GREMLIN Database
YLAL - Uncharacterized protein YlaL
UniProt: O07636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (158)
Sequences: 182 (146)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_F158_I4.0910.99
65_T69_E4.0320.99
140_I155_V3.7590.99
73_E76_K3.6190.99
66_L69_E3.5340.98
83_A122_I2.8060.93
105_V159_E2.6280.90
135_G154_D2.4640.87
86_L90_L2.1900.80
29_S83_A2.1700.79
82_F132_I2.1580.79
74_K88_T2.1320.78
132_I135_G2.0730.76
123_V138_V2.0290.74
123_V158_I2.0010.73
16_I25_D1.9880.73
65_T68_T1.9770.72
3_V94_E1.9580.72
91_K119_L1.9340.71
25_D64_P1.9180.70
121_S140_I1.8910.69
25_D54_R1.8610.67
9_N98_S1.8000.65
12_Y95_P1.7790.64
54_R66_L1.7330.62
34_G146_V1.7290.62
74_K82_F1.7170.61
84_M90_L1.7150.61
54_R64_P1.7010.60
41_L45_G1.6960.60
49_D104_F1.6950.60
9_N96_N1.6530.58
44_A51_D1.6490.58
81_S124_H1.6220.56
71_Q153_T1.5980.55
64_P69_E1.5950.55
135_G153_T1.5680.54
29_S32_R1.5650.54
33_K83_A1.5200.51
86_L102_C1.4810.49
137_P151_P1.4730.49
46_D53_E1.4240.47
49_D55_V1.4220.47
20_V73_E1.4200.46
128_A140_I1.3980.45
93_A138_V1.3690.44
47_E155_V1.3460.43
48_S51_D1.3450.43
144_D147_H1.2790.40
34_G145_P1.2760.40
7_K157_E1.2730.39
19_S104_F1.2480.38
61_I64_P1.2390.38
46_D49_D1.2090.36
52_P56_I1.1980.36
39_T45_G1.1980.36
9_N109_G1.1720.35
59_G126_S1.1550.34
19_S68_T1.1540.34
35_D117_T1.1510.34
12_Y25_D1.1420.33
99_A115_L1.1290.33
61_I66_L1.1240.33
31_D91_K1.1160.32
61_I65_T1.1130.32
48_S114_S1.1080.32
64_P68_T1.0740.31
58_E66_L1.0610.30
83_A118_A1.0590.30
60_R116_E1.0550.30
29_S80_G1.0490.29
30_F33_K1.0480.29
32_R80_G1.0340.29
92_N99_A1.0190.28
124_H141_Y0.9990.27
44_A55_V0.9870.27
61_I69_E0.9840.27
29_S122_I0.9840.27
9_N70_K0.9840.27
58_E69_E0.9810.27
103_V109_G0.9800.27
28_F85_R0.9720.26
77_L124_H0.9610.26
124_H127_E0.9540.26
93_A99_A0.9370.25
7_K160_I0.9370.25
138_V155_V0.9360.25
42_Q114_S0.9310.25
146_V151_P0.9170.24
5_Q13_P0.9150.24
29_S60_R0.9020.24
16_I123_V0.9000.24
44_A49_D0.8950.24
58_E80_G0.8900.23
3_V81_S0.8780.23
25_D65_T0.8750.23
5_Q141_Y0.8560.22
28_F71_Q0.8550.22
56_I65_T0.8470.22
28_F81_S0.8440.22
59_G69_E0.8430.22
42_Q74_K0.8400.22
121_S155_V0.8390.22
100_T112_A0.8040.20
71_Q128_A0.8030.20
106_T155_V0.8010.20
97_S110_K0.7950.20
67_K90_L0.7930.20
14_I154_D0.7880.20
147_H151_P0.7870.20
95_P125_F0.7850.20
107_S110_K0.7840.20
52_P88_T0.7760.20
28_F82_F0.7730.20
12_Y88_T0.7730.20
118_A122_I0.7720.19
34_G147_H0.7710.19
98_S128_A0.7680.19
19_S126_S0.7670.19
46_D55_V0.7580.19
49_D75_Q0.7560.19
102_C118_A0.7550.19
88_T125_F0.7480.19
84_M126_S0.7390.18
78_M122_I0.7350.18
4_I14_I0.7320.18
30_F76_K0.7320.18
