GREMLIN Database
FTSW - Putative lipid II flippase FtsW
UniProt: O07639 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (354)
Sequences: 7975 (5488)
Seq/√Len: 291.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_G323_S3.9171.00
10_D302_K3.7641.00
303_G368_L3.5101.00
178_C324_S3.3281.00
108_K111_G3.3041.00
99_V104_Q2.7951.00
16_A298_F2.7531.00
70_Y315_G2.7491.00
281_A289_V2.7281.00
229_D232_K2.7141.00
21_C55_L2.7141.00
248_I281_A2.7051.00
233_Y236_S2.5511.00
65_M363_G2.4811.00
319_A368_L2.4801.00
58_G362_L2.4421.00
43_S49_M2.4071.00
82_I123_V2.3921.00
86_S123_V2.3711.00
17_I365_M2.3681.00
280_I292_V2.2251.00
16_A299_V2.2191.00
322_I368_L2.1851.00
157_C169_A2.1811.00
86_S120_V2.1531.00
277_M289_V2.1351.00
270_E273_T2.1241.00
350_F365_M2.1071.00
182_C320_I2.0951.00
62_F369_A2.0541.00
300_V327_A2.0071.00
27_M280_I2.0051.00
101_G270_E1.9631.00
92_S107_F1.9581.00
350_F361_L1.9381.00
74_A314_F1.9371.00
46_F50_R1.9181.00
231_F242_I1.9091.00
25_L48_F1.8611.00
153_T176_A1.8371.00
305_Y309_K1.8271.00
179_M321_G1.8251.00
241_V343_I1.8241.00
336_G343_I1.8211.00
27_M284_L1.7651.00
108_K113_S1.7541.00
258_L284_L1.7271.00
92_S96_F1.7251.00
335_G341_I1.7241.00
234_A242_I1.7131.00
303_G319_A1.7031.00
330_S334_L1.6901.00
322_I364_S1.6711.00
158_G162_M1.6621.00
84_L88_L1.6601.00
261_S279_V1.6541.00
52_L56_I1.6401.00
310_C371_I1.6391.00
23_F280_I1.6231.00
90_L120_V1.6181.00
30_S283_E1.5931.00
319_A371_I1.5751.00
222_A237_S1.5471.00
290_L294_F1.5451.00
25_L51_Q1.5281.00
132_Y179_M1.5261.00
117_G168_T1.5151.00
93_L107_F1.5011.00
256_L262_I1.4991.00
277_M334_L1.4961.00
54_A355_G1.4951.00
78_F81_G1.4891.00
126_L318_L1.4891.00
293_I334_L1.4881.00
315_G371_I1.4871.00
243_N263_Q1.4821.00
91_I95_V1.4811.00
81_G85_V1.4771.00
98_H113_S1.4721.00
21_C362_L1.4641.00
98_H108_K1.4581.00
171_I346_V1.4541.00
31_S279_V1.4541.00
307_A319_A1.4431.00
49_M52_L1.4241.00
296_L330_S1.4211.00
254_F287_F1.4181.00
175_I325_M1.4141.00
160_I172_I1.3951.00
347_T357_S1.3931.00
125_I321_G1.3871.00
83_L156_I1.3721.00
280_I351_I1.3631.00
253_I286_I1.3611.00
326_I361_L1.3591.00
202_I205_S1.3581.00
312_D315_G1.3551.00
62_F366_G1.3521.00
300_V330_S1.3491.00
61_L363_G1.3441.00
16_A295_L1.3411.00
114_I119_F1.3361.00
23_F292_V1.3331.00
27_M276_I1.3291.00
17_I362_L1.3291.00
218_E221_L1.3241.00
261_S283_E1.3231.00
241_V339_G1.3211.00
370_N374_F1.3191.00
217_T220_R1.3191.00
56_I60_A1.3031.00
275_F343_I1.2931.00
179_M317_L1.2921.00
174_L328_I1.2921.00
300_V323_S1.2851.00
70_Y370_N1.2801.00
130_A134_K1.2591.00
244_S337_V1.2591.00
105_S117_G1.2561.00
124_V172_I1.2561.00
25_L52_L1.2481.00
238_G242_I1.2321.00
233_Y237_S1.2301.00
55_L358_L1.2151.00
221_L225_E1.2131.00
29_Y48_F1.2081.00
216_L220_R1.2061.00
87_V155_I1.1951.00
306_I319_A1.1931.00
60_A64_L1.1861.00
186_S189_T1.1841.00
