GREMLIN Database
YHFT - Uncharacterized acyl--CoA ligase YhfT
UniProt: O07619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (463)
Sequences: 71914 (51954)
Seq/√Len: 2414.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_P161_T3.8991.00
399_C435_W3.2071.00
335_I362_G3.0871.00
37_S72_A2.9761.00
316_R338_K2.9221.00
54_A98_A2.8231.00
51_N99_D2.8101.00
95_I149_F2.8031.00
163_S344_S2.7931.00
363_Y371_Y2.7631.00
33_D72_A2.7521.00
21_Q210_T2.6471.00
334_K357_T2.5701.00
48_S75_C2.5291.00
185_K210_T2.4581.00
381_V386_N2.4211.00
18_V26_Q2.3971.00
404_S457_E2.3831.00
97_N348_N2.3671.00
42_W46_Q2.3561.00
397_L405_A2.3321.00
14_S17_R2.3291.00
8_S33_D2.3131.00
318_E326_R2.3091.00
52_R78_I2.2881.00
35_L65_Q2.2811.00
320_R336_F2.2581.00
336_F357_T2.2551.00
321_N325_E2.2431.00
95_I349_G2.1971.00
91_E156_K2.1901.00
10_T14_S2.1751.00
332_I361_M2.1731.00
365_D371_Y2.1621.00
33_D37_S2.1411.00
464_A467_R2.1261.00
66_L102_V2.1261.00
378_G465_R2.0821.00
70_A75_C2.0651.00
396_L421_A2.0521.00
420_V450_V2.0431.00
224_E228_R2.0421.00
22_T61_L2.0311.00
184_D256_K1.9881.00
363_Y373_S1.9781.00
398_A439_K1.9661.00
140_D143_H1.9661.00
266_A270_K1.9221.00
365_D369_F1.9061.00
21_Q26_Q1.9031.00
39_T65_Q1.8861.00
318_E336_F1.8841.00
184_D232_S1.8811.00
90_K94_S1.8421.00
307_S371_Y1.8371.00
16_G30_H1.8321.00
391_E444_K1.8021.00
44_R73_A1.7871.00
467_R470_K1.7781.00
21_Q229_E1.7491.00
36_V72_A1.7421.00
364_V370_L1.7341.00
30_H34_R1.7021.00
9_S13_T1.6961.00
332_I373_S1.6931.00
393_E407_V1.6851.00
397_L404_S1.6821.00
212_C231_I1.6501.00
64_L201_A1.6481.00
28_T31_D1.6461.00
163_S166_S1.6441.00
230_S254_P1.6421.00
382_Y387_I1.6261.00
329_P364_V1.6111.00
408_V422_V1.6041.00
144_P344_S1.5931.00
54_A80_I1.5901.00
52_R76_T1.5821.00
423_I451_F1.5801.00
58_P104_L1.5631.00
71_A145_F1.5581.00
149_F159_A1.5541.00
175_E207_L1.5481.00
27_I65_Q1.5351.00
10_T13_T1.5311.00
422_V468_V1.5301.00
236_T241_T1.5261.00
15_P30_H1.5241.00
424_L455_L1.5211.00
221_K224_E1.5131.00
280_K298_P1.5051.00
435_W439_K1.5031.00
428_N431_T1.5031.00
37_S41_N1.5011.00
401_E431_T1.5011.00
8_S72_A1.4991.00
294_T337_V1.4881.00
319_I362_G1.4821.00
53_V70_A1.4751.00
407_V421_A1.4741.00
11_A33_D1.4691.00
18_V21_Q1.4671.00
204_T209_G1.4671.00
411_P417_E1.4621.00
142_E165_R1.4581.00
176_T313_H1.4541.00
99_D116_T1.4461.00
161_T347_V1.4431.00
147_M347_V1.4391.00
46_Q117_P1.4311.00
395_V439_K1.4291.00
