YHFS - BACSU - GREMLIN Contacts

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YHFS - Putative acetyl-CoA C-acetyltransferase YhfS

UniProt:	O07618	Sequences: MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQVDEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGTMYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQRSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSGIADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVTPDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYEAKRRPDCQYAVAAIGSGGGIGLALLFEVLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	364 (355)
Sequences:	15058 (8083)
Seq/√Len:	429.0

ECOLI - ATOB PAAJ YQEF FADI FADA
BACSU - YHFS THL FADA
HALSA - Q9HNK4 Q9HRI8 Q9HQZ8
SULSO - Q97VV9 Q97W61 Q97VJ9 Q97UW8 Q97WQ7 Q97VU9 Q97WQ6 Q97UA5 Q97VD4 Q7LXW2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_L	161_R	3.374	1.00
150_M	298_Q	3.337	1.00
233_K	237_L	3.323	1.00
101_G	104_Y	2.920	1.00
89_V	328_V	2.896	1.00
35_C	38_R	2.884	1.00
156_L	193_I	2.881	1.00
331_L	344_A	2.758	1.00
4_V	234_A	2.738	1.00
231_E	235_A	2.735	1.00
157_L	160_Q	2.730	1.00
164_N	168_E	2.679	1.00
269_L	273_H	2.655	1.00
151_Q	210_T	2.624	1.00
142_A	205_D	2.541	1.00
233_K	236_A	2.531	1.00
36_L	227_L	2.508	1.00
269_L	359_L	2.503	1.00
8_A	329_T	2.482	1.00
96_I	228_V	2.478	1.00
33_I	105_I	2.416	1.00
335_A	341_C	2.349	1.00
167_D	189_K	2.259	1.00
9_K	39_K	2.227	1.00
96_I	230_E	2.180	1.00
282_L	309_V	2.158	1.00
172_R	182_E	2.134	1.00
103_M	229_M	2.124	1.00
244_R	361_E	2.096	1.00
247_G	273_H	2.074	1.00
29_A	49_L	2.047	1.00
92_A	104_Y	2.040	1.00
186_A	218_G	2.033	1.00
147_S	150_M	1.996	1.00
197_I	214_A	1.992	1.00
242_V	336_K	1.951	1.00
6_V	229_M	1.943	1.00
31_P	178_L	1.943	1.00
166_H	187_F	1.937	1.00
247_G	269_L	1.919	1.00
243_L	332_F	1.910	1.00
275_V	343_Y	1.896	1.00
224_A	325_A	1.892	1.00
140_T	146_I	1.891	1.00
149_S	153_E	1.883	1.00
163_R	187_F	1.811	1.00
229_M	234_A	1.755	1.00
205_D	208_S	1.749	1.00
134_G	204_F	1.745	1.00
310_R	334_E	1.732	1.00
266_I	347_A	1.729	1.00
43_Q	237_L	1.727	1.00
172_R	183_T	1.718	1.00
166_H	175_V	1.715	1.00
281_D	341_C	1.670	1.00
19_L	181_L	1.668	1.00
334_E	338_R	1.661	1.00
297_S	307_I	1.653	1.00
229_M	233_K	1.646	1.00
102_T	230_E	1.628	1.00
275_V	280_I	1.626	1.00
338_R	341_C	1.616	1.00
29_A	63_S	1.612	1.00
92_A	228_V	1.611	1.00
280_I	283_F	1.600	1.00
267_R	271_H	1.592	1.00
226_L	325_A	1.587	1.00
195_A	199_R	1.581	1.00
280_I	359_L	1.579	1.00
166_H	183_T	1.572	1.00
7_D	36_L	1.569	1.00
297_S	304_F	1.567	1.00
49_L	107_G	1.540	1.00
230_E	233_K	1.535	1.00
277_P	283_F	1.533	1.00
275_V	359_L	1.531	1.00
111_S	114_Q	1.521	1.00
33_I	63_S	1.513	1.00
303_P	306_K	1.505	1.00
4_V	244_R	1.499	1.00
