CHIS - BACSU - GREMLIN Contacts

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CHIS - Chitosanase

UniProt:	O07921	Sequences: MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKRRAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNNKLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKRSDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNKFLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	277 (233)
Sequences:	266 (156)
Seq/√Len:	10.2

BACSU - CHIS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_N	205_S	6.043	1.00
93_E	112_R	4.105	0.99
62_Y	146_D	3.774	0.98
127_G	131_A	3.359	0.96
184_D	193_A	3.278	0.96
98_A	147_K	3.080	0.94
103_K	131_A	2.867	0.91
83_T	88_A	2.784	0.90
107_Y	127_G	2.732	0.89
96_T	105_K	2.727	0.89
197_R	226_D	2.449	0.83
94_V	98_A	2.391	0.81
55_N	64_Y	2.320	0.79
221_D	250_R	2.243	0.77
142_R	146_D	2.204	0.76
124_N	129_A	2.112	0.72
224_Y	247_D	2.111	0.72
124_N	131_A	2.081	0.71
184_D	192_Y	2.035	0.69
243_V	247_D	2.004	0.68
225_D	229_N	2.000	0.68
86_G	115_A	1.980	0.67
44_R	48_Q	1.945	0.66
94_V	147_K	1.931	0.65
103_K	134_S	1.893	0.63
47_E	72_R	1.868	0.62
135_L	138_D	1.867	0.62
139_K	142_R	1.866	0.62
83_T	194_L	1.866	0.62
113_R	204_G	1.833	0.61
124_N	127_G	1.830	0.61
194_L	222_V	1.823	0.60
106_K	131_A	1.819	0.60
167_K	259_N	1.765	0.58
57_T	60_I	1.745	0.57
171_A	264_I	1.744	0.57
27_L	30_S	1.715	0.56
107_Y	134_S	1.700	0.55
107_Y	131_A	1.668	0.53
99_V	138_D	1.661	0.53
49_L	166_L	1.619	0.51
130_S	134_S	1.608	0.51
179_V	191_F	1.592	0.50
197_R	261_N	1.588	0.50
120_D	123_S	1.578	0.49
72_R	230_P	1.544	0.48
160_R	169_A	1.506	0.46
193_A	197_R	1.496	0.45
148_V	152_L	1.480	0.45
143_A	146_D	1.463	0.44
64_Y	68_L	1.462	0.44
83_T	135_L	1.462	0.44
206_P	223_R	1.459	0.44
181_Q	240_R	1.458	0.44
166_L	215_W	1.440	0.43
72_R	223_R	1.437	0.43
194_L	253_A	1.418	0.42
72_R	240_R	1.414	0.42
142_R	179_V	1.385	0.40
181_Q	230_P	1.382	0.40
187_D	190_S	1.380	0.40
204_G	208_D	1.372	0.40
107_Y	124_N	1.371	0.40
82_T	148_V	1.364	0.39
49_L	56_G	1.352	0.39
189_D	197_R	1.351	0.39
101_N	179_V	1.332	0.38
190_S	196_K	1.319	0.37
106_K	159_K	1.306	0.37
159_K	213_K	1.306	0.37
140_E	144_A	1.305	0.37
139_K	265_H	1.301	0.37
57_T	91_V	1.288	0.36
143_A	147_K	1.275	0.36
251_S	255_E	1.274	0.36
197_R	225_D	1.261	0.35
64_Y	72_R	1.255	0.35
94_V	139_K	1.243	0.34
65_V	76_C	1.241	0.34
190_S	226_D	1.237	0.34
63_G	134_S	1.237	0.34
140_E	167_K	1.236	0.34
39_N	137_N	1.235	0.34
88_A	141_F	1.231	0.34
27_L	36_A	1.185	0.32
49_L	252_I	1.173	0.31
86_G	138_D	1.165	0.31
51_S	86_G	1.160	0.31
31_E	34_F	1.158	0.31
47_E	61_Q	1.143	0.30
113_R	196_K	1.132	0.30
189_D	225_D	1.105	0.29
113_R	267_R	1.096	0.28
142_R	160_R	1.083	0.28
34_F	63_G	1.083	0.28
52_I	266_V	1.073	0.28
230_P	240_R	1.067	0.27
40_K	118_E	1.064	0.27
101_N	105_K	1.055	0.27
27_L	31_E	1.051	0.27
130_S	159_K	1.051	0.27
43_K	150_D	1.051	0.27
64_Y	223_R	1.045	0.27
185_G	192_Y	1.037	0.26
131_A	146_D	1.031	0.26
126_K	129_A	1.030	0.26
27_L	32_T	1.027	0.26
39_N	101_N	1.021	0.26