18_V210_T1.4251.00
241_T257_I1.4221.00
96_S149_F1.4171.00
187_L231_I1.4141.00
433_K449_W1.4131.00
287_T356_M1.4111.00
458_T464_A1.4071.00
362_G372_I1.4051.00
27_I61_L1.4021.00
304_K367_E1.3981.00
270_K274_A1.3971.00
321_N327_C1.3951.00
430_R434_A1.3941.00
361_M376_E1.3911.00
184_D233_V1.3891.00
218_S221_K1.3881.00
239_T262_A1.3851.00
93_L98_A1.3851.00
161_T345_G1.3821.00
181_S184_D1.3811.00
166_S291_S1.3761.00
17_R183_D1.3761.00
141_P165_R1.3651.00
78_I96_S1.3651.00
295_F317_I1.3601.00
332_I363_Y1.3581.00
185_K212_C1.3561.00
22_T25_E1.3491.00
328_Q331_E1.3491.00
54_A93_L1.3451.00
225_W229_E1.3311.00
317_I337_V1.3301.00
422_V452_A1.3301.00
53_V75_C1.3271.00
227_C250_F1.3221.00
19_A32_W1.3171.00
310_R369_F1.3151.00
338_K355_W1.3141.00
423_I449_W1.3101.00
214_L225_W1.3081.00
48_S51_N1.3071.00
39_T69_G1.3061.00
318_E355_W1.2971.00
304_K369_F1.2941.00
52_R147_M1.2841.00
380_I389_P1.2811.00
433_K437_K1.2751.00
434_A438_Q1.2711.00
420_V448_K1.2651.00
95_I348_N1.2651.00
68_A205_L1.2631.00
259_S264_W1.2601.00
412_D418_I1.2581.00
91_E95_I1.2571.00
437_K445_I1.2531.00
52_R347_V1.2461.00
165_R340_P1.2451.00
404_S424_L1.2381.00
410_I420_V1.2371.00
95_I156_K1.2371.00
311_P317_I1.2361.00
185_K231_I1.2281.00
86_P110_K1.2231.00
76_T144_P1.2231.00
435_W438_Q1.2221.00
35_L38_Q1.2171.00
390_E394_R1.2161.00
161_T344_S1.2151.00
23_E215_K1.2131.00
334_K376_E1.2121.00
378_G390_E1.1941.00
86_P90_K1.1921.00
50_P143_H1.1911.00
409_G417_E1.1821.00
147_M159_A1.1821.00
418_I447_K1.1751.00
234_L255_V1.1701.00
196_H235_Y1.1701.00
272_L276_W1.1671.00
437_K442_S1.1661.00
55_I66_L1.1631.00
297_S369_F1.1631.00
385_L443_Y1.1531.00
139_I143_H1.1531.00
19_A29_Y1.1531.00
429_A451_F1.1481.00
335_I372_I1.1441.00
34_R38_Q1.1431.00
25_E61_L1.1421.00
32_W68_A1.1401.00
422_V469_K1.1301.00
246_R271_K1.1281.00
418_I448_K1.1271.00
56_L89_C1.1251.00
242_D268_S1.1231.00
327_C331_E1.1211.00
27_I35_L1.1211.00
8_S37_S1.1191.00
69_G73_A1.1151.00
48_S53_V1.1131.00
26_Q229_E1.1051.00
94_S156_K1.1011.00
226_L254_P1.1001.00
162_R166_S1.0891.00
21_Q212_C1.0871.00
40_A72_A1.0841.00
42_W45_S1.0831.00
31_D34_R1.0821.00
142_E163_S1.0821.00
245_A271_K1.0771.00
35_L62_A1.0761.00
185_K232_S1.0711.00
421_A449_W1.0671.00
212_C229_E1.0651.00
265_P268_S1.0611.00
63_F192_L1.0601.00
336_F355_W1.0601.00
32_W65_Q1.0601.00
403_E424_L1.0591.00
322_A376_E1.0571.00
150_T160_F1.0551.00
190_G196_H1.0541.00
