GREMLIN Database
LPLJ - Lipoate-protein ligase LplJ
UniProt: O07608 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (309)
Sequences: 1418 (1046)
Seq/√Len: 59.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_D186_S4.0131.00
269_K274_E3.5921.00
230_Q234_E3.3971.00
183_A188_F3.3691.00
256_R261_S3.2721.00
111_H116_E2.8531.00
78_H84_N2.8391.00
104_E108_Q2.8281.00
167_K171_E2.6601.00
36_Y86_S2.6551.00
227_T230_Q2.5981.00
59_V66_V2.5561.00
112_Q205_H2.4951.00
120_S126_V2.4871.00
58_Y62_N2.3521.00
194_T197_E2.3241.00
39_Q65_I2.3201.00
62_N162_A2.2831.00
277_K292_E2.2821.00
113_L201_H2.2731.00
71_S138_F2.2021.00
291_I312_V2.1851.00
170_I174_G2.0971.00
302_R306_A2.0911.00
58_Y162_A2.0791.00
42_I59_V2.0781.00
44_I50_T2.0691.00
132_I183_A2.0261.00
169_K281_D2.0131.00
125_I132_I1.9751.00
117_A127_V1.9211.00
82_N149_T1.8891.00
239_W244_G1.8791.00
38_N78_H1.8731.00
57_K61_E1.8671.00
304_V307_D1.8661.00
130_R183_A1.8651.00
83_L195_T1.8141.00
299_Q304_V1.8131.00
116_E128_D1.8101.00
298_K308_V1.8050.99
70_L235_R1.7660.99
301_E304_V1.7390.99
123_N169_K1.7000.99
15_N38_N1.6850.99
133_S149_T1.6800.99
130_R187_E1.6730.99
10_N80_L1.6630.99
20_E24_K1.6610.99
221_T224_D1.6570.99
112_Q208_N1.6500.99
231_I236_Y1.6440.99
108_Q208_N1.6380.99
275_D296_V1.6360.99
286_G291_I1.5930.99
249_F300_Y1.5840.99
67_V242_N1.5800.99
151_M154_S1.5800.99
250_N267_E1.5760.99
24_K140_T1.5720.99
294_L312_V1.5710.99
52_E176_K1.5600.98
183_A187_E1.5570.98
272_K299_Q1.5500.98
14_I225_W1.5440.98
43_I76_V1.5130.98
266_L276_C1.4990.98
155_A158_H1.4870.98
286_G316_H1.4850.98
56_T60_E1.4840.98
36_Y43_I1.4760.98
52_E172_S1.4640.98
43_I78_H1.4590.98
85_F148_G1.4490.98
232_S237_Q1.4470.98
127_V185_I1.4420.97
64_I162_A1.4270.97
22_C26_L1.4250.97
38_N84_N1.4230.97
126_V129_G1.4130.97
117_A125_I1.4120.97
20_E235_R1.4000.97
307_D310_E1.3920.97
239_W246_S1.3870.97
31_Q90_K1.3780.97
41_S78_H1.3680.97
43_I82_N1.3670.96
239_W299_Q1.3660.96
313_N316_H1.3650.96
249_F268_V1.3370.96
156_I160_V1.3360.96
220_L228_I1.3330.96
78_H82_N1.3260.96
136_A147_H1.3170.96
223_K226_E1.3140.96
38_N67_V1.3060.95
152_F193_M1.2810.95
308_V311_G1.2810.95
169_K181_R1.2770.95
229_H233_K1.2770.95
20_E236_Y1.2740.95
76_V82_N1.2720.95
86_S146_S1.2700.95
127_V188_F1.2700.95
37_V195_T1.2510.94
19_E147_H1.2340.94
76_V149_T1.2300.94
298_K304_V1.2280.94
18_I228_I1.2270.94
252_N265_H1.2260.94
231_I235_R1.2180.93
123_N260_G1.2140.93
274_E297_G1.2080.93
62_N158_H1.2020.93
6_N199_R1.1960.93
83_L198_F1.1930.93
159_V182_V1.1890.93
152_F198_F1.1810.92
109_A205_H1.1800.92
308_V312_V1.1780.92
91_D142_G1.1770.92
25_H227_T1.1690.92
16_L236_Y1.1670.92
118_E129_G1.1640.92
257_Y262_I1.1640.92
293_N296_V1.1600.92
123_N181_R1.1420.91
276_C295_L1.1410.91
11_D237_Q1.1380.91
181_R281_D1.1350.91
44_I75_A1.1350.91
50_T66_V1.1220.90
108_Q205_H1.1220.90
307_D311_G1.1210.90
42_I54_I1.1180.90
91_D144_I1.1090.90
16_L19_E1.1050.90
230_Q233_K1.1040.89
78_H154_S1.0960.89
121_G181_R1.0950.89
52_E170_I1.0940.89
170_I251_L1.0940.89
58_Y64_I1.0930.89
233_K237_Q1.0890.89
157_D160_V1.0850.89
16_L78_H1.0810.88
