GREMLIN Database
YLAK - Uncharacterized protein YlaK
UniProt: O07635 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (428)
Sequences: 1097 (573)
Seq/√Len: 27.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_L422_G8.9551.00
360_F388_V5.8741.00
163_K195_Q5.2331.00
12_L54_V4.7101.00
250_E276_Q4.3311.00
13_L40_K3.6751.00
244_L272_A3.6081.00
4_I124_V3.3561.00
273_G360_F3.3551.00
196_F246_L3.3431.00
398_H401_L3.1831.00
129_K146_D3.1711.00
196_F245_E3.1141.00
361_I385_S2.9531.00
252_I422_G2.9121.00
198_L238_V2.7741.00
230_I244_L2.6971.00
243_A257_L2.6610.99
288_V317_I2.6190.99
211_G220_L2.5890.99
276_Q280_L2.4900.99
254_L434_L2.3980.99
159_Y195_Q2.3360.99
250_E282_I2.3070.98
191_F197_A2.2810.98
291_P348_L2.2360.98
14_Q150_D2.1910.98
66_R69_E2.1890.98
26_E122_R2.1870.98
101_D104_I2.1610.98
20_F57_L2.1590.98
244_L268_L2.1530.98
39_S99_T2.1200.97
273_G286_L2.0970.97
73_L79_L2.0850.97
415_F421_S2.0530.97
253_P433_G2.0440.97
7_L12_L2.0250.96
176_Y208_S2.0110.96
331_G335_A1.9990.96
128_S144_A1.9560.96
297_K373_E1.9400.95
38_D41_K1.9230.95
26_E80_R1.9090.95
389_L411_V1.9070.95
41_K130_D1.8900.95
167_I199_M1.8880.95
319_D354_R1.8630.94
233_I267_L1.8300.94
413_E416_K1.8270.94
129_K136_K1.7980.93
133_V242_M1.7890.93
14_Q405_N1.7780.93
275_L280_L1.7730.93
13_L47_V1.7610.92
294_P349_T1.7530.92
201_D206_S1.7350.92
15_D147_F1.7290.92
128_S355_S1.7270.92
172_F176_Y1.7120.91
10_N38_D1.6940.91
4_I26_E1.6900.91
4_I122_R1.6820.91
253_P420_I1.6810.91
6_V107_V1.6640.90
180_Q233_I1.6580.90
13_L51_A1.6570.90
230_I275_L1.6340.89
82_E85_H1.6320.89
169_Q172_F1.6250.89
137_A144_A1.5990.88
436_Q440_D1.5970.88
109_K112_S1.5840.88
21_S149_N1.5810.88
256_T423_S1.5780.88
62_R67_L1.5550.87
8_D11_V1.5460.86
229_H234_R1.5320.86
6_V28_V1.5160.85
41_K52_R1.5090.85
105_L133_V1.5080.85
59_D134_R1.5070.85
150_D436_Q1.5000.85
196_F422_G1.4950.85
56_K130_D1.4920.84
10_N41_K1.4880.84
184_N190_A1.4850.84
142_L197_A1.4840.84
358_D384_G1.4710.84
24_E77_G1.4650.83
35_E102_N1.4640.83
4_I28_V1.4640.83
125_I301_Y1.4590.83
136_K146_D1.4560.83
164_D200_K1.4490.83
62_R138_D1.4470.82
173_S182_S1.4320.82
19_I39_S1.4300.82
361_I387_I1.4260.82
192_Y416_K1.4170.81
25_N77_G1.4140.81
419_P433_G1.4060.81
169_Q173_S1.4060.81
283_Y298_D1.4050.81
306_K347_A1.4040.81
269_A390_M1.3930.80
320_N381_V1.3920.80
173_S176_Y1.3900.80
58_I79_L1.3900.80
270_L320_N1.3870.80
162_Y242_M1.3860.80
277_T388_V1.3860.80
49_R412_V1.3800.79
10_N70_H1.3650.79
41_K56_K1.3640.79
36_E41_K1.3640.79
151_R405_N1.3580.78
289_A348_L1.3540.78
348_L351_I1.3530.78
352_R397_D1.3380.77
30_P33_V1.3330.77
37_V55_S1.3320.77
20_F360_F1.3180.76
285_K359_Q1.3180.76
51_A233_I1.3140.76
125_I143_L1.3110.76
