GREMLIN Database
YLAN - UPF0358 protein YlaN
UniProt: O07638 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (85)
Sequences: 194 (77)
Seq/√Len: 8.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_D57_E3.9530.97
54_L75_L2.8770.86
29_R33_D2.3980.74
54_L64_L2.0220.60
34_N63_R1.9850.59
11_Q76_L1.9690.58
47_L51_M1.9150.56
62_V66_L1.9100.56
38_P54_L1.9090.56
56_R86_L1.8910.55
10_R71_D1.8710.54
25_L82_E1.7900.51
23_K76_L1.6980.47
11_Q90_F1.6600.45
42_L59_D1.5620.41
28_I86_L1.5510.41
16_L56_R1.5350.40
36_T54_L1.5020.39
14_F75_L1.4490.37
36_T43_Y1.4310.36
35_L61_A1.4090.35
43_Y47_L1.3990.35
51_M77_Y1.3790.34
7_V78_T1.3050.31
46_V90_F1.2410.29
7_V85_A1.2370.29
38_P87_H1.1990.28
9_H68_D1.1850.27
30_V43_Y1.1820.27
7_V83_L1.1800.27
39_Q50_Q1.1350.26
6_I79_L1.1340.26
28_I51_M1.1300.25
36_T47_L1.1270.25
52_F82_E1.1250.25
73_K88_D1.1130.25
34_N47_L1.1080.25
6_I25_L1.1070.25
47_L66_L1.0950.24
39_Q64_L1.0710.24
23_K59_D1.0670.23
30_V36_T1.0600.23
41_P57_E1.0530.23
6_I15_E1.0350.23
25_L87_H1.0220.22
64_L86_L1.0170.22
68_D71_D1.0120.22
12_K26_K1.0040.22
16_L54_L0.9860.21
37_M41_P0.9770.21
13_A72_G0.9730.21
78_T84_S0.9720.21
26_K70_K0.9680.21
52_F77_Y0.9500.20
83_L86_L0.9380.20
29_R70_K0.9200.19
26_K69_E0.9110.19
50_Q87_H0.9000.19
18_K67_V0.8920.19
30_V66_L0.8820.18
18_K71_D0.8760.18
10_R19_V0.8490.18
55_S58_I0.8420.17
74_D78_T0.8410.17
21_A88_D0.8350.17
32_M89_A0.8300.17
58_I90_F0.8300.17
30_V47_L0.8210.17
6_I71_D0.8180.17
13_A28_I0.8090.17
22_E78_T0.7950.16
14_F83_L0.7920.16
6_I69_E0.7890.16
36_T89_A0.7860.16
18_K78_T0.7860.16
33_D65_G0.7700.16
42_L83_L0.7590.15
85_A90_F0.7560.15
52_F71_D0.7490.15
39_Q76_L0.7380.15
30_V51_M0.7300.15
14_F71_D0.7270.15
58_I85_A0.7160.15
19_V23_K0.7070.14
51_M56_R0.7070.14
63_R69_E0.6960.14
36_T57_E0.6860.14
51_M76_L0.6840.14
42_L47_L0.6830.14
10_R68_D0.6820.14
16_L75_L0.6820.14
36_T42_L0.6780.14
30_V37_M0.6750.14
19_V74_D0.6690.14
46_V80_E0.6670.14
73_K83_L0.6600.13
32_M88_D0.6590.13
37_M64_L0.6540.13
37_M56_R0.6490.13
39_Q84_S0.6410.13
19_V78_T0.6370.13
25_L74_D0.6300.13
14_F52_F0.6300.13
60_F67_V0.6220.13
74_D77_Y0.6080.12
28_I57_E0.6040.12
54_L76_L0.6040.12
12_K23_K0.6000.12
28_I81_R0.5910.12
54_L58_I0.5900.12
84_S89_A0.5890.12
43_Y73_K0.5850.12
36_T87_H0.5840.12
68_D85_A0.5810.12
26_K66_L0.5640.12
11_Q56_R0.5630.12
68_D81_R0.5610.12
6_I9_H0.5590.12
25_L59_D0.5580.12
29_R85_A0.5520.11
79_L84_S0.5420.11
15_E78_T0.5400.11
14_F69_E0.5330.11
16_L64_L0.5300.11
9_H34_N0.5190.11
37_M87_H0.5150.11
37_M52_F0.5090.11
6_I10_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gboA 4 0.8817 100 0.072 Contact Map
2odmA 2 0.9032 100 0.077 Contact Map
3iyuX 3 0.4301 27.6 0.925 Contact Map
3fzvA 4 0.6022 11.2 0.938 Contact Map
3czgA 1 0.4301 8.6 0.941 Contact Map
1zkrA 2 0.5914 7.8 0.942 Contact Map
3r4vA 1 0.8925 7 0.943 Contact Map
3o2tA 1 0.8925 7 0.943 Contact Map
1vw41 1 0.8602 6.9 0.943 Contact Map
1twfA 1 0.6882 6.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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