103_K	107_Y	1.019	0.26
64_Y	190_S	1.016	0.25
28_M	31_E	1.013	0.25
31_E	36_A	1.001	0.25
80_G	87_D	1.000	0.25
148_V	151_H	0.996	0.25
189_D	229_N	0.996	0.25
29_M	33_V	0.987	0.24
239_W	242_S	0.983	0.24
73_G	81_F	0.977	0.24
197_R	201_K	0.976	0.24
179_V	185_G	0.975	0.24
91_V	155_Q	0.974	0.24
101_N	121_D	0.972	0.24
76_C	82_T	0.967	0.24
196_K	267_R	0.964	0.24
196_K	200_K	0.954	0.23
30_S	39_N	0.953	0.23
42_Q	181_Q	0.952	0.23
40_K	63_G	0.950	0.23
92_V	111_L	0.950	0.23
50_T	122_T	0.948	0.23
72_R	239_W	0.947	0.23
121_D	208_D	0.946	0.23
253_A	258_Y	0.945	0.23
86_G	243_V	0.944	0.23
180_I	195_I	0.943	0.23
193_A	196_K	0.937	0.23
61_Q	68_L	0.930	0.23
97_K	139_K	0.929	0.23
97_K	113_R	0.927	0.22
103_K	106_K	0.927	0.22
82_T	105_K	0.921	0.22
181_Q	246_V	0.917	0.22
187_D	229_N	0.911	0.22
75_T	182_H	0.901	0.22
72_R	181_Q	0.898	0.22
133_K	197_R	0.892	0.21
61_Q	135_L	0.890	0.21
47_E	230_P	0.881	0.21
157_A	255_E	0.872	0.21
155_Q	161_S	0.871	0.21
238_E	241_E	0.863	0.20
227_L	239_W	0.862	0.20
97_K	265_H	0.861	0.20
197_R	200_K	0.861	0.20
86_G	160_R	0.860	0.20
91_V	152_L	0.856	0.20
199_N	207_K	0.856	0.20
95_Y	182_H	0.847	0.20
132_W	219_F	0.847	0.20
101_N	169_A	0.844	0.20
187_D	217_N	0.842	0.20
230_P	239_W	0.833	0.20
189_D	226_D	0.832	0.20
73_G	219_F	0.829	0.19
61_Q	138_D	0.828	0.19
156_P	176_Y	0.825	0.19
43_K	268_S	0.821	0.19
28_M	32_T	0.819	0.19
40_K	121_D	0.819	0.19
201_K	254_K	0.818	0.19
195_I	210_I	0.815	0.19
174_V	185_G	0.815	0.19
39_N	94_V	0.812	0.19
114_L	122_T	0.811	0.19
153_Y	176_Y	0.811	0.19
47_E	57_T	0.809	0.19
204_G	207_K	0.801	0.19
47_E	181_Q	0.801	0.19
163_N	255_E	0.795	0.19
36_A	40_K	0.794	0.18
83_T	138_D	0.790	0.18
83_T	222_V	0.787	0.18
77_G	145_Q	0.780	0.18
36_A	39_N	0.779	0.18
93_E	113_R	0.773	0.18
185_G	190_S	0.772	0.18
143_A	259_N	0.771	0.18
139_K	143_A	0.770	0.18
117_E	133_K	0.769	0.18
160_R	191_F	0.768	0.18
196_K	228_M	0.768	0.18
178_T	219_F	0.767	0.18
67_R	175_M	0.764	0.18
103_K	135_L	0.762	0.18
73_G	87_D	0.755	0.17
108_L	246_V	0.750	0.17
115_A	129_A	0.749	0.17
99_V	140_E	0.749	0.17
55_N	268_S	0.747	0.17
140_E	143_A	0.747	0.17
200_K	224_Y	0.747	0.17
30_S	34_F	0.743	0.17
75_T	223_R	0.728	0.17
217_N	250_R	0.726	0.17
95_Y	223_R	0.724	0.17
132_W	171_A	0.721	0.17
164_A	172_R	0.719	0.16
184_D	197_R	0.719	0.16
37_G	140_E	0.718	0.16
83_T	239_W	0.711	0.16
62_Y	157_A	0.711	0.16
27_L	33_V	0.704	0.16
51_S	61_Q	0.704	0.16
179_V	184_D	0.704	0.16
36_A	163_N	0.703	0.16
88_A	181_Q	0.703	0.16
196_K	214_K	0.695	0.16
130_S	254_K	0.695	0.16
35_A	39_N	0.694	0.16
245_R	260_L	0.694	0.16
86_G	90_E	0.694	0.16
224_Y	241_E	0.693	0.16
43_K	47_E	0.691	0.16
144_A	191_F	0.687	0.16
158_M	180_I	0.685	0.16
34_F	190_S	0.682	0.16
81_F	132_W	0.681	0.16
52_I	92_V	0.678	0.15
196_K	254_K	0.677	0.15
106_K	204_G	0.676	0.15
181_Q	239_W	0.672	0.15
63_G	130_S	0.670	0.15
34_F	91_V	0.669	0.15
190_S	193_A	0.665	0.15
64_Y	206_P	0.658	0.15
102_N	178_T	0.654	0.15
164_A	175_M	0.652	0.15
113_R	155_Q	0.650	0.15
31_E	35_A	0.649	0.15
174_V	179_V	0.649	0.15
