GREMLIN Database
HEMAT - Heme-based aerotactic transducer HemAT
UniProt: O07621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (394)
Sequences: 14433 (12258)
Seq/√Len: 617.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_K172_E3.3621.00
77_S80_M2.8941.00
278_K352_Q2.5651.00
167_K175_L2.5101.00
268_S362_D2.2501.00
189_D192_E2.2311.00
166_T183_E2.1011.00
229_G232_Q2.0931.00
129_L133_Y2.0751.00
98_R102_E2.0531.00
282_I352_Q2.0391.00
176_V196_N2.0381.00
152_I156_Q2.0341.00
202_I209_I2.0121.00
285_Q288_K1.9801.00
291_G295_G1.9641.00
267_T271_Q1.9461.00
265_I370_S1.9351.00
161_A185_N1.8981.00
36_K40_M1.8611.00
260_K264_K1.8491.00
365_E369_E1.8401.00
151_S155_Q1.8371.00
276_M356_V1.8161.00
105_A109_D1.8001.00
71_K75_H1.7991.00
176_V193_E1.7861.00
162_I183_E1.7831.00
257_V260_K1.7801.00
335_T339_V1.7721.00
354_N358_K1.7711.00
49_Y53_Q1.7681.00
68_A71_K1.7581.00
52_E56_P1.7561.00
250_G253_K1.7551.00
287_E350_N1.7541.00
239_V242_S1.7471.00
48_L52_E1.7461.00
166_T170_N1.7451.00
281_E284_Q1.7441.00
368_S372_E1.7441.00
270_V368_S1.7441.00
361_K365_E1.7231.00
375_T379_R1.7131.00
288_K291_G1.7081.00
277_V281_E1.7071.00
343_S347_N1.7051.00
282_I348_N1.7011.00
259_Q378_N1.6961.00
253_K257_V1.6881.00
192_E196_N1.6721.00
411_E414_R1.6721.00
330_K333_E1.6701.00
46_A49_Y1.6611.00
87_S91_R1.6591.00
239_V243_T1.6551.00
278_K281_E1.6491.00
45_D48_L1.6441.00
70_Y74_D1.6371.00
365_E368_S1.6351.00
133_Y137_F1.6341.00
101_Q105_A1.6271.00
275_E355_I1.6221.00
274_K278_K1.6161.00
280_D357_S1.6001.00
185_N191_Q1.5901.00
185_N189_D1.5711.00
181_Q185_N1.5511.00
271_Q274_K1.5501.00
277_V361_K1.5401.00
333_E337_K1.5391.00
196_N200_Q1.5341.00
116_R120_A1.5241.00
176_V189_D1.5191.00
417_S421_A1.5111.00
243_T246_E1.5101.00
294_T343_S1.5091.00
90_D94_Q1.5081.00
263_N375_T1.4991.00
372_E376_Q1.4941.00
369_E372_E1.4921.00
337_K341_T1.4861.00
112_F116_R1.4841.00
358_K362_D1.4771.00
279_L356_V1.4611.00
192_E195_K1.4571.00
165_T191_Q1.4531.00
249_I253_K1.4491.00
274_K277_V1.4441.00
242_S246_E1.4391.00
67_D71_K1.4381.00
267_T270_V1.4371.00
270_V274_K1.4341.00
266_D371_K1.4241.00
89_V93_K1.4211.00
53_Q57_L1.4201.00
203_Q207_G1.3971.00
168_I192_E1.3921.00
225_D229_G1.3871.00
155_Q158_L1.3851.00
195_K198_L1.3831.00
52_E55_Q1.3761.00
165_T188_R1.3721.00
376_Q379_R1.3701.00
154_N157_E1.3601.00
362_D365_E1.3581.00
347_N351_T1.3581.00
383_E386_H1.3521.00
236_A239_V1.3481.00
264_K366_L1.3441.00
71_K74_D1.3421.00
189_D193_E1.3411.00
249_I389_K1.3411.00
36_K39_K1.3401.00
