GREMLIN Database
BIOY - Probable biotin transporter BioY
UniProt: O07620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (170)
Sequences: 2707 (2152)
Seq/√Len: 165.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_M58_Q4.0091.00
62_L90_L3.1541.00
65_V72_L3.0801.00
20_L41_G2.9781.00
51_P105_N2.8811.00
50_R101_S2.7041.00
10_I53_S2.6551.00
6_D53_S2.4561.00
136_A143_L2.4251.00
50_R54_A2.4001.00
96_A127_I2.2501.00
55_F94_P2.1811.00
99_L126_F2.1011.00
47_S168_A1.9721.00
145_Q149_M1.9051.00
59_L94_P1.8971.00
18_A71_L1.8751.00
13_F45_A1.8611.00
132_I150_S1.8281.00
64_L69_A1.8171.00
128_Y157_D1.7901.00
87_A134_V1.7501.00
55_F98_W1.7201.00
14_T60_V1.7071.00
148_F151_L1.6911.00
62_L94_P1.6891.00
92_A130_L1.6521.00
28_L31_T1.6501.00
36_T39_T1.6481.00
21_G61_F1.6111.00
38_Q93_Y1.6071.00
142_D145_Q1.6051.00
147_A151_L1.6051.00
95_L130_L1.5301.00
84_G87_A1.5291.00
103_A119_H1.5271.00
154_V158_L1.4941.00
54_A101_S1.4781.00
128_Y150_S1.4521.00
14_T18_A1.4491.00
76_R81_V1.4481.00
14_T57_S1.4461.00
132_I146_A1.4311.00
51_P98_W1.3891.00
47_S120_I1.3801.00
92_A127_I1.3761.00
130_L133_P1.3631.00
65_V71_L1.3621.00
22_F75_G1.3611.00
14_T64_L1.3591.00
17_M45_A1.3371.00
4_L8_M1.3261.00
89_F135_Q1.2861.00
135_Q139_M1.2841.00
100_I123_G1.2511.00
124_I128_Y1.2471.00
56_L59_L1.2451.00
151_L155_P1.2361.00
62_L82_F1.2251.00
111_T114_R1.1791.00
132_I147_A1.1771.00
135_Q141_I1.1751.00
47_S104_A1.1711.00
134_V138_I1.1701.00
158_L162_A1.1681.00
27_F31_T1.1531.00
36_T93_Y1.1531.00
61_F72_L1.1291.00
135_Q146_A1.1241.00
17_M42_V1.1171.00
66_A79_F1.1161.00
141_I149_M1.1141.00
129_L133_P1.1011.00
40_L163_V1.1001.00
40_L164_S1.0891.00
134_V137_F1.0771.00
120_I161_A1.0670.99
152_A155_P1.0610.99
27_F30_F1.0610.99
66_A77_G1.0580.99
46_G54_A1.0440.99
45_A49_L1.0280.99
51_P101_S1.0260.99
58_Q97_S1.0240.99
79_F83_F1.0210.99
49_L57_S1.0170.99
100_I119_H1.0150.99
53_S57_S1.0100.99
61_F65_V1.0020.99
64_L71_L0.9950.99
61_F93_Y0.9900.99
51_P102_L0.9890.99
95_L126_F0.9890.99
89_F127_I0.9860.99
52_K105_N0.9840.99
66_A87_A0.9800.99
153_Y160_K0.9570.99
50_R53_S0.9540.99
87_A91_I0.9530.99
35_I156_G0.9470.99
82_F90_L0.9400.99
141_I145_Q0.9370.99
92_A96_A0.9360.99
98_W102_L0.9300.99
95_L99_L0.9270.99
156_G160_K0.9270.99
16_L41_G0.9260.98
141_I146_A0.9260.98
124_I161_A0.9250.98
103_A122_F0.9230.98
9_H53_S0.9190.98
43_M100_I0.9190.98
45_A58_Q0.9160.98
37_L40_L0.9130.98
170_K174_A0.8920.98
102_L106_R0.8820.98
170_K173_Q0.8710.98
89_F150_S0.8680.98
45_A57_S0.8680.98
144_S148_F0.8600.98
161_A165_A0.8590.98
13_F49_L0.8550.97
17_M41_G0.8530.97
4_L7_M0.8410.97
118_T122_F0.8390.97
74_G84_G0.8330.97
39_T127_I0.8310.97
133_P136_A0.8310.97
165_A169_I0.8270.97
18_A22_F0.8270.97
89_F128_Y0.8270.97
39_T124_I0.8060.96
169_I172_T0.8060.96
43_M124_I0.8040.96
7_M11_A0.7900.96