157_L	304_F	1.497	1.00
334_E	337_R	1.491	1.00
31_P	176_V	1.490	1.00
170_F	334_E	1.479	1.00
20_L	181_L	1.477	1.00
249_A	269_L	1.469	1.00
342_Q	361_E	1.464	1.00
173_E	336_K	1.453	1.00
170_F	310_R	1.452	1.00
102_T	233_K	1.447	1.00
156_L	160_Q	1.444	1.00
264_V	267_R	1.439	1.00
94_S	100_A	1.430	1.00
143_R	257_F	1.428	1.00
163_R	167_D	1.424	1.00
76_M	91_Y	1.423	1.00
35_C	176_V	1.419	1.00
280_I	343_Y	1.417	1.00
35_C	39_K	1.412	1.00
282_L	334_E	1.405	1.00
95_L	101_G	1.396	1.00
153_E	157_L	1.396	1.00
160_Q	190_T	1.371	1.00
283_F	345_V	1.369	1.00
32_I	225_A	1.356	1.00
27_D	66_Q	1.342	1.00
34_R	38_R	1.339	1.00
246_I	361_E	1.333	1.00
328_V	360_F	1.323	1.00
59_L	109_S	1.316	1.00
103_M	233_K	1.315	1.00
83_G	356_L	1.303	1.00
83_G	350_S	1.293	1.00
90_R	358_L	1.291	1.00
270_L	277_P	1.283	1.00
32_I	223_A	1.279	1.00
345_V	359_L	1.279	1.00
105_I	227_L	1.269	1.00
249_A	268_Q	1.268	1.00
332_F	336_K	1.260	1.00
13_F	322_A	1.259	1.00
150_M	153_E	1.250	1.00
89_V	226_L	1.249	1.00
160_Q	164_N	1.247	1.00
3_A	228_V	1.234	1.00
153_E	193_I	1.232	1.00
265_A	357_A	1.226	1.00
71_L	254_H	1.222	1.00
309_V	334_E	1.215	1.00
44_V	103_M	1.209	1.00
331_L	346_A	1.204	1.00
134_G	203_V	1.197	1.00
280_I	345_V	1.194	1.00
138_E	205_D	1.190	1.00
268_Q	271_H	1.189	1.00
232_E	236_A	1.188	1.00
4_V	229_M	1.188	1.00
120_R	125_P	1.177	1.00
163_R	190_T	1.176	1.00
329_T	333_Y	1.173	1.00
23_F	31_P	1.173	1.00
49_L	225_A	1.170	1.00
45_D	101_G	1.162	1.00
148_R	212_T	1.160	1.00
267_R	299_E	1.157	1.00
146_I	151_Q	1.152	1.00
4_V	231_E	1.148	1.00
33_I	69_L	1.146	1.00
8_A	333_Y	1.141	1.00
13_F	316_L	1.138	1.00
12_I	181_L	1.136	1.00
48_I	104_Y	1.132	1.00
174_E	330_R	1.121	1.00
170_F	337_R	1.117	1.00
253_I	260_A	1.112	1.00
245_F	358_L	1.106	1.00
251_S	264_V	1.102	1.00
260_A	263_V	1.095	1.00
92_A	106_A	1.095	1.00
281_D	306_K	1.094	1.00
135_I	205_D	1.093	1.00
281_D	335_A	1.085	1.00
326_A	330_R	1.083	1.00
86_L	328_V	1.080	1.00
30_A	66_Q	1.079	1.00
273_H	359_L	1.079	1.00
90_R	248_S	1.077	1.00
309_V	338_R	1.077	1.00
7_D	39_K	1.077	1.00
87_E	91_Y	1.075	1.00
173_E	337_R	1.065	1.00
154_Y	293_I	1.065	1.00
100_A	272_T	1.049	1.00
191_R	197_I	1.047	1.00
9_K	176_V	1.047	1.00
247_G	272_T	1.042	1.00
120_R	123_F	1.042	1.00
50_G	84_S	1.041	1.00
146_I	294_C	1.037	1.00
143_R	256_N	1.029	1.00
247_G	359_L	1.021	1.00
45_D	102_T	1.017	1.00
31_P	35_C	1.017	1.00
156_L	197_I	1.015	1.00
282_L	338_R	1.009	1.00
154_Y	294_C	1.005	1.00
97_Q	100_A	1.003	1.00
302_I	307_I	1.002	1.00
139_Y	143_R	1.002	1.00
37_S	69_L	1.000	1.00
246_I	343_Y	0.999	1.00
43_Q	233_K	0.982	1.00
8_A	332_F	0.979	1.00
231_E	244_R	0.977	1.00
257_F	260_A	0.973	1.00
14_G	185_E	0.973	1.00
276_T	279_D	0.964	1.00
144_Y	260_A	0.963	1.00
