GREMLIN Database
GLSA2 - Glutaminase 2
UniProt: O07637 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (299)
Sequences: 1602 (1075)
Seq/√Len: 62.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_C200_E6.1831.00
145_R224_E4.8631.00
167_M174_Y4.2931.00
39_D59_K4.1711.00
218_R225_Q3.4071.00
166_S194_T3.3951.00
70_L209_I3.3511.00
45_Y207_A3.3331.00
78_E138_Y3.2971.00
41_S203_S3.0251.00
6_N10_E2.9761.00
210_G268_M2.9091.00
15_K299_I2.8041.00
11_A303_M2.6041.00
40_L296_L2.5741.00
257_I269_G2.5351.00
24_E27_S2.5331.00
53_S57_V2.4691.00
88_V123_V2.4541.00
247_A285_D2.3931.00
254_K298_E2.3711.00
60_T205_D2.2611.00
66_I266_G2.2511.00
19_V295_K2.2181.00
14_K17_K2.2101.00
35_A39_D2.1241.00
46_Y50_V2.0491.00
259_A269_G2.0281.00
163_Y191_D2.0271.00
137_D141_S2.0131.00
19_V22_K1.9981.00
26_A29_I1.9441.00
240_V252_A1.9161.00
31_A34_K1.9101.00
279_I293_G1.9021.00
58_E204_L1.8941.00
63_L67_S1.8901.00
83_K86_S1.8901.00
10_E54_A1.8811.00
140_L199_I1.8751.00
43_A204_L1.8631.00
45_Y51_C1.8591.00
219_H222_T1.8251.00
28_Y263_V1.8071.00
172_M176_M1.7771.00
13_V40_L1.7630.99
31_A157_E1.7600.99
67_S196_Q1.7550.99
163_Y194_T1.7470.99
31_A161_S1.7330.99
42_V296_L1.7250.99
77_M228_S1.7200.99
71_S139_L1.7060.99
93_T116_I1.6690.99
163_Y166_S1.6590.99
281_G292_A1.6580.99
60_T202_N1.6400.99
51_C204_L1.6380.99
269_G297_L1.6210.99
13_V54_A1.6050.99
121_L194_T1.6050.99
156_R195_K1.5990.99
42_V54_A1.5950.99
156_R160_E1.5830.99
84_V126_L1.5590.99
167_M177_K1.5430.99
16_A299_I1.5250.98
43_A53_S1.5190.98
66_I69_V1.5070.98
77_M231_V1.5020.98
29_I32_L1.4980.98
124_T192_L1.4590.98
73_A212_V1.4550.98
39_D56_D1.4410.98
53_S58_E1.4410.98
219_H226_V1.4280.98
271_S275_F1.4130.97
295_K298_E1.4070.97
139_L196_Q1.3800.97
244_M259_A1.3740.97
299_I303_M1.3730.97
58_E202_N1.3680.97
35_A264_S1.3620.97
208_K219_H1.3610.97
172_M175_Y1.3550.97
36_D39_D1.3430.97
143_I152_I1.3410.97
43_A203_S1.3390.97
34_K157_E1.3340.96
26_A263_V1.2990.96
142_F146_L1.2870.96
72_L85_F1.2810.96
129_G184_D1.2740.95
62_T158_V1.2680.95
210_G276_G1.2670.95
121_L166_S1.2480.95
101_I105_T1.2480.95
122_V176_M1.2450.95
228_S231_V1.2370.95
131_T134_E1.2310.94
160_E164_S1.2280.94
190_M194_T1.2230.94
30_P165_T1.2160.94
64_Q162_E1.2150.94
211_S220_P1.2150.94
39_D280_F1.2130.94
92_P242_C1.1900.93
136_L154_Y1.1790.93
28_Y32_L1.1770.93
185_D188_A1.1640.93
71_S143_I1.1620.93