68_A72_N1.3391.00
281_E285_Q1.3371.00
397_K400_V1.3311.00
215_E218_R1.3291.00
271_Q362_D1.3291.00
272_I360_I1.3281.00
418_H421_A1.3261.00
264_K369_E1.3251.00
160_K178_E1.3201.00
88_S91_R1.3181.00
65_I68_A1.3141.00
235_K239_V1.3131.00
193_E197_L1.3061.00
55_Q59_Q1.3021.00
246_E250_G1.3021.00
211_N215_E1.3001.00
159_L162_I1.2991.00
268_S366_L1.2981.00
257_V373_K1.2971.00
191_Q199_H1.2901.00
39_K55_Q1.2851.00
99_H102_E1.2811.00
285_Q348_N1.2771.00
59_Q63_V1.2731.00
109_D113_I1.2681.00
351_T355_I1.2681.00
94_Q98_R1.2681.00
275_E356_V1.2641.00
272_I363_V1.2621.00
113_I117_N1.2611.00
283_A353_I1.2601.00
53_Q56_P1.2601.00
389_K393_E1.2601.00
379_R383_E1.2591.00
285_Q341_T1.2591.00
164_A177_L1.2571.00
244_V388_M1.2561.00
107_V110_D1.2471.00
263_N267_T1.2451.00
37_Q40_M1.2401.00
183_E186_Q1.2391.00
308_S326_N1.2391.00
273_E364_N1.2371.00
132_W136_A1.2341.00
390_I393_E1.2331.00
185_N192_E1.2301.00
209_I213_F1.2301.00
252_K256_E1.2261.00
194_K197_L1.2201.00
176_V192_E1.2201.00
382_D386_H1.2191.00
275_E359_H1.2121.00
265_I367_V1.2051.00
153_T157_E1.2021.00
252_K382_D1.2011.00
182_S185_N1.1941.00
117_N121_S1.1921.00
191_Q195_K1.1921.00
184_Y191_Q1.1811.00
404_A407_G1.1801.00
264_K267_T1.1791.00
284_Q354_N1.1721.00
294_T298_E1.1711.00
262_M370_S1.1681.00
261_Q369_E1.1671.00
162_I166_T1.1631.00
425_S428_I1.1621.00
45_D49_Y1.1611.00
44_G47_E1.1551.00
39_K42_R1.1501.00
108_I112_F1.1491.00
205_T209_I1.1441.00
262_M265_I1.1401.00
195_K199_H1.1381.00
130_P133_Y1.1301.00
168_I191_Q1.1261.00
272_I359_H1.1251.00
253_K256_E1.1241.00
56_P60_E1.1241.00
126_I129_L1.1211.00
247_K383_E1.1191.00
240_T244_V1.1171.00
211_N214_S1.1151.00
166_T190_E1.1131.00
348_N352_Q1.1121.00
184_Y195_K1.1121.00
172_E175_L1.1091.00
83_I87_S1.1011.00
163_K166_T1.1001.00
256_E260_K1.1001.00
282_I285_Q1.0971.00
414_R418_H1.0961.00
197_L200_Q1.0951.00
162_I187_T1.0951.00
161_A188_R1.0921.00
276_M357_S1.0901.00
155_Q159_L1.0881.00
237_G395_S1.0831.00
119_I123_H1.0831.00
214_S218_R1.0811.00
421_A425_S1.0801.00
184_Y188_R1.0751.00
160_K163_K1.0751.00
166_T187_T1.0731.00
261_Q366_L1.0671.00
161_A184_Y1.0631.00
358_K361_K1.0571.00
64_N68_A1.0571.00
184_Y192_E1.0541.00
292_I338_T1.0531.00
254_E376_Q1.0511.00
204_E208_S1.0511.00
242_S396_G1.0511.00
268_S271_Q1.0501.00
49_Y52_E1.0491.00
379_R382_D1.0491.00
160_K164_A1.0481.00
68_A88_S1.0471.00
54_L58_I1.0451.00
67_D70_Y1.0431.00
283_A349_T1.0431.00
400_V403_Q1.0391.00
326_N329_R1.0391.00
128_L132_W1.0371.00
78_S82_I1.0341.00