173_E	333_Y	0.959	1.00
5_I	360_F	0.957	1.00
47_V	64_A	0.955	1.00
277_P	280_I	0.955	1.00
193_I	198_P	0.954	1.00
89_V	228_V	0.952	1.00
266_I	345_V	0.952	1.00
350_S	356_L	0.951	1.00
200_A	214_A	0.948	1.00
32_I	35_C	0.943	1.00
9_K	35_C	0.941	1.00
37_S	40_L	0.939	1.00
343_Y	359_L	0.937	1.00
163_R	189_K	0.937	1.00
6_V	239_L	0.936	1.00
11_T	32_I	0.934	1.00
327_L	346_A	0.931	1.00
224_A	322_A	0.928	1.00
3_A	230_E	0.927	1.00
157_L	305_S	0.927	1.00
69_L	73_V	0.919	1.00
251_S	268_Q	0.918	1.00
166_H	172_R	0.916	1.00
13_F	220_A	0.914	1.00
36_L	105_I	0.913	1.00
43_Q	236_A	0.908	1.00
242_V	332_F	0.906	1.00
121_A	125_P	0.905	1.00
343_Y	361_E	0.905	1.00
156_L	190_T	0.901	1.00
93_C	245_F	0.898	1.00
80_R	87_E	0.897	1.00
94_S	98_A	0.894	1.00
51_N	55_R	0.892	1.00
192_P	195_A	0.887	1.00
11_T	31_P	0.886	1.00
12_I	31_P	0.883	1.00
32_I	36_L	0.881	1.00
229_M	239_L	0.877	1.00
231_E	234_A	0.869	1.00
313_A	323_S	0.868	1.00
200_A	212_T	0.866	1.00
138_E	142_A	0.862	1.00
283_F	302_I	0.859	1.00
24_L	27_D	0.859	1.00
11_T	178_L	0.851	1.00
162_S	187_F	0.847	1.00
140_T	260_A	0.847	1.00
160_Q	163_R	0.846	1.00
152_D	215_N	0.844	1.00
310_R	338_R	0.843	1.00
3_A	97_Q	0.842	1.00
260_A	299_E	0.840	1.00
136_A	258_P	0.838	1.00
88_A	325_A	0.837	1.00
47_V	73_V	0.836	1.00
224_A	329_T	0.832	1.00
13_F	326_A	0.828	1.00
282_L	331_L	0.818	1.00
260_A	295_V	0.818	1.00
168_E	337_R	0.817	1.00
48_I	88_A	0.816	1.00
297_S	302_I	0.815	1.00
106_A	226_L	0.813	1.00
149_S	198_P	0.812	1.00
100_A	248_S	0.811	1.00
268_Q	272_T	0.809	1.00
310_R	337_R	0.804	1.00
281_D	343_Y	0.802	1.00
201_K	213_A	0.798	1.00
11_T	28_L	0.796	1.00
202_P	205_D	0.796	1.00
215_N	290_A	0.792	1.00
285_I	347_A	0.786	1.00
290_A	314_L	0.782	1.00
139_Y	142_A	0.779	1.00
113_S	221_D	0.777	1.00
30_A	34_R	0.777	1.00
191_R	195_A	0.776	1.00
105_I	225_A	0.776	1.00
253_I	264_V	0.776	1.00
263_V	267_R	0.775	1.00
86_L	346_A	0.773	1.00
293_I	297_S	0.771	1.00
48_I	76_M	0.771	1.00
266_I	357_A	0.770	1.00
245_F	248_S	0.770	1.00
266_I	300_L	0.767	1.00
275_V	279_D	0.766	1.00
45_D	268_Q	0.766	1.00
48_I	92_A	0.766	1.00
150_M	294_C	0.765	1.00
328_V	358_L	0.764	1.00
43_Q	103_M	0.753	1.00
232_E	235_A	0.753	1.00
65_L	71_L	0.751	1.00
25_P	109_S	0.749	1.00
350_S	354_I	0.749	1.00
144_Y	299_E	0.748	1.00
140_T	295_V	0.748	1.00
332_F	360_F	0.746	1.00
266_I	285_I	0.746	1.00
37_S	44_V	0.745	1.00
205_D	209_G	0.745	1.00
15_N	186_A	0.741	1.00
141_A	291_V	0.739	1.00
44_V	105_I	0.739	1.00
119_E	123_F	0.738	1.00
8_A	226_L	0.735	1.00
3_A	96_I	0.730	1.00
23_F	114_Q	0.729	1.00
86_L	358_L	0.729	1.00
24_L	114_Q	0.727	1.00
93_C	97_Q	0.727	1.00
137_A	291_V	0.726	1.00
45_D	104_Y	0.726	1.00
144_Y	257_F	0.723	1.00
46_E	250_V	0.722	1.00
240_K	336_K	0.717	1.00
