GREMLIN Database
YHFK - Uncharacterized sugar epimerase YhfK
UniProt: O07609 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (196)
Sequences: 62750 (42188)
Seq/√Len: 3013.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A30_A3.1991.00
19_L182_K2.5051.00
87_L91_D2.4721.00
31_M51_A2.3511.00
69_A188_L2.2991.00
72_F110_M2.2571.00
183_T200_L2.2491.00
107_R146_T2.2151.00
55_G59_E2.0621.00
19_L185_I2.0261.00
4_F67_C1.9781.00
61_A102_I1.9651.00
111_V184_V1.9601.00
29_R67_C1.9281.00
51_A59_E1.9281.00
29_R47_E1.8711.00
19_L24_P1.8491.00
152_P184_V1.8111.00
81_G84_K1.8051.00
5_L17_V1.7991.00
29_R49_V1.7911.00
9_N32_V1.7561.00
93_A136_A1.7421.00
140_L147_Y1.7351.00
6_I72_F1.7251.00
57_P98_E1.6951.00
83_D87_L1.6721.00
71_I188_L1.6541.00
94_A98_E1.6121.00
110_M140_L1.6121.00
54_E87_L1.6001.00
61_A99_A1.5871.00
27_S47_E1.5861.00
134_H138_K1.5501.00
16_L181_A1.5221.00
182_K186_A1.5211.00
12_I155_L1.5161.00
59_E62_A1.4931.00
19_L22_D1.4931.00
107_R148_T1.4841.00
73_T111_V1.4841.00
57_P95_K1.4811.00
117_H199_D1.4751.00
94_A139_I1.4711.00
24_P189_D1.4641.00
89_D132_A1.4591.00
150_I187_S1.4591.00
57_P61_A1.4371.00
112_S116_A1.4281.00
91_D94_A1.4161.00
3_V20_F1.4131.00
68_D106_K1.4111.00
17_V30_A1.4111.00
101_A143_S1.3681.00
19_L181_A1.3591.00
24_P185_I1.3531.00
156_R176_S1.3531.00
150_I184_V1.3421.00
16_L73_T1.3311.00
53_L92_G1.3301.00
86_L135_Y1.3301.00
90_L135_Y1.3231.00
185_I189_D1.3221.00
30_A46_A1.2891.00
137_D151_R1.2821.00
34_K37_Q1.2821.00
16_L71_I1.2801.00
15_R178_D1.2761.00
3_V26_H1.2761.00
112_S137_D1.2741.00
3_V69_A1.2701.00
111_V152_P1.2551.00
34_K48_A1.2181.00
151_R197_A1.2151.00
173_G203_G1.2031.00
61_A103_A1.2011.00
186_A190_E1.1981.00
19_L178_D1.1981.00
70_I100_A1.1841.00
21_Q46_A1.1591.00
53_L74_A1.1591.00
61_A65_K1.1571.00
35_E50_L1.1471.00
60_I99_A1.1471.00
96_A108_F1.1471.00
26_H189_D1.1401.00
88_V92_G1.1391.00
8_A17_V1.1301.00
152_P180_V1.1301.00
129_Y133_K1.1251.00
131_V135_Y1.1241.00
98_E101_A1.1191.00
62_A65_K1.1181.00
18_S159_P1.1171.00
177_R181_A1.1151.00
97_I108_F1.1151.00
55_G58_E1.1151.00
31_M63_A1.1091.00
4_F31_M1.1071.00
18_S22_D1.1071.00
11_Q157_N1.1041.00
176_S179_D1.1001.00
91_D95_K1.0981.00
71_I184_V1.0921.00
100_A108_F1.0921.00
70_I96_A1.0921.00
109_I150_I1.0781.00
20_F185_I1.0691.00
86_L90_L1.0681.00
72_F93_A1.0441.00
100_A105_I1.0431.00
6_I96_A1.0431.00
21_Q45_G1.0401.00
76_S88_V1.0261.00
110_M136_A1.0211.00
175_I180_V1.0161.00
73_T184_V1.0141.00
16_L184_V1.0131.00
64_A70_I1.0091.00
27_S45_G0.9991.00
179_D202_E0.9901.00
155_L175_I0.9901.00
148_T187_S0.9871.00
14_Q18_S0.9861.00
58_E62_A0.9731.00
146_T194_E0.9721.00
65_K103_A0.9691.00
155_L180_V0.9681.00
83_D91_D0.9611.00
15_R18_S0.9551.00
110_M149_I0.9551.00
58_E61_A0.9541.00
151_R199_D0.9511.00
35_E39_A0.9411.00
20_F188_L0.9411.00
98_E102_I0.9361.00
64_A99_A0.9341.00
95_K98_E0.9281.00
11_Q177_R0.9161.00
29_R66_G0.9091.00
32_V48_A0.8991.00
26_H68_D0.8881.00
85_T132_A0.8861.00
64_A67_C0.8861.00
86_L91_D0.8811.00
49_V63_A0.8811.00
60_I95_K0.8771.00
114_L153_G0.8771.00
100_A103_A0.8751.00
57_P102_I0.8651.00
97_I139_I0.8571.00
31_M60_I0.8501.00
15_R19_L0.8491.00
33_R52_N0.8461.00
70_I108_F0.8421.00
