GREMLIN Database
YHFW - Putative Rieske 2Fe-2S iron-sulfur protein YhfW
UniProt: O07622 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (424)
Sequences: 3041 (2368)
Seq/√Len: 115.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_C59_V6.1921.00
194_I199_G5.0191.00
221_K224_H4.7791.00
36_T219_V4.4561.00
47_T232_I4.0421.00
113_K127_E3.8981.00
140_V171_L3.8481.00
36_T228_S3.6901.00
107_N374_T3.4591.00
61_I226_I3.1731.00
40_G66_V3.0761.00
57_R200_R2.9961.00
40_G60_L2.9251.00
59_V202_Y2.9141.00
158_D164_P2.9061.00
206_V222_S2.8951.00
43_T361_F2.8321.00
36_T226_I2.8021.00
61_I207_A2.7221.00
124_E185_Q2.6711.00
53_K118_E2.6031.00
162_D166_P2.5251.00
165_I172_A2.5011.00
63_A206_V2.4751.00
147_H151_T2.4701.00
32_E227_K2.4671.00
232_I380_V2.4341.00
36_T61_I2.4051.00
43_T358_A2.3131.00
358_A376_L2.2851.00
449_F452_E2.2561.00
207_A219_V2.2151.00
45_I191_L2.2091.00
48_A58_V2.1701.00
46_T50_E2.1641.00
34_D229_R2.1241.00
33_C36_T2.1131.00
137_E170_K2.0841.00
261_K326_S2.0711.00
114_G118_E2.0611.00
33_C57_R2.0511.00
32_E229_R2.0401.00
144_H148_E2.0291.00
209_D220_T2.0081.00
161_K164_P2.0071.00
45_I187_L1.9891.00
52_T199_G1.9721.00
150_Y157_R1.9431.00
191_L201_I1.9291.00
211_K218_V1.8901.00
218_V225_A1.8701.00
33_C200_R1.8591.00
415_H419_G1.8541.00
42_I369_S1.8541.00
148_E152_K1.8331.00
131_Y172_A1.8321.00
312_E316_Q1.8251.00
54_R381_E1.8111.00
129_D174_V1.7921.00
378_D385_N1.7841.00
308_S312_E1.7721.00
186_Y370_A1.7491.00
213_G216_P1.7441.00
148_E151_T1.7261.00
158_D174_V1.7051.00
158_D176_K1.6981.00
80_A106_Q1.6721.00
434_G452_E1.6571.00
141_Q144_H1.6491.00
59_V226_I1.6481.00
110_D127_E1.6091.00
45_I60_L1.6081.00
49_Y193_Q1.6081.00
356_L376_L1.6081.00
315_R319_E1.5641.00
230_F354_N1.5611.00
35_V51_L1.5581.00
80_A175_M1.5541.00
218_V227_K1.5511.00
35_V56_F1.5411.00
230_F356_L1.5391.00
116_V121_I1.5281.00
52_T197_K1.5101.00
211_K220_T1.5081.00
67_L187_L1.5041.00
37_I47_T1.5031.00
230_F380_V1.4811.00
220_T225_A1.4661.00
425_D435_E1.4551.00
37_I48_A1.4341.00
40_G62_E1.4301.00
208_L220_T1.4281.00
121_I189_A1.4281.00
143_I173_L1.4251.00
409_N412_V1.4251.00
125_W179_A1.4211.00
415_H418_K1.4171.00
279_V282_R1.4071.00
373_A377_S1.4051.00
60_L201_I1.4021.00
147_H173_L1.4011.00
411_D415_H1.3971.00
129_D176_K1.3931.00
189_A193_Q1.3861.00
202_Y205_T1.3861.00
447_G452_E1.3831.00
255_S335_D1.3761.00
297_V313_T1.3681.00
42_I71_T1.3631.00
182_H185_Q1.3571.00
49_Y53_K1.3571.00
30_D225_A1.3531.00
48_A199_G1.3491.00
114_G117_D1.3331.00
256_Y299_H1.3291.00
448_A452_E1.3291.00
52_T194_I1.3271.00
116_V123_C1.3231.00
65_Q203_E1.3141.00
410_A413_A1.3141.00
46_T370_A1.3101.00
113_K125_W1.3091.00
160_I164_P1.2880.99
66_V203_E1.2800.99
