FTSW - BACSU - GREMLIN Contacts

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FTSW - Putative lipid II flippase FtsW

UniProt:	O07639	Sequences: MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSSNFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGNAQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLIAMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTEGRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFIMAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINLGGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGMKKKQLKKTVYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	403 (354)
Sequences:	7975 (5488)
Seq/√Len:	291.7

ECOLI - FTSW RODA
BACSU - FTSW SP5E RODA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
303_G	323_S	3.917	1.00
10_D	302_K	3.764	1.00
303_G	368_L	3.510	1.00
178_C	324_S	3.328	1.00
108_K	111_G	3.304	1.00
99_V	104_Q	2.795	1.00
16_A	298_F	2.753	1.00
70_Y	315_G	2.749	1.00
281_A	289_V	2.728	1.00
229_D	232_K	2.714	1.00
21_C	55_L	2.714	1.00
248_I	281_A	2.705	1.00
233_Y	236_S	2.551	1.00
65_M	363_G	2.481	1.00
319_A	368_L	2.480	1.00
58_G	362_L	2.442	1.00
43_S	49_M	2.407	1.00
82_I	123_V	2.392	1.00
86_S	123_V	2.371	1.00
17_I	365_M	2.368	1.00
280_I	292_V	2.225	1.00
16_A	299_V	2.219	1.00
322_I	368_L	2.185	1.00
157_C	169_A	2.181	1.00
86_S	120_V	2.153	1.00
277_M	289_V	2.135	1.00
270_E	273_T	2.124	1.00
350_F	365_M	2.107	1.00
182_C	320_I	2.095	1.00
62_F	369_A	2.054	1.00
300_V	327_A	2.007	1.00
27_M	280_I	2.005	1.00
101_G	270_E	1.963	1.00
92_S	107_F	1.958	1.00
350_F	361_L	1.938	1.00
74_A	314_F	1.937	1.00
46_F	50_R	1.918	1.00
231_F	242_I	1.909	1.00
25_L	48_F	1.861	1.00
153_T	176_A	1.837	1.00
305_Y	309_K	1.827	1.00
179_M	321_G	1.825	1.00
241_V	343_I	1.824	1.00
336_G	343_I	1.821	1.00
27_M	284_L	1.765	1.00
108_K	113_S	1.754	1.00
258_L	284_L	1.727	1.00
92_S	96_F	1.725	1.00
335_G	341_I	1.724	1.00
234_A	242_I	1.713	1.00
303_G	319_A	1.703	1.00
330_S	334_L	1.690	1.00
322_I	364_S	1.671	1.00
158_G	162_M	1.662	1.00
84_L	88_L	1.660	1.00
261_S	279_V	1.654	1.00
52_L	56_I	1.640	1.00
310_C	371_I	1.639	1.00
23_F	280_I	1.623	1.00
90_L	120_V	1.618	1.00
30_S	283_E	1.593	1.00
319_A	371_I	1.575	1.00
222_A	237_S	1.547	1.00
290_L	294_F	1.545	1.00
25_L	51_Q	1.528	1.00
132_Y	179_M	1.526	1.00
117_G	168_T	1.515	1.00
93_L	107_F	1.501	1.00
256_L	262_I	1.499	1.00
277_M	334_L	1.496	1.00
54_A	355_G	1.495	1.00
78_F	81_G	1.489	1.00
126_L	318_L	1.489	1.00
293_I	334_L	1.488	1.00
315_G	371_I	1.487	1.00
243_N	263_Q	1.482	1.00
91_I	95_V	1.481	1.00
81_G	85_V	1.477	1.00
98_H	113_S	1.472	1.00
21_C	362_L	1.464	1.00
98_H	108_K	1.458	1.00
171_I	346_V	1.454	1.00
31_S	279_V	1.454	1.00
307_A	319_A	1.443	1.00