91_E246_N1.1600.92
47_S215_L1.1550.92
213_F235_C1.1510.92
122_V181_I1.1440.92
25_V37_K1.1320.92
51_C207_A1.1310.91
12_L296_L1.1250.91
212_V219_H1.1190.91
53_S204_L1.1160.91
275_F306_L1.1060.91
101_I176_M1.1040.90
26_A32_L1.1010.90
71_S124_T1.1010.90
121_L189_V1.0940.90
60_T182_F1.0930.90
8_E303_M1.0920.90
129_G134_E1.0910.90
206_L278_G1.0900.90
30_P161_S1.0830.90
257_I270_I1.0810.90
267_I290_S1.0800.89
29_I162_E1.0760.89
71_S196_Q1.0630.89
103_L111_P1.0530.88
139_L192_L1.0520.88
295_K299_I1.0510.88
78_E128_R1.0460.88
87_Y183_E1.0350.87
47_S211_S1.0280.87
170_R187_E1.0280.87
46_Y52_L1.0210.87
168_I178_Q1.0190.87
121_L190_M1.0160.86
66_I206_L1.0150.86
144_R147_T1.0120.86
250_E254_K1.0050.86
29_I161_S0.9830.85
129_G135_R0.9820.84
10_E14_K0.9810.84
159_A163_Y0.9770.84
144_R150_Q0.9740.84
208_K212_V0.9700.84
209_I213_F0.9670.84
212_V226_V0.9610.83
184_D189_V0.9560.83
37_K283_A0.9520.83
13_V17_K0.9500.82
87_Y181_I0.9460.82
38_H283_A0.9440.82
51_C208_K0.9420.82
92_P111_P0.9410.82
283_A292_A0.9350.81
43_A51_C0.9330.81
259_A285_D0.9310.81
73_A213_F0.9270.81
42_V300_M0.9210.80
12_L299_I0.9210.80
170_R174_Y0.9140.80
71_S127_I0.9060.79
93_T112_L0.9050.79
144_R152_I0.8980.79
270_I276_G0.8970.79
85_F234_I0.8900.78
67_S71_S0.8860.78
234_I253_I0.8790.77
47_S214_A0.8760.77
8_E304_Y0.8710.77
132_V192_L0.8650.76
109_S112_L0.8600.76
44_I277_I0.8510.75
111_P162_E0.8490.75
147_T152_I0.8490.75
267_I279_I0.8460.74
16_A19_V0.8390.74
92_P246_N0.8360.74
76_L88_V0.8340.73
182_F189_V0.8320.73
127_I139_L0.8290.73
75_V79_Y0.8250.73
225_Q229_K0.8240.73
140_L144_R0.8220.72
63_L264_S0.8190.72
65_S68_K0.8170.72
6_N52_L0.8160.72
171_A174_Y0.8130.71
237_T307_S0.8110.71
147_T209_I0.8080.71
29_I33_A0.7980.70
252_A271_S0.7920.70
116_I242_C0.7910.69
130_R134_E0.7890.69
91_E242_C0.7880.69
41_S57_V0.7880.69
91_E94_G0.7850.69
250_E266_G0.7840.69
150_Q205_D0.7830.69
244_M285_D0.7800.68
143_I199_I0.7790.68
124_T196_Q0.7750.68
154_Y195_K0.7710.67
28_Y161_S0.7690.67
158_V161_S0.7680.67
23_G32_L0.7680.67
137_D140_L0.7610.66
122_V125_S0.7610.66
103_L112_L0.7590.66
13_V296_L0.7580.66
60_T151_E0.7550.66
271_S274_D0.7520.65
131_T135_R0.7480.65
92_P103_L0.7470.65
25_V33_A0.7470.65
62_T280_F0.7450.65
240_V309_F0.7440.65
45_Y49_N0.7430.65
46_Y213_F0.7420.64
42_V279_I0.7410.64
62_T159_A0.7400.64
141_S145_R0.7380.64
227_I232_A0.7370.64
188_A191_D0.7340.64