436_C445_I1.0531.00
308_A372_I1.0471.00
80_I89_C1.0461.00
379_M388_F1.0451.00
401_E425_G1.0421.00
315_V341_M1.0411.00
429_A449_W1.0381.00
105_A122_D1.0361.00
51_N75_C1.0341.00
86_P113_D1.0331.00
399_C432_L1.0321.00
39_T102_V1.0311.00
395_V398_A1.0261.00
429_A433_K1.0251.00
452_A471_W1.0251.00
410_I448_K1.0241.00
212_C225_W1.0231.00
337_V358_V1.0201.00
452_A455_L1.0171.00
431_T434_A1.0161.00
166_S342_R1.0111.00
383_G415_W1.0091.00
393_E465_R1.0091.00
100_L117_P1.0061.00
271_K275_A1.0011.00
184_D209_G1.0001.00
455_L463_I1.0001.00
186_V204_T0.9981.00
88_E444_K0.9981.00
339_S342_R0.9971.00
119_V123_N0.9941.00
467_R471_W0.9891.00
466_S470_K0.9841.00
160_F343_F0.9831.00
338_K353_D0.9731.00
267_E271_K0.9711.00
441_A444_K0.9691.00
36_V69_G0.9671.00
27_I32_W0.9671.00
17_R210_T0.9661.00
87_A439_K0.9661.00
169_E340_P0.9591.00
151_S460_S0.9591.00
52_R97_N0.9551.00
406_A455_L0.9531.00
297_S307_S0.9521.00
91_E94_S0.9521.00
119_V122_D0.9521.00
18_V28_T0.9481.00
48_S100_L0.9471.00
243_A414_Y0.9461.00
20_I64_L0.9421.00
380_I419_A0.9421.00
39_T66_L0.9421.00
84_W92_R0.9381.00
317_I370_L0.9371.00
148_G288_S0.9361.00
319_I327_C0.9361.00
242_D265_P0.9351.00
91_E149_F0.9341.00
87_A91_E0.9321.00
295_F370_L0.9301.00
67_F77_A0.9281.00
57_L60_S0.9281.00
81_D193_M0.9271.00
7_Y11_A0.9231.00
264_W269_K0.9211.00
187_L214_L0.9181.00
169_E314_N0.9141.00
434_A437_K0.9131.00
170_S292_F0.9121.00
87_A90_K0.9091.00
41_N131_A0.9081.00
241_T272_L0.9071.00
43_L70_A0.9071.00
321_N331_E0.9061.00
61_L65_Q0.9041.00
62_A65_Q0.9031.00
41_N44_R0.9021.00
317_I335_I0.8981.00
399_C431_T0.8971.00
171_F206_F0.8941.00
32_W36_V0.8941.00
395_V436_C0.8931.00
304_K365_D0.8931.00
361_M374_G0.8911.00
271_K274_A0.8901.00
25_E35_L0.8871.00
54_A101_V0.8861.00
398_A435_W0.8831.00
352_P357_T0.8821.00
227_C251_P0.8811.00
55_I77_A0.8731.00
217_F240_M0.8721.00
382_Y409_G0.8711.00
162_R291_S0.8681.00
57_L121_L0.8681.00
104_L107_F0.8681.00
91_E349_G0.8681.00
258_I284_F0.8661.00
319_I370_L0.8641.00
58_P106_F0.8611.00
411_P414_Y0.8611.00
44_R49_M0.8591.00
382_Y447_K0.8591.00
204_T211_V0.8591.00
21_Q185_K0.8581.00
67_F198_L0.8581.00
431_T435_W0.8531.00
43_L102_V0.8511.00
31_D35_L0.8491.00
40_A73_A0.8461.00
9_S12_E0.8411.00
324_G336_F0.8401.00
307_S369_F0.8401.00
35_L61_L0.8391.00
145_F164_H0.8331.00
162_R343_F0.8321.00
406_A468_V0.8311.00
8_S12_E0.8291.00
33_D36_V0.8281.00
195_S287_T0.8281.00