27_L30_D1.2760.99
260_I294_F1.2760.99
50_E373_A1.2700.99
159_L173_L1.2580.99
36_T59_V1.2580.99
34_D57_R1.2550.99
243_G357_V1.2480.99
228_S231_I1.2450.99
38_I233_C1.2420.99
140_V144_H1.2390.99
71_T187_L1.2370.99
186_Y190_L1.2350.99
66_V201_I1.2330.99
46_T373_A1.2290.99
391_F395_R1.2240.99
417_I424_P1.2220.99
130_A178_Q1.2190.99
50_E111_Y1.2190.99
391_F396_F1.2100.99
307_M310_H1.2100.99
112_I186_Y1.2070.99
150_Y154_G1.2040.99
448_A451_D1.2010.99
257_V293_L1.1870.99
56_F381_E1.1820.99
78_V112_I1.1790.99
47_T234_C1.1780.99
212_K217_E1.1610.99
356_L380_V1.1610.99
60_L191_L1.1570.99
32_E57_R1.1550.99
395_R399_N1.1480.99
144_H159_L1.1480.99
145_T148_E1.1430.99
46_T186_Y1.1380.99
50_E54_R1.1340.99
67_L184_L1.1210.99
407_S413_A1.1190.99
451_D457_H1.1120.98
205_T223_R1.1100.98
340_D346_G1.1080.98
53_K197_K1.1050.98
140_V170_K1.1040.98
147_H159_L1.1000.98
393_P398_L1.0980.98
450_R456_L1.0950.98
141_Q145_T1.0930.98
136_N139_A1.0830.98
220_T224_H1.0780.98
384_E388_E1.0770.98
412_V415_H1.0740.98
407_S410_A1.0730.98
50_E374_T1.0730.98
297_V310_H1.0730.98
255_S295_S1.0710.98
64_N68_N1.0640.98
104_A391_F1.0640.98
111_Y115_I1.0510.98
205_T221_K1.0510.98
106_Q110_D1.0510.98
159_L171_L1.0440.98
377_S380_V1.0430.98
46_T369_S1.0390.98
113_K117_D1.0370.98
119_H193_Q1.0320.98
404_K407_S1.0300.97
405_V409_N1.0280.97
109_I125_W1.0280.97
112_I370_A1.0260.97
191_L195_V1.0250.97
432_S435_E1.0240.97
384_E387_Y1.0240.97
104_A375_L1.0170.97
122_D185_Q1.0160.97
205_T226_I1.0030.97
414_K418_K1.0020.97
66_V191_L1.0010.97
54_R377_S0.9990.97
65_Q204_E0.9960.97
111_Y114_G0.9890.97
33_C226_I0.9870.97
48_A60_L0.9870.97
150_Y155_I0.9850.97
371_V374_T0.9820.97
137_E141_Q0.9820.97
378_D383_K0.9810.97
165_I169_S0.9800.97
267_P270_M0.9780.97
422_E435_E0.9740.96
406_I413_A0.9700.96
76_A366_M0.9650.96
210_I231_I0.9650.96
406_I409_N0.9600.96
396_F399_N0.9560.96
408_Y413_A0.9550.96
409_N413_A0.9530.96
43_T234_C0.9480.96
338_T341_K0.9470.96
59_V200_R0.9450.96
103_E107_N0.9420.96
411_D414_K0.9400.96
162_D165_I0.9370.96
51_L380_V0.9370.96
210_I355_I0.9370.96
259_A331_W0.9360.96
254_R334_Q0.9360.96
46_T190_L0.9350.96
181_F186_Y0.9340.96
242_G245_L0.9330.96
447_G451_D0.9290.95
380_V384_E0.9260.95
210_I217_E0.9250.95
396_F400_P0.9240.95
261_K289_E0.9230.95
405_V413_A0.9190.95
47_T376_L0.9140.95
338_T360_G0.9100.95
134_T143_I0.9090.95
315_R330_Y0.9080.95
442_N445_R0.8970.94
160_I165_I0.8970.94
121_I124_E0.8960.94
446_A452_E0.8960.94
294_F318_A0.8960.94
337_V341_K0.8950.94
442_N447_G0.8930.94
208_L222_S0.8890.94
139_A275_D0.8840.94
90_I152_K0.8820.94
232_I376_L0.8810.94
127_E177_N0.8800.94
142_K145_T0.8800.94
217_E352_E0.8790.94
434_G437_K0.8760.94