107_Y	146_D	0.648	0.15
218_K	222_V	0.646	0.15
131_A	242_S	0.646	0.15
47_E	239_W	0.645	0.15
99_V	103_K	0.641	0.15
173_A	227_L	0.639	0.15
35_A	101_N	0.637	0.14
130_S	155_Q	0.637	0.14
82_T	112_R	0.637	0.14
99_V	106_K	0.631	0.14
201_K	204_G	0.630	0.14
41_D	256_N	0.629	0.14
42_Q	246_V	0.626	0.14
31_E	137_N	0.626	0.14
81_F	87_D	0.621	0.14
127_G	134_S	0.621	0.14
73_G	80_G	0.619	0.14
118_E	241_E	0.617	0.14
187_D	255_E	0.617	0.14
107_Y	126_K	0.615	0.14
142_R	247_D	0.613	0.14
133_K	200_K	0.610	0.14
46_A	173_A	0.609	0.14
45_R	181_Q	0.606	0.14
106_K	130_S	0.603	0.14
65_V	129_A	0.599	0.14
161_S	166_L	0.597	0.14
84_A	182_H	0.597	0.14
181_Q	227_L	0.596	0.14
35_A	205_S	0.595	0.14
87_D	219_F	0.595	0.14
208_D	254_K	0.595	0.14
135_L	211_D	0.592	0.13
90_E	254_K	0.592	0.13
192_Y	196_K	0.590	0.13
175_M	195_I	0.587	0.13
101_N	137_N	0.584	0.13
175_M	252_I	0.584	0.13
39_N	42_Q	0.582	0.13
157_A	222_V	0.582	0.13
70_D	245_R	0.582	0.13
99_V	142_R	0.580	0.13
90_E	204_G	0.580	0.13
81_F	141_F	0.580	0.13
80_G	219_F	0.575	0.13
39_N	82_T	0.575	0.13
134_S	143_A	0.575	0.13
39_N	144_A	0.575	0.13
71_G	110_E	0.574	0.13
189_D	265_H	0.573	0.13
70_D	260_L	0.572	0.13
88_A	135_L	0.571	0.13
146_D	176_Y	0.570	0.13
145_Q	156_P	0.569	0.13
200_K	228_M	0.569	0.13
76_C	132_W	0.566	0.13
174_V	186_D	0.566	0.13
42_Q	169_A	0.563	0.13
94_V	201_K	0.563	0.13
105_K	256_N	0.563	0.13
32_T	91_V	0.562	0.13
62_Y	98_A	0.561	0.13
81_F	216_L	0.556	0.13
37_G	214_K	0.546	0.13
247_D	253_A	0.546	0.13
143_A	188_P	0.543	0.12
60_I	72_R	0.538	0.12
67_R	198_T	0.538	0.12
62_Y	193_A	0.537	0.12
127_G	142_R	0.536	0.12
201_K	217_N	0.535	0.12
133_K	152_L	0.534	0.12
47_E	60_I	0.532	0.12
121_D	196_K	0.532	0.12
61_Q	90_E	0.531	0.12
211_D	214_K	0.528	0.12
62_Y	226_D	0.528	0.12
141_F	145_Q	0.526	0.12
98_A	254_K	0.526	0.12
42_Q	142_R	0.526	0.12
199_N	208_D	0.525	0.12
196_K	213_K	0.525	0.12
31_E	228_M	0.523	0.12
94_V	265_H	0.522	0.12
34_F	62_Y	0.521	0.12
108_L	136_A	0.521	0.12
103_K	161_S	0.519	0.12
35_A	196_K	0.517	0.12
50_T	252_I	0.517	0.12
131_A	244_A	0.515	0.12
61_Q	83_T	0.515	0.12
66_E	246_V	0.515	0.12
132_W	216_L	0.512	0.12
186_D	192_Y	0.512	0.12
134_S	251_S	0.512	0.12
64_Y	186_D	0.510	0.12
38_L	247_D	0.510	0.12
27_L	137_N	0.509	0.12
54_E	223_R	0.509	0.12
39_N	160_R	0.508	0.12
130_S	214_K	0.506	0.12
74_Y	175_M	0.505	0.12
100_P	131_A	0.504	0.12
71_G	105_K	0.504	0.12
66_E	85_T	0.503	0.12
60_I	267_R	0.503	0.12
121_D	254_K	0.502	0.12
177_D	245_R	0.501	0.12
32_T	211_D	0.501	0.12
202_A	218_K	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ilyA	1	0.8881	100	0.21	Contact Map
4oltA	1	0.8412	100	0.215	Contact Map
1qgiA	1	0.8917	100	0.29	Contact Map
4nsoA	1	0.6679	99.7	0.83	Contact Map
4nooA	1	0.6534	97.7	0.919	Contact Map
2nr7A	1	0.5126	73.6	0.958	Contact Map
4grhA	1	0.4332	26.5	0.969	Contact Map
1i1qA	2	0.4332	25.2	0.969	Contact Map
3h9mA	1	0.3538	23.4	0.97	Contact Map
1k0eA	1	0.4404	13.4	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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