143_S146_D1.0311.00
337_K340_S1.0271.00
50_V53_Q1.0221.00
308_S329_R1.0141.00
179_A189_D1.0121.00
63_V67_D1.0101.00
163_K167_K1.0091.00
276_M360_I1.0091.00
104_F107_V1.0081.00
161_A165_T1.0021.00
341_T344_E0.9961.00
95_T99_H0.9951.00
280_D284_Q0.9911.00
148_Y152_I0.9901.00
393_E397_K0.9871.00
97_K101_Q0.9861.00
280_D354_N0.9861.00
248_S385_V0.9851.00
93_K97_K0.9831.00
269_L367_V0.9831.00
218_R222_E0.9821.00
130_P134_M0.9821.00
95_T98_R0.9791.00
106_G109_D0.9771.00
246_E249_I0.9751.00
221_Q413_S0.9711.00
260_K263_N0.9691.00
38_L41_V0.9611.00
204_E207_G0.9591.00
248_S251_G0.9571.00
410_Q413_S0.9551.00
277_V280_D0.9531.00
57_L99_H0.9521.00
279_L349_T0.9501.00
271_Q359_H0.9491.00
192_E198_L0.9461.00
386_H390_I0.9461.00
118_R122_I0.9391.00
340_S343_S0.9391.00
91_R95_T0.9361.00
57_L60_E0.9361.00
142_L146_D0.9341.00
396_G400_V0.9311.00
232_Q236_A0.9291.00
102_E105_A0.9271.00
139_E142_L0.9231.00
344_E348_N0.9231.00
91_R94_Q0.9171.00
344_E347_N0.9171.00
66_V70_Y0.9161.00
109_D112_F0.9141.00
261_Q373_K0.9121.00
407_G411_E0.9111.00
84_N88_S0.9101.00
400_V404_A0.9081.00
230_I244_V0.9071.00
410_Q414_R0.9061.00
184_Y198_L0.9061.00
404_A408_G0.9051.00
192_E199_H0.8991.00
58_I96_L0.8981.00
424_D428_I0.8981.00
165_T187_T0.8971.00
191_Q196_N0.8961.00
278_K355_I0.8951.00
372_E375_T0.8951.00
340_S344_E0.8931.00
403_Q407_G0.8931.00
42_R51_L0.8911.00
355_I358_K0.8871.00
77_S81_D0.8851.00
46_A50_V0.8851.00
72_N80_M0.8821.00
225_D228_E0.8771.00
167_K170_N0.8751.00
42_R48_L0.8751.00
232_Q235_K0.8661.00
278_K282_I0.8631.00
93_K96_L0.8611.00
96_L99_H0.8611.00
56_P59_Q0.8591.00
115_K119_I0.8581.00
334_D341_T0.8521.00
164_A188_R0.8501.00
222_E225_D0.8491.00
190_E194_K0.8481.00
289_I338_T0.8461.00
264_K268_S0.8451.00
177_L189_D0.8431.00
390_I394_Q0.8421.00
186_Q189_D0.8391.00
159_L163_K0.8391.00
285_Q345_L0.8331.00
332_S335_T0.8311.00
90_D93_K0.8291.00
201_K204_E0.8271.00
247_K250_G0.8251.00
190_E193_E0.8221.00
60_E64_N0.8211.00
117_N120_A0.8181.00
284_Q288_K0.8161.00
61_N65_I0.8141.00
72_N77_S0.8121.00
223_L234_S0.8101.00
114_E117_N0.8101.00
50_V106_G0.8091.00
182_S186_Q0.8081.00
178_E189_D0.8011.00
73_L76_E0.8001.00
64_N67_D0.8001.00
414_R417_S0.7991.00
289_I345_L0.7971.00
219_S222_E0.7951.00
373_K376_Q0.7951.00
47_E50_V0.7951.00
295_G298_E0.7941.00
294_T339_V0.7901.00
191_Q194_K0.7881.00
350_N354_N0.7881.00
393_E396_G0.7841.00
218_R221_Q0.7841.00
179_A186_Q0.7831.00
367_V370_S0.7811.00
197_L201_K0.7801.00
208_S212_L0.7761.00
421_A424_D0.7721.00