101_A145_L0.8341.00
115_Q130_Y0.8321.00
59_E63_A0.8321.00
136_A140_L0.8311.00
76_S85_T0.8311.00
99_A103_A0.8281.00
14_Q159_P0.8191.00
182_K185_I0.8141.00
108_F140_L0.8131.00
17_V28_I0.8111.00
6_I74_A0.8071.00
64_A100_A0.7971.00
31_M59_E0.7971.00
106_K146_T0.7961.00
34_K50_L0.7941.00
76_S84_K0.7941.00
21_Q28_I0.7931.00
64_A103_A0.7911.00
69_A107_R0.7891.00
72_F96_A0.7881.00
16_L20_F0.7851.00
15_R177_R0.7791.00
10_G158_E0.7721.00
86_L131_V0.7711.00
181_A185_I0.7691.00
54_E88_V0.7671.00
26_H69_A0.7641.00
140_L149_I0.7641.00
99_A102_I0.7641.00
64_A96_A0.7591.00
97_I140_L0.7591.00
153_G201_T0.7551.00
116_A137_D0.7481.00
165_S168_K0.7481.00
93_A97_I0.7341.00
4_F51_A0.7301.00
101_A144_G0.7231.00
66_G103_A0.7211.00
42_E46_A0.7191.00
135_Y138_K0.7191.00
15_R181_A0.7181.00
55_G60_I0.7091.00
93_A140_L0.7071.00
152_P155_L0.7041.00
113_A116_A0.7021.00
52_N55_G0.7001.00
84_K87_L0.6981.00
116_A151_R0.6961.00
95_K99_A0.6861.00
149_I197_A0.6861.00
34_K39_A0.6731.00
5_L20_F0.6731.00
186_A189_D0.6681.00
3_V71_I0.6671.00
51_A63_A0.6651.00
173_G202_E0.6641.00
147_Y195_N0.6621.00
131_V138_K0.6601.00
37_Q40_S0.6601.00
10_G14_Q0.6571.00
158_E176_S0.6571.00
43_A46_A0.6551.00
135_Y139_I0.6511.00
30_A48_A0.6481.00
4_F64_A0.6451.00
12_I180_V0.6441.00
86_L132_A0.6401.00
3_V188_L0.6401.00
89_D133_K0.6381.00
191_K194_E0.6341.00
98_E139_I0.6341.00
84_K88_V0.6321.00
107_R191_K0.6301.00
20_F26_H0.6281.00
37_Q41_L0.6271.00
4_F63_A0.6241.00
38_K48_A0.6241.00
109_I187_S0.6211.00
57_P99_A0.6141.00
150_I200_L0.6091.00
116_A134_H0.6071.00
78_G84_K0.6061.00
125_A134_H0.6041.00
149_I195_N0.6031.00
154_G174_F0.6031.00
125_A130_Y0.5971.00
18_S178_D0.5911.00
54_E84_K0.5891.00
82_Y128_P0.5891.00
60_I96_A0.5891.00
92_G95_K0.5871.00
150_I183_T0.5851.00
128_P132_A0.5851.00
79_S128_P0.5791.00
73_T152_P0.5781.00
109_I188_L0.5771.00
36_E39_A0.5751.00
31_M49_V0.5741.00
179_D182_K0.5731.00
119_R126_L0.5731.00
51_A60_I0.5721.00
21_Q43_A0.5691.00
75_G89_D0.5681.00
137_D149_I0.5601.00
117_H151_R0.5581.00
69_A109_I0.5541.00
112_S149_I0.5531.00
76_S89_D0.5501.00
153_G173_G0.5481.00
9_N34_K0.5461.00
127_K130_Y0.5461.00
60_I64_A0.5461.00
185_I188_L0.5431.00
112_S151_R0.5391.00
42_E45_G0.5361.00
17_V21_Q0.5351.00
38_K41_L0.5351.00
29_R63_A0.5341.00
128_P131_V0.5341.00
78_G81_G0.5311.00
82_Y131_V0.5311.00
141_E144_G0.5291.00
133_K136_A0.5291.00
69_A106_K0.5231.00
32_V50_L0.5211.00
129_Y132_A0.5201.00
164_V167_A0.5161.00
85_T128_P0.5111.00
63_A67_C0.5111.00
71_I111_V0.5111.00
131_V134_H0.5071.00
93_A110_M0.5071.00
89_D129_Y0.5061.00
148_T191_K0.5051.00
34_K38_K0.5031.00
27_S68_D0.5021.00
57_P60_I0.5011.00
100_A104_G0.5011.00
11_Q15_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pzmA 2 0.9813 100 0.218 Contact Map
2x4gA 2 0.9346 100 0.223 Contact Map
1sb8A 2 0.9813 100 0.224 Contact Map
2c20A 2 0.9907 100 0.23 Contact Map
2c5aA 2 0.9813 100 0.231 Contact Map
3rufA 2 0.9907 100 0.232 Contact Map
3slgA 4 0.986 100 0.233 Contact Map
2bllA 2 0.9907 100 0.237 Contact Map
1gy8A 2 0.9907 100 0.237 Contact Map
1i24A 4 0.986 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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