164_D195_Q1.3100.76
187_K419_P1.3090.76
128_S324_L1.3050.75
109_K126_L1.2980.75
2_S26_E1.2970.75
49_R324_L1.2950.75
231_W324_L1.2920.75
109_K140_I1.2740.74
43_Y48_G1.2730.73
3_K25_N1.2690.73
34_L131_V1.2630.73
80_R177_G1.2520.72
36_E52_R1.2490.72
133_V312_P1.2410.72
381_V434_L1.2400.71
257_L424_V1.2300.71
10_N14_Q1.2170.70
270_L321_L1.2110.70
34_L350_Y1.2080.69
284_K326_N1.2040.69
102_N136_K1.2020.69
52_R56_K1.2020.69
368_N401_L1.1950.69
35_E136_K1.1900.68
286_L337_L1.1810.68
384_G418_Q1.1750.67
125_I185_D1.1720.67
82_E103_R1.1700.67
48_G65_G1.1630.66
356_I387_I1.1610.66
193_P417_G1.1600.66
331_G334_D1.1570.66
32_V97_E1.1560.66
168_S218_T1.1480.65
233_I385_S1.1440.65
14_Q132_L1.1430.65
212_I245_E1.1420.65
19_I301_Y1.1370.65
416_K425_K1.1330.64
80_R220_L1.1310.64
21_S147_F1.1290.64
169_Q233_I1.1280.64
35_E375_K1.1260.64
292_I315_Q1.1230.64
190_A220_L1.1200.63
326_N358_D1.1190.63
257_L409_A1.1160.63
289_A401_L1.1080.63
378_L387_I1.1050.62
6_V111_L1.1050.62
85_H103_R1.1030.62
256_T310_L1.0890.61
299_I350_Y1.0870.61
3_K123_P1.0850.61
38_D56_K1.0820.61
381_V385_S1.0790.61
32_V100_N1.0770.60
40_K43_Y1.0750.60
123_P143_L1.0700.60
317_I324_L1.0680.60
384_G417_G1.0680.60
438_A442_L1.0680.60
63_Q251_D1.0660.60
145_E150_D1.0570.59
52_R130_D1.0560.59
14_Q146_D1.0540.59
194_N212_I1.0540.59
84_N110_N1.0520.59
128_S331_G1.0510.58
247_L272_A1.0490.58
305_E308_E1.0480.58
284_K358_D1.0450.58
258_I425_K1.0430.58
243_A268_L1.0380.57
129_K147_F1.0370.57
199_M211_G1.0310.57
72_P75_T1.0250.57
296_G313_W1.0230.56
260_K440_D1.0180.56
181_I301_Y1.0160.56
16_P435_A1.0150.56
65_G273_G1.0150.56
64_K142_L1.0120.56
198_L208_S1.0110.55
3_K145_E1.0090.55
250_E280_L1.0040.55
58_I121_G0.9980.54
392_D437_L0.9960.54
55_S235_P0.9960.54
346_E359_Q0.9880.54
250_E389_L0.9880.54
53_H144_A0.9860.54
53_H57_L0.9850.53
301_Y305_E0.9830.53
20_F28_V0.9810.53
305_E324_L0.9770.53
182_S286_L0.9760.53
22_F70_H0.9740.53
332_E335_A0.9710.52
312_P379_T0.9710.52
120_N123_P0.9690.52
72_P78_T0.9690.52
171_L174_S0.9670.52
138_D356_I0.9570.51
173_S207_S0.9540.51
29_I51_A0.9520.51
14_Q70_H0.9510.51
19_I170_Q0.9510.51
144_A427_L0.9510.51
181_I184_N0.9480.51
260_K436_Q0.9460.51
270_L378_L0.9410.50
208_S238_V0.9400.50
126_L312_P0.9390.50
63_Q184_N0.9380.50
24_E145_E0.9380.50
125_I145_E0.9370.50
312_P429_G0.9360.50
2_S6_V0.9350.50
62_R65_G0.9340.50
126_L133_V0.9330.50
273_G288_V0.9310.49
167_I171_L0.9290.49
51_A81_I0.9260.49
168_S171_L0.9210.49
10_N102_N0.9150.48
316_P346_E0.9140.48
34_L363_I0.9130.48
14_Q147_F0.9100.48
165_L307_E0.9090.48
143_L419_P0.9060.47
237_N379_T0.9050.47
82_E110_N0.9050.47
369_L376_T0.8970.47
28_V82_E0.8890.46
139_A235_P0.8880.46
