PHOE - BACSU - GREMLIN Contacts

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PHOE - Uncharacterized phosphatase PhoE

UniProt:	O07617	Sequences: MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVKDFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPDNIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQSTRLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	193 (175)
Sequences:	14567 (10430)
Seq/√Len:	788.5

ECOLI - GPMB COBC GPMA SIXA
BACSU - PHOE
SULSO - Q97WI1 Q97YV8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_D	124_K	2.945	1.00
55_P	81_K	2.858	1.00
60_K	76_E	2.726	1.00
87_D	107_N	2.693	1.00
3_A	169_N	2.682	1.00
33_E	61_R	2.654	1.00
119_M	149_E	2.422	1.00
3_A	133_K	2.385	1.00
118_L	142_A	2.371	1.00
79_D	120_G	2.243	1.00
11_E	31_T	2.200	1.00
79_D	121_G	2.170	1.00
50_I	75_V	2.138	1.00
80_F	121_G	2.051	1.00
138_A	142_A	1.920	1.00
37_R	65_I	1.915	1.00
7_V	39_T	1.898	1.00
3_A	171_E	1.854	1.00
27_P	61_R	1.853	1.00
33_E	65_I	1.839	1.00
11_E	29_N	1.820	1.00
61_R	64_E	1.744	1.00
48_W	135_L	1.743	1.00
13_D	29_N	1.713	1.00
23_K	81_K	1.703	1.00
27_P	57_K	1.656	1.00
77_M	124_K	1.618	1.00
51_I	67_N	1.615	1.00
91_M	99_R	1.607	1.00
51_I	63_A	1.584	1.00
5_C	48_W	1.575	1.00
109_E	117_R	1.574	1.00
7_V	66_I	1.568	1.00
110_T	113_E	1.552	1.00
49_D	132_K	1.536	1.00
60_K	64_E	1.536	1.00
138_A	143_I	1.529	1.00
53_T	76_E	1.489	1.00
77_M	121_G	1.488	1.00
55_P	78_D	1.474	1.00
143_I	162_L	1.463	1.00
13_D	17_Q	1.463	1.00
34_R	37_R	1.461	1.00
41_E	69_Y	1.446	1.00
49_D	133_K	1.430	1.00
7_V	135_L	1.427	1.00
23_K	84_D	1.415	1.00
31_T	35_Q	1.410	1.00
5_C	133_K	1.409	1.00
34_R	38_E	1.397	1.00
5_C	169_N	1.389	1.00
11_E	16_L	1.375	1.00
92_P	95_E	1.368	1.00
66_I	137_V	1.350	1.00
33_E	37_R	1.339	1.00
119_M	123_A	1.330	1.00
172_F	177_W	1.312	1.00
36_A	62_T	1.302	1.00
31_T	34_R	1.292	1.00
30_A	33_E	1.292	1.00
100_Y	103_N	1.282	1.00
14_W	26_I	1.254	1.00
52_V	121_G	1.252	1.00
118_L	146_L	1.237	1.00
14_W	21_Q	1.220	1.00
57_K	61_R	1.215	1.00
112_E	116_D	1.196	1.00
91_M	95_E	1.195	1.00
14_W	19_K	1.181	1.00
64_E	68_E	1.151	1.00
87_D	106_P	1.150	1.00
113_E	116_D	1.150	1.00
54_S	139_H	1.150	1.00
54_S	59_A	1.144	1.00
50_I	132_K	1.124	1.00
115_T	119_M	1.121	1.00
15_N	164_N	1.117	1.00
114_L	142_A	1.102	1.00
6_L	143_I	1.096	1.00
38_E	41_E	1.091	1.00
67_N	74_I	1.088	1.00
53_T	74_I	1.084	1.00
52_V	77_M	1.045	1.00
29_N	32_G	1.044	1.00
41_E	44_K	1.040	1.00
63_A	137_V	1.031	1.00
56_L	81_K	1.021	1.00
52_V	129_Y	1.015	1.00
84_D	89_E	1.008	1.00
24_T	89_E	1.002	1.00
50_I	134_V	1.001	1.00
37_R	68_E	1.000	1.00
63_A	74_I	0.988	1.00
80_F	136_I	0.987	1.00
121_G	125_V	0.980	1.00
78_D	81_K	0.973	1.00
53_T	60_K	0.966	1.00
6_L	146_L	0.960	1.00
11_E	35_Q	0.936	1.00
44_K	69_Y	0.934	1.00
147_L	151_S	0.931	1.00
173_A	176_K	0.929	1.00
64_E	74_I	0.928	1.00
163_V	166_C	0.923	1.00
59_A	139_H	0.922	1.00
162_L	168_S	0.920	1.00
55_P	76_E	0.916	1.00
115_T	149_E	0.916	1.00
65_I	68_E	0.911	1.00
121_G	136_I	0.909	1.00
129_Y	132_K	0.907	1.00
21_Q	26_I	0.905	1.00
5_C	46_F	0.900	1.00
122_L	146_L	0.898	1.00
25_D	57_K	0.896	1.00
114_L	145_A	0.891	1.00
48_W	133_K	0.887	1.00
51_I	72_L	0.887	1.00
23_K	55_P	0.881	1.00
50_I	128_A	0.880	1.00
12_T	164_N	0.879	1.00
116_D	120_G	0.876	1.00
114_L	118_L	0.875	1.00
40_G	65_I	0.874	1.00
115_T	145_A	0.864	1.00
30_A	34_R	0.862	1.00
53_T	59_A	0.858	1.00
12_T	21_Q	0.854	1.00
125_V	136_I	0.851	1.00
88_A	96_R	0.850	1.00