49_M	52_L	1.424	1.00
296_L	330_S	1.421	1.00
254_F	287_F	1.418	1.00
175_I	325_M	1.414	1.00
160_I	172_I	1.395	1.00
347_T	357_S	1.393	1.00
125_I	321_G	1.387	1.00
83_L	156_I	1.372	1.00
280_I	351_I	1.363	1.00
253_I	286_I	1.361	1.00
326_I	361_L	1.359	1.00
202_I	205_S	1.358	1.00
312_D	315_G	1.355	1.00
62_F	366_G	1.352	1.00
300_V	330_S	1.349	1.00
61_L	363_G	1.344	1.00
16_A	295_L	1.341	1.00
114_I	119_F	1.336	1.00
23_F	292_V	1.333	1.00
27_M	276_I	1.329	1.00
17_I	362_L	1.329	1.00
218_E	221_L	1.324	1.00
261_S	283_E	1.323	1.00
241_V	339_G	1.321	1.00
370_N	374_F	1.319	1.00
217_T	220_R	1.319	1.00
56_I	60_A	1.303	1.00
275_F	343_I	1.293	1.00
179_M	317_L	1.292	1.00
174_L	328_I	1.292	1.00
300_V	323_S	1.285	1.00
70_Y	370_N	1.280	1.00
130_A	134_K	1.259	1.00
244_S	337_V	1.259	1.00
105_S	117_G	1.256	1.00
124_V	172_I	1.256	1.00
25_L	52_L	1.248	1.00
238_G	242_I	1.232	1.00
233_Y	237_S	1.230	1.00
55_L	358_L	1.215	1.00
221_L	225_E	1.213	1.00
29_Y	48_F	1.208	1.00
216_L	220_R	1.206	1.00
87_V	155_I	1.195	1.00
306_I	319_A	1.193	1.00
60_A	64_L	1.186	1.00
186_S	189_T	1.184	1.00
92_S	95_V	1.175	1.00
88_L	92_S	1.174	1.00
93_L	116_P	1.171	1.00
286_I	290_L	1.170	1.00
74_A	130_A	1.169	1.00
120_V	156_I	1.167	1.00
73_L	367_I	1.158	1.00
154_L	158_G	1.151	1.00
218_E	222_A	1.149	1.00
20_L	351_I	1.149	1.00
26_V	258_L	1.141	1.00
239_L	269_P	1.131	1.00
49_M	53_F	1.130	1.00
299_V	365_M	1.124	1.00
128_L	176_A	1.122	1.00
304_F	323_S	1.121	1.00
246_Y	263_Q	1.121	1.00
74_A	133_A	1.119	1.00
191_V	195_I	1.112	1.00
118_E	121_K	1.111	1.00
9_Y	14_I	1.108	1.00
329_Q	357_S	1.107	1.00
151_V	155_I	1.096	1.00
293_I	330_S	1.089	1.00
125_I	175_I	1.087	1.00
128_L	149_P	1.085	1.00
105_S	167_G	1.070	1.00
12_S	298_F	1.066	1.00
318_L	371_I	1.060	1.00
70_Y	312_D	1.058	1.00
13_L	299_V	1.056	1.00
250_S	256_L	1.052	1.00
325_M	364_S	1.046	1.00
47_F	353_Y	1.045	1.00
129_A	179_M	1.042	1.00
369_A	372_S	1.042	1.00
193_L	197_G	1.039	1.00
125_I	325_M	1.030	1.00
243_N	246_Y	1.030	1.00
306_I	372_S	1.028	1.00
292_V	351_I	1.026	1.00
222_A	225_E	1.023	1.00
78_F	82_I	1.021	1.00
29_Y	45_N	1.010	1.00
323_S	368_L	1.007	1.00
66_A	366_G	1.005	1.00
47_F	272_H	1.001	1.00
100_A	113_S	1.000	1.00
268_L	278_A	0.996	1.00
167_G	336_G	0.993	1.00
215_I	218_E	0.992	1.00
62_F	65_M	0.992	1.00
81_G	84_L	0.992	1.00
167_G	344_T	0.991	1.00
245_Y	339_G	0.986	1.00
66_A	370_N	0.985	1.00
280_I	284_L	0.982	1.00
87_V	156_I	0.980	1.00
329_Q	347_T	0.980	1.00
58_G	358_L	0.979	1.00
70_Y	371_I	0.977	1.00
187_G	191_V	0.977	1.00
239_L	243_N	0.975	1.00
46_F	49_M	0.975	1.00
197_G	201_F	0.973	1.00
20_L	299_V	0.972	1.00
273_T	353_Y	0.967	1.00
170_M	174_L	0.965	1.00
119_F	360_L	0.960	1.00
80_K	127_Y	0.960	1.00
