GREMLIN Database
YHFS - Putative acetyl-CoA C-acetyltransferase YhfS
UniProt: O07618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (355)
Sequences: 15058 (8083)
Seq/√Len: 429.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_L161_R3.3741.00
150_M298_Q3.3371.00
233_K237_L3.3231.00
101_G104_Y2.9201.00
89_V328_V2.8961.00
35_C38_R2.8841.00
156_L193_I2.8811.00
331_L344_A2.7581.00
4_V234_A2.7381.00
231_E235_A2.7351.00
157_L160_Q2.7301.00
164_N168_E2.6791.00
269_L273_H2.6551.00
151_Q210_T2.6241.00
142_A205_D2.5411.00
233_K236_A2.5311.00
36_L227_L2.5081.00
269_L359_L2.5031.00
8_A329_T2.4821.00
96_I228_V2.4781.00
33_I105_I2.4161.00
335_A341_C2.3491.00
167_D189_K2.2591.00
9_K39_K2.2271.00
96_I230_E2.1801.00
282_L309_V2.1581.00
172_R182_E2.1341.00
103_M229_M2.1241.00
244_R361_E2.0961.00
247_G273_H2.0741.00
29_A49_L2.0471.00
92_A104_Y2.0401.00
186_A218_G2.0331.00
147_S150_M1.9961.00
197_I214_A1.9921.00
242_V336_K1.9511.00
6_V229_M1.9431.00
31_P178_L1.9431.00
166_H187_F1.9371.00
247_G269_L1.9191.00
243_L332_F1.9101.00
275_V343_Y1.8961.00
224_A325_A1.8921.00
140_T146_I1.8911.00
149_S153_E1.8831.00
163_R187_F1.8111.00
229_M234_A1.7551.00
205_D208_S1.7491.00
134_G204_F1.7451.00
310_R334_E1.7321.00
266_I347_A1.7291.00
43_Q237_L1.7271.00
172_R183_T1.7181.00
166_H175_V1.7151.00
281_D341_C1.6701.00
19_L181_L1.6681.00
334_E338_R1.6611.00
297_S307_I1.6531.00
229_M233_K1.6461.00
102_T230_E1.6281.00
275_V280_I1.6261.00
338_R341_C1.6161.00
29_A63_S1.6121.00
92_A228_V1.6111.00
280_I283_F1.6001.00
267_R271_H1.5921.00
226_L325_A1.5871.00
195_A199_R1.5811.00
280_I359_L1.5791.00
166_H183_T1.5721.00
7_D36_L1.5691.00
297_S304_F1.5671.00
49_L107_G1.5401.00
230_E233_K1.5351.00
277_P283_F1.5331.00
275_V359_L1.5311.00
111_S114_Q1.5211.00
33_I63_S1.5131.00
303_P306_K1.5051.00
4_V244_R1.4991.00
157_L304_F1.4971.00
334_E337_R1.4911.00
31_P176_V1.4901.00
170_F334_E1.4791.00
20_L181_L1.4771.00
249_A269_L1.4691.00
342_Q361_E1.4641.00
173_E336_K1.4531.00
170_F310_R1.4521.00
102_T233_K1.4471.00
156_L160_Q1.4441.00
264_V267_R1.4391.00
94_S100_A1.4301.00
143_R257_F1.4281.00
163_R167_D1.4241.00
76_M91_Y1.4231.00
35_C176_V1.4191.00
280_I343_Y1.4171.00
35_C39_K1.4121.00
282_L334_E1.4051.00
95_L101_G1.3961.00
153_E157_L1.3961.00
160_Q190_T1.3711.00
283_F345_V1.3691.00
32_I225_A1.3561.00
27_D66_Q1.3421.00
34_R38_R1.3391.00
246_I361_E1.3331.00
328_V360_F1.3231.00
59_L109_S1.3161.00
103_M233_K1.3151.00
83_G356_L1.3031.00
83_G350_S1.2931.00
90_R358_L1.2911.00
270_L277_P1.2831.00
32_I223_A1.2791.00
345_V359_L1.2791.00
105_I227_L1.2691.00
249_A268_Q1.2681.00
332_F336_K1.2601.00
13_F322_A1.2591.00
150_M153_E1.2501.00
89_V226_L1.2491.00
160_Q164_N1.2471.00
3_A228_V1.2341.00
153_E193_I1.2321.00
265_A357_A1.2261.00
71_L254_H1.2221.00
309_V334_E1.2151.00