10_I56_L0.7880.96
55_F58_Q0.7870.96
39_T156_G0.7840.96
48_I171_I0.7800.96
42_V97_S0.7790.96
17_M20_L0.7780.96
26_L31_T0.7780.96
92_A126_F0.7730.95
25_P29_S0.7650.95
20_L23_M0.7650.95
28_L32_P0.7550.95
91_I95_L0.7530.95
136_A146_A0.7450.94
144_S151_L0.7420.94
121_V161_A0.7390.94
10_I14_T0.7390.94
124_I157_D0.7350.94
82_F87_A0.7340.94
81_V84_G0.7250.94
16_L20_L0.7210.93
47_S119_H0.7200.93
68_G78_G0.7190.93
91_I130_L0.7180.93
166_F170_K0.7160.93
13_F48_I0.7130.93
73_P76_R0.7080.93
91_I134_V0.6930.92
97_S101_S0.6920.92
13_F57_S0.6900.92
6_D10_I0.6830.91
78_G87_A0.6780.91
130_L134_V0.6770.91
43_M127_I0.6760.91
136_A142_D0.6760.91
112_V116_F0.6710.91
11_A15_A0.6710.91
99_L122_F0.6680.91
95_L98_W0.6680.91
55_F97_S0.6670.90
125_I129_L0.6630.90
15_A64_L0.6620.90
128_Y132_I0.6550.90
150_S154_V0.6550.90
112_V115_L0.6530.90
18_A69_A0.6510.89
102_L105_N0.6480.89
140_H144_S0.6460.89
26_L35_I0.6430.89
86_S90_L0.6420.89
139_M149_M0.6420.89
133_P137_F0.6390.89
46_G100_I0.6370.88
82_F91_I0.6360.88
33_V135_Q0.6360.88
11_A60_V0.6360.88
93_Y97_S0.6330.88
126_F130_L0.6280.88
18_A64_L0.6270.88
47_S165_A0.6250.87
83_F87_A0.6230.87
43_M120_I0.6170.87
162_A166_F0.6130.86
101_S104_A0.6110.86
43_M96_A0.6100.86
72_L82_F0.6090.86
61_F71_L0.6020.85
42_V46_G0.5970.85
33_V153_Y0.5970.85
99_L103_A0.5940.85
55_F95_L0.5910.84
34_P73_P0.5910.84
136_A140_H0.5880.84
145_Q148_F0.5870.84
96_A126_F0.5850.84
122_F126_F0.5840.84
121_V125_I0.5800.83
86_S152_A0.5790.83
139_M145_Q0.5780.83
143_L147_A0.5780.83
94_P97_S0.5740.83
26_L29_S0.5630.81
66_A82_F0.5620.81
39_T42_V0.5610.81
34_P135_Q0.5610.81
33_V86_S0.5580.81
155_P158_L0.5580.81
48_I174_A0.5570.81
15_A19_V0.5550.81
101_S105_N0.5540.80
40_L167_L0.5540.80
81_V87_A0.5530.80
46_G55_F0.5510.80
63_L66_A0.5500.80
87_A136_A0.5490.80
105_N114_R0.5450.79
124_I158_L0.5440.79
120_I165_A0.5390.79
167_L171_I0.5390.79
89_F147_A0.5340.78
98_W105_N0.5340.78
100_I103_A0.5340.78
6_D9_H0.5330.78
66_A91_I0.5330.78
76_R79_F0.5250.77
107_L114_R0.5230.76
42_V58_Q0.5200.76
120_I124_I0.5200.76
94_P98_W0.5180.76
39_T160_K0.5160.76
8_M12_I0.5130.75
17_M21_G0.5120.75
48_I168_A0.5100.75
49_L53_S0.5090.75
21_G73_P0.5080.74
112_V169_I0.5070.74
18_A61_F0.5070.74
93_Y127_I0.5060.74
117_F165_A0.5030.74
31_T149_M0.5010.73
17_M57_S0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dveA 3 0.9785 100 0.26 Contact Map
3p5nA 2 0.8602 99.8 0.601 Contact Map
4z7fA 2 0.8871 99.8 0.607 Contact Map
4huqS 1 0.8602 99.8 0.616 Contact Map
4hzuS 1 0.8495 99.8 0.636 Contact Map
4tkrA 2 0.8871 99.7 0.644 Contact Map
3rlbA 1 0.8925 99.7 0.654 Contact Map
4rfsS 1 0.8978 99.7 0.664 Contact Map
4m5bA 1 0.8817 90.9 0.898 Contact Map
4cz8A 2 0.7957 13.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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