92_S95_V1.1751.00
88_L92_S1.1741.00
93_L116_P1.1711.00
286_I290_L1.1701.00
74_A130_A1.1691.00
120_V156_I1.1671.00
73_L367_I1.1581.00
154_L158_G1.1511.00
218_E222_A1.1491.00
20_L351_I1.1491.00
26_V258_L1.1411.00
239_L269_P1.1311.00
49_M53_F1.1301.00
299_V365_M1.1241.00
128_L176_A1.1221.00
304_F323_S1.1211.00
246_Y263_Q1.1211.00
74_A133_A1.1191.00
191_V195_I1.1121.00
118_E121_K1.1111.00
9_Y14_I1.1081.00
329_Q357_S1.1071.00
151_V155_I1.0961.00
293_I330_S1.0891.00
125_I175_I1.0871.00
128_L149_P1.0851.00
105_S167_G1.0701.00
12_S298_F1.0661.00
318_L371_I1.0601.00
70_Y312_D1.0581.00
13_L299_V1.0561.00
250_S256_L1.0521.00
325_M364_S1.0461.00
47_F353_Y1.0451.00
129_A179_M1.0421.00
369_A372_S1.0421.00
193_L197_G1.0391.00
125_I325_M1.0301.00
243_N246_Y1.0301.00
306_I372_S1.0281.00
292_V351_I1.0261.00
222_A225_E1.0231.00
78_F82_I1.0211.00
29_Y45_N1.0101.00
323_S368_L1.0071.00
66_A366_G1.0051.00
47_F272_H1.0011.00
100_A113_S1.0001.00
268_L278_A0.9961.00
167_G336_G0.9931.00
215_I218_E0.9921.00
62_F65_M0.9921.00
81_G84_L0.9921.00
167_G344_T0.9911.00
245_Y339_G0.9861.00
66_A370_N0.9851.00
280_I284_L0.9821.00
87_V156_I0.9801.00
329_Q347_T0.9801.00
58_G358_L0.9791.00
70_Y371_I0.9771.00
187_G191_V0.9771.00
239_L243_N0.9751.00
46_F49_M0.9751.00
197_G201_F0.9731.00
20_L299_V0.9721.00
273_T353_Y0.9671.00
170_M174_L0.9651.00
119_F360_L0.9601.00
80_K127_Y0.9601.00
83_L87_V0.9581.00
14_I369_A0.9521.00
313_P316_S0.9511.00
59_G63_I0.9501.00
253_I287_F0.9481.00
301_I305_Y0.9461.00
126_L314_F0.9461.00
231_F245_Y0.9411.00
51_Q54_A0.9411.00
13_L306_I0.9381.00
19_L295_L0.9321.00
80_K84_L0.9301.00
226_S237_S0.9291.00
122_L363_G0.9291.00
15_F19_L0.9261.00
200_V204_V0.9251.00
122_L367_I0.9251.00
336_G344_T0.9241.00
318_L367_I0.9221.00
326_I330_S0.9201.00
50_R54_A0.9101.00
244_S278_A0.9091.00
62_F365_M0.9091.00
230_P238_G0.9041.00
91_I94_F0.9001.00
94_F162_M0.8991.00
122_L360_L0.8971.00
66_A373_M0.8951.00
28_V276_I0.8911.00
12_S302_K0.8891.00
131_V149_P0.8881.00
348_L351_I0.8871.00
50_R353_Y0.8831.00
320_I324_S0.8821.00
50_R53_F0.8821.00
307_A323_S0.8811.00
79_Q314_F0.8801.00
87_V91_I0.8791.00
69_P72_A0.8791.00
30_S257_G0.8781.00
165_D168_T0.8721.00
125_I322_I0.8721.00
181_L187_G0.8701.00
157_C173_G0.8691.00
36_A47_F0.8671.00
147_A151_V0.8661.00
175_I178_C0.8651.00
168_T347_T0.8611.00
28_V31_S0.8551.00
233_Y238_G0.8521.00
257_G283_E0.8511.00
57_A359_V0.8491.00
173_G177_T0.8491.00
230_P242_I0.8481.00
240_Q244_S0.8481.00
297_G301_I0.8471.00
79_Q130_A0.8461.00
36_A46_F0.8451.00
307_A320_I0.8441.00
190_L194_V0.8441.00
222_A226_S0.8411.00
17_I299_V0.8361.00
108_K112_M0.8341.00
132_Y183_S0.8271.00
22_G26_V0.8251.00
366_G370_N0.8211.00
357_S361_L0.8201.00
83_L127_Y0.8201.00
23_F295_L0.8181.00
368_L371_I0.8181.00
335_G340_L0.8151.00
272_H353_Y0.8151.00
