GREMLIN Database
PHOE - Uncharacterized phosphatase PhoE
UniProt: O07617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (175)
Sequences: 14567 (10430)
Seq/√Len: 788.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_D124_K2.9451.00
55_P81_K2.8581.00
60_K76_E2.7261.00
87_D107_N2.6931.00
3_A169_N2.6821.00
33_E61_R2.6541.00
119_M149_E2.4221.00
3_A133_K2.3851.00
118_L142_A2.3711.00
79_D120_G2.2431.00
11_E31_T2.2001.00
79_D121_G2.1701.00
50_I75_V2.1381.00
80_F121_G2.0511.00
138_A142_A1.9201.00
37_R65_I1.9151.00
7_V39_T1.8981.00
3_A171_E1.8541.00
27_P61_R1.8531.00
33_E65_I1.8391.00
11_E29_N1.8201.00
61_R64_E1.7441.00
48_W135_L1.7431.00
13_D29_N1.7131.00
23_K81_K1.7031.00
27_P57_K1.6561.00
77_M124_K1.6181.00
51_I67_N1.6151.00
91_M99_R1.6071.00
51_I63_A1.5841.00
5_C48_W1.5751.00
109_E117_R1.5741.00
7_V66_I1.5681.00
110_T113_E1.5521.00
49_D132_K1.5361.00
60_K64_E1.5361.00
138_A143_I1.5291.00
53_T76_E1.4891.00
77_M121_G1.4881.00
55_P78_D1.4741.00
143_I162_L1.4631.00
13_D17_Q1.4631.00
34_R37_R1.4611.00
41_E69_Y1.4461.00
49_D133_K1.4301.00
7_V135_L1.4271.00
23_K84_D1.4151.00
31_T35_Q1.4101.00
5_C133_K1.4091.00
34_R38_E1.3971.00
5_C169_N1.3891.00
11_E16_L1.3751.00
92_P95_E1.3681.00
66_I137_V1.3501.00
33_E37_R1.3391.00
119_M123_A1.3301.00
172_F177_W1.3121.00
36_A62_T1.3021.00
31_T34_R1.2921.00
30_A33_E1.2921.00
100_Y103_N1.2821.00
14_W26_I1.2541.00
52_V121_G1.2521.00
118_L146_L1.2371.00
14_W21_Q1.2201.00
57_K61_R1.2151.00
112_E116_D1.1961.00
91_M95_E1.1951.00
14_W19_K1.1811.00
64_E68_E1.1511.00
87_D106_P1.1501.00
113_E116_D1.1501.00
54_S139_H1.1501.00
54_S59_A1.1441.00
50_I132_K1.1241.00
115_T119_M1.1211.00
15_N164_N1.1171.00
114_L142_A1.1021.00
6_L143_I1.0961.00
38_E41_E1.0911.00
67_N74_I1.0881.00
53_T74_I1.0841.00
52_V77_M1.0451.00
29_N32_G1.0441.00
41_E44_K1.0401.00
63_A137_V1.0311.00
56_L81_K1.0211.00
52_V129_Y1.0151.00
84_D89_E1.0081.00
24_T89_E1.0021.00
50_I134_V1.0011.00
37_R68_E1.0001.00
63_A74_I0.9881.00
80_F136_I0.9871.00
121_G125_V0.9801.00
78_D81_K0.9731.00
53_T60_K0.9661.00
6_L146_L0.9601.00
11_E35_Q0.9361.00
44_K69_Y0.9341.00
147_L151_S0.9311.00
173_A176_K0.9291.00
64_E74_I0.9281.00
163_V166_C0.9231.00
59_A139_H0.9221.00
162_L168_S0.9201.00
55_P76_E0.9161.00
115_T149_E0.9161.00
65_I68_E0.9111.00
121_G136_I0.9091.00
129_Y132_K0.9071.00
21_Q26_I0.9051.00
5_C46_F0.9001.00
122_L146_L0.8981.00
25_D57_K0.8961.00
114_L145_A0.8911.00
48_W133_K0.8871.00
51_I72_L0.8871.00
23_K55_P0.8811.00
50_I128_A0.8801.00
12_T164_N0.8791.00
116_D120_G0.8761.00
114_L118_L0.8751.00
40_G65_I0.8741.00
115_T145_A0.8641.00
30_A34_R0.8621.00
53_T59_A0.8581.00
12_T21_Q0.8541.00
125_V136_I0.8511.00
88_A96_R0.8501.00
57_K60_K0.8441.00
13_D27_P0.8421.00
124_K128_A0.8411.00
26_I29_N0.8401.00
91_M96_R0.8361.00
52_V75_V0.8341.00
37_R69_Y0.8241.00
125_V128_A0.8241.00
