GREMLIN Database
YHFP - Putative quinone oxidoreductase YhfP
UniProt: O07615 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (302)
Sequences: 52961 (36353)
Seq/√Len: 2091.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_E312_G3.0191.00
39_A122_L2.9551.00
37_K74_V2.9011.00
39_A72_T2.8511.00
11_E22_K2.8301.00
35_L74_V2.7071.00
153_S177_D2.6011.00
121_S124_E2.5521.00
34_V113_L2.5401.00
172_N197_S2.4371.00
82_A85_D2.4141.00
305_V316_D2.4061.00
85_D115_P2.4041.00
86_E116_L2.3541.00
37_K72_T2.3011.00
26_T105_Y2.2531.00
11_E20_H2.2391.00
123_K304_E2.2361.00
303_R316_D2.1901.00
9_Q22_K2.1671.00
290_S294_P2.1621.00
37_K105_Y2.1561.00
154_V171_L2.1361.00
188_A192_K2.1181.00
80_R110_G2.1111.00
177_D198_E2.1001.00
30_P33_G2.0831.00
69_A101_G2.0811.00
189_D193_Q2.0341.00
306_S309_E2.0271.00
119_N293_K2.0121.00
31_K78_D2.0111.00
168_V196_A1.9961.00
315_K319_Q1.9611.00
148_S152_G1.9351.00
69_A89_A1.9241.00
28_D75_S1.8981.00
70_A122_L1.8891.00
208_G211_K1.8581.00
35_L107_S1.8471.00
74_V105_Y1.8261.00
86_E122_L1.8121.00
52_K318_L1.8091.00
185_R189_D1.8011.00
132_G166_I1.7821.00
189_D192_K1.7781.00
173_K296_Q1.7751.00
312_G315_K1.7711.00
219_Q238_Q1.7161.00
155_L181_S1.7141.00
316_D321_R1.7051.00
155_L218_W1.7011.00
152_G242_S1.6881.00
242_S267_S1.6851.00
305_V313_A1.6741.00
179_V218_W1.6631.00
116_L122_L1.6491.00
312_G316_D1.6441.00
190_Y193_Q1.6401.00
182_T188_A1.6391.00
188_A199_V1.6331.00
76_S83_E1.6001.00
157_T233_L1.5771.00
177_D197_S1.5721.00
8_L310_T1.5711.00
242_S269_L1.5651.00
6_Q23_T1.5551.00
81_F115_P1.5521.00
75_S83_E1.5351.00
29_L107_S1.5211.00
81_F85_D1.5061.00
185_R201_S1.4991.00
237_I266_V1.4991.00
35_L105_Y1.4981.00
145_N220_G1.4981.00
33_G109_P1.4861.00
237_I243_V1.4791.00
72_T86_E1.4521.00
38_V69_A1.4381.00
32_D109_P1.4321.00
116_L125_A1.4281.00
29_L35_L1.4231.00
6_Q308_E1.4181.00
221_A237_I1.4041.00
311_P315_K1.4031.00
102_L314_L1.4031.00
237_I241_G1.4021.00
6_Q104_E1.3961.00
168_V180_A1.3771.00
40_Y123_K1.3771.00
221_A233_L1.3751.00
33_G107_S1.3621.00
302_D316_D1.3451.00
201_S204_D1.3441.00
7_A24_I1.3401.00
185_R204_D1.3341.00
73_V81_F1.3321.00
35_L75_S1.3261.00
86_E118_Q1.3231.00
160_T180_A1.3181.00
34_V81_F1.2951.00
290_S293_K1.2871.00
173_K291_D1.2821.00
72_T122_L1.2821.00
153_S179_V1.2651.00
157_T181_S1.2451.00
143_E287_R1.2381.00
167_A222_V1.2381.00
8_L21_V1.2381.00
51_G314_L1.2321.00
209_T212_A1.2301.00
183_G188_A1.2201.00