166_Y202_E0.8860.46
302_L319_D0.8790.45
136_K371_R0.8750.45
25_N316_P0.8710.45
202_E220_L0.8680.45
242_M246_L0.8680.45
378_L411_V0.8680.45
161_G435_A0.8600.44
212_I417_G0.8590.44
437_L441_L0.8580.44
302_L354_R0.8580.44
12_L16_P0.8530.43
68_H440_D0.8530.43
379_T429_G0.8530.43
55_S132_L0.8500.43
239_Q390_M0.8480.43
37_V286_L0.8470.43
384_G422_G0.8460.43
136_K150_D0.8450.43
391_G396_I0.8450.43
389_L392_D0.8450.43
249_R252_I0.8430.43
133_V379_T0.8420.43
146_D370_T0.8390.42
297_K372_H0.8350.42
128_S424_V0.8340.42
78_T233_I0.8340.42
267_L323_F0.8320.42
310_L313_W0.8310.42
176_Y209_A0.8280.42
247_L268_L0.8240.41
361_I381_V0.8220.41
36_E130_D0.8180.41
175_F222_R0.8170.41
128_S301_Y0.8170.41
85_H110_N0.8170.41
38_D130_D0.8170.41
70_H150_D0.8150.41
149_N370_T0.8100.40
260_K437_L0.8090.40
182_S185_D0.8080.40
368_N396_I0.8070.40
429_G439_A0.8060.40
305_E323_F0.8030.40
84_N103_R0.7990.39
434_L438_A0.7970.39
418_Q437_L0.7970.39
97_E103_R0.7970.39
269_A273_G0.7960.39
18_A108_A0.7940.39
8_D130_D0.7930.39
170_Q417_G0.7900.39
351_I373_E0.7890.39
40_K132_L0.7880.39
40_K371_R0.7860.39
77_G312_P0.7850.38
282_I386_K0.7850.38
174_S219_V0.7840.38
37_V381_V0.7820.38
15_D21_S0.7790.38
380_R395_Q0.7780.38
37_V54_V0.7770.38
31_A95_F0.7760.38
256_T294_P0.7710.37
313_W376_T0.7710.37
320_N368_N0.7700.37
193_P215_K0.7680.37
316_P406_N0.7680.37
82_E107_V0.7650.37
30_P136_K0.7630.37
10_N132_L0.7610.37
26_E78_T0.7600.37
146_D299_I0.7550.36
432_S435_A0.7530.36
192_Y417_G0.7530.36
420_I437_L0.7530.36
35_E324_L0.7530.36
168_S202_E0.7530.36
170_Q173_S0.7490.36
378_L401_L0.7480.36
5_Y25_N0.7460.36
313_W349_T0.7450.36
123_P224_V0.7440.36
274_L379_T0.7440.36
12_L213_A0.7430.35
24_E105_L0.7410.35
59_D320_N0.7390.35
273_G278_E0.7380.35
10_N36_E0.7370.35
165_L173_S0.7360.35
291_P402_D0.7340.35
39_S424_V0.7340.35
213_A216_T0.7330.35
158_M161_G0.7310.35
157_E160_S0.7310.35
316_P373_E0.7310.35
382_G432_S0.7300.35
245_E394_E0.7270.34
266_T377_L0.7270.34
242_M379_T0.7250.34
95_F270_L0.7230.34
48_G392_D0.7230.34
380_R391_G0.7220.34
391_G395_Q0.7220.34
127_V139_A0.7220.34
181_I186_V0.7180.34
39_S75_T0.7180.34
57_L144_A0.7170.34
124_V416_K0.7140.33
379_T387_I0.7140.33
64_K160_S0.7110.33
22_F129_K0.7090.33
112_S143_L0.7070.33
41_K104_I0.7060.33
31_A97_E0.7050.33
391_G406_N0.7040.33
379_T438_A0.7020.33
53_H424_V0.7000.33
263_T430_E0.6990.32
20_F387_I0.6950.32
138_D393_P0.6940.32
39_S100_N0.6890.32
215_K233_I0.6860.32
295_V376_T0.6860.32
66_R135_V0.6830.31
27_V64_K0.6830.31
289_A293_V0.6820.31
258_I412_V0.6820.31
232_G356_I0.6800.31
349_T415_F0.6790.31
345_V429_G0.6770.31
69_E75_T0.6750.31
128_S416_K0.6740.31
303_P312_P0.6730.31
5_Y378_L0.6730.31
