GREMLIN Database
YHFO - Uncharacterized N-acetyltransferase YhfO
UniProt: O07614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (137)
Sequences: 4564 (3363)
Seq/√Len: 287.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_I58_F3.0881.00
4_R53_E3.0601.00
20_Q85_V2.7891.00
122_R126_S2.7811.00
59_I88_A2.6401.00
100_A103_D2.4451.00
95_G130_Q2.3311.00
13_A16_P2.3251.00
50_L100_A2.3231.00
62_T101_A2.2781.00
12_A35_E2.2021.00
8_T39_K2.0671.00
4_R10_D2.0461.00
52_A93_A2.0291.00
104_Y108_N1.8651.00
41_R68_F1.7851.00
19_N23_E1.7051.00
115_L133_Y1.7021.00
50_L104_Y1.6881.00
16_P85_V1.6691.00
102_K113_L1.6171.00
126_S129_E1.5891.00
105_A110_A1.5801.00
66_P108_N1.5241.00
104_Y107_Q1.5231.00
59_I93_A1.5231.00
100_A104_Y1.5071.00
54_E91_K1.4781.00
98_L131_N1.4521.00
6_A49_I1.4321.00
102_K133_Y1.4251.00
13_A58_F1.4181.00
36_A39_K1.4181.00
48_V108_N1.4091.00
53_E56_G1.4061.00
27_Q71_V1.3941.00
95_G99_S1.3881.00
103_D107_Q1.3801.00
57_E85_V1.3501.00
20_Q83_F1.3421.00
102_K106_G1.3401.00
62_T79_L1.3391.00
57_E87_H1.3221.00
2_N53_E1.3011.00
88_A91_K1.2911.00
53_E58_F1.2871.00
48_V64_L1.2871.00
50_L64_L1.2671.00
66_P110_A1.2601.00
64_L101_A1.2571.00
95_G131_N1.2541.00
54_E59_I1.2461.00
11_A35_E1.2441.00
27_Q30_D1.2381.00
67_T78_I1.2311.00
23_E28_A1.2221.00
105_A113_L1.2051.00
35_E39_K1.1591.00
11_A15_A1.1381.00
44_N47_S1.0831.00
16_P20_Q1.0821.00
77_Y105_A1.0741.00
129_E135_E1.0721.00
129_E137_T1.0671.00
78_I116_Q1.0611.00
90_T94_G1.0561.00
98_L133_Y1.0481.00
125_R129_E1.0401.00
21_Y25_Y1.0391.00
117_T125_R1.0321.00
77_Y110_A1.0251.00
72_S111_K1.0231.00
122_R125_R1.0191.00
33_G73_M1.0181.00
85_V88_A1.0131.00
11_A38_L1.0101.00
67_T76_I0.9981.00
6_A14_I0.9921.00
74_K111_K0.9861.00
64_L104_Y0.9821.00
15_A31_L0.9801.00
17_L58_F0.9691.00
34_A37_F0.9651.00
69_S80_N0.9471.00
13_A51_I0.9441.00
54_E88_A0.9341.00
77_Y113_L0.9241.00
46_E68_F0.9201.00
14_I49_I0.9151.00
26_R120_H0.8941.00
99_S131_N0.8941.00
99_S102_K0.8941.00
19_N28_A0.8801.00
39_K43_E0.8721.00
13_A57_E0.8471.00
21_Y81_D0.8451.00
79_L98_L0.8371.00
3_I96_R0.8281.00
84_V93_A0.8281.00
97_L100_A0.8251.00
37_F40_A0.8241.00
117_T121_N0.8241.00
20_Q86_P0.8171.00
76_I114_T0.8161.00
54_E57_E0.8090.99
13_A85_V0.8020.99
25_Y118_E0.8010.99
76_I112_C0.7990.99
49_I63_Q0.7880.99
13_A17_L0.7850.99
117_T124_A0.7820.99
14_I61_F0.7820.99
92_G95_G0.7760.99
65_Y80_N0.7710.99
124_A128_Y0.7670.99
70_S81_D0.7660.99
17_L83_F0.7640.99
5_Q48_V0.7580.99
123_K126_S0.7570.99
15_A19_N0.7560.99
15_A35_E0.7550.99
96_R99_S0.7540.99
115_L128_Y0.7490.99
84_V97_L0.7490.99
52_A60_G0.7470.99
5_Q104_Y0.7470.99
22_R25_Y0.7430.99
126_S130_Q0.7410.99
103_D106_G0.7400.99
52_A97_L0.7380.99
48_V66_P0.7310.99
135_E138_G0.7310.99
96_R100_A0.7260.99
129_E134_E0.7210.99
18_F81_D0.7210.99
100_A107_Q0.7080.99
61_F83_F0.7070.99
66_P104_Y0.7030.99
19_N31_L0.7010.99
121_N124_A0.6940.98
98_L127_L0.6920.98
18_F63_Q0.6870.98
24_F124_A0.6740.98
11_A39_K0.6730.98
3_I93_A0.6700.98
15_A33_G0.6570.98
92_G96_R0.6540.98
88_A93_A0.6500.98
11_A14_I0.6430.97
78_I81_D0.6420.97
8_T44_N0.6340.97
94_G127_L0.6280.97
48_V104_Y0.6250.97
33_G37_F0.6250.97
119_H138_G0.6230.97
31_L35_E0.6190.97
77_Y101_A0.6150.97
90_T126_S0.6100.97
3_I97_L0.6080.96
60_G97_L0.6070.96
50_L62_T0.6060.96
21_Y118_E0.6050.96
68_F73_M0.6030.96
121_N128_Y0.5970.96
63_Q70_S0.5950.96
125_R135_E0.5930.96
4_R51_I0.5910.96
54_E93_A0.5890.96
79_L115_L0.5880.96
69_S76_I0.5820.95
21_Y83_F0.5770.95
69_S81_D0.5760.95
63_Q81_D0.5730.95
57_E88_A0.5730.95
22_R71_V0.5720.95
37_F74_K0.5720.95
24_F123_K0.5690.95
77_Y108_N0.5660.95
24_F83_F0.5650.95
23_E26_R0.5630.95
3_I50_L0.5610.94
69_S112_C0.5610.94
101_A113_L0.5600.94
36_A40_A0.5530.94
78_I114_T0.5520.94
65_Y70_S0.5510.94
41_R47_S0.5290.93
79_L127_L0.5290.93
53_E59_I0.5260.92
4_R13_A0.5260.92
52_A59_I0.5240.92
70_S80_N0.5220.92
18_F22_R0.5200.92
17_L61_F0.5180.92
99_S103_D0.5170.92
22_R73_M0.5160.92
79_L101_A0.5150.92
20_Q23_E0.5110.91
18_F38_L0.5090.91
32_Q35_E0.5090.91
102_K131_N0.5070.91
16_P19_N0.5070.91
59_I91_K0.5050.91
82_L131_N0.5020.91
64_L108_N0.5010.90
93_A96_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2euiA 2 1 99.9 0.328 Contact Map
2b5gA 2 0.9933 99.9 0.33 Contact Map
3fynA 2 0.9463 99.9 0.335 Contact Map
2fe7A 3 1 99.9 0.337 Contact Map
3i9sA 4 1 99.9 0.342 Contact Map
2beiA 2 0.9732 99.9 0.348 Contact Map
1qsmA 3 0.9732 99.9 0.351 Contact Map
1s3zA 2 0.953 99.9 0.354 Contact Map
3dr6A 2 0.9866 99.9 0.355 Contact Map
3dsbA 2 0.9866 99.9 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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