70_A77_A0.8281.00
20_I61_L0.8271.00
64_L213_L0.8211.00
195_S292_F0.8191.00
108_K112_T0.8161.00
17_R182_S0.8131.00
185_K230_S0.8091.00
54_A78_I0.8051.00
235_Y293_V0.8041.00
232_S256_K0.8041.00
330_G366_E0.8011.00
6_T172_T0.7961.00
18_V22_T0.7961.00
65_Q69_G0.7961.00
67_F71_A0.7931.00
424_L454_S0.7821.00
378_G393_E0.7821.00
290_L356_M0.7811.00
322_A334_K0.7811.00
432_L449_W0.7781.00
335_I370_L0.7781.00
38_Q42_W0.7771.00
290_L342_R0.7761.00
220_A224_E0.7731.00
7_Y68_A0.7721.00
49_M75_C0.7721.00
107_F110_K0.7661.00
316_R355_W0.7641.00
46_Q100_L0.7631.00
189_P240_M0.7611.00
105_A120_L0.7611.00
48_S73_A0.7601.00
241_T259_S0.7591.00
242_D246_R0.7591.00
237_V240_M0.7581.00
362_G370_L0.7571.00
131_A134_D0.7561.00
318_E338_K0.7541.00
411_P415_W0.7531.00
406_A463_I0.7521.00
139_I164_H0.7481.00
183_D232_S0.7481.00
338_K354_E0.7471.00
6_T10_T0.7441.00
427_A432_L0.7441.00
433_K445_I0.7431.00
32_W64_L0.7421.00
7_Y33_D0.7421.00
70_A73_A0.7411.00
175_E203_S0.7391.00
144_P163_S0.7381.00
242_D271_K0.7371.00
25_E62_A0.7361.00
317_I362_G0.7351.00
87_A156_K0.7351.00
146_Y162_R0.7331.00
332_I376_E0.7321.00
320_R326_R0.7321.00
290_L337_V0.7311.00
78_I98_A0.7311.00
131_A135_P0.7301.00
396_L405_A0.7301.00
224_E227_C0.7281.00
181_S256_K0.7261.00
196_H260_S0.7261.00
442_S445_I0.7261.00
199_Y235_Y0.7251.00
26_Q210_T0.7231.00
430_R433_K0.7221.00
45_S131_A0.7201.00
47_P75_C0.7191.00
57_L63_F0.7191.00
109_N112_T0.7181.00
221_K225_W0.7171.00
170_S291_S0.7171.00
276_W279_L0.7161.00
227_C253_S0.7111.00
422_V471_W0.7111.00
226_L231_I0.7101.00
92_R159_A0.7091.00
105_A123_N0.7061.00
436_C440_L0.7051.00
180_I233_V0.7051.00
194_S385_L0.7041.00
77_A198_L0.7041.00
145_F167_W0.7031.00
395_V435_W0.7021.00
357_T376_E0.7021.00
282_Y298_P0.7021.00
60_S104_L0.7001.00
5_H8_S0.7001.00
410_I418_I0.6981.00
5_H9_S0.6981.00
67_F202_V0.6961.00
16_G28_T0.6941.00
267_E270_K0.6931.00
390_E393_E0.6921.00
56_L101_V0.6911.00
250_F253_S0.6901.00
290_L294_T0.6891.00
54_A96_S0.6891.00
329_P366_E0.6891.00
40_A69_G0.6811.00
342_R356_M0.6811.00
411_P416_G0.6801.00
56_L107_F0.6791.00
66_L70_A0.6781.00
235_Y284_F0.6781.00
103_T120_L0.6771.00
33_D134_D0.6771.00
39_T43_L0.6771.00
39_T42_W0.6771.00
41_N133_A0.6761.00
284_F293_V0.6741.00
53_V100_L0.6731.00
120_L123_N0.6721.00
187_L225_W0.6711.00
188_I200_G0.6701.00
14_S30_H0.6681.00
177_D313_H0.6671.00
257_I272_L0.6671.00
186_V233_V0.6661.00
264_W281_L0.6641.00