83_L	87_V	0.958	1.00
14_I	369_A	0.952	1.00
313_P	316_S	0.951	1.00
59_G	63_I	0.950	1.00
253_I	287_F	0.948	1.00
301_I	305_Y	0.946	1.00
126_L	314_F	0.946	1.00
231_F	245_Y	0.941	1.00
51_Q	54_A	0.941	1.00
13_L	306_I	0.938	1.00
19_L	295_L	0.932	1.00
80_K	84_L	0.930	1.00
226_S	237_S	0.929	1.00
122_L	363_G	0.929	1.00
15_F	19_L	0.926	1.00
200_V	204_V	0.925	1.00
122_L	367_I	0.925	1.00
336_G	344_T	0.924	1.00
318_L	367_I	0.922	1.00
326_I	330_S	0.920	1.00
50_R	54_A	0.910	1.00
244_S	278_A	0.909	1.00
62_F	365_M	0.909	1.00
230_P	238_G	0.904	1.00
91_I	94_F	0.900	1.00
94_F	162_M	0.899	1.00
122_L	360_L	0.897	1.00
66_A	373_M	0.895	1.00
28_V	276_I	0.891	1.00
12_S	302_K	0.889	1.00
131_V	149_P	0.888	1.00
348_L	351_I	0.887	1.00
50_R	353_Y	0.883	1.00
320_I	324_S	0.882	1.00
50_R	53_F	0.882	1.00
307_A	323_S	0.881	1.00
79_Q	314_F	0.880	1.00
87_V	91_I	0.879	1.00
69_P	72_A	0.879	1.00
30_S	257_G	0.878	1.00
165_D	168_T	0.872	1.00
125_I	322_I	0.872	1.00
181_L	187_G	0.870	1.00
157_C	173_G	0.869	1.00
36_A	47_F	0.867	1.00
147_A	151_V	0.866	1.00
175_I	178_C	0.865	1.00
168_T	347_T	0.861	1.00
28_V	31_S	0.855	1.00
233_Y	238_G	0.852	1.00
257_G	283_E	0.851	1.00
57_A	359_V	0.849	1.00
173_G	177_T	0.849	1.00
230_P	242_I	0.848	1.00
240_Q	244_S	0.848	1.00
297_G	301_I	0.847	1.00
79_Q	130_A	0.846	1.00
36_A	46_F	0.845	1.00
307_A	320_I	0.844	1.00
190_L	194_V	0.844	1.00
222_A	226_S	0.841	1.00
17_I	299_V	0.836	1.00
108_K	112_M	0.834	1.00
132_Y	183_S	0.827	1.00
22_G	26_V	0.825	1.00
366_G	370_N	0.821	1.00
357_S	361_L	0.820	1.00
83_L	127_Y	0.820	1.00
23_F	295_L	0.818	1.00
368_L	371_I	0.818	1.00
335_G	340_L	0.815	1.00
272_H	353_Y	0.815	1.00
18_V	22_G	0.813	1.00
122_L	364_S	0.810	1.00
135_K	148_P	0.809	1.00
125_I	179_M	0.809	1.00
65_M	73_L	0.807	1.00
196_L	200_V	0.807	1.00
161_A	169_A	0.807	1.00
241_V	244_S	0.805	1.00
58_G	359_V	0.805	1.00
182_C	324_S	0.804	1.00
268_L	271_S	0.802	0.99
192_R	196_L	0.800	0.99
271_S	279_V	0.798	0.99
114_I	360_L	0.797	0.99
124_V	153_T	0.794	0.99
127_Y	152_M	0.793	0.99
277_M	292_V	0.792	0.99
166_F	220_R	0.780	0.99
199_I	202_I	0.780	0.99
336_G	341_I	0.779	0.99
97_G	104_Q	0.776	0.99
79_Q	123_V	0.776	0.99
289_V	293_I	0.776	0.99
71_K	312_D	0.775	0.99
89_A	119_F	0.775	0.99
160_I	168_T	0.774	0.99
53_F	56_I	0.773	0.99
58_G	366_G	0.772	0.99
28_V	51_Q	0.771	0.99
23_F	27_M	0.771	0.99
54_A	359_V	0.767	0.99
314_F	318_L	0.767	0.99
289_V	338_S	0.766	0.99
219_G	222_A	0.764	0.99
63_I	67_L	0.762	0.99
20_L	292_V	0.758	0.99
244_S	275_F	0.757	0.99
189_T	193_L	0.756	0.99
205_S	221_L	0.753	0.99
88_L	94_F	0.753	0.99
195_I	199_I	0.750	0.99
64_L	68_F	0.748	0.99
149_P	176_A	0.748	0.99
370_N	373_M	0.746	0.99
294_F	298_F	0.745	0.99
12_S	16_A	0.745	0.99