9_K	32_I	0.714	1.00
49_L	60_A	0.712	1.00
29_A	107_G	0.712	1.00
347_A	350_S	0.710	1.00
159_H	314_L	0.709	1.00
4_V	233_K	0.708	1.00
191_R	214_A	0.707	1.00
253_I	261_A	0.705	1.00
91_Y	94_S	0.703	1.00
166_H	189_K	0.700	1.00
267_R	300_L	0.698	1.00
149_S	193_I	0.697	1.00
9_K	36_L	0.697	1.00
127_A	131_P	0.696	1.00
162_S	315_A	0.696	1.00
229_M	237_L	0.694	1.00
285_I	296_C	0.691	1.00
246_I	273_H	0.689	1.00
92_A	101_G	0.687	1.00
5_I	228_V	0.684	1.00
159_H	187_F	0.683	1.00
156_L	195_A	0.683	1.00
23_F	27_D	0.682	1.00
278_D	306_K	0.681	1.00
335_A	344_A	0.679	1.00
46_E	95_L	0.677	1.00
36_L	225_A	0.676	1.00
344_A	347_A	0.675	1.00
156_L	192_P	0.675	1.00
80_R	250_V	0.675	1.00
156_L	191_R	0.674	1.00
312_G	315_A	0.674	1.00
122_R	125_P	0.674	1.00
263_V	299_E	0.673	1.00
161_R	164_N	0.672	1.00
350_S	355_G	0.670	1.00
95_L	100_A	0.667	1.00
3_A	93_C	0.666	1.00
186_A	220_A	0.663	1.00
91_Y	95_L	0.662	1.00
4_V	230_E	0.661	1.00
112_S	320_Y	0.659	0.99
126_D	131_P	0.655	0.99
69_L	105_I	0.654	0.99
323_S	327_L	0.654	0.99
132_D	135_I	0.650	0.99
159_H	186_A	0.650	0.99
167_D	183_T	0.648	0.99
242_V	333_Y	0.646	0.99
266_I	277_P	0.645	0.99
250_V	356_L	0.643	0.99
54_G	114_Q	0.641	0.99
270_L	275_V	0.639	0.99
159_H	190_T	0.639	0.99
7_D	242_V	0.638	0.99
6_V	234_A	0.637	0.99
48_I	91_Y	0.635	0.99
137_A	211_V	0.634	0.99
316_L	326_A	0.634	0.99
33_I	37_S	0.634	0.99
163_R	188_L	0.633	0.99
146_I	150_M	0.633	0.99
277_P	302_I	0.633	0.99
292_K	296_C	0.631	0.99
103_M	237_L	0.631	0.99
17_N	113_S	0.630	0.99
51_N	59_L	0.629	0.99
64_A	75_G	0.628	0.99
135_I	139_Y	0.628	0.99
164_N	170_F	0.627	0.99
46_E	80_R	0.625	0.99
288_A	318_H	0.625	0.99
138_E	209_G	0.623	0.99
49_L	63_S	0.623	0.99
162_S	166_H	0.623	0.99
127_A	130_D	0.622	0.99
343_Y	346_A	0.622	0.99
52_A	320_Y	0.622	0.99
47_V	105_I	0.622	0.99
76_M	87_E	0.617	0.99
152_D	193_I	0.617	0.99
245_F	360_F	0.617	0.99
283_F	347_A	0.617	0.99
102_T	272_T	0.616	0.99
278_D	301_G	0.615	0.99
226_L	329_T	0.615	0.99
33_I	67_A	0.614	0.99
295_V	299_E	0.612	0.99
94_S	97_Q	0.612	0.99
164_N	167_D	0.611	0.99
159_H	163_R	0.610	0.99
27_D	30_A	0.610	0.99
63_S	67_A	0.607	0.99
269_L	345_V	0.606	0.99
33_I	225_A	0.606	0.99
161_R	304_F	0.605	0.99
269_L	280_I	0.605	0.99
4_V	237_L	0.603	0.99
254_H	257_F	0.602	0.99
95_L	104_Y	0.600	0.99
90_R	356_L	0.600	0.99
58_N	354_I	0.599	0.99
136_A	259_P	0.598	0.99
44_V	69_L	0.595	0.99
33_I	47_V	0.595	0.99
155_A	290_A	0.594	0.99
203_V	213_A	0.594	0.99
89_V	325_A	0.593	0.99
246_I	275_V	0.590	0.99
194_E	199_R	0.589	0.99
64_A	69_L	0.588	0.99
328_V	346_A	0.588	0.99
228_V	245_F	0.588	0.99
271_H	276_T	0.587	0.99
119_E	125_P	0.585	0.99
19_L	185_E	0.585	0.99
87_E	250_V	0.584	0.99
74_P	250_V	0.583	0.99
17_N	122_R	0.581	0.99