206_S209_I0.7711.00
398_I401_D0.7701.00
92_L95_T0.7661.00
179_A185_N0.7661.00
223_L226_K0.7651.00
203_Q209_I0.7631.00
184_Y199_H0.7611.00
38_L47_E0.7601.00
126_I130_P0.7601.00
38_L42_R0.7591.00
164_A175_L0.7571.00
255_L377_I0.7561.00
228_E232_Q0.7551.00
116_R119_I0.7531.00
353_I357_S0.7531.00
426_L429_L0.7491.00
156_Q160_K0.7441.00
290_F294_T0.7421.00
353_I356_V0.7421.00
251_G381_F0.7421.00
207_G211_N0.7391.00
230_I233_A0.7371.00
175_L179_A0.7361.00
270_V364_N0.7341.00
283_A289_I0.7341.00
273_E361_K0.7331.00
157_E181_Q0.7331.00
98_R101_Q0.7331.00
134_M138_Q0.7311.00
317_H328_V0.7281.00
185_N199_H0.7281.00
94_Q97_K0.7271.00
191_Q198_L0.7261.00
298_E309_I0.7251.00
366_L369_E0.7231.00
188_R191_Q0.7211.00
234_S237_G0.7181.00
119_I122_I0.7141.00
69_F89_V0.7111.00
158_L181_Q0.7101.00
223_L237_G0.7081.00
79_L82_I0.7071.00
241_S244_V0.7061.00
92_L96_L0.7051.00
164_A167_K0.7021.00
259_Q263_N0.7011.00
219_S223_L0.7001.00
222_E408_G0.6891.00
399_D402_L0.6851.00
44_G48_L0.6841.00
411_E415_A0.6831.00
167_K191_Q0.6781.00
89_V97_K0.6751.00
420_A424_D0.6751.00
238_T241_S0.6741.00
295_G334_D0.6731.00
216_T220_V0.6711.00
110_D113_I0.6681.00
65_I69_F0.6661.00
286_I346_V0.6641.00
209_I212_L0.6641.00
301_N329_R0.6621.00
58_I62_I0.6611.00
269_L363_V0.6591.00
424_D427_V0.6581.00
228_E410_Q0.6551.00
348_N351_T0.6541.00
64_N71_K0.6531.00
47_E107_V0.6471.00
127_G131_K0.6471.00
258_Q377_I0.6461.00
291_G294_T0.6451.00
61_N76_E0.6441.00
139_E146_D0.6441.00
136_A139_E0.6431.00
114_E118_R0.6431.00
223_L409_L0.6431.00
76_E79_L0.6421.00
364_N368_S0.6401.00
287_E290_F0.6381.00
108_I111_E0.6381.00
69_F73_L0.6371.00
173_Q195_K0.6371.00
289_I335_T0.6351.00
254_E257_V0.6341.00
129_L132_W0.6331.00
227_S234_S0.6321.00
210_A214_S0.6311.00
159_L183_E0.6301.00
216_T219_S0.6291.00
96_L103_M0.6271.00
179_A182_S0.6251.00
425_S429_L0.6251.00
157_E182_S0.6241.00
289_I292_I0.6231.00
76_E80_M0.6231.00
206_S213_F0.6221.00
213_F216_T0.6201.00
413_S417_S0.6161.00
105_A108_I0.6161.00
416_V420_A0.6161.00
349_T353_I0.6151.00
39_K51_L0.6151.00
72_N75_H0.6141.00
188_R192_E0.6131.00
184_Y189_D0.6121.00
58_I61_N0.6121.00
223_L244_V0.6121.00
101_Q104_F0.6111.00
257_V369_E0.6101.00
133_Y136_A0.6091.00
168_I188_R0.6061.00
79_L83_I0.6061.00
187_T192_E0.6051.00
156_Q159_L0.6011.00
326_N330_K0.6011.00
234_S244_V0.6011.00
115_K118_R0.6001.00
42_R55_Q0.5991.00
223_L227_S0.5991.00
302_L309_I0.5981.00
289_I346_V0.5981.00
66_V69_F0.5981.00
43_L47_E0.5961.00
93_K107_V0.5961.00
155_Q181_Q0.5961.00