358_A372_A0.8730.94
446_A449_F0.8730.94
75_T283_Y0.8730.94
151_T156_E0.8720.94
38_I231_I0.8720.94
233_C355_I0.8710.94
219_V224_H0.8710.94
273_S280_A0.8710.94
275_D280_A0.8680.93
255_S298_S0.8680.93
26_A202_Y0.8570.93
433_P456_L0.8570.93
317_L320_S0.8540.93
78_V125_W0.8530.93
361_F372_A0.8480.93
31_T59_V0.8480.93
37_I201_I0.8480.93
416_L419_G0.8440.92
375_L379_L0.8430.92
231_I354_N0.8410.92
390_I395_R0.8360.92
375_L378_D0.8360.92
210_I240_Y0.8330.92
79_T364_W0.8320.92
56_F230_F0.8260.92
345_I376_L0.8240.92
281_L285_V0.8230.91
258_L327_I0.8170.91
282_R285_V0.8140.91
42_I187_L0.8110.91
49_Y190_L0.8100.91
75_T366_M0.8100.91
53_K119_H0.8100.91
35_V232_I0.8080.91
45_I201_I0.8070.91
356_L379_L0.8060.91
215_R229_R0.8060.91
146_E150_Y0.8040.91
115_I119_H0.8030.90
50_E377_S0.7980.90
116_V186_Y0.7970.90
75_T257_V0.7970.90
343_P346_G0.7960.90
390_I393_P0.7950.90
99_R103_E0.7920.90
441_I446_A0.7920.90
34_D56_F0.7910.90
335_D364_W0.7880.90
447_G450_R0.7880.90
230_F384_E0.7870.90
339_I343_P0.7850.89
105_N364_W0.7830.89
37_I194_I0.7830.89
335_D368_S0.7820.89
26_A223_R0.7820.89
78_V113_K0.7820.89
140_V161_K0.7810.89
423_K436_G0.7800.89
440_T445_R0.7790.89
309_T312_E0.7780.89
273_S279_V0.7770.89
131_Y269_G0.7760.89
143_I147_H0.7730.89
53_K193_Q0.7710.89
280_A283_Y0.7700.89
194_I198_G0.7700.89
48_A194_I0.7680.88
73_H333_T0.7670.88
426_V430_D0.7650.88
117_D222_S0.7650.88
213_G227_K0.7650.88
49_Y119_H0.7650.88
426_V434_G0.7640.88
28_Q223_R0.7640.88
37_I58_V0.7620.88
86_Y149_A0.7610.88
74_T366_M0.7600.88
111_Y374_T0.7590.88
147_H157_R0.7560.88
431_I434_G0.7560.88
277_P280_A0.7560.88
40_G191_L0.7540.87
374_T377_S0.7540.87
255_S297_V0.7530.87
70_T237_F0.7520.87
284_T322_I0.7520.87
297_V335_D0.7520.87
42_I366_M0.7500.87
194_I201_I0.7480.87
303_Q411_D0.7450.87
80_A178_Q0.7440.87
285_V293_L0.7420.87
150_Y153_L0.7410.87
193_Q197_K0.7400.86
47_T373_A0.7380.86
439_V443_G0.7360.86
76_A184_L0.7360.86
392_T395_R0.7340.86
36_T207_A0.7310.86
144_H171_L0.7300.86
77_K335_D0.7280.86
281_L284_T0.7280.86
263_K325_E0.7270.86
107_N110_D0.7260.85
134_T171_L0.7250.85
423_K440_T0.7240.85
405_V410_A0.7230.85
215_R218_V0.7230.85
81_Q132_L0.7150.85
134_T139_A0.7140.84
450_R457_H0.7080.84
421_L424_P0.7080.84
35_V230_F0.7060.84
348_M351_N0.7050.84
256_Y332_S0.7040.84
413_A417_I0.7030.84
408_Y416_L0.7020.83
442_N446_A0.7010.83
129_D134_T0.7010.83
157_R175_M0.7010.83
243_G247_A0.7000.83
31_T57_R0.7000.83
414_K417_I0.6990.83
235_S239_F0.6980.83
209_D389_S0.6970.83
156_E176_K0.6970.83
273_S321_T0.6970.83
311_Y330_Y0.6940.83
31_T226_I0.6940.83
335_D363_K0.6940.83
446_A451_D0.6920.83
149_A153_L0.6920.83
119_H189_A0.6910.83
265_E290_K0.6910.83
448_A458_L0.6900.82