69_E167_I0.6720.31
18_A256_T0.6710.31
371_R385_S0.6690.30
249_R264_G0.6690.30
284_K322_E0.6670.30
396_I400_Y0.6650.30
386_K438_A0.6640.30
140_I194_N0.6640.30
239_Q253_P0.6630.30
375_K379_T0.6620.30
267_L429_G0.6610.30
22_F30_P0.6600.30
124_V409_A0.6590.30
184_N307_E0.6590.30
10_N130_D0.6570.30
213_A217_G0.6560.30
190_A419_P0.6530.29
25_N145_E0.6500.29
77_G106_A0.6490.29
60_A81_I0.6490.29
417_G421_S0.6480.29
235_P418_Q0.6480.29
126_L333_L0.6470.29
31_A239_Q0.6470.29
159_Y409_A0.6450.29
200_K214_D0.6450.29
163_K417_G0.6440.29
135_V148_L0.6430.29
19_I27_V0.6430.29
5_Y418_Q0.6420.29
124_V261_A0.6410.29
374_V389_L0.6400.29
126_L150_D0.6370.28
313_W415_F0.6360.28
373_E376_T0.6350.28
37_V121_G0.6350.28
170_Q221_K0.6350.28
294_P348_L0.6350.28
270_L401_L0.6330.28
7_L32_V0.6330.28
291_P315_Q0.6330.28
3_K125_I0.6300.28
295_V350_Y0.6300.28
60_A174_S0.6290.28
292_I349_T0.6290.28
291_P294_P0.6260.28
166_Y424_V0.6260.28
92_Q278_E0.6250.28
85_H440_D0.6240.28
184_N219_V0.6240.28
23_E123_P0.6240.28
178_K234_R0.6240.28
173_S211_G0.6230.28
132_L371_R0.6220.28
131_V426_L0.6210.27
348_L387_I0.6210.27
194_N422_G0.6210.27
311_K318_F0.6190.27
65_G301_Y0.6180.27
298_D387_I0.6180.27
392_D402_D0.6170.27
277_T283_Y0.6160.27
169_Q202_E0.6160.27
135_V235_P0.6160.27
111_L370_T0.6150.27
80_R111_L0.6140.27
182_S219_V0.6140.27
316_P402_D0.6140.27
192_Y195_Q0.6140.27
52_R101_D0.6140.27
58_I143_L0.6130.27
314_M430_E0.6130.27
326_N441_L0.6130.27
306_K361_I0.6130.27
328_K355_S0.6120.27
89_H111_L0.6110.27
259_G392_D0.6110.27
391_G408_L0.6110.27
63_Q174_S0.6110.27
310_L321_L0.6110.27
52_R104_I0.6080.27
266_T396_I0.6080.27
213_A248_L0.6070.27
38_D132_L0.6050.27
34_L251_D0.6040.26
76_G344_Q0.6030.26
291_P392_D0.6020.26
10_N195_Q0.6010.26
214_D221_K0.6010.26
196_F242_M0.6000.26
392_D406_N0.5990.26
363_I401_L0.5990.26
194_N252_I0.5970.26
178_K301_Y0.5970.26
212_I249_R0.5950.26
34_L301_Y0.5950.26
275_L279_D0.5950.26
143_L190_A0.5950.26
320_N401_L0.5940.26
60_A164_D0.5940.26
315_Q351_I0.5920.26
297_K306_K0.5910.26
423_S437_L0.5910.26
257_L376_T0.5890.26
178_K185_D0.5890.26
46_E57_L0.5880.26
62_R317_I0.5880.26
58_I277_T0.5880.26
395_Q431_R0.5860.25
380_R431_R0.5860.25
66_R87_S0.5850.25
29_I128_S0.5850.25
8_D41_K0.5840.25
70_H434_L0.5840.25
166_Y170_Q0.5830.25
169_Q201_D0.5820.25
269_A400_Y0.5810.25
32_V311_K0.5810.25
351_I372_H0.5780.25
237_N267_L0.5780.25
78_T219_V0.5760.25
133_V150_D0.5760.25
91_L107_V0.5760.25
75_T220_L0.5750.25
420_I433_G0.5740.25
172_F186_V0.5740.25
64_K185_D0.5730.25
157_E416_K0.5730.25
177_G228_E0.5700.24
285_K383_E0.5700.24
298_D360_F0.5700.24
289_A310_L0.5680.24
195_Q416_K0.5680.24
214_D249_R0.5670.24
14_Q24_E0.5660.24