135_N138_F1.0810.88
304_V308_V1.0760.88
289_S293_N1.0760.88
306_A310_E1.0750.88
127_V183_A1.0720.88
35_F86_S1.0630.88
102_F105_P1.0550.87
13_R65_I1.0490.87
33_L206_I1.0490.87
22_C32_Y1.0490.87
166_K254_S1.0470.87
260_G281_D1.0460.87
107_I125_I1.0360.86
22_C31_Q1.0200.85
12_P78_H1.0190.85
43_I149_T1.0140.85
200_S204_R1.0090.85
36_Y146_S1.0050.84
100_K104_E1.0040.84
16_L43_I1.0030.84
38_N82_N1.0030.84
15_N78_H1.0020.84
168_D256_R1.0020.84
294_L308_V0.9970.84
33_L249_F0.9950.84
12_P67_V0.9890.84
128_D188_F0.9840.83
9_I14_I0.9740.83
14_I18_I0.9710.82
127_V132_I0.9710.82
286_G290_E0.9590.82
12_P84_N0.9550.81
20_E138_F0.9540.81
193_M201_H0.9530.81
39_Q80_L0.9480.81
103_T119_L0.9460.81
107_I117_A0.9290.80
137_Q146_S0.9250.79
151_M156_I0.9240.79
276_C296_V0.9210.79
37_V199_R0.9180.79
48_Q53_E0.9180.79
7_Q18_I0.9160.79
156_I159_V0.9110.78
110_L132_I0.9090.78
21_Y25_H0.9070.78
109_A201_H0.9040.78
71_S145_F0.9020.77
252_N263_D0.8980.77
40_P158_H0.8960.77
60_E302_R0.8920.77
76_V84_N0.8910.77
298_K305_I0.8910.77
256_R259_V0.8910.77
168_D254_S0.8890.76
169_K260_G0.8850.76
75_A163_L0.8820.76
278_I288_V0.8800.76
121_G169_K0.8730.75
36_Y41_S0.8730.75
85_F135_N0.8700.75
294_L311_G0.8680.75
122_R178_I0.8680.75
207_F215_V0.8660.75
205_H208_N0.8640.74
50_T246_S0.8640.74
111_H115_V0.8630.74
47_N138_F0.8630.74
196_E200_S0.8590.74
123_N173_K0.8560.74
56_T243_Y0.8520.73
218_Y224_D0.8520.73
49_N241_W0.8470.73
37_V83_L0.8470.73
132_I185_I0.8460.73
38_N43_I0.8430.73
86_S147_H0.8400.72
257_Y260_G0.8390.72
99_F122_R0.8390.72
239_W271_G0.8380.72
55_N58_Y0.8330.72
16_L84_N0.8300.71
83_L199_R0.8300.71
23_V47_N0.8250.71
143_R156_I0.8220.71
38_N76_V0.8190.70
121_G281_D0.8190.70
15_N19_E0.8190.70
267_E275_D0.8160.70
303_S307_D0.8160.70
47_N137_Q0.8120.70
158_H161_S0.8060.69
264_L278_I0.8050.69
89_T144_I0.8040.69
23_V149_T0.8030.69
55_N164_K0.8030.69
7_Q34_L0.8000.69
18_I34_L0.8000.69
70_L138_F0.7990.68
58_Y161_S0.7950.68
88_I145_F0.7910.68
123_N281_D0.7880.67
57_K60_E0.7850.67
239_W242_N0.7830.67
226_E230_Q0.7790.66
43_I84_N0.7790.66
256_R281_D0.7780.66
86_S145_F0.7750.66
246_S271_G0.7740.66
251_L300_Y0.7700.66
248_K269_K0.7680.65
303_S308_V0.7640.65
226_E229_H0.7640.65
224_D227_T0.7580.64
290_E308_V0.7560.64
54_I280_G0.7540.64
294_L301_E0.7520.64
14_I232_S0.7520.64
169_K173_K0.7490.63
70_L135_N0.7420.63
51_I249_F0.7390.62
157_D293_N0.7310.62
72_G134_G0.7280.61
54_I59_V0.7280.61
12_P44_I0.7270.61
7_Q14_I0.7220.61
88_I148_G0.7210.60
115_V127_V0.7200.60
197_E200_S0.7190.60
36_Y71_S0.7160.60
78_H147_H0.7160.60
12_P38_N0.7150.60
226_E233_K0.7130.60
58_Y61_E0.7130.60
43_I180_S0.7080.59
87_F106_V0.7050.59
21_Y228_I0.7050.59
13_R236_Y0.7030.59
288_V292_E0.7020.58
24_K197_E0.7010.58
47_N149_T0.7010.58
143_R185_I0.6960.58
116_E188_F0.6930.57
295_L298_K0.6920.57
81_G184_N0.6910.57
170_I175_I0.6910.57
273_I305_I0.6910.57
117_A132_I0.6900.57
185_I198_F0.6890.57
71_S135_N0.6870.57
40_P64_I0.6840.56
302_R312_V0.6840.56
198_F202_L0.6820.56
37_V40_P0.6810.56
102_F137_Q0.6790.56
52_E265_H0.6750.55
23_V140_T0.6740.55
