YHFO - BACSU - GREMLIN Contacts

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YHFO - Uncharacterized N-acetyltransferase YhfO

UniProt:	O07614	Sequences: MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLENHESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAKDYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	149 (137)
Sequences:	4564 (3363)
Seq/√Len:	287.3

ECOLI - PHNO YJGM YPEA RIMI MNAT YEDL YAFP YIAC YJAB YHHY
BACSU - YHFO YHDJ YQJY YWNH YTMI PAIA YESJ YSNE RIMI YUAI YYAR YBFA YYCN SPSD YDGE YVBK BLTD YBBJ
HALSA - Q9HQD2 Q9HMF0 Q9HSL3 Q9HMI8 Q9HRK6
SULSO - Y209 Q7LXZ8 Q97UX1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_I	58_F	3.088	1.00
4_R	53_E	3.060	1.00
20_Q	85_V	2.789	1.00
122_R	126_S	2.781	1.00
59_I	88_A	2.640	1.00
100_A	103_D	2.445	1.00
95_G	130_Q	2.331	1.00
13_A	16_P	2.325	1.00
50_L	100_A	2.323	1.00
62_T	101_A	2.278	1.00
12_A	35_E	2.202	1.00
8_T	39_K	2.067	1.00
4_R	10_D	2.046	1.00
52_A	93_A	2.029	1.00
104_Y	108_N	1.865	1.00
41_R	68_F	1.785	1.00
19_N	23_E	1.705	1.00
115_L	133_Y	1.702	1.00
50_L	104_Y	1.688	1.00
16_P	85_V	1.669	1.00
102_K	113_L	1.617	1.00
126_S	129_E	1.589	1.00
105_A	110_A	1.580	1.00
66_P	108_N	1.524	1.00
104_Y	107_Q	1.523	1.00
59_I	93_A	1.523	1.00
100_A	104_Y	1.507	1.00
54_E	91_K	1.478	1.00
98_L	131_N	1.452	1.00
6_A	49_I	1.432	1.00
102_K	133_Y	1.425	1.00
13_A	58_F	1.418	1.00
36_A	39_K	1.418	1.00
48_V	108_N	1.409	1.00
53_E	56_G	1.406	1.00
27_Q	71_V	1.394	1.00
95_G	99_S	1.388	1.00
103_D	107_Q	1.380	1.00
57_E	85_V	1.350	1.00
20_Q	83_F	1.342	1.00
102_K	106_G	1.340	1.00
62_T	79_L	1.339	1.00
57_E	87_H	1.322	1.00
2_N	53_E	1.301	1.00
88_A	91_K	1.291	1.00
53_E	58_F	1.287	1.00
48_V	64_L	1.287	1.00
50_L	64_L	1.267	1.00
66_P	110_A	1.260	1.00
64_L	101_A	1.257	1.00
95_G	131_N	1.254	1.00
54_E	59_I	1.246	1.00
11_A	35_E	1.244	1.00
27_Q	30_D	1.238	1.00
67_T	78_I	1.231	1.00
23_E	28_A	1.222	1.00
105_A	113_L	1.205	1.00
35_E	39_K	1.159	1.00
11_A	15_A	1.138	1.00
44_N	47_S	1.083	1.00
16_P	20_Q	1.082	1.00
77_Y	105_A	1.074	1.00
129_E	135_E	1.072	1.00
129_E	137_T	1.067	1.00
78_I	116_Q	1.061	1.00
90_T	94_G	1.056	1.00
98_L	133_Y	1.048	1.00
125_R	129_E	1.040	1.00
21_Y	25_Y	1.039	1.00
117_T	125_R	1.032	1.00
77_Y	110_A	1.025	1.00
72_S	111_K	1.023	1.00
122_R	125_R	1.019	1.00
33_G	73_M	1.018	1.00
85_V	88_A	1.013	1.00
11_A	38_L	1.010	1.00
67_T	76_I	0.998	1.00
6_A	14_I	0.992	1.00
74_K	111_K	0.986	1.00
64_L	104_Y	0.982	1.00
15_A	31_L	0.980	1.00
17_L	58_F	0.969	1.00
34_A	37_F	0.965	1.00
69_S	80_N	0.947	1.00
13_A	51_I	0.944	1.00
54_E	88_A	0.934	1.00
77_Y	113_L	0.924	1.00
46_E	68_F	0.920	1.00
14_I	49_I	0.915	1.00
26_R	120_H	0.894	1.00
99_S	131_N	0.894	1.00
99_S	102_K	0.894	1.00
19_N	28_A	0.880	1.00
39_K	43_E	0.872	1.00
13_A	57_E	0.847	1.00
21_Y	81_D	0.845	1.00
79_L	98_L	0.837	1.00
3_I	96_R	0.828	1.00
84_V	93_A	0.828	1.00