44_V103_M1.2091.00
331_L346_A1.2041.00
134_G203_V1.1971.00
280_I345_V1.1941.00
138_E205_D1.1901.00
268_Q271_H1.1891.00
232_E236_A1.1881.00
4_V229_M1.1881.00
120_R125_P1.1771.00
163_R190_T1.1761.00
329_T333_Y1.1731.00
23_F31_P1.1731.00
49_L225_A1.1701.00
45_D101_G1.1621.00
148_R212_T1.1601.00
267_R299_E1.1571.00
146_I151_Q1.1521.00
4_V231_E1.1481.00
33_I69_L1.1461.00
8_A333_Y1.1411.00
13_F316_L1.1381.00
12_I181_L1.1361.00
48_I104_Y1.1321.00
174_E330_R1.1211.00
170_F337_R1.1171.00
253_I260_A1.1121.00
245_F358_L1.1061.00
251_S264_V1.1021.00
260_A263_V1.0951.00
92_A106_A1.0951.00
281_D306_K1.0941.00
135_I205_D1.0931.00
281_D335_A1.0851.00
326_A330_R1.0831.00
86_L328_V1.0801.00
30_A66_Q1.0791.00
273_H359_L1.0791.00
90_R248_S1.0771.00
309_V338_R1.0771.00
7_D39_K1.0771.00
87_E91_Y1.0751.00
173_E337_R1.0651.00
154_Y293_I1.0651.00
100_A272_T1.0491.00
191_R197_I1.0471.00
9_K176_V1.0471.00
247_G272_T1.0421.00
120_R123_F1.0421.00
50_G84_S1.0411.00
146_I294_C1.0371.00
143_R256_N1.0291.00
247_G359_L1.0211.00
45_D102_T1.0171.00
31_P35_C1.0171.00
156_L197_I1.0151.00
282_L338_R1.0091.00
154_Y294_C1.0051.00
97_Q100_A1.0031.00
302_I307_I1.0021.00
139_Y143_R1.0021.00
37_S69_L1.0001.00
246_I343_Y0.9991.00
43_Q233_K0.9821.00
8_A332_F0.9791.00
231_E244_R0.9771.00
257_F260_A0.9731.00
14_G185_E0.9731.00
276_T279_D0.9641.00
144_Y260_A0.9631.00
173_E333_Y0.9591.00
5_I360_F0.9571.00
47_V64_A0.9551.00
277_P280_I0.9551.00
193_I198_P0.9541.00
89_V228_V0.9521.00
266_I345_V0.9521.00
350_S356_L0.9511.00
200_A214_A0.9481.00
32_I35_C0.9431.00
9_K35_C0.9411.00
37_S40_L0.9391.00
343_Y359_L0.9371.00
163_R189_K0.9371.00
6_V239_L0.9361.00
11_T32_I0.9341.00
327_L346_A0.9311.00
224_A322_A0.9281.00
3_A230_E0.9271.00
157_L305_S0.9271.00
69_L73_V0.9191.00
251_S268_Q0.9181.00
166_H172_R0.9161.00
13_F220_A0.9141.00
36_L105_I0.9131.00
43_Q236_A0.9081.00
242_V332_F0.9061.00
121_A125_P0.9051.00
343_Y361_E0.9051.00
156_L190_T0.9011.00
93_C245_F0.8981.00
80_R87_E0.8971.00
94_S98_A0.8941.00
51_N55_R0.8921.00
192_P195_A0.8871.00
11_T31_P0.8861.00
12_I31_P0.8831.00
32_I36_L0.8811.00
229_M239_L0.8771.00
231_E234_A0.8691.00
313_A323_S0.8681.00
200_A212_T0.8661.00
138_E142_A0.8621.00
283_F302_I0.8591.00
24_L27_D0.8591.00
11_T178_L0.8511.00
162_S187_F0.8471.00
140_T260_A0.8471.00
160_Q163_R0.8461.00
152_D215_N0.8441.00
310_R338_R0.8431.00
3_A97_Q0.8421.00
260_A299_E0.8401.00
136_A258_P0.8381.00
88_A325_A0.8371.00
47_V73_V0.8361.00
224_A329_T0.8321.00
13_F326_A0.8281.00
282_L331_L0.8181.00
260_A295_V0.8181.00
168_E337_R0.8171.00
48_I88_A0.8161.00
297_S302_I0.8151.00
106_A226_L0.8131.00
149_S198_P0.8121.00
100_A248_S0.8111.00
268_Q272_T0.8091.00
310_R337_R0.8041.00
281_D343_Y0.8021.00
201_K213_A0.7981.00
11_T28_L0.7961.00
202_P205_D0.7961.00
215_N290_A0.7921.00
285_I347_A0.7861.00