79_T335_D0.6900.82
77_K363_K0.6890.82
235_S242_G0.6890.82
27_L226_I0.6870.82
26_A29_E0.6870.82
204_E222_S0.6860.82
187_L254_R0.6860.82
266_Y270_M0.6840.82
134_T140_V0.6830.82
78_V181_F0.6810.82
27_L202_Y0.6800.82
77_K364_W0.6770.81
423_K439_V0.6770.81
45_I194_I0.6770.81
160_I169_S0.6760.81
409_N415_H0.6730.81
408_Y411_D0.6720.81
412_V419_G0.6720.81
291_L431_I0.6710.81
116_V125_W0.6700.81
342_I346_G0.6700.81
435_E439_V0.6700.81
110_D156_E0.6680.80
115_I193_Q0.6670.80
426_V432_S0.6670.80
412_V418_K0.6610.80
413_A420_K0.6610.80
210_I233_C0.6610.80
132_L274_I0.6600.80
311_Y314_L0.6590.79
266_Y271_Y0.6580.79
192_E444_R0.6570.79
101_Y105_N0.6560.79
425_D444_R0.6540.79
62_E203_E0.6540.79
54_R383_K0.6540.79
452_E455_C0.6540.79
50_E370_A0.6530.79
291_L328_P0.6530.79
106_Q155_I0.6510.79
216_P229_R0.6490.78
405_V408_Y0.6490.78
254_R332_S0.6490.78
403_Q407_S0.6480.78
422_E439_V0.6480.78
216_P354_N0.6470.78
251_Y300_K0.6460.78
110_D113_K0.6460.78
82_H178_Q0.6410.78
345_I368_S0.6390.77
31_T202_Y0.6390.77
79_T130_A0.6390.77
64_N204_E0.6380.77
406_I414_K0.6380.77
83_D298_S0.6370.77
260_I318_A0.6360.77
300_K303_Q0.6350.77
338_T343_P0.6350.77
35_V58_V0.6350.77
70_T336_L0.6330.77
261_K328_P0.6320.77
184_L188_K0.6290.76
361_F369_S0.6290.76
337_V362_K0.6270.76
280_A285_V0.6260.76
340_D347_P0.6260.76
111_Y370_A0.6260.76
109_I367_T0.6250.76
76_A181_F0.6250.76
121_I186_Y0.6250.76
31_T200_R0.6250.76
340_D344_F0.6240.76
410_A414_K0.6230.76
215_R227_K0.6220.75
263_K323_G0.6220.75
428_F434_G0.6210.75
339_I344_F0.6210.75
151_T154_G0.6190.75
257_V297_V0.6180.75
406_I410_A0.6170.75
253_D298_S0.6160.75
115_I190_L0.6130.74
280_A284_T0.6130.74
236_H333_T0.6130.74
295_S298_S0.6120.74
315_R327_I0.6120.74
207_A239_F0.6100.74
105_N367_T0.6100.74
110_D177_N0.6100.74
345_I349_S0.6070.74
340_D345_I0.6050.73
244_G247_A0.6040.73
313_T317_L0.6030.73
446_A450_R0.6030.73
440_T443_G0.6030.73
426_V444_R0.6020.73
79_T82_H0.6020.73
253_D362_K0.6020.73
260_I263_K0.6020.73
43_T372_A0.5980.73
195_V201_I0.5960.72
441_I458_L0.5960.72
233_C239_F0.5950.72
416_L420_K0.5940.72
302_G332_S0.5930.72
65_Q450_R0.5930.72
278_S281_L0.5910.72
429_E458_L0.5910.72
149_A152_K0.5900.72
445_R450_R0.5900.72
262_P292_I0.5890.71
275_D278_S0.5890.71
442_N448_A0.5880.71
428_F433_P0.5870.71
260_I327_I0.5860.71
389_S392_T0.5860.71
73_H236_H0.5860.71
194_I197_K0.5850.71
430_D453_T0.5850.71
49_Y197_K0.5840.71
258_L311_Y0.5830.71
230_F383_K0.5820.71
231_I355_I0.5820.71
254_R299_H0.5800.70
415_H420_K0.5800.70
131_Y160_I0.5790.70
47_T377_S0.5780.70
193_Q196_Q0.5770.70
393_P396_F0.5760.70
444_R447_G0.5760.70
391_F394_S0.5750.70
195_V199_G0.5740.70
373_A376_L0.5730.69
441_I452_E0.5720.69