57_K	60_K	0.844	1.00
13_D	27_P	0.842	1.00
124_K	128_A	0.841	1.00
26_I	29_N	0.840	1.00
91_M	96_R	0.836	1.00
52_V	75_V	0.834	1.00
37_R	69_Y	0.824	1.00
125_V	128_A	0.824	1.00
5_C	167_L	0.820	1.00
147_L	168_S	0.819	1.00
151_S	160_T	0.814	1.00
162_L	166_C	0.807	1.00
14_W	24_T	0.803	1.00
94_E	97_T	0.802	1.00
82_E	140_G	0.801	1.00
151_S	170_I	0.801	1.00
19_K	92_P	0.792	1.00
39_T	165_A	0.787	1.00
10_G	62_T	0.785	1.00
46_F	133_K	0.780	1.00
52_V	125_V	0.766	1.00
123_A	126_N	0.763	1.00
85_Y	89_E	0.750	1.00
95_E	98_K	0.741	1.00
10_G	28_L	0.740	1.00
16_L	31_T	0.740	1.00
42_Y	167_L	0.738	1.00
75_V	128_A	0.731	1.00
12_T	29_N	0.728	1.00
125_V	134_V	0.727	1.00
23_K	56_L	0.726	1.00
97_T	101_P	0.721	1.00
52_V	134_V	0.721	1.00
123_A	127_Q	0.718	1.00
13_D	16_L	0.718	1.00
148_T	153_G	0.716	1.00
147_L	170_I	0.716	1.00
83_R	114_L	0.715	1.00
35_Q	164_N	0.715	1.00
94_E	98_K	0.710	1.00
40_G	69_Y	0.702	1.00
15_N	21_Q	0.701	1.00
22_G	89_E	0.692	1.00
143_I	168_S	0.690	1.00
36_A	40_G	0.686	1.00
80_F	125_V	0.684	1.00
129_Y	134_V	0.684	1.00
36_A	165_A	0.680	1.00
65_I	69_Y	0.676	1.00
50_I	129_Y	0.676	1.00
61_R	65_I	0.674	1.00
51_I	70_L	0.673	1.00
111_L	145_A	0.673	1.00
157_L	160_T	0.672	1.00
52_V	128_A	0.672	1.00
53_T	63_A	0.671	1.00
67_N	72_L	0.670	1.00
97_T	102_D	0.667	1.00
37_R	41_E	0.665	1.00
28_L	32_G	0.661	1.00
22_G	56_L	0.660	1.00
36_A	65_I	0.659	1.00
4_V	122_L	0.659	1.00
7_V	167_L	0.659	1.00
7_V	137_V	0.654	1.00
100_Y	104_I	0.653	1.00
6_L	170_I	0.642	1.00
97_T	104_I	0.641	1.00
96_R	104_I	0.637	1.00
12_T	15_N	0.633	1.00
37_R	40_G	0.629	1.00
119_M	146_L	0.629	1.00
126_N	172_F	0.629	1.00
48_W	70_L	0.627	1.00
150_I	170_I	0.624	1.00
39_T	167_L	0.624	1.00
121_G	124_K	0.623	1.00
46_F	70_L	0.612	1.00
116_D	119_M	0.609	1.00
95_E	99_R	0.608	1.00
98_K	101_P	0.606	1.00
148_T	155_P	0.603	1.00
47_S	133_K	0.598	1.00
51_I	135_L	0.597	1.00
10_G	35_Q	0.597	1.00
114_L	141_A	0.594	1.00
88_A	105_Y	0.592	1.00
27_P	33_E	0.591	1.00
40_G	44_K	0.590	1.00
82_E	141_A	0.588	1.00
170_I	177_W	0.588	1.00
18_Q	21_Q	0.588	1.00
120_G	124_K	0.587	1.00
32_G	35_Q	0.582	1.00
47_S	70_L	0.580	1.00
86_G	108_M	0.579	1.00
25_D	56_L	0.578	1.00
10_G	32_G	0.574	1.00
93_L	97_T	0.570	1.00
13_D	26_I	0.569	1.00
67_N	70_L	0.569	1.00
67_N	71_H	0.567	1.00
97_T	100_Y	0.566	1.00
28_L	36_A	0.566	1.00
118_L	149_E	0.558	1.00
16_L	29_N	0.558	1.00
101_P	104_I	0.557	1.00
46_F	169_N	0.555	1.00
32_G	36_A	0.554	1.00
148_T	157_L	0.553	1.00
83_R	111_L	0.551	1.00
105_Y	108_M	0.547	1.00
56_L	59_A	0.546	1.00
123_A	149_E	0.545	1.00
6_L	136_I	0.543	1.00
24_T	90_G	0.536	1.00
26_I	57_K	0.535	1.00
21_Q	140_G	0.533	1.00
12_T	26_I	0.531	1.00
96_R	100_Y	0.528	1.00
138_A	162_L	0.527	1.00
91_M	100_Y	0.522	1.00
64_E	76_E	0.520	1.00
19_K	22_G	0.520	1.00
20_C	85_Y	0.515	1.00
62_T	165_A	0.511	1.00
153_G	160_T	0.510	1.00
5_C	43_V	0.509	1.00
18_Q	94_E	0.507	1.00
4_V	172_F	0.505	1.00
9_H	82_E	0.503	1.00
35_Q	38_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3gp3A	1	0.9482	100	0.146	Contact Map
4pzaA	2	0.9741	100	0.149	Contact Map
1h2eA	1	1	100	0.152	Contact Map
1e58A	2	1	100	0.154	Contact Map
4ij5A	2	1	100	0.154	Contact Map
3r7aA	1	0.9845	100	0.155	Contact Map
3kkkA	3	0.9482	100	0.162	Contact Map
3d8hA	2	0.9534	100	0.163	Contact Map
4embA	2	1	100	0.168	Contact Map
2hhjA	2	1	100	0.179	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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