290_A314_L0.7821.00
139_Y142_A0.7791.00
113_S221_D0.7771.00
30_A34_R0.7771.00
191_R195_A0.7761.00
105_I225_A0.7761.00
253_I264_V0.7761.00
263_V267_R0.7751.00
86_L346_A0.7731.00
293_I297_S0.7711.00
48_I76_M0.7711.00
266_I357_A0.7701.00
245_F248_S0.7701.00
266_I300_L0.7671.00
275_V279_D0.7661.00
45_D268_Q0.7661.00
48_I92_A0.7661.00
150_M294_C0.7651.00
328_V358_L0.7641.00
43_Q103_M0.7531.00
232_E235_A0.7531.00
65_L71_L0.7511.00
25_P109_S0.7491.00
350_S354_I0.7491.00
144_Y299_E0.7481.00
140_T295_V0.7481.00
332_F360_F0.7461.00
266_I285_I0.7461.00
37_S44_V0.7451.00
205_D209_G0.7451.00
15_N186_A0.7411.00
141_A291_V0.7391.00
44_V105_I0.7391.00
119_E123_F0.7381.00
8_A226_L0.7351.00
3_A96_I0.7301.00
23_F114_Q0.7291.00
86_L358_L0.7291.00
24_L114_Q0.7271.00
93_C97_Q0.7271.00
137_A291_V0.7261.00
45_D104_Y0.7261.00
144_Y257_F0.7231.00
46_E250_V0.7221.00
240_K336_K0.7171.00
9_K32_I0.7141.00
49_L60_A0.7121.00
29_A107_G0.7121.00
347_A350_S0.7101.00
159_H314_L0.7091.00
4_V233_K0.7081.00
191_R214_A0.7071.00
253_I261_A0.7051.00
91_Y94_S0.7031.00
166_H189_K0.7001.00
267_R300_L0.6981.00
149_S193_I0.6971.00
9_K36_L0.6971.00
127_A131_P0.6961.00
162_S315_A0.6961.00
229_M237_L0.6941.00
285_I296_C0.6911.00
246_I273_H0.6891.00
92_A101_G0.6871.00
5_I228_V0.6841.00
159_H187_F0.6831.00
156_L195_A0.6831.00
23_F27_D0.6821.00
278_D306_K0.6811.00
335_A344_A0.6791.00
46_E95_L0.6771.00
36_L225_A0.6761.00
344_A347_A0.6751.00
156_L192_P0.6751.00
80_R250_V0.6751.00
156_L191_R0.6741.00
312_G315_A0.6741.00
122_R125_P0.6741.00
263_V299_E0.6731.00
161_R164_N0.6721.00
350_S355_G0.6701.00
95_L100_A0.6671.00
3_A93_C0.6661.00
186_A220_A0.6631.00
91_Y95_L0.6621.00
4_V230_E0.6611.00
112_S320_Y0.6590.99
126_D131_P0.6550.99
69_L105_I0.6540.99
323_S327_L0.6540.99
132_D135_I0.6500.99
159_H186_A0.6500.99
167_D183_T0.6480.99
242_V333_Y0.6460.99
266_I277_P0.6450.99
250_V356_L0.6430.99
54_G114_Q0.6410.99
270_L275_V0.6390.99
159_H190_T0.6390.99
7_D242_V0.6380.99
6_V234_A0.6370.99
48_I91_Y0.6350.99
137_A211_V0.6340.99
316_L326_A0.6340.99
33_I37_S0.6340.99
163_R188_L0.6330.99
146_I150_M0.6330.99
277_P302_I0.6330.99
292_K296_C0.6310.99
103_M237_L0.6310.99
17_N113_S0.6300.99
51_N59_L0.6290.99
64_A75_G0.6280.99
135_I139_Y0.6280.99
164_N170_F0.6270.99
46_E80_R0.6250.99
288_A318_H0.6250.99
138_E209_G0.6230.99
49_L63_S0.6230.99
162_S166_H0.6230.99
127_A130_D0.6220.99
343_Y346_A0.6220.99
52_A320_Y0.6220.99
47_V105_I0.6220.99
76_M87_E0.6170.99
152_D193_I0.6170.99
245_F360_F0.6170.99
283_F347_A0.6170.99
102_T272_T0.6160.99
278_D301_G0.6150.99
226_L329_T0.6150.99
33_I67_A0.6140.99
295_V299_E0.6120.99
94_S97_Q0.6120.99
164_N167_D0.6110.99
159_H163_R0.6100.99
27_D30_A0.6100.99
63_S67_A0.6070.99
269_L345_V0.6060.99
33_I225_A0.6060.99
161_R304_F0.6050.99
269_L280_I0.6050.99
4_V237_L0.6030.99