5_C167_L0.8201.00
147_L168_S0.8191.00
151_S160_T0.8141.00
162_L166_C0.8071.00
14_W24_T0.8031.00
94_E97_T0.8021.00
82_E140_G0.8011.00
151_S170_I0.8011.00
19_K92_P0.7921.00
39_T165_A0.7871.00
10_G62_T0.7851.00
46_F133_K0.7801.00
52_V125_V0.7661.00
123_A126_N0.7631.00
85_Y89_E0.7501.00
95_E98_K0.7411.00
10_G28_L0.7401.00
16_L31_T0.7401.00
42_Y167_L0.7381.00
75_V128_A0.7311.00
12_T29_N0.7281.00
125_V134_V0.7271.00
23_K56_L0.7261.00
97_T101_P0.7211.00
52_V134_V0.7211.00
123_A127_Q0.7181.00
13_D16_L0.7181.00
148_T153_G0.7161.00
147_L170_I0.7161.00
83_R114_L0.7151.00
35_Q164_N0.7151.00
94_E98_K0.7101.00
40_G69_Y0.7021.00
15_N21_Q0.7011.00
22_G89_E0.6921.00
143_I168_S0.6901.00
36_A40_G0.6861.00
80_F125_V0.6841.00
129_Y134_V0.6841.00
36_A165_A0.6801.00
65_I69_Y0.6761.00
50_I129_Y0.6761.00
61_R65_I0.6741.00
51_I70_L0.6731.00
111_L145_A0.6731.00
157_L160_T0.6721.00
52_V128_A0.6721.00
53_T63_A0.6711.00
67_N72_L0.6701.00
97_T102_D0.6671.00
37_R41_E0.6651.00
28_L32_G0.6611.00
22_G56_L0.6601.00
36_A65_I0.6591.00
4_V122_L0.6591.00
7_V167_L0.6591.00
7_V137_V0.6541.00
100_Y104_I0.6531.00
6_L170_I0.6421.00
97_T104_I0.6411.00
96_R104_I0.6371.00
12_T15_N0.6331.00
37_R40_G0.6291.00
119_M146_L0.6291.00
126_N172_F0.6291.00
48_W70_L0.6271.00
150_I170_I0.6241.00
39_T167_L0.6241.00
121_G124_K0.6231.00
46_F70_L0.6121.00
116_D119_M0.6091.00
95_E99_R0.6081.00
98_K101_P0.6061.00
148_T155_P0.6031.00
47_S133_K0.5981.00
51_I135_L0.5971.00
10_G35_Q0.5971.00
114_L141_A0.5941.00
88_A105_Y0.5921.00
27_P33_E0.5911.00
40_G44_K0.5901.00
82_E141_A0.5881.00
170_I177_W0.5881.00
18_Q21_Q0.5881.00
120_G124_K0.5871.00
32_G35_Q0.5821.00
47_S70_L0.5801.00
86_G108_M0.5791.00
25_D56_L0.5781.00
10_G32_G0.5741.00
93_L97_T0.5701.00
13_D26_I0.5691.00
67_N70_L0.5691.00
67_N71_H0.5671.00
97_T100_Y0.5661.00
28_L36_A0.5661.00
118_L149_E0.5581.00
16_L29_N0.5581.00
101_P104_I0.5571.00
46_F169_N0.5551.00
32_G36_A0.5541.00
148_T157_L0.5531.00
83_R111_L0.5511.00
105_Y108_M0.5471.00
56_L59_A0.5461.00
123_A149_E0.5451.00
6_L136_I0.5431.00
24_T90_G0.5361.00
26_I57_K0.5351.00
21_Q140_G0.5331.00
12_T26_I0.5311.00
96_R100_Y0.5281.00
138_A162_L0.5271.00
91_M100_Y0.5221.00
64_E76_E0.5201.00
19_K22_G0.5201.00
20_C85_Y0.5151.00
62_T165_A0.5111.00
153_G160_T0.5101.00
5_C43_V0.5091.00
18_Q94_E0.5071.00
4_V172_F0.5051.00
9_H82_E0.5031.00
35_Q38_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gp3A 1 0.9482 100 0.146 Contact Map
4pzaA 2 0.9741 100 0.149 Contact Map
1h2eA 1 1 100 0.152 Contact Map
1e58A 2 1 100 0.154 Contact Map
4ij5A 2 1 100 0.154 Contact Map
3r7aA 1 0.9845 100 0.155 Contact Map
3kkkA 3 0.9482 100 0.162 Contact Map
3d8hA 2 0.9534 100 0.163 Contact Map
4embA 2 1 100 0.168 Contact Map
2hhjA 2 1 100 0.179 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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