331_F	340_L	0.742	0.99
178_C	328_I	0.741	0.99
277_M	348_L	0.741	0.99
48_F	52_L	0.740	0.99
199_I	203_L	0.739	0.99
21_C	59_G	0.738	0.99
275_F	337_V	0.737	0.99
93_L	104_Q	0.735	0.99
129_A	133_A	0.735	0.99
241_V	275_F	0.734	0.99
302_K	305_Y	0.734	0.99
334_L	338_S	0.734	0.99
89_A	93_L	0.734	0.99
296_L	348_L	0.732	0.99
72_A	78_F	0.732	0.99
29_Y	259_G	0.729	0.99
200_V	203_L	0.725	0.99
105_S	164_P	0.719	0.99
226_S	232_K	0.718	0.99
248_I	338_S	0.717	0.99
120_V	123_V	0.717	0.99
319_A	323_S	0.709	0.99
145_G	148_P	0.709	0.99
202_I	215_I	0.708	0.99
276_I	351_I	0.708	0.99
128_L	153_T	0.707	0.99
279_V	283_E	0.707	0.99
334_L	348_L	0.700	0.99
62_F	362_L	0.697	0.99
144_T	148_P	0.696	0.99
103_A	163_Q	0.693	0.99
367_I	371_I	0.692	0.98
304_F	324_S	0.691	0.98
103_A	164_P	0.690	0.98
129_A	314_F	0.690	0.98
185_F	190_L	0.690	0.98
261_S	264_K	0.690	0.98
72_A	77_K	0.687	0.98
166_F	170_M	0.686	0.98
45_N	48_F	0.686	0.98
332_I	341_I	0.685	0.98
284_L	288_G	0.685	0.98
153_T	157_C	0.684	0.98
90_L	159_L	0.684	0.98
89_A	114_I	0.683	0.98
189_T	192_R	0.681	0.98
33_M	264_K	0.681	0.98
315_G	318_L	0.680	0.98
324_S	328_I	0.678	0.98
68_F	73_L	0.678	0.98
16_A	302_K	0.676	0.98
59_G	62_F	0.676	0.98
299_V	303_G	0.675	0.98
142_L	145_G	0.674	0.98
61_L	359_V	0.673	0.98
299_V	326_I	0.673	0.98
198_G	202_I	0.666	0.98
310_C	315_G	0.665	0.98
119_F	363_G	0.662	0.98
125_I	318_L	0.660	0.98
142_L	189_T	0.660	0.98
166_F	217_T	0.660	0.98
148_P	151_V	0.658	0.98
224_F	228_E	0.657	0.98
91_I	159_L	0.656	0.98
361_L	364_S	0.655	0.98
229_D	238_G	0.654	0.98
131_V	152_M	0.654	0.98
294_F	297_G	0.652	0.98
246_Y	249_S	0.650	0.98
90_L	164_P	0.649	0.98
77_K	81_G	0.646	0.98
101_G	272_H	0.644	0.98
132_Y	149_P	0.642	0.98
146_V	180_I	0.639	0.97
90_L	93_L	0.638	0.97
174_L	178_C	0.636	0.97
276_I	280_I	0.636	0.97
64_L	67_L	0.635	0.97
264_K	283_E	0.635	0.97
51_Q	55_L	0.634	0.97
333_N	337_V	0.632	0.97
146_V	150_V	0.628	0.97
45_N	49_M	0.628	0.97
136_Q	139_I	0.625	0.97
313_P	317_L	0.624	0.97
356_S	360_L	0.623	0.97
243_N	269_P	0.620	0.97
43_S	46_F	0.620	0.97
225_E	229_D	0.620	0.97
360_L	364_S	0.618	0.97
188_K	192_R	0.618	0.97
220_R	224_F	0.616	0.97
90_L	160_I	0.615	0.97
138_Y	144_T	0.615	0.97
70_Y	318_L	0.612	0.97
130_A	314_F	0.612	0.97
132_Y	317_L	0.612	0.97
277_M	293_I	0.608	0.97
67_L	373_M	0.608	0.97
292_V	296_L	0.606	0.97
80_K	130_A	0.604	0.96
94_F	104_Q	0.604	0.96
69_P	315_G	0.604	0.96
245_Y	249_S	0.602	0.96
135_K	145_G	0.602	0.96
226_S	238_G	0.599	0.96
79_Q	126_L	0.597	0.96
226_S	241_V	0.594	0.96
226_S	230_P	0.593	0.96
57_A	61_L	0.591	0.96
309_K	372_S	0.590	0.96
88_L	95_V	0.590	0.96
143_L	147_A	0.588	0.96
225_E	233_Y	0.588	0.96
304_F	308_R	0.585	0.96
109_I	113_S	0.582	0.96