162_S	316_L	0.580	0.99
270_L	273_H	0.577	0.99
294_C	298_Q	0.576	0.99
48_I	78_I	0.575	0.99
345_V	348_I	0.575	0.99
78_I	91_Y	0.574	0.99
282_L	341_C	0.573	0.99
335_A	360_F	0.572	0.99
154_Y	312_G	0.571	0.99
30_A	67_A	0.570	0.99
249_A	272_T	0.567	0.98
6_V	233_K	0.566	0.98
152_D	198_P	0.565	0.98
281_D	342_Q	0.565	0.98
211_V	216_S	0.563	0.98
107_G	225_A	0.562	0.98
283_F	306_K	0.562	0.98
87_E	90_R	0.562	0.98
174_E	333_Y	0.561	0.98
97_Q	248_S	0.561	0.98
153_E	304_F	0.558	0.98
157_L	293_I	0.558	0.98
34_R	68_G	0.558	0.98
238_G	241_P	0.558	0.98
193_I	197_I	0.558	0.98
146_I	298_Q	0.558	0.98
241_P	244_R	0.557	0.98
31_P	34_R	0.556	0.98
258_P	262_P	0.555	0.98
322_A	325_A	0.554	0.98
28_L	178_L	0.553	0.98
142_A	208_S	0.553	0.98
5_I	332_F	0.553	0.98
134_G	209_G	0.552	0.98
42_D	72_S	0.552	0.98
34_R	67_A	0.551	0.98
133_M	288_A	0.550	0.98
117_F	122_R	0.549	0.98
63_S	109_S	0.548	0.98
17_N	123_F	0.547	0.98
190_T	195_A	0.544	0.98
119_E	122_R	0.543	0.98
137_A	141_A	0.543	0.98
293_I	307_I	0.541	0.98
343_Y	350_S	0.540	0.98
29_A	109_S	0.540	0.98
12_I	175_V	0.539	0.98
134_G	205_D	0.537	0.98
152_D	197_I	0.537	0.98
345_V	350_S	0.537	0.98
249_A	273_H	0.536	0.98
26_E	55_R	0.536	0.98
45_D	73_V	0.535	0.98
53_T	115_S	0.534	0.98
40_L	227_L	0.534	0.98
285_I	293_I	0.532	0.98
56_G	62_L	0.531	0.98
7_D	227_L	0.531	0.98
26_E	66_Q	0.530	0.98
67_A	70_P	0.530	0.98
288_A	292_K	0.529	0.98
12_I	182_E	0.529	0.98
86_L	356_L	0.528	0.98
297_S	303_P	0.527	0.98
23_F	111_S	0.525	0.98
102_T	236_A	0.525	0.98
346_A	350_S	0.521	0.97
325_A	329_T	0.520	0.97
48_I	95_L	0.520	0.97
170_F	338_R	0.520	0.97
169_G	172_R	0.519	0.97
119_E	124_S	0.519	0.97
140_T	144_Y	0.518	0.97
279_D	343_Y	0.517	0.97
47_V	63_S	0.516	0.97
46_E	101_G	0.516	0.97
144_Y	295_V	0.515	0.97
183_T	187_F	0.515	0.97
70_P	73_V	0.513	0.97
45_D	74_P	0.512	0.97
57_G	81_Q	0.512	0.97
344_A	352_G	0.511	0.97
52_A	81_Q	0.511	0.97
312_G	323_S	0.511	0.97
40_L	43_Q	0.509	0.97
148_R	200_A	0.509	0.97
316_L	330_R	0.509	0.97
246_I	359_L	0.509	0.97
282_L	310_R	0.508	0.97
84_S	321_G	0.506	0.97
175_V	183_T	0.505	0.97
41_E	70_P	0.505	0.97
265_A	269_L	0.503	0.97
22_P	114_Q	0.502	0.97
234_A	237_L	0.501	0.97
348_I	351_G	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ulqA	4	0.989	100	0.258	Contact Map
2wu9A	2	0.9918	100	0.259	Contact Map
2vu1A	4	0.989	100	0.267	Contact Map
3ss6A	4	0.989	100	0.268	Contact Map
4n46A	4	0.989	100	0.274	Contact Map
1wdkC	2	0.989	100	0.274	Contact Map
1afwA	2	0.9863	100	0.277	Contact Map
3goaA	2	0.9725	100	0.278	Contact Map
4nzsA	4	0.9918	100	0.278	Contact Map
4e1lA	4	0.9863	100	0.28	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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