6810.46
94_S99_T0.6730.45
24_F29_I0.6640.44
72_I79_A0.6610.44
13_A93_L0.6560.44
75_L108_L0.6550.44
24_F53_G0.6530.43
54_L66_L0.6490.43
36_T50_A0.6420.42
70_H73_P0.6410.42
66_L70_H0.6300.41
76_V99_T0.6300.41
75_L79_A0.6230.41
85_H107_Q0.6220.40
32_S35_P0.6210.40
83_L97_G0.6150.40
7_Q19_T0.6150.40
84_L87_W0.6130.40
10_I67_S0.6020.39
33_G51_V0.6000.38
35_P41_Q0.5950.38
31_P34_K0.5930.38
20_M81_V0.5920.38
30_F47_L0.5890.37
46_V103_M0.5860.37
28_M108_L0.5830.37
42_Y92_L0.5730.36
73_P105_L0.5690.36
88_K94_S0.5650.35
90_N101_V0.5650.35
49_S96_A0.5650.35
36_T39_Y0.5610.35
15_V49_S0.5600.35
53_G108_L0.5580.35
78_A96_A0.5560.34
52_I96_A0.5530.34
54_L106_V0.5480.34
7_Q10_I0.5470.34
36_T91_M0.5430.33
14_M65_L0.5430.33
93_L97_G0.5410.33
64_S67_S0.5400.33
37_P98_G0.5400.33
41_Q56_V0.5400.33
75_L78_A0.5390.33
37_P106_V0.5360.33
19_T24_F0.5340.32
47_L53_G0.5320.32
16_V20_M0.5300.32
55_L93_L0.5200.31
49_S89_K0.5200.31
100_V108_L0.5200.31
82_V86_L0.5180.31
81_V87_W0.5130.31
40_V44_G0.5120.31
99_T105_L0.5100.30
22_T36_T0.5090.30
14_M21_L0.5070.30
15_V22_T0.5070.30
14_M29_I0.5040.30
10_I75_L0.5030.30
28_M79_A0.5010.30
47_L57_I0.5000.30
38_K57_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.9364 6.8 0.939 Contact Map
3qe7A 2 0.9182 6.6 0.94 Contact Map
3p5nA 2 0.9545 4.3 0.945 Contact Map
4hfiA 3 0.5727 2.8 0.95 Contact Map
3rqwA 4 0.5364 2.7 0.95 Contact Map
4wfeA 2 0.2091 2.4 0.951 Contact Map
4xk8I 1 0.2636 2.3 0.952 Contact Map
3wu2X 1 0.2545 1.8 0.954 Contact Map
2m59A 2 0.3364 1.5 0.957 Contact Map
2wscI 1 0.2727 1.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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