GREMLIN Database
AZLB - Transcriptional regulator AzlB
UniProt: O07920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (140)
Sequences: 13604 (8854)
Seq/√Len: 748.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D30_K2.9071.00
46_V54_F2.9071.00
98_E111_K2.5161.00
105_S138_D2.5031.00
74_N136_G2.4921.00
24_N42_T2.2981.00
115_K119_S2.2861.00
61_K118_E2.1351.00
52_K59_D2.0431.00
15_D22_I2.0241.00
9_D41_R2.0221.00
44_N48_A1.9981.00
76_S135_S1.8741.00
70_L100_Y1.8571.00
82_T85_S1.8241.00
93_F127_S1.8111.00
68_T111_K1.7911.00
52_K57_I1.7881.00
8_T33_L1.7321.00
97_Q113_V1.7231.00
43_K47_E1.6941.00
93_F123_F1.6731.00
15_D18_E1.6681.00
33_L37_A1.6571.00
72_L140_S1.6201.00
25_L29_K1.5731.00
116_D119_S1.5561.00
22_I30_K1.5371.00
119_S122_N1.4971.00
26_N29_K1.4921.00
89_D92_K1.4861.00
25_L35_P1.4671.00
33_L38_C1.4631.00
95_Q119_S1.4601.00
145_T148_R1.4381.00
89_D131_N1.4231.00
86_F90_I1.4221.00
34_S37_A1.4061.00
12_I27_L1.4011.00
24_N39_L1.3941.00
87_L91_N1.3701.00
31_I38_C1.3661.00
73_I110_L1.3591.00
21_S54_F1.3381.00
71_A112_I1.3321.00
122_N126_D1.3241.00
84_H88_E1.3161.00
7_E11_A1.2861.00
74_N105_S1.2771.00
22_I27_L1.2761.00
72_L106_H1.2751.00
16_L42_T1.2661.00
67_V117_M1.2391.00
65_I115_K1.2391.00
121_R144_S1.2321.00
75_L86_F1.2311.00
26_N30_K1.2291.00
8_T11_A1.1981.00
18_E30_K1.1941.00
43_K46_V1.1891.00
74_N135_S1.1791.00
87_L144_S1.1691.00
95_Q127_S1.1641.00
23_S26_N1.1571.00
19_D30_K1.1541.00
6_D41_R1.1291.00
15_D27_L1.1211.00
8_T31_I1.0751.00
53_K57_I1.0651.00
72_L138_D1.0561.00
24_N28_S1.0491.00
11_A14_R1.0291.00
11_A15_D1.0241.00
68_T113_V1.0141.00
96_V112_I1.0131.00
14_R18_E1.0041.00
87_L108_Y1.0001.00
99_C110_L0.9891.00
114_A120_Y0.9871.00
22_I26_N0.9831.00
28_S38_C0.9751.00
85_S89_D0.9721.00
88_E91_N0.9581.00
70_L109_M0.9571.00
114_A119_S0.9531.00
112_I123_F0.9531.00
39_L43_K0.9391.00
20_A54_F0.9251.00
70_L111_K0.9231.00
59_D62_K0.9221.00
102_L109_M0.9181.00
35_P39_L0.9151.00
66_E116_D0.9151.00
114_A123_F0.9091.00
24_N35_P0.9061.00
21_S46_V0.8991.00
11_A31_I0.8981.00
100_Y111_K0.8971.00
5_L10_K0.8931.00
88_E92_K0.8901.00
28_S33_L0.8861.00
45_L50_I0.8471.00
105_S136_G0.8421.00
60_E113_V0.8361.00
70_L142_V0.8331.00
96_V99_C0.8091.00
96_V110_L0.8091.00
25_L39_L0.8071.00
9_D44_N0.8021.00
20_A26_N0.7991.00
100_Y145_T0.7981.00
76_S82_T0.7981.00
10_K14_R0.7971.00
100_Y142_V0.7961.00
90_I99_C0.7921.00
124_I139_T0.7851.00
6_D9_D0.7751.00
89_D93_F0.7721.00
78_L82_T0.7701.00
85_S88_E0.7681.00
73_I86_F0.7641.00
122_N127_S0.7601.00
20_A56_T0.7571.00
27_L38_C0.7491.00
72_L109_M0.7481.00
83_I108_Y0.7421.00
103_T141_I0.7391.00
36_S40_A0.7341.00
84_H87_L0.7341.00
106_H138_D0.7291.00
12_I38_C0.7241.00
27_L42_T0.7191.00
5_L50_I0.7161.00
12_I41_R0.7081.00
69_A120_Y0.7071.00
19_D22_I0.7021.00
85_S133_A0.6901.00
12_I22_I0.6861.00
129_M137_V0.6851.00
15_D19_D0.6831.00
65_I113_V0.6821.00
71_A137_V0.6741.00
86_F108_Y0.6741.00
74_N106_H0.6701.00
13_L45_L0.6641.00
40_A44_N0.6631.00
7_E10_K0.6631.00
95_Q123_F0.6621.00
118_E121_R0.6611.00
65_I95_Q0.6581.00
50_I62_K0.6571.00
72_L105_S0.6541.00
118_E122_N0.6531.00
117_M141_I0.6521.00
87_L146_E0.6461.00
101_T108_Y0.6441.00
71_A110_L0.6401.00
28_S35_P0.6381.00
90_I110_L0.6371.00
40_A43_K0.6291.00
76_S133_A0.6281.00
20_A53_K0.6221.00
68_T142_V0.6211.00
12_I15_D0.6201.00
69_A141_I0.6171.00
77_P82_T0.6171.00
73_I134_I0.6161.00
49_G52_K0.6081.00
95_Q115_K0.6051.00
68_T145_T0.6041.00
93_F131_N0.6031.00
102_L106_H0.6021.00
58_V63_L0.6001.00
9_D45_L0.5991.00
124_I137_V0.5951.00
36_S39_L0.5951.00
69_A139_T0.5941.00
12_I42_T0.5901.00
41_R45_L0.5891.00
24_N38_C0.5871.00
59_D63_L0.5871.00
68_T100_Y0.5701.00
51_I54_F0.5671.00
119_S123_F0.5661.00
12_I45_L0.5541.00
73_I137_V0.5501.00
84_H130_Q0.5471.00
8_T37_A0.5441.00
127_S131_N0.5431.00
117_M143_M0.5371.00
123_F127_S0.5331.00
98_E148_R0.5331.00
93_F96_V0.5291.00
44_N47_E0.5281.00
19_D26_N0.5261.00
123_F128_L0.5211.00
14_R17_Q0.5201.00
89_D133_A0.5181.00
101_T121_R0.5181.00
25_L28_S0.5181.00
102_L142_V0.5181.00
75_L107_D0.5151.00
85_S132_P0.5151.00
82_T133_A0.5121.00
69_A114_A0.5111.00
105_S140_S0.5111.00
17_Q55_T0.5071.00
72_L102_L0.5061.00
75_L83_I0.5031.00
120_Y141_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8662 100 0.169 Contact Map
2e1cA 1 0.9363 100 0.181 Contact Map
4un1B 1 0.9554 100 0.187 Contact Map
2p5vA 5 0.9936 100 0.189 Contact Map
4un1A 1 0.9045 100 0.189 Contact Map
4pcqA 2 0.9618 100 0.213 Contact Map
3i4pA 5 0.9682 100 0.217 Contact Map
2cyyA 2 0.9618 100 0.235 Contact Map
2pn6A 5 0.9363 100 0.242 Contact Map
2cg4A 6 0.949 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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