GREMLIN Database
YLAH - Uncharacterized membrane protein YlaH
UniProt: O07632 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (96)
Sequences: 132 (94)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_K98_K3.5580.97
49_P52_K3.0140.92
40_F53_S2.9800.92
34_V38_I2.6350.85
50_V54_A2.4310.80
39_V83_A2.4190.80
33_F61_A2.3860.79
41_K88_I2.3670.78
59_F88_I1.8860.60
91_K94_L1.8590.59
46_K99_K1.6790.51
29_Y61_A1.6540.50
94_L98_K1.6380.49
69_F73_F1.6060.48
33_F37_V1.5930.47
37_V61_A1.5680.46
62_L101_Q1.5300.45
59_F86_I1.5130.44
61_A65_T1.4800.42
17_V25_M1.4410.41
88_I91_K1.4330.40
88_I92_I1.4250.40
71_G77_A1.4070.39
39_V91_K1.3740.38
32_I64_C1.3730.38
10_F31_T1.3650.37
59_F85_L1.3470.37
51_L58_V1.3360.36
77_A99_K1.3140.35
41_K59_F1.2990.35
95_Y98_K1.2930.34
24_G28_L1.2880.34
54_A102_S1.2600.33
41_K97_S1.2580.33
60_L93_R1.2440.33
89_I101_Q1.2440.33
32_I35_L1.2270.32
41_K53_S1.2200.32
79_G88_I1.2100.31
29_Y51_L1.1380.28
28_L71_G1.0870.27
36_A54_A1.0810.26
41_K60_L1.0710.26
26_W83_A1.0630.26
83_A91_K1.0570.26
74_L79_G1.0440.25
15_Y31_T1.0190.24
30_G34_V1.0190.24
92_I98_K0.9610.22
55_V101_Q0.9600.22
60_L79_G0.9480.22
17_V72_V0.9460.22
82_V86_I0.9380.22
9_S52_K0.9340.22
14_L48_L0.9260.21
92_I100_G0.9190.21
62_L71_G0.9170.21
11_F25_M0.9130.21
56_V74_L0.9060.21
23_A27_L0.9010.21
11_F31_T0.8960.21
33_F49_P0.8910.20
49_P61_A0.8790.20
8_L13_A0.8770.20
8_L16_Q0.8770.20
12_A28_L0.8740.20
14_L17_V0.8650.20
32_I70_L0.8620.20
31_T82_V0.8570.19
81_V96_Q0.8490.19
11_F17_V0.8470.19
46_K88_I0.8450.19
74_L78_E0.8420.19
55_V95_Y0.8370.19
46_K55_V0.8310.19
91_K96_Q0.8190.18
59_F79_G0.8040.18
16_Q37_V0.8000.18
64_C74_L0.7990.18
32_I37_V0.7930.18
42_L87_L0.7890.18
51_L61_A0.7860.17
46_K59_F0.7850.17
40_F47_R0.7830.17
81_V102_S0.7740.17
67_L73_F0.7590.17
39_V84_A0.7560.17
68_T71_G0.7520.17
30_G66_V0.7470.17
54_A95_Y0.7440.16
34_V101_Q0.7280.16
20_Q69_F0.7220.16
10_F25_M0.7220.16
21_P72_V0.7220.16
24_G77_A0.7150.16
52_K95_Y0.7070.16
15_Y30_G0.6990.15
30_G40_F0.6900.15
29_Y49_P0.6800.15
81_V85_L0.6790.15
41_K46_K0.6680.15
47_R56_V0.6610.14
13_A16_Q0.6530.14
48_L52_K0.6510.14
68_T78_E0.6480.14
7_R10_F0.6440.14
85_L88_I0.6420.14
40_F85_L0.6400.14
46_K62_L0.6340.14
16_Q30_G0.6260.14
16_Q70_L0.6230.14
52_K61_A0.6160.14
55_V86_I0.6110.13
38_I85_L0.6110.13
38_I58_V0.6080.13
10_F35_L0.6050.13
67_L93_R0.6020.13
18_D24_G0.6010.13
36_A47_R0.5930.13
32_I91_K0.5920.13
66_V77_A0.5910.13
25_M56_V0.5830.13
64_C93_R0.5800.13
56_V59_F0.5690.13
38_I100_G0.5650.12
70_L94_L0.5530.12
20_Q61_A0.5530.12
28_L32_I0.5530.12
66_V73_F0.5510.12
8_L25_M0.5400.12
38_I46_K0.5380.12
26_W31_T0.5310.12
36_A98_K0.5300.12
28_L67_L0.5270.12
47_R70_L0.5220.12
25_M79_G0.5210.12
9_S77_A0.5200.12
29_Y56_V0.5160.12
8_L11_F0.5120.11
66_V82_V0.5120.11
25_M72_V0.5110.11
58_V62_L0.5070.11
40_F56_V0.5040.11
95_Y99_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.8571 38.5 0.921 Contact Map
2xq2A 2 0.6667 26.2 0.928 Contact Map
2bg9C 1 0.8571 17.4 0.934 Contact Map
2k1aA 1 0.3238 15 0.936 Contact Map
2bg9E 1 0.8667 12.6 0.938 Contact Map
3l1lA 2 0.9143 10.1 0.94 Contact Map
4ev6A 3 0.4667 9.6 0.941 Contact Map
4hfiA 3 0.8 9.5 0.941 Contact Map
4cofA 3 0.7619 8.8 0.942 Contact Map
4aq5E 1 0.7333 8.4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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