147_L176_Y1.2161.00
207_D211_K1.2141.00
183_G202_R1.2081.00
32_D110_G1.1721.00
39_A86_E1.1721.00
185_R188_A1.1711.00
81_F113_L1.1701.00
26_T35_L1.1631.00
192_K199_V1.1491.00
198_E212_A1.1351.00
205_V208_G1.1311.00
287_R290_S1.1241.00
124_E298_L1.1241.00
12_K18_S1.1211.00
36_I71_G1.1181.00
143_E284_V1.1111.00
29_L33_G1.1081.00
38_V106_A1.1041.00
188_A201_S1.1041.00
235_S260_P1.1031.00
208_G212_A1.1011.00
153_S219_Q1.0971.00
160_T182_T1.0911.00
169_S298_L1.0881.00
152_G219_Q1.0861.00
282_A286_E1.0831.00
108_V113_L1.0831.00
192_K198_E1.0761.00
8_L307_L1.0691.00
74_V83_E1.0651.00
43_I313_A1.0501.00
291_D296_Q1.0331.00
32_D78_D1.0301.00
286_E290_S1.0281.00
137_L284_V1.0271.00
190_Y323_Q1.0271.00
179_V198_E1.0261.00
41_S102_L1.0171.00
145_N244_A1.0161.00
180_A196_A1.0151.00
135_A167_A1.0121.00
36_I87_V1.0101.00
51_G318_L1.0081.00
144_Q267_S1.0061.00
21_V308_E0.9951.00
225_V229_Q0.9931.00
210_L213_L0.9791.00
9_Q24_I0.9751.00
39_A70_A0.9751.00
40_Y122_L0.9711.00
206_Y210_L0.9631.00
209_T213_L0.9621.00
135_A170_M0.9601.00
102_L310_T0.9451.00
26_T75_S0.9441.00
231_A235_S0.9421.00
120_L125_A0.9371.00
315_K318_L0.9351.00
171_L176_Y0.9341.00
310_T328_V0.9341.00
132_G288_M0.9291.00
7_A64_I0.9271.00
138_S246_S0.9251.00
179_V200_I0.9241.00
32_D77_N0.9211.00
44_N68_D0.9211.00
136_A287_R0.9181.00
316_D326_V0.9151.00
168_V178_V0.9111.00
232_S235_S0.9101.00
76_S79_P0.9091.00
206_Y209_T0.9071.00
8_L19_V0.9051.00
223_D226_G0.8981.00
9_Q64_I0.8951.00
37_K104_E0.8901.00
170_M288_M0.8881.00
48_G317_I0.8871.00
156_V167_A0.8861.00
260_P264_R0.8811.00
261_F268_L0.8761.00
12_K17_V0.8761.00
138_S222_V0.8741.00
156_V171_L0.8731.00
69_A106_A0.8721.00
155_L236_K0.8711.00
41_S101_G0.8701.00
40_Y327_I0.8671.00
6_Q21_V0.8661.00
180_A191_L0.8621.00
165_G190_Y0.8611.00
207_D210_L0.8611.00
26_T74_V0.8561.00
128_Y292_L0.8531.00
28_D35_L0.8531.00
213_L216_Q0.8531.00
184_N187_A0.8461.00
157_T221_A0.8461.00
88_I289_S0.8421.00
152_G220_G0.8421.00
186_E189_D0.8421.00
82_A115_P0.8411.00
181_S202_R0.8401.00
193_Q298_L0.8391.00
183_G203_E0.8331.00
29_L77_N0.8321.00
30_P107_S0.8321.00
210_L214_S0.8291.00
44_N67_I0.8281.00
63_L99_D0.8271.00
102_L328_V0.8241.00
148_S151_K0.8241.00
42_G68_D0.8221.00
187_A323_Q0.8221.00
287_R291_D0.8211.00
240_G265_G0.8201.00
283_A287_R0.8141.00
139_V171_L0.8131.00
133_F284_V0.8131.00
160_T191_L0.8111.00
147_L152_G0.8111.00
24_I99_D0.8111.00