406_A465_R0.6641.00
11_A15_P0.6611.00
242_D267_E0.6611.00
10_T208_G0.6601.00
166_S344_S0.6591.00
103_T118_V0.6591.00
362_G373_S0.6581.00
456_P468_V0.6571.00
382_Y419_A0.6551.00
224_E250_F0.6521.00
85_S88_E0.6511.00
248_E275_A0.6491.00
287_T290_L0.6491.00
132_A135_P0.6481.00
170_S199_Y0.6471.00
412_D415_W0.6471.00
41_N132_A0.6431.00
214_L222_A0.6431.00
142_E344_S0.6421.00
187_L226_L0.6411.00
44_R137_P0.6401.00
12_E33_D0.6401.00
22_T215_K0.6401.00
57_L102_V0.6391.00
417_E469_K0.6371.00
44_R134_D0.6361.00
273_A280_K0.6351.00
103_T107_F0.6331.00
200_G235_Y0.6291.00
36_V40_A0.6281.00
68_A202_V0.6281.00
423_I432_L0.6271.00
285_Y294_T0.6271.00
312_F315_V0.6261.00
27_I31_D0.6261.00
36_V39_T0.6261.00
283_D306_H0.6231.00
408_V469_K0.6231.00
57_L66_L0.6221.00
14_S208_G0.6201.00
172_T206_F0.6191.00
190_G235_Y0.6161.00
268_S271_K0.6151.00
189_P237_V0.6141.00
226_L234_L0.6131.00
427_A431_T0.6131.00
382_Y415_W0.6121.00
103_T108_K0.6111.00
326_R336_F0.6111.00
389_P407_V0.6091.00
172_T176_T0.6071.00
389_P465_R0.6061.00
217_F222_A0.6051.00
180_I184_D0.6051.00
170_S293_V0.6051.00
20_I211_V0.6051.00
41_N134_D0.6041.00
225_W228_R0.6041.00
249_G252_D0.6031.00
330_G363_Y0.6021.00
287_T358_V0.6021.00
97_N347_V0.5991.00
14_S182_S0.5991.00
45_S130_E0.5981.00
234_L257_I0.5971.00
227_C254_P0.5961.00
171_F202_V0.5951.00
110_K113_D0.5951.00
319_I364_V0.5941.00
210_T229_E0.5931.00
6_T168_M0.5921.00
78_I149_F0.5921.00
62_A104_L0.5921.00
146_Y167_W0.5921.00
95_I347_V0.5911.00
422_V450_V0.5901.00
52_R348_N0.5901.00
345_G350_S0.5901.00
147_M161_T0.5891.00
131_A136_L0.5891.00
450_V471_W0.5881.00
76_T147_M0.5881.00
38_Q41_N0.5851.00
108_K120_L0.5851.00
180_I209_G0.5831.00
34_R132_A0.5821.00
308_A362_G0.5821.00
188_I211_V0.5821.00
6_T206_F0.5821.00
174_T199_Y0.5811.00
156_K349_G0.5811.00
402_V405_A0.5791.00
146_Y198_L0.5781.00
272_L281_L0.5761.00
143_H164_H0.5741.00
270_K273_A0.5731.00
37_S44_R0.5731.00
396_L436_C0.5721.00
263_D372_I0.5721.00
380_I409_G0.5711.00
49_M99_D0.5711.00
222_A226_L0.5701.00
395_V440_L0.5681.00
29_Y209_G0.5671.00
95_I159_A0.5661.00
57_L103_T0.5651.00
57_L104_L0.5641.00
41_N45_S0.5641.00
377_N417_E0.5631.00
196_H258_I0.5631.00
264_W283_D0.5621.00
76_T347_V0.5611.00
56_L111_L0.5611.00
101_V111_L0.5591.00
191_A194_S0.5591.00
21_Q24_S0.5591.00
18_V185_K0.5581.00
319_I335_I0.5581.00
428_N451_F0.5581.00
170_S174_T0.5571.00
402_V423_I0.5571.00