191_V	194_V	0.581	0.96
83_L	152_M	0.581	0.96
365_M	368_L	0.581	0.96
257_G	282_E	0.581	0.96
93_L	97_G	0.580	0.96
332_I	336_G	0.578	0.95
123_V	127_Y	0.574	0.95
225_E	232_K	0.573	0.95
54_A	58_G	0.573	0.95
164_P	219_G	0.572	0.95
220_R	227_L	0.571	0.95
129_A	321_G	0.571	0.95
126_L	367_I	0.570	0.95
298_F	302_K	0.568	0.95
132_Y	180_I	0.568	0.95
242_I	246_Y	0.567	0.95
84_L	87_V	0.566	0.95
98_H	104_Q	0.565	0.95
58_G	61_L	0.564	0.95
261_S	282_E	0.563	0.95
101_G	104_Q	0.562	0.95
105_S	344_T	0.560	0.95
268_L	279_V	0.560	0.95
8_S	373_M	0.560	0.95
322_I	371_I	0.559	0.95
74_A	312_D	0.558	0.95
127_Y	131_V	0.555	0.94
177_T	194_V	0.553	0.94
129_A	318_L	0.553	0.94
10_D	372_S	0.552	0.94
83_L	155_I	0.552	0.94
61_L	64_L	0.551	0.94
306_I	310_C	0.551	0.94
86_S	119_F	0.551	0.94
19_L	22_G	0.551	0.94
241_V	245_Y	0.551	0.94
232_K	238_G	0.550	0.94
114_I	356_S	0.547	0.94
231_F	238_G	0.546	0.94
286_I	289_V	0.546	0.94
160_I	169_A	0.546	0.94
25_L	55_L	0.545	0.94
303_G	365_M	0.545	0.94
51_Q	358_L	0.544	0.94
135_K	138_Y	0.544	0.94
247_A	268_L	0.542	0.94
47_F	50_R	0.541	0.94
77_K	94_F	0.541	0.94
129_A	317_L	0.541	0.94
24_G	351_I	0.539	0.94
16_A	19_L	0.538	0.93
70_Y	374_F	0.538	0.93
135_K	139_I	0.538	0.93
310_C	319_A	0.537	0.93
29_Y	33_M	0.537	0.93
361_L	365_M	0.537	0.93
139_I	142_L	0.535	0.93
362_L	366_G	0.534	0.93
71_K	74_A	0.532	0.93
242_I	245_Y	0.531	0.93
105_S	168_T	0.530	0.93
115_Q	118_E	0.529	0.93
141_H	144_T	0.529	0.93
54_A	356_S	0.528	0.93
105_S	163_Q	0.526	0.93
183_S	317_L	0.526	0.93
65_M	366_G	0.526	0.93
105_S	346_V	0.524	0.93
244_S	338_S	0.523	0.92
292_V	330_S	0.523	0.92
155_I	158_G	0.522	0.92
337_V	343_I	0.522	0.92
66_A	369_A	0.521	0.92
100_A	104_Q	0.520	0.92
296_L	350_F	0.519	0.92
322_I	367_I	0.518	0.92
16_A	294_F	0.516	0.92
331_F	335_G	0.515	0.92
119_F	123_V	0.515	0.92
339_G	343_I	0.515	0.92
262_I	265_Y	0.513	0.92
172_I	176_A	0.511	0.92
226_S	233_Y	0.511	0.92
98_H	101_G	0.510	0.92
80_K	91_I	0.510	0.92
54_A	353_Y	0.509	0.91
322_I	325_M	0.507	0.91
159_L	163_Q	0.507	0.91
296_L	351_I	0.507	0.91
13_L	302_K	0.507	0.91
181_L	190_L	0.504	0.91
177_T	190_L	0.502	0.91
222_A	232_K	0.502	0.91
244_S	268_L	0.501	0.91
229_D	233_Y	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f35D	2	0.536	35.1	0.966	Contact Map
4px7A	1	0.5633	12.1	0.973	Contact Map
2cfqA	1	0.4417	10.5	0.973	Contact Map
4pd6A	3	0.5211	10.1	0.974	Contact Map
3wajA	1	0.7146	9.4	0.974	Contact Map
4x5mA	2	0.2333	6.7	0.976	Contact Map
3qe7A	2	0.7022	5.8	0.976	Contact Map
2rddB	1	0.0868	4.6	0.977	Contact Map
3sokA	1	0.1266	4.5	0.978	Contact Map
1oqwA	1	0.1266	3.9	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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