GREMLIN Database
YLAI - Uncharacterized protein YlaI
UniProt: O07633 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 69 (64)
Sequences: 116 (92)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L24_R5.9151.00
45_K48_E4.6631.00
28_R31_H2.5710.89
15_I19_T2.0570.75
3_R34_M2.0210.74
14_T63_K1.9190.70
4_V22_A1.8120.65
43_A47_E1.7620.63
50_L57_F1.5650.53
39_H50_L1.5120.51
56_T65_E1.5070.50
11_K57_F1.4570.48
7_S10_D1.4350.47
13_E36_Q1.2840.40
29_P60_G1.2770.39
18_D45_K1.2650.39
29_P32_T1.2580.38
20_L28_R1.2190.37
22_A55_F1.1890.35
36_Q39_H1.1640.34
44_K48_E1.1340.33
17_D45_K1.0960.31
3_R14_T1.0890.31
47_E50_L1.0800.31
54_K65_E1.0780.30
57_F61_Q1.0700.30
36_Q54_K1.0680.30
17_D29_P1.0680.30
11_K63_K1.0550.29
40_D51_K1.0380.29
12_I32_T1.0320.29
29_P50_L1.0290.28
14_T18_D1.0290.28
37_E60_G1.0250.28
33_Y36_Q0.9420.25
16_D21_I0.9260.25
8_I45_K0.9240.24
2_M6_C0.9200.24
21_I65_E0.9130.24
50_L63_K0.9020.24
54_K64_K0.8930.23
47_E51_K0.8830.23
17_D30_I0.8780.23
16_D40_D0.8490.22
44_K59_P0.8430.22
19_T47_E0.8410.22
36_Q40_D0.8350.21
44_K62_Q0.8310.21
11_K37_E0.8040.20
14_T54_K0.7740.19
21_I56_T0.7730.19
15_I62_Q0.7630.19
13_E40_D0.7610.19
5_K14_T0.7540.19
7_S34_M0.7270.18
16_D19_T0.7210.18
49_R53_G0.7140.18
3_R32_T0.7040.17
14_T37_E0.7000.17
15_I20_L0.6930.17
44_K50_L0.6870.17
4_V7_S0.6790.17
47_E54_K0.6780.17
12_I33_Y0.6740.17
30_I34_M0.6720.16
16_D54_K0.6700.16
52_T55_F0.6620.16
28_R32_T0.6600.16
20_L44_K0.6510.16
16_D43_A0.6510.16
12_I60_G0.6370.16
39_H56_T0.6050.15
17_D25_L0.6010.15
11_K24_R0.6000.15
26_R34_M0.5980.15
39_H65_E0.5900.14
19_T45_K0.5840.14
37_E63_K0.5800.14
22_A28_R0.5710.14
48_E62_Q0.5540.14
21_I54_K0.5530.14
50_L61_Q0.5490.13
59_P65_E0.5470.13
18_D64_K0.5400.13
4_V34_M0.5340.13
15_I24_R0.5330.13
8_I48_E0.5310.13
34_M59_P0.5260.13
40_D48_E0.5220.13
24_R47_E0.5170.13
29_P45_K0.5160.13
13_E21_I0.5130.13
44_K47_E0.5020.12
39_H43_A0.5020.12
17_D48_E0.5010.12
40_D57_F0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga8A 1 0.8551 69.3 0.884 Contact Map
3o9xA 2 0.971 68.9 0.884 Contact Map
4bpe6 1 0.7246 43.1 0.901 Contact Map
3j7a4 1 0.7391 42 0.902 Contact Map
4ujpc 1 0.7101 39.8 0.903 Contact Map
3zeyW 1 0.7101 38.6 0.904 Contact Map
3j60b 1 0.7391 33.2 0.907 Contact Map
1twfL 1 0.6232 21.4 0.915 Contact Map
1yuzA 2 0.4928 16.4 0.92 Contact Map
4tmaI 1 0.7536 14.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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