259_S281_L0.5561.00
172_T175_E0.5561.00
115_Q119_V0.5551.00
399_C402_V0.5551.00
319_I333_G0.5551.00
392_I419_A0.5531.00
189_P236_T0.5521.00
52_R98_A0.5521.00
389_P409_G0.5521.00
117_P120_L0.5521.00
394_R398_A0.5511.00
173_C177_D0.5501.00
79_P148_G0.5501.00
67_F201_A0.5501.00
99_D117_P0.5501.00
37_S134_D0.5481.00
55_I70_A0.5481.00
185_K188_I0.5481.00
188_I213_L0.5481.00
404_S455_L0.5471.00
55_I63_F0.5471.00
326_R364_V0.5471.00
320_R355_W0.5461.00
412_D416_G0.5461.00
193_M385_L0.5451.00
394_R397_L0.5451.00
35_L39_T0.5441.00
448_K451_F0.5441.00
44_R135_P0.5431.00
42_W128_I0.5431.00
38_Q132_A0.5421.00
43_L100_L0.5421.00
247_I275_A0.5391.00
393_E421_A0.5391.00
235_Y260_S0.5381.00
123_N127_D0.5381.00
155_G388_F0.5371.00
96_S159_A0.5371.00
295_F308_A0.5361.00
401_E435_W0.5361.00
445_I449_W0.5361.00
188_I197_F0.5341.00
429_A448_K0.5341.00
199_Y293_V0.5321.00
84_W89_C0.5311.00
260_S284_F0.5311.00
100_L119_V0.5311.00
29_Y205_L0.5311.00
94_S114_S0.5301.00
187_L222_A0.5301.00
88_E391_E0.5301.00
410_I422_V0.5291.00
76_T79_P0.5281.00
186_V209_G0.5261.00
433_K436_C0.5251.00
413_E416_G0.5251.00
382_Y417_E0.5241.00
37_S133_A0.5241.00
96_S147_M0.5241.00
160_F288_S0.5241.00
331_E363_Y0.5221.00
297_S300_D0.5221.00
316_R353_D0.5201.00
238_P262_A0.5181.00
270_K305_P0.5171.00
33_D135_P0.5171.00
232_S254_P0.5161.00
103_T111_L0.5161.00
243_A246_R0.5161.00
374_G389_P0.5131.00
257_I279_L0.5131.00
133_A136_L0.5121.00
259_S283_D0.5111.00
114_S119_V0.5101.00
359_D377_N0.5101.00
466_S469_K0.5101.00
454_S457_E0.5091.00
337_V342_R0.5081.00
378_G389_P0.5081.00
43_L75_C0.5071.00
320_R324_G0.5071.00
247_I250_F0.5071.00
379_M386_N0.5061.00
58_P107_F0.5061.00
41_N135_P0.5051.00
269_K283_D0.5051.00
56_L110_K0.5051.00
20_I27_I0.5041.00
343_F356_M0.5041.00
78_I92_R0.5041.00
5_H138_T0.5021.00
75_C100_L0.5021.00
215_K221_K0.5011.00
294_T315_V0.5001.00
245_A268_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tsyA 2 0.7891 100 0.121 Contact Map
2vsqA 1 0.9958 100 0.129 Contact Map
4lgcA 1 0.7578 100 0.13 Contact Map
1mdbA 1 0.9958 100 0.132 Contact Map
3wvnA 1 0.762 100 0.133 Contact Map
3ni2A 1 0.9833 100 0.135 Contact Map
3g7sA 2 0.9081 100 0.137 Contact Map
3o83A 1 0.7871 100 0.137 Contact Map
2d1sA 1 0.9916 100 0.138 Contact Map
3etcA 2 0.9499 100 0.141 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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