97_L	100_A	0.825	1.00
37_F	40_A	0.824	1.00
117_T	121_N	0.824	1.00
20_Q	86_P	0.817	1.00
76_I	114_T	0.816	1.00
54_E	57_E	0.809	0.99
13_A	85_V	0.802	0.99
25_Y	118_E	0.801	0.99
76_I	112_C	0.799	0.99
49_I	63_Q	0.788	0.99
13_A	17_L	0.785	0.99
117_T	124_A	0.782	0.99
14_I	61_F	0.782	0.99
92_G	95_G	0.776	0.99
65_Y	80_N	0.771	0.99
124_A	128_Y	0.767	0.99
70_S	81_D	0.766	0.99
17_L	83_F	0.764	0.99
5_Q	48_V	0.758	0.99
123_K	126_S	0.757	0.99
15_A	19_N	0.756	0.99
15_A	35_E	0.755	0.99
96_R	99_S	0.754	0.99
115_L	128_Y	0.749	0.99
84_V	97_L	0.749	0.99
52_A	60_G	0.747	0.99
5_Q	104_Y	0.747	0.99
22_R	25_Y	0.743	0.99
126_S	130_Q	0.741	0.99
103_D	106_G	0.740	0.99
52_A	97_L	0.738	0.99
48_V	66_P	0.731	0.99
135_E	138_G	0.731	0.99
96_R	100_A	0.726	0.99
129_E	134_E	0.721	0.99
18_F	81_D	0.721	0.99
100_A	107_Q	0.708	0.99
61_F	83_F	0.707	0.99
66_P	104_Y	0.703	0.99
19_N	31_L	0.701	0.99
121_N	124_A	0.694	0.98
98_L	127_L	0.692	0.98
18_F	63_Q	0.687	0.98
24_F	124_A	0.674	0.98
11_A	39_K	0.673	0.98
3_I	93_A	0.670	0.98
15_A	33_G	0.657	0.98
92_G	96_R	0.654	0.98
88_A	93_A	0.650	0.98
11_A	14_I	0.643	0.97
78_I	81_D	0.642	0.97
8_T	44_N	0.634	0.97
94_G	127_L	0.628	0.97
48_V	104_Y	0.625	0.97
33_G	37_F	0.625	0.97
119_H	138_G	0.623	0.97
31_L	35_E	0.619	0.97
77_Y	101_A	0.615	0.97
90_T	126_S	0.610	0.97
3_I	97_L	0.608	0.96
60_G	97_L	0.607	0.96
50_L	62_T	0.606	0.96
21_Y	118_E	0.605	0.96
68_F	73_M	0.603	0.96
121_N	128_Y	0.597	0.96
63_Q	70_S	0.595	0.96
125_R	135_E	0.593	0.96
4_R	51_I	0.591	0.96
54_E	93_A	0.589	0.96
79_L	115_L	0.588	0.96
69_S	76_I	0.582	0.95
21_Y	83_F	0.577	0.95
69_S	81_D	0.576	0.95
63_Q	81_D	0.573	0.95
57_E	88_A	0.573	0.95
22_R	71_V	0.572	0.95
37_F	74_K	0.572	0.95
24_F	123_K	0.569	0.95
77_Y	108_N	0.566	0.95
24_F	83_F	0.565	0.95
23_E	26_R	0.563	0.95
3_I	50_L	0.561	0.94
69_S	112_C	0.561	0.94
101_A	113_L	0.560	0.94
36_A	40_A	0.553	0.94
78_I	114_T	0.552	0.94
65_Y	70_S	0.551	0.94
41_R	47_S	0.529	0.93
79_L	127_L	0.529	0.93
53_E	59_I	0.526	0.92
4_R	13_A	0.526	0.92
52_A	59_I	0.524	0.92
70_S	80_N	0.522	0.92
18_F	22_R	0.520	0.92
17_L	61_F	0.518	0.92
99_S	103_D	0.517	0.92
22_R	73_M	0.516	0.92
79_L	101_A	0.515	0.92
20_Q	23_E	0.511	0.91
18_F	38_L	0.509	0.91
32_Q	35_E	0.509	0.91
102_K	131_N	0.507	0.91
16_P	19_N	0.507	0.91
59_I	91_K	0.505	0.91
82_L	131_N	0.502	0.91
64_L	108_N	0.501	0.90
93_A	96_R	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2euiA	2	1	99.9	0.328	Contact Map
2b5gA	2	0.9933	99.9	0.33	Contact Map
3fynA	2	0.9463	99.9	0.335	Contact Map
2fe7A	3	1	99.9	0.337	Contact Map
3i9sA	4	1	99.9	0.342	Contact Map
2beiA	2	0.9732	99.9	0.348	Contact Map
1qsmA	3	0.9732	99.9	0.351	Contact Map
1s3zA	2	0.953	99.9	0.354	Contact Map
3dr6A	2	0.9866	99.9	0.355	Contact Map
3dsbA	2	0.9866	99.9	0.359	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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