9_T52_R0.5640.24
417_G424_V0.5640.24
424_V427_L0.5640.24
80_R305_E0.5630.24
320_N361_I0.5620.24
96_I301_Y0.5620.24
381_V387_I0.5590.24
235_P397_D0.5590.24
352_R367_Q0.5580.24
31_A132_L0.5550.24
147_F269_A0.5540.24
23_E105_L0.5520.23
93_E192_Y0.5510.23
146_D371_R0.5500.23
391_G431_R0.5500.23
95_F371_R0.5490.23
348_L356_I0.5470.23
294_P372_H0.5460.23
412_V423_S0.5450.23
275_L286_L0.5450.23
195_Q244_L0.5450.23
172_F374_V0.5450.23
112_S440_D0.5450.23
184_N216_T0.5440.23
101_D236_K0.5430.23
90_Q174_S0.5420.23
381_V386_K0.5410.23
83_L426_L0.5410.23
247_L384_G0.5400.23
92_Q95_F0.5390.23
263_T429_G0.5380.23
34_L390_M0.5370.23
277_T426_L0.5360.23
209_A349_T0.5360.23
289_A373_E0.5360.23
127_V270_L0.5340.23
57_L60_A0.5330.22
239_Q389_L0.5330.22
368_N399_P0.5310.22
277_T342_S0.5310.22
86_R301_Y0.5310.22
8_D52_R0.5310.22
172_F184_N0.5310.22
226_D251_D0.5300.22
174_S185_D0.5300.22
2_S121_G0.5300.22
108_A120_N0.5290.22
246_L361_I0.5290.22
266_T368_N0.5270.22
248_L308_E0.5260.22
2_S64_K0.5250.22
260_K439_A0.5250.22
327_A363_I0.5250.22
347_A351_I0.5250.22
39_S281_G0.5240.22
279_D358_D0.5240.22
100_N385_S0.5230.22
74_D185_D0.5220.22
156_D160_S0.5220.22
11_V430_E0.5210.22
91_L142_L0.5200.22
54_V94_I0.5190.22
298_D370_T0.5190.22
168_S186_V0.5190.22
152_V324_L0.5190.22
50_N346_E0.5180.22
291_P349_T0.5180.22
294_P314_M0.5170.22
293_V343_I0.5170.22
74_D171_L0.5160.22
221_K417_G0.5160.22
317_I346_E0.5150.22
234_R419_P0.5150.22
324_L413_E0.5150.22
10_N52_R0.5150.22
318_F349_T0.5140.21
139_A226_D0.5140.21
254_L388_V0.5140.21
33_V71_V0.5130.21
39_S363_I0.5130.21
91_L104_I0.5120.21
23_E197_A0.5120.21
153_V301_Y0.5120.21
187_K234_R0.5110.21
174_S180_Q0.5110.21
237_N429_G0.5100.21
112_S125_I0.5090.21
94_I100_N0.5090.21
81_I125_I0.5090.21
315_Q346_E0.5080.21
310_L314_M0.5080.21
306_K410_Y0.5080.21
60_A63_Q0.5080.21
303_P319_D0.5080.21
362_I366_A0.5080.21
72_P202_E0.5070.21
266_T391_G0.5060.21
106_A243_A0.5060.21
90_Q188_Q0.5060.21
69_E123_P0.5060.21
100_N111_L0.5050.21
225_F245_E0.5040.21
80_R157_E0.5040.21
230_I248_L0.5030.21
23_E218_T0.5020.21
157_E307_E0.5020.21
306_K359_Q0.5010.21
306_K344_Q0.5010.21
51_A279_D0.5000.21
123_P183_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hwyA 1 0.2466 100 0.802 Contact Map
2dokA 2 0.3281 100 0.834 Contact Map
3b85A 3 0.4118 99.9 0.863 Contact Map
3i8oA 2 0.3032 99.9 0.866 Contact Map
3ix7A 2 0.2851 99.8 0.883 Contact Map
3upuA 1 0.4208 99.7 0.892 Contact Map
3e1sA 1 0.6425 99.6 0.9 Contact Map
4c2uA 1 0.4706 99.6 0.9 Contact Map
1w36D 1 0.7285 99.6 0.902 Contact Map
3lfuA 1 0.4638 99.5 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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