254_H257_F0.6020.99
95_L104_Y0.6000.99
90_R356_L0.6000.99
58_N354_I0.5990.99
136_A259_P0.5980.99
44_V69_L0.5950.99
33_I47_V0.5950.99
155_A290_A0.5940.99
203_V213_A0.5940.99
89_V325_A0.5930.99
246_I275_V0.5900.99
194_E199_R0.5890.99
64_A69_L0.5880.99
328_V346_A0.5880.99
228_V245_F0.5880.99
271_H276_T0.5870.99
119_E125_P0.5850.99
19_L185_E0.5850.99
87_E250_V0.5840.99
74_P250_V0.5830.99
17_N122_R0.5810.99
162_S316_L0.5800.99
270_L273_H0.5770.99
294_C298_Q0.5760.99
48_I78_I0.5750.99
345_V348_I0.5750.99
78_I91_Y0.5740.99
282_L341_C0.5730.99
335_A360_F0.5720.99
154_Y312_G0.5710.99
30_A67_A0.5700.99
249_A272_T0.5670.98
6_V233_K0.5660.98
152_D198_P0.5650.98
281_D342_Q0.5650.98
211_V216_S0.5630.98
107_G225_A0.5620.98
283_F306_K0.5620.98
87_E90_R0.5620.98
174_E333_Y0.5610.98
97_Q248_S0.5610.98
153_E304_F0.5580.98
157_L293_I0.5580.98
34_R68_G0.5580.98
238_G241_P0.5580.98
193_I197_I0.5580.98
146_I298_Q0.5580.98
241_P244_R0.5570.98
31_P34_R0.5560.98
258_P262_P0.5550.98
322_A325_A0.5540.98
28_L178_L0.5530.98
142_A208_S0.5530.98
5_I332_F0.5530.98
134_G209_G0.5520.98
42_D72_S0.5520.98
34_R67_A0.5510.98
133_M288_A0.5500.98
117_F122_R0.5490.98
63_S109_S0.5480.98
17_N123_F0.5470.98
190_T195_A0.5440.98
119_E122_R0.5430.98
137_A141_A0.5430.98
293_I307_I0.5410.98
343_Y350_S0.5400.98
29_A109_S0.5400.98
12_I175_V0.5390.98
134_G205_D0.5370.98
152_D197_I0.5370.98
345_V350_S0.5370.98
249_A273_H0.5360.98
26_E55_R0.5360.98
45_D73_V0.5350.98
53_T115_S0.5340.98
40_L227_L0.5340.98
285_I293_I0.5320.98
56_G62_L0.5310.98
7_D227_L0.5310.98
26_E66_Q0.5300.98
67_A70_P0.5300.98
288_A292_K0.5290.98
12_I182_E0.5290.98
86_L356_L0.5280.98
297_S303_P0.5270.98
23_F111_S0.5250.98
102_T236_A0.5250.98
346_A350_S0.5210.97
325_A329_T0.5200.97
48_I95_L0.5200.97
170_F338_R0.5200.97
169_G172_R0.5190.97
119_E124_S0.5190.97
140_T144_Y0.5180.97
279_D343_Y0.5170.97
47_V63_S0.5160.97
46_E101_G0.5160.97
144_Y295_V0.5150.97
183_T187_F0.5150.97
70_P73_V0.5130.97
45_D74_P0.5120.97
57_G81_Q0.5120.97
344_A352_G0.5110.97
52_A81_Q0.5110.97
312_G323_S0.5110.97
40_L43_Q0.5090.97
148_R200_A0.5090.97
316_L330_R0.5090.97
246_I359_L0.5090.97
282_L310_R0.5080.97
84_S321_G0.5060.97
175_V183_T0.5050.97
41_E70_P0.5050.97
265_A269_L0.5030.97
22_P114_Q0.5020.97
234_A237_L0.5010.97
348_I351_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.989 100 0.258 Contact Map
2wu9A 2 0.9918 100 0.259 Contact Map
2vu1A 4 0.989 100 0.267 Contact Map
3ss6A 4 0.989 100 0.268 Contact Map
4n46A 4 0.989 100 0.274 Contact Map
1wdkC 2 0.989 100 0.274 Contact Map
1afwA 2 0.9863 100 0.277 Contact Map
3goaA 2 0.9725 100 0.278 Contact Map
4nzsA 4 0.9918 100 0.278 Contact Map
4e1lA 4 0.9863 100 0.28 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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