76_S82_A0.8091.00
191_L196_A0.8001.00
184_N201_S0.7991.00
153_S218_W0.7991.00
257_T260_P0.7981.00
11_E18_S0.7971.00
118_Q293_K0.7961.00
305_V309_E0.7961.00
79_P110_G0.7951.00
170_M291_D0.7941.00
144_Q269_L0.7901.00
209_T214_S0.7881.00
43_I317_I0.7831.00
182_T199_V0.7771.00
317_I326_V0.7761.00
34_V110_G0.7751.00
283_A286_E0.7721.00
8_L311_P0.7701.00
138_S167_A0.7671.00
193_Q300_I0.7661.00
21_V307_L0.7601.00
221_A243_V0.7581.00
291_D294_P0.7531.00
157_T229_Q0.7521.00
171_L178_V0.7481.00
183_G191_L0.7481.00
29_L75_S0.7471.00
291_D295_D0.7461.00
174_R287_R0.7461.00
135_A166_I0.7431.00
87_V113_L0.7401.00
233_L243_V0.7401.00
303_R312_G0.7371.00
178_V197_S0.7361.00
228_K232_S0.7341.00
261_F270_G0.7321.00
114_V286_E0.7321.00
117_P293_K0.7321.00
154_V176_Y0.7281.00
147_L220_G0.7261.00
316_D319_Q0.7261.00
322_I326_V0.7201.00
146_G242_S0.7191.00
153_S216_Q0.7191.00
224_P246_S0.7181.00
46_K67_I0.7171.00
89_A108_V0.7111.00
135_A163_V0.7111.00
120_L292_L0.7101.00
261_F266_V0.7081.00
101_G106_A0.7061.00
303_R326_V0.7041.00
44_N47_D0.7021.00
80_R282_A0.6991.00
137_L265_G0.6931.00
24_I64_I0.6931.00
136_A288_M0.6931.00
40_Y304_E0.6911.00
301_V304_E0.6901.00
305_V328_V0.6901.00
68_D130_T0.6891.00
70_A126_M0.6861.00
43_I102_L0.6841.00
10_A18_S0.6841.00
239_Y264_R0.6841.00
88_I116_L0.6831.00
200_I205_V0.6821.00
206_Y232_S0.6801.00
245_V268_L0.6751.00
17_V315_K0.6741.00
29_L32_D0.6711.00
146_G269_L0.6691.00
146_G267_S0.6661.00
170_M174_R0.6651.00
55_G59_R0.6631.00
220_G244_A0.6601.00
136_A291_D0.6581.00
135_A139_V0.6571.00
156_V180_A0.6551.00
32_D111_D0.6551.00
121_S125_A0.6531.00
230_L243_V0.6531.00
44_N130_T0.6531.00
76_S85_D0.6511.00
12_K20_H0.6511.00
176_Y220_G0.6491.00
80_R115_P0.6481.00
190_Y300_I0.6471.00
114_V285_W0.6461.00
216_Q238_Q0.6461.00
27_E107_S0.6451.00
165_G300_I0.6421.00
218_W221_A0.6421.00
231_A260_P0.6421.00
80_R83_E0.6401.00
190_Y194_L0.6391.00
88_I129_G0.6391.00
44_N131_A0.6381.00
289_S293_K0.6381.00
213_L217_Q0.6361.00
31_K77_N0.6351.00
95_G99_D0.6351.00
218_W236_K0.6341.00
143_E174_R0.6321.00
305_V326_V0.6321.00
114_V289_S0.6311.00
127_V327_I0.6281.00
40_Y70_A0.6271.00
86_E119_N0.6231.00
70_A116_L0.6231.00
145_N242_S0.6191.00
67_I130_T0.6191.00
168_V194_L0.6191.00
34_V73_V0.6171.00
205_V209_T0.6131.00
168_V191_L0.6121.00
36_I89_A0.6111.00
38_V41_S0.6101.00
314_L318_L0.6101.00
85_D118_Q0.6091.00
131_A166_I0.6041.00
220_G242_S0.6021.00
