GREMLIN Database
YRAH - Uncharacterized protein YraH
UniProt: O07918 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (110)
Sequences: 4336 (3319)
Seq/√Len: 316.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_D110_R4.2021.00
90_L114_F3.7431.00
90_L95_V2.7471.00
12_D15_K2.5711.00
88_D92_E2.5581.00
103_D110_R2.3371.00
96_K115_R2.1751.00
89_D92_E2.1131.00
87_Y112_A2.1061.00
82_D85_K2.0961.00
116_D120_N2.0921.00
18_E22_D2.0581.00
80_V86_T1.9991.00
87_Y97_C1.9561.00
78_F122_I1.9111.00
88_D91_H1.8951.00
87_Y101_P1.8641.00
86_T124_I1.8141.00
91_H100_K1.8061.00
89_D93_K1.7721.00
45_T48_E1.7621.00
75_L123_E1.7421.00
21_K28_I1.7401.00
114_F124_I1.6341.00
113_H123_E1.6071.00
14_K17_V1.5341.00
17_V28_I1.5201.00
114_F122_I1.5191.00
98_E115_R1.4981.00
14_K18_E1.4961.00
83_V126_K1.4801.00
112_A124_I1.4731.00
115_R121_L1.4081.00
39_L42_N1.3991.00
99_N102_H1.3391.00
91_H97_C1.2991.00
83_V124_I1.2961.00
86_T89_D1.2801.00
18_E21_K1.2631.00
85_K89_D1.2471.00
85_K88_D1.2151.00
8_L74_F1.2021.00
82_D126_K1.1971.00
10_V16_S1.1381.00
7_R77_Q1.1311.00
83_V87_Y1.1111.00
99_N113_H1.0901.00
29_S49_L1.0631.00
83_V110_R1.0611.00
17_V30_W0.9971.00
40_F44_E0.9871.00
80_V124_I0.9641.00
87_Y114_F0.9581.00
11_N72_S0.9571.00
84_D103_D0.9321.00
60_G64_K0.9311.00
21_K27_P0.9311.00
39_L46_K0.9251.00
54_T57_E0.9001.00
98_E121_L0.8991.00
13_F17_V0.8861.00
27_P49_L0.8841.00
57_E60_G0.8781.00
90_L122_I0.8721.00
59_V62_E0.8631.00
61_E67_E0.8501.00
75_L113_H0.8501.00
41_D44_E0.8501.00
15_K18_E0.8491.00
74_F120_N0.8391.00
102_H111_V0.8271.00
109_A125_Y0.8261.00
62_E65_S0.8231.00
83_V112_A0.8061.00
20_Y116_D0.7951.00
98_E113_H0.7841.00
61_E64_K0.7791.00
10_V113_H0.7781.00
87_Y91_H0.7731.00
75_L121_L0.7690.99
13_F60_G0.7520.99
61_E66_L0.7510.99
104_R125_Y0.7410.99
104_R111_V0.7370.99
78_F118_D0.7330.99
84_D88_D0.7320.99
77_Q123_E0.7310.99
79_K125_Y0.7250.99
55_M58_I0.7240.99
30_W33_N0.7240.99
8_L120_N0.7080.99
60_G65_S0.7030.99
57_E61_E0.7030.99
63_K67_E0.7010.99
44_E47_I0.7010.99
44_E48_E0.7000.99
20_Y74_F0.6920.99
49_L52_R0.6920.99
56_A61_E0.6900.99
40_F45_T0.6900.99
77_Q111_V0.6900.99
85_K92_E0.6880.99
9_L75_L0.6860.99
16_S20_Y0.6770.99
104_R108_S0.6750.99
52_R55_M0.6750.99
29_S41_D0.6660.99
26_L74_F0.6630.98
59_V63_K0.6630.98
84_D101_P0.6610.98
42_N45_T0.6610.98
95_V114_F0.6600.98
47_I54_T0.6560.98
58_I63_K0.6530.98
17_V21_K0.6440.98
13_F58_I0.6430.98
27_P41_D0.6360.98
42_N46_K0.6290.98
77_Q104_R0.6240.98
28_I48_E0.6190.98
52_R57_E0.6180.98
63_K66_L0.6150.98
45_T49_L0.6150.98
74_F117_P0.6070.97
22_D49_L0.6040.97
9_L73_K0.6040.97
48_E56_A0.6030.97
60_G63_K0.6010.97
39_L45_T0.6000.97
43_G47_I0.6000.97
104_R109_A0.5970.97
87_Y95_V0.5890.97
105_K108_S0.5870.97
40_F43_G0.5790.96
94_G97_C0.5740.96
39_L44_E0.5720.96
52_R56_A0.5720.96
35_M42_N0.5680.96
101_P110_R0.5670.96
83_V101_P0.5660.96
26_L104_R0.5620.96
24_L50_L0.5590.96
51_S56_A0.5510.95
64_K67_E0.5450.95
35_M39_L0.5440.95
113_H121_L0.5410.95
7_R111_V0.5380.95
7_R10_V0.5320.94
54_T58_I0.5310.94
10_V78_F0.5280.94
42_N105_K0.5280.94
54_T60_G0.5240.94
94_G117_P0.5230.94
24_L125_Y0.5220.94
42_N47_I0.5220.94
111_V125_Y0.5200.94
10_V120_N0.5190.94
78_F123_E0.5170.94
81_E86_T0.5110.93
97_C112_A0.5090.93
46_K49_L0.5080.93
105_K126_K0.5060.93
41_D45_T0.5050.93
100_K112_A0.5010.92
76_L120_N0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbbA 2 0.9688 99.8 0.376 Contact Map
2i7rA 2 0.8984 99.8 0.382 Contact Map
2qntA 2 0.9219 99.7 0.395 Contact Map
2a4xA 2 0.9609 99.7 0.399 Contact Map
4nvsA 2 0.9453 99.7 0.399 Contact Map
1xy7A 2 0.8984 99.7 0.407 Contact Map
4mymA 2 0.9688 99.7 0.419 Contact Map
3l20A 2 0.9062 99.7 0.421 Contact Map
2rk9A 2 0.8984 99.7 0.423 Contact Map
3bqxA 2 0.9453 99.7 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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