25_D68_T0.7310.18
20_V139_H0.7290.18
99_A114_S0.7260.18
11_T114_S0.7170.18
6_V103_V0.7120.18
136_G151_P0.7080.18
44_A59_G0.7070.18
18_P136_G0.7010.17
9_N75_Q0.7000.17
39_T108_S0.6950.17
4_I75_Q0.6930.17
37_Q110_K0.6910.17
12_Y94_E0.6900.17
36_S98_S0.6850.17
18_P131_P0.6830.17
91_K150_Q0.6810.17
86_L123_V0.6790.17
4_I7_K0.6730.17
96_N111_A0.6720.17
33_K82_F0.6710.17
68_T130_K0.6690.16
49_D77_L0.6680.16
52_P55_V0.6650.16
49_D53_E0.6580.16
56_I135_G0.6540.16
75_Q113_V0.6530.16
12_Y47_E0.6530.16
27_K102_C0.6520.16
128_A153_T0.6390.16
118_A126_S0.6390.16
32_R102_C0.6380.16
107_S112_A0.6320.16
61_I142_F0.6310.15
41_L44_A0.6290.15
73_E78_M0.6250.15
4_I66_L0.6240.15
131_P139_H0.6240.15
52_P89_V0.6230.15
34_G152_I0.6230.15
31_D148_H0.6220.15
20_V131_P0.6210.15
150_Q153_T0.6200.15
82_F133_Q0.6200.15
100_T157_E0.6170.15
109_G141_Y0.6160.15
7_K128_A0.6130.15
131_P151_P0.6120.15
53_E141_Y0.6120.15
108_S153_T0.6100.15
48_S139_H0.6080.15
36_S115_L0.6080.15
70_K76_K0.6050.15
107_S156_K0.6010.15
34_G151_P0.6010.15
58_E65_T0.5980.15
46_D139_H0.5940.15
137_P145_P0.5930.15
36_S149_K0.5900.14
45_G74_K0.5900.14
6_V87_G0.5880.14
9_N120_N0.5870.14
63_P104_F0.5840.14
9_N123_V0.5840.14
81_S121_S0.5790.14
9_N97_S0.5780.14
82_F90_L0.5750.14
79_N141_Y0.5740.14
64_P67_K0.5710.14
156_K160_I0.5680.14
62_A78_M0.5670.14
7_K159_E0.5650.14
11_T94_E0.5600.14
13_P68_T0.5580.14
104_F121_S0.5570.14
95_P128_A0.5550.14
49_D159_E0.5540.14
87_G121_S0.5540.14
90_L118_A0.5520.14
3_V159_E0.5510.14
98_S105_V0.5500.14
46_D85_R0.5500.14
35_D48_S0.5500.14
76_K131_P0.5490.13
22_I26_R0.5440.13
101_Q114_S0.5410.13
14_I75_Q0.5400.13
14_I84_M0.5380.13
49_D60_R0.5380.13
19_S128_A0.5360.13
33_K124_H0.5360.13
59_G82_F0.5330.13
16_I65_T0.5320.13
11_T153_T0.5320.13
45_G49_D0.5300.13
94_E147_H0.5290.13
76_K104_F0.5260.13
103_V159_E0.5260.13
20_V153_T0.5250.13
9_N100_T0.5230.13
6_V67_K0.5220.13
75_Q79_N0.5200.13
66_L85_R0.5120.13
97_S134_E0.5100.13
10_V13_P0.5080.13
62_A122_I0.5070.13
41_L113_V0.5040.12
11_T96_N0.5030.12
5_Q75_Q0.5030.12
10_V90_L0.5010.12
4_I16_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2biiA 2 0.8447 98.8 0.845 Contact Map
2xtsA 2 0.8571 98.2 0.874 Contact Map
2bihA 2 0.8882 98.1 0.876 Contact Map
1xdyA 3 0.7764 98 0.878 Contact Map
2blfA 1 0.9441 98 0.88 Contact Map
4pw3A 2 0.9689 97.9 0.882 Contact Map
1ogpA 4 0.9193 97.3 0.895 Contact Map
2a9dA 2 0.9317 97.2 0.897 Contact Map
1soxA 2 0.9317 96.4 0.907 Contact Map
3a24A 1 0.3789 17.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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