153_T200_E0.7330.64
9_L248_S0.7270.63
230_D302_E0.7250.63
12_L16_A0.7240.63
32_L161_S0.7240.63
104_E109_S0.7240.63
37_K281_G0.7230.62
240_V308_I0.7180.62
65_S245_Y0.7150.62
64_Q198_A0.7130.61
117_N169_N0.7120.61
68_K245_Y0.7100.61
217_G220_P0.7090.61
104_E107_N0.7090.61
231_V235_C0.7040.60
21_D283_A0.7010.60
162_E263_V0.7010.60
155_C158_V0.7000.60
26_A165_T0.6990.60
18_K21_D0.6960.59
163_Y190_M0.6950.59
83_K134_E0.6930.59
222_T238_F0.6920.59
215_L220_P0.6910.59
176_M182_F0.6900.59
56_D280_F0.6890.59
9_L13_V0.6880.59
140_L151_E0.6850.58
25_V283_A0.6810.58
247_A294_V0.6810.58
100_I172_M0.6800.58
117_N260_K0.6780.58
272_P281_G0.6780.58
129_G138_Y0.6760.57
29_I263_V0.6760.57
79_Y126_L0.6730.57
31_A158_V0.6720.57
75_V255_V0.6710.57
251_F255_V0.6660.56
167_M187_E0.6650.56
98_N116_I0.6650.56
132_V135_R0.6650.56
146_L227_I0.6640.56
168_I179_Y0.6620.56
40_L292_A0.6620.56
73_A146_L0.6590.55
165_T170_R0.6580.55
45_Y208_K0.6580.55
17_K56_D0.6570.55
170_R190_M0.6530.55
296_L300_M0.6480.54
148_N211_S0.6470.54
26_A162_E0.6420.53
32_L62_T0.6400.53
236_K270_I0.6390.53
263_V288_G0.6380.53
241_T252_A0.6360.53
141_S151_E0.6330.52
92_P252_A0.6330.52
63_L108_P0.6320.52
7_D14_K0.6320.52
291_I294_V0.6320.52
245_Y260_K0.6310.52
159_A191_D0.6310.52
12_L15_K0.6310.52
94_G249_G0.6300.52
60_T200_E0.6300.52
6_N17_K0.6290.52
160_E163_Y0.6260.52
255_V301_S0.6250.52
73_A227_I0.6240.51
260_K263_V0.6230.51
16_A295_K0.6230.51
162_E198_A0.6210.51
95_D241_T0.6180.51
11_A18_K0.6180.51
76_L231_V0.6170.51
13_V292_A0.6140.50
218_R222_T0.6130.50
159_A198_A0.6130.50
124_T139_L0.6110.50
182_F196_Q0.6100.50
69_V115_M0.6040.49
185_D232_A0.6020.49
283_A291_I0.6010.49
214_A217_G0.6010.49
247_A250_E0.5990.49
113_N199_I0.5970.48
210_G275_F0.5960.48
29_I97_F0.5930.48
204_L208_K0.5930.48
133_K195_K0.5900.48
140_L286_E0.5890.47
70_L213_F0.5880.47
23_G29_I0.5860.47
136_L195_K0.5850.47
41_S60_T0.5850.47
88_V111_P0.5820.47
75_V192_L0.5810.46
47_S216_N0.5810.46
24_E130_R0.5790.46
9_L95_D0.5790.46
211_S214_A0.5780.46
139_L172_M0.5770.46
197_C263_V0.5770.46
218_R221_E0.5760.46
285_D289_N0.5760.46
25_V166_S0.5760.46
64_Q263_V0.5750.46
267_I293_G0.5740.46
45_Y211_S0.5730.46
159_A195_K0.5730.46
73_A235_C0.5730.46
175_Y248_S0.5730.46
105_T175_Y0.5700.45
10_E38_H0.5680.45
70_L143_I0.5680.45
9_L54_A0.5680.45
29_I64_Q0.5680.45
217_G226_V0.5670.45
44_I271_S0.5660.45