185_N195_K0.5951.00
256_E378_N0.5951.00
336_K340_S0.5941.00
139_E143_S0.5931.00
157_E160_K0.5931.00
53_Q99_H0.5931.00
177_L185_N0.5931.00
107_V111_E0.5921.00
351_T354_N0.5911.00
363_V367_V0.5901.00
201_K205_T0.5891.00
189_D199_H0.5891.00
85_D91_R0.5881.00
85_D88_S0.5871.00
89_V96_L0.5871.00
102_E106_G0.5861.00
165_T168_I0.5851.00
181_Q187_T0.5851.00
171_L195_K0.5851.00
308_S334_D0.5811.00
170_N190_E0.5801.00
131_K135_G0.5781.00
334_D337_K0.5741.00
136_A143_S0.5731.00
72_N84_N0.5731.00
158_L184_Y0.5731.00
379_R386_H0.5731.00
243_T247_K0.5731.00
263_N371_K0.5731.00
138_Q142_L0.5721.00
288_K341_T0.5701.00
290_F343_S0.5701.00
162_I165_T0.5701.00
227_S402_L0.5671.00
275_E352_Q0.5651.00
165_T184_Y0.5611.00
264_K362_D0.5591.00
96_L100_I0.5591.00
121_S124_L0.5581.00
420_A423_V0.5581.00
268_S359_H0.5581.00
269_L360_I0.5571.00
391_S395_S0.5571.00
221_Q225_D0.5551.00
288_K292_I0.5541.00
171_L191_Q0.5531.00
160_K179_A0.5511.00
50_V102_E0.5511.00
57_L95_T0.5511.00
80_M83_I0.5470.99
173_Q199_H0.5460.99
279_L289_I0.5430.99
189_D196_N0.5400.99
198_L202_I0.5400.99
251_G255_L0.5390.99
54_L96_L0.5390.99
202_I206_S0.5380.99
57_L61_N0.5370.99
361_K364_N0.5370.99
157_E161_A0.5330.99
70_Y76_E0.5320.99
81_D84_N0.5310.99
237_G241_S0.5290.99
271_Q275_E0.5230.99
294_T340_S0.5220.99
304_S329_R0.5220.99
63_V66_V0.5210.99
149_E152_I0.5210.99
357_S361_K0.5190.99
122_I125_R0.5190.99
200_Q204_E0.5190.99
273_E277_V0.5180.99
398_I405_F0.5170.99
61_N68_A0.5170.99
154_N158_L0.5170.99
397_K401_D0.5160.99
84_N87_S0.5150.99
187_T195_K0.5130.99
273_E360_I0.5130.99
269_L272_I0.5110.99
283_A350_N0.5110.99
185_N188_R0.5110.99
169_L190_E0.5100.99
251_G377_I0.5100.99
86_H90_D0.5090.99
226_K408_G0.5090.99
60_E92_L0.5080.99
279_L353_I0.5080.99
422_S426_L0.5070.99
295_G330_K0.5050.99
168_I171_L0.5050.99
103_M107_V0.5040.99
262_M371_K0.5040.99
252_K378_N0.5010.99
122_I126_I0.5010.99
160_K180_F0.5000.99
298_E336_K0.5000.99
86_H89_V0.5000.99
271_Q355_I0.5000.99
38_L107_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.6505 100 0.347 Contact Map
1qu7A 2 0.4954 100 0.458 Contact Map
2ch7A 2 0.6227 100 0.468 Contact Map
3g67A 2 0.4931 100 0.52 Contact Map
4i3mA 2 0.331 99.9 0.729 Contact Map
2f95B 2 0.1227 98.3 0.875 Contact Map
4cq4A 4 0.1921 98.1 0.884 Contact Map
4gycB 2 0.1412 98 0.886 Contact Map
3zccA 2 0.2338 97.9 0.889 Contact Map
4i5sA 2 0.6019 97.5 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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