18_V22_G0.8131.00
122_L364_S0.8101.00
135_K148_P0.8091.00
125_I179_M0.8091.00
65_M73_L0.8071.00
196_L200_V0.8071.00
161_A169_A0.8071.00
241_V244_S0.8051.00
58_G359_V0.8051.00
182_C324_S0.8041.00
268_L271_S0.8020.99
192_R196_L0.8000.99
271_S279_V0.7980.99
114_I360_L0.7970.99
124_V153_T0.7940.99
127_Y152_M0.7930.99
277_M292_V0.7920.99
166_F220_R0.7800.99
199_I202_I0.7800.99
336_G341_I0.7790.99
97_G104_Q0.7760.99
79_Q123_V0.7760.99
289_V293_I0.7760.99
71_K312_D0.7750.99
89_A119_F0.7750.99
160_I168_T0.7740.99
53_F56_I0.7730.99
58_G366_G0.7720.99
28_V51_Q0.7710.99
23_F27_M0.7710.99
54_A359_V0.7670.99
314_F318_L0.7670.99
289_V338_S0.7660.99
219_G222_A0.7640.99
63_I67_L0.7620.99
20_L292_V0.7580.99
244_S275_F0.7570.99
189_T193_L0.7560.99
205_S221_L0.7530.99
88_L94_F0.7530.99
195_I199_I0.7500.99
64_L68_F0.7480.99
149_P176_A0.7480.99
370_N373_M0.7460.99
294_F298_F0.7450.99
12_S16_A0.7450.99
331_F340_L0.7420.99
178_C328_I0.7410.99
277_M348_L0.7410.99
48_F52_L0.7400.99
199_I203_L0.7390.99
21_C59_G0.7380.99
275_F337_V0.7370.99
93_L104_Q0.7350.99
129_A133_A0.7350.99
241_V275_F0.7340.99
302_K305_Y0.7340.99
334_L338_S0.7340.99
89_A93_L0.7340.99
296_L348_L0.7320.99
72_A78_F0.7320.99
29_Y259_G0.7290.99
200_V203_L0.7250.99
105_S164_P0.7190.99
226_S232_K0.7180.99
248_I338_S0.7170.99
120_V123_V0.7170.99
319_A323_S0.7090.99
145_G148_P0.7090.99
202_I215_I0.7080.99
276_I351_I0.7080.99
128_L153_T0.7070.99
279_V283_E0.7070.99
334_L348_L0.7000.99
62_F362_L0.6970.99
144_T148_P0.6960.99
103_A163_Q0.6930.99
367_I371_I0.6920.98
304_F324_S0.6910.98
103_A164_P0.6900.98
129_A314_F0.6900.98
185_F190_L0.6900.98
261_S264_K0.6900.98
72_A77_K0.6870.98
166_F170_M0.6860.98
45_N48_F0.6860.98
332_I341_I0.6850.98
284_L288_G0.6850.98
153_T157_C0.6840.98
90_L159_L0.6840.98
89_A114_I0.6830.98
189_T192_R0.6810.98
33_M264_K0.6810.98
315_G318_L0.6800.98
324_S328_I0.6780.98
68_F73_L0.6780.98
16_A302_K0.6760.98
59_G62_F0.6760.98
299_V303_G0.6750.98
142_L145_G0.6740.98
61_L359_V0.6730.98
299_V326_I0.6730.98
198_G202_I0.6660.98
310_C315_G0.6650.98
119_F363_G0.6620.98
125_I318_L0.6600.98
142_L189_T0.6600.98
166_F217_T0.6600.98
148_P151_V0.6580.98
224_F228_E0.6570.98
91_I159_L0.6560.98
361_L364_S0.6550.98
229_D238_G0.6540.98
131_V152_M0.6540.98
294_F297_G0.6520.98
246_Y249_S0.6500.98
90_L164_P0.6490.98
77_K81_G0.6460.98
101_G272_H0.6440.98
132_Y149_P0.6420.98
146_V180_I0.6390.97
90_L93_L0.6380.97
174_L178_C0.6360.97
276_I280_I0.6360.97
64_L67_L0.6350.97
264_K283_E0.6350.97
51_Q55_L0.6340.97
333_N337_V0.6320.97
146_V150_V0.6280.97
45_N49_M0.6280.97
136_Q139_I0.6250.97
313_P317_L0.6240.97
356_S360_L0.6230.97
243_N269_P0.6200.97
43_S46_F0.6200.97
225_E229_D0.6200.97
360_L364_S0.6180.97
188_K192_R0.6180.97
220_R224_F0.6160.97
90_L160_I0.6150.97
138_Y144_T0.6150.97
70_Y318_L0.6120.97