134_T163_V0.6021.00
169_S194_L0.6021.00
70_A86_E0.6021.00
136_A284_V0.6021.00
223_D243_V0.5991.00
130_T134_T0.5981.00
131_A162_G0.5961.00
206_Y235_S0.5951.00
229_Q233_L0.5941.00
55_G58_V0.5921.00
45_Y49_L0.5911.00
46_K50_A0.5901.00
30_P77_N0.5891.00
48_G318_L0.5881.00
160_T168_V0.5871.00
259_Y262_I0.5861.00
231_A253_E0.5851.00
188_A191_L0.5851.00
204_D208_G0.5831.00
228_K231_A0.5811.00
182_T191_L0.5811.00
138_S271_I0.5801.00
182_T201_S0.5801.00
221_A236_K0.5791.00
172_N178_V0.5771.00
292_L299_T0.5771.00
49_L54_G0.5761.00
206_Y213_L0.5751.00
265_G275_Y0.5751.00
27_E105_Y0.5721.00
89_A113_L0.5721.00
181_S200_I0.5631.00
154_V220_G0.5631.00
167_A246_S0.5631.00
155_L221_A0.5631.00
16_D315_K0.5631.00
110_G113_L0.5611.00
76_S81_F0.5601.00
12_K16_D0.5601.00
188_A202_R0.5591.00
79_P82_A0.5591.00
136_A174_R0.5561.00
114_V282_A0.5521.00
143_E146_G0.5491.00
27_E35_L0.5491.00
66_G102_L0.5481.00
179_V212_A0.5461.00
90_T114_V0.5451.00
60_E63_L0.5451.00
70_A125_A0.5431.00
48_G52_K0.5421.00
260_P266_V0.5411.00
26_T107_S0.5411.00
166_I170_M0.5401.00
26_T29_L0.5401.00
316_D322_I0.5391.00
134_T246_S0.5381.00
27_E33_G0.5371.00
262_I270_G0.5341.00
81_F110_G0.5331.00
19_V314_L0.5331.00
121_S304_E0.5331.00
62_P66_G0.5321.00
46_K49_L0.5321.00
45_Y161_G0.5311.00
182_T202_R0.5311.00
56_N59_R0.5301.00
182_T187_A0.5291.00
244_A271_I0.5291.00
44_N325_R0.5281.00
21_V310_T0.5261.00
25_S28_D0.5251.00
160_T187_A0.5241.00
10_A51_G0.5241.00
260_P263_L0.5231.00
127_V299_T0.5231.00
139_V170_M0.5211.00
18_S311_P0.5211.00
271_I274_V0.5201.00
204_D209_T0.5151.00
139_V167_A0.5151.00
271_I275_Y0.5141.00
143_E283_A0.5121.00
253_E257_T0.5111.00
172_N196_A0.5111.00
78_D110_G0.5101.00
231_A255_P0.5101.00
41_S328_V0.5091.00
305_V312_G0.5081.00
138_S244_A0.5081.00
196_A199_V0.5041.00
191_L199_V0.5041.00
223_D247_G0.5031.00
34_V76_S0.5021.00
115_P118_Q0.5011.00
42_G126_M0.5011.00
17_V51_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tt7A 5 0.9939 100 0.153 Contact Map
3nx4A 2 0.9758 100 0.158 Contact Map
4j6fA 2 0.9667 100 0.169 Contact Map
4gi2A 2 0.9788 100 0.17 Contact Map
3uogA 4 0.9636 100 0.172 Contact Map
4jxkA 2 0.9818 100 0.173 Contact Map
1zsyA 2 0.9758 100 0.18 Contact Map
4a27A 2 0.9152 100 0.18 Contact Map
1xa0A 2 0.9758 100 0.182 Contact Map
4dupA 2 0.9697 100 0.186 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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