115_M244_M0.5650.45
227_I231_V0.5650.45
234_I264_S0.5650.45
173_C182_F0.5630.44
94_G246_N0.5630.44
67_S98_N0.5620.44
25_V194_T0.5600.44
74_L127_I0.5600.44
152_I235_C0.5590.44
298_E302_E0.5590.44
47_S208_K0.5590.44
92_P116_I0.5590.44
152_I274_D0.5580.44
10_E22_K0.5570.44
211_S215_L0.5560.44
44_I275_F0.5550.44
23_G162_E0.5550.44
134_E138_Y0.5540.43
155_C268_M0.5520.43
128_R182_F0.5520.43
64_Q168_I0.5510.43
74_L142_F0.5510.43
123_V126_L0.5510.43
15_K303_M0.5500.43
175_Y251_F0.5490.43
24_E286_E0.5480.43
152_I201_M0.5470.43
245_Y263_V0.5470.43
73_A231_V0.5450.42
238_F246_N0.5430.42
25_V186_V0.5430.42
64_Q91_E0.5420.42
215_L302_E0.5420.42
135_R188_A0.5420.42
50_V121_L0.5400.42
69_V239_M0.5390.42
279_I297_L0.5390.42
137_D151_E0.5370.42
231_V234_I0.5370.42
26_A161_S0.5370.42
116_I181_I0.5360.41
117_N197_C0.5360.41
90_Q253_I0.5350.41
62_T115_M0.5350.41
173_C186_V0.5340.41
31_A164_S0.5340.41
65_S117_N0.5340.41
9_L44_I0.5330.41
72_L235_C0.5320.41
36_D223_G0.5310.41
268_M278_G0.5310.41
108_P235_C0.5290.41
56_D59_K0.5290.41
127_I207_A0.5290.41
57_V60_T0.5280.41
18_K22_K0.5260.40
242_C297_L0.5250.40
69_V152_I0.5250.40
139_L147_T0.5240.40
217_G222_T0.5240.40
34_K204_L0.5230.40
206_L266_G0.5220.40
78_E129_G0.5210.40
10_E137_D0.5210.40
85_F264_S0.5190.40
97_F260_K0.5170.39
159_A298_E0.5170.39
11_A15_K0.5170.39
59_K202_N0.5170.39
237_T240_V0.5170.39
145_R226_V0.5150.39
17_K86_S0.5140.39
73_A194_T0.5140.39
174_Y276_G0.5140.39
59_K280_F0.5110.39
45_Y214_A0.5100.39
92_P241_T0.5100.39
97_F117_N0.5100.39
237_T253_I0.5090.38
11_A14_K0.5080.38
24_E160_E0.5080.38
166_S246_N0.5070.38
228_S270_I0.5060.38
147_T150_Q0.5050.38
113_N242_C0.5040.38
21_D38_H0.5040.38
172_M232_A0.5040.38
202_N205_D0.5020.38
244_M250_E0.5020.38
68_K117_N0.5010.38
125_S159_A0.5010.38
27_S58_E0.5010.38
99_S104_E0.5010.38
126_L220_P0.5010.38
212_V222_T0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pbyA 3 0.945 100 -0.009 Contact Map
1u60A 4 0.9903 100 0.001 Contact Map
1mkiA 3 0.9579 100 0.006 Contact Map
4bqmA 3 0.9741 100 0.015 Contact Map
3uo9A 3 0.9871 100 0.017 Contact Map
3agdA 2 0.9871 100 0.042 Contact Map
1ghpA 1 0.754 98.6 0.915 Contact Map
4m3kA 1 0.7573 98.4 0.919 Contact Map
4ua6A 1 0.7702 98.1 0.925 Contact Map
1n9bA 1 0.7767 98 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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