130_A314_F0.6120.97
132_Y317_L0.6120.97
277_M293_I0.6080.97
67_L373_M0.6080.97
292_V296_L0.6060.97
80_K130_A0.6040.96
94_F104_Q0.6040.96
69_P315_G0.6040.96
245_Y249_S0.6020.96
135_K145_G0.6020.96
226_S238_G0.5990.96
79_Q126_L0.5970.96
226_S241_V0.5940.96
226_S230_P0.5930.96
57_A61_L0.5910.96
309_K372_S0.5900.96
88_L95_V0.5900.96
143_L147_A0.5880.96
225_E233_Y0.5880.96
304_F308_R0.5850.96
109_I113_S0.5820.96
191_V194_V0.5810.96
83_L152_M0.5810.96
365_M368_L0.5810.96
257_G282_E0.5810.96
93_L97_G0.5800.96
332_I336_G0.5780.95
123_V127_Y0.5740.95
225_E232_K0.5730.95
54_A58_G0.5730.95
164_P219_G0.5720.95
220_R227_L0.5710.95
129_A321_G0.5710.95
126_L367_I0.5700.95
298_F302_K0.5680.95
132_Y180_I0.5680.95
242_I246_Y0.5670.95
84_L87_V0.5660.95
98_H104_Q0.5650.95
58_G61_L0.5640.95
261_S282_E0.5630.95
101_G104_Q0.5620.95
105_S344_T0.5600.95
268_L279_V0.5600.95
8_S373_M0.5600.95
322_I371_I0.5590.95
74_A312_D0.5580.95
127_Y131_V0.5550.94
177_T194_V0.5530.94
129_A318_L0.5530.94
10_D372_S0.5520.94
83_L155_I0.5520.94
61_L64_L0.5510.94
306_I310_C0.5510.94
86_S119_F0.5510.94
19_L22_G0.5510.94
241_V245_Y0.5510.94
232_K238_G0.5500.94
114_I356_S0.5470.94
231_F238_G0.5460.94
286_I289_V0.5460.94
160_I169_A0.5460.94
25_L55_L0.5450.94
303_G365_M0.5450.94
51_Q358_L0.5440.94
135_K138_Y0.5440.94
247_A268_L0.5420.94
47_F50_R0.5410.94
77_K94_F0.5410.94
129_A317_L0.5410.94
24_G351_I0.5390.94
16_A19_L0.5380.93
70_Y374_F0.5380.93
135_K139_I0.5380.93
310_C319_A0.5370.93
29_Y33_M0.5370.93
361_L365_M0.5370.93
139_I142_L0.5350.93
362_L366_G0.5340.93
71_K74_A0.5320.93
242_I245_Y0.5310.93
105_S168_T0.5300.93
115_Q118_E0.5290.93
141_H144_T0.5290.93
54_A356_S0.5280.93
105_S163_Q0.5260.93
183_S317_L0.5260.93
65_M366_G0.5260.93
105_S346_V0.5240.93
244_S338_S0.5230.92
292_V330_S0.5230.92
155_I158_G0.5220.92
337_V343_I0.5220.92
66_A369_A0.5210.92
100_A104_Q0.5200.92
296_L350_F0.5190.92
322_I367_I0.5180.92
16_A294_F0.5160.92
331_F335_G0.5150.92
119_F123_V0.5150.92
339_G343_I0.5150.92
262_I265_Y0.5130.92
172_I176_A0.5110.92
226_S233_Y0.5110.92
98_H101_G0.5100.92
80_K91_I0.5100.92
54_A353_Y0.5090.91
322_I325_M0.5070.91
159_L163_Q0.5070.91
296_L351_I0.5070.91
13_L302_K0.5070.91
181_L190_L0.5040.91
177_T190_L0.5020.91
222_A232_K0.5020.91
244_S268_L0.5010.91
229_D233_Y0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.536 35.1 0.966 Contact Map
4px7A 1 0.5633 12.1 0.973 Contact Map
2cfqA 1 0.4417 10.5 0.973 Contact Map
4pd6A 3 0.5211 10.1 0.974 Contact Map
3wajA 1 0.7146 9.4 0.974 Contact Map
4x5mA 2 0.2333 6.7 0.976 Contact Map
3qe7A 2 0.7022 5.8 0.976 Contact Map
2rddB 1 0.0868 4.6 0.977 Contact Map
3sokA 1 0.1266 4.5 0.978 Contact Map
1oqwA 1 0.1266 3.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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