217_E231_I0.5710.69
141_Q148_E0.5690.69
105_N368_S0.5690.69
311_Y315_R0.5680.69
163_L166_P0.5680.69
275_D282_R0.5670.69
256_Y310_H0.5670.69
74_T183_P0.5670.69
130_A175_M0.5660.68
415_H443_G0.5620.68
343_P348_M0.5620.68
77_K178_Q0.5620.68
374_T378_D0.5610.68
128_Q270_M0.5610.68
78_V367_T0.5600.68
38_I242_G0.5590.67
90_I153_L0.5590.67
255_S363_K0.5590.67
70_T74_T0.5580.67
391_F398_L0.5550.67
210_I245_L0.5540.67
205_T208_L0.5530.67
151_T213_G0.5530.67
253_D300_K0.5510.66
105_N109_I0.5510.66
283_Y294_F0.5500.66
77_K105_N0.5490.66
417_I420_K0.5480.66
43_T187_L0.5480.66
211_K216_P0.5470.66
258_L314_L0.5470.66
212_K354_N0.5470.66
205_T222_S0.5460.66
65_Q68_N0.5460.66
160_I172_A0.5430.65
279_V283_Y0.5420.65
407_S416_L0.5410.65
346_G349_S0.5400.65
116_V119_H0.5370.64
103_E117_D0.5360.64
135_A321_T0.5350.64
393_P405_V0.5350.64
105_N108_A0.5350.64
206_V241_D0.5350.64
86_Y98_A0.5340.64
132_L272_L0.5340.64
316_Q320_S0.5330.64
274_I277_P0.5330.64
430_D433_P0.5320.64
106_Q109_I0.5280.63
433_P437_K0.5280.63
445_R448_A0.5280.63
163_L169_S0.5270.63
121_I181_F0.5270.63
358_A361_F0.5270.63
338_T362_K0.5260.63
392_T398_L0.5260.63
62_E207_A0.5260.63
78_V366_M0.5250.63
409_N420_K0.5250.63
211_K225_A0.5250.63
429_E432_S0.5240.63
30_D227_K0.5240.63
70_T236_H0.5240.63
437_K448_A0.5230.62
237_F334_Q0.5230.62
440_T448_A0.5220.62
413_A419_G0.5220.62
276_Q280_A0.5200.62
168_G320_S0.5190.62
90_I98_A0.5180.62
148_E181_F0.5170.62
78_V109_I0.5170.62
195_V446_A0.5170.62
453_T457_H0.5150.61
101_Y364_W0.5140.61
306_A330_Y0.5130.61
249_R405_V0.5130.61
380_V385_N0.5130.61
254_R301_T0.5130.61
249_R339_I0.5130.61
178_Q270_M0.5120.61
258_L315_R0.5120.61
81_Q175_M0.5120.61
416_L421_L0.5120.61
83_D105_N0.5110.61
387_Y390_I0.5110.61
112_I369_S0.5100.60
259_A329_Y0.5100.60
131_Y165_I0.5100.60
212_K218_V0.5090.60
79_T255_S0.5090.60
362_K368_S0.5090.60
274_I285_V0.5080.60
77_K280_A0.5070.60
278_S282_R0.5070.60
208_L211_K0.5070.60
377_S381_E0.5040.60
45_I190_L0.5040.60
342_I345_I0.5040.60
62_E66_V0.5030.59
338_T344_F0.5030.59
418_K421_L0.5030.59
397_H401_G0.5030.59
440_T444_R0.5030.59
62_E226_I0.5010.59
444_R448_A0.5010.59
67_L191_L0.5000.59
52_T195_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.6935 100 0.586 Contact Map
4x9mA 1 0.6974 100 0.602 Contact Map
3pvcA 1 0.7544 100 0.613 Contact Map
2rghA 2 0.9057 100 0.613 Contact Map
3da1A 1 0.8094 100 0.614 Contact Map
1ryiA 4 0.6778 100 0.615 Contact Map
3ps9A 1 0.7505 100 0.615 Contact Map
2qcuA 2 0.8487 100 0.616 Contact Map
1y56B 1 0.6955 100 0.617 Contact Map
2gf3A 1 0.7033 100 0.619 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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