130_R188_F0.6730.55
60_E303_S0.6730.55
19_E43_I0.6720.55
14_I23_V0.6690.55
36_Y96_F0.6690.55
268_V271_G0.6680.55
280_G283_F0.6670.55
103_T135_N0.6620.54
194_T233_K0.6620.54
16_L33_L0.6600.54
135_N148_G0.6600.54
44_I115_V0.6580.54
186_S192_K0.6580.54
20_E70_L0.6560.53
100_K118_E0.6550.53
71_S147_H0.6530.53
40_P77_Y0.6520.53
222_E225_W0.6480.52
139_A144_I0.6480.52
12_P16_L0.6460.52
153_D220_L0.6420.52
47_N82_N0.6420.52
311_G314_L0.6410.52
103_T125_I0.6400.52
111_H117_A0.6400.52
75_A181_R0.6390.51
166_K261_S0.6390.51
168_D255_K0.6390.51
34_L102_F0.6340.51
55_N161_S0.6330.51
290_E293_N0.6320.51
78_H149_T0.6310.51
303_S312_V0.6260.50
43_I146_S0.6250.50
290_E304_V0.6250.50
50_T242_N0.6240.50
195_T199_R0.6230.50
204_R208_N0.6180.49
204_R211_D0.6180.49
66_V246_S0.6180.49
181_R260_G0.6170.49
36_Y137_Q0.6170.49
254_S263_D0.6170.49
152_F186_S0.6150.49
11_D67_V0.6150.49
83_L150_L0.6130.49
266_L273_I0.6110.48
62_N161_S0.6080.48
26_L30_Q0.6070.48
12_P65_I0.6060.48
91_D139_A0.6060.48
197_E201_H0.6040.48
210_N216_P0.6030.47
290_E294_L0.6020.47
121_G260_G0.6020.47
166_K256_R0.6010.47
112_Q115_V0.5990.47
77_Y172_S0.5980.47
30_Q90_K0.5960.47
46_K147_H0.5950.47
78_H184_N0.5940.46
135_N147_H0.5940.46
222_E311_G0.5920.46
70_L75_A0.5910.46
19_E86_S0.5900.46
150_L185_I0.5890.46
38_N41_S0.5880.46
170_I178_I0.5860.46
268_V276_C0.5850.45
169_K256_R0.5850.45
40_P99_F0.5850.45
4_I127_V0.5840.45
133_S148_G0.5840.45
34_L170_I0.5820.45
303_S310_E0.5820.45
132_I167_K0.5820.45
209_T215_V0.5800.45
193_M204_R0.5800.45
86_S136_A0.5780.45
120_S180_S0.5770.45
23_V101_K0.5760.44
82_N177_S0.5750.44
223_K240_D0.5750.44
148_G184_N0.5730.44
4_I194_T0.5710.44
169_K280_G0.5690.44
152_F194_T0.5690.44
282_F288_V0.5680.44
103_T137_Q0.5670.43
208_N296_V0.5660.43
203_L305_I0.5660.43
272_K296_V0.5650.43
82_N180_S0.5650.43
79_D177_S0.5640.43
82_N147_H0.5630.43
203_L207_F0.5630.43
47_N96_F0.5620.43
36_Y152_F0.5610.43
102_F142_G0.5600.43
70_L236_Y0.5590.43
7_Q22_C0.5580.42
169_K282_F0.5570.42
5_D9_I0.5560.42
46_K136_A0.5560.42
225_W229_H0.5530.42
16_L38_N0.5500.42
267_E274_E0.5490.41
16_L231_I0.5490.41
201_H204_R0.5480.41
204_R219_K0.5480.41
23_V88_I0.5460.41
190_D233_K0.5450.41
37_V41_S0.5440.41
165_V170_I0.5420.41
222_E226_E0.5400.40
227_T231_I0.5390.40
15_N49_N0.5380.40
161_S243_Y0.5380.40
165_V281_D0.5370.40
55_N151_M0.5360.40
160_V178_I0.5360.40
122_R180_S0.5360.40
173_K260_G0.5330.40
105_P110_L0.5330.40
78_H83_L0.5320.40
112_Q204_R0.5320.40
112_Q193_M0.5320.40
70_L145_F0.5300.39
166_K171_E0.5300.39
280_G284_G0.5290.39
298_K310_E0.5280.39
289_S292_E0.5270.39
75_A260_G0.5260.39
299_Q313_N0.5250.39
43_I147_H0.5230.39
76_V180_S0.5210.38
15_N36_Y0.5180.38
190_D269_K0.5170.38
293_N315_K0.5170.38
272_K275_D0.5160.38
11_D65_I0.5150.38
111_H202_L0.5150.38
43_I184_N0.5130.38
311_G316_H0.5120.38
122_R177_S0.5120.38
75_A169_K0.5100.37
29_E230_Q0.5080.37
5_D18_I0.5070.37
101_K104_E0.5060.37
42_I178_I0.5060.37
50_T59_V0.5040.37
91_D95_S0.5030.37
41_S242_N0.5030.37
77_Y243_Y0.5030.37
180_S271_G0.5030.37
256_R260_G0.5030.37
54_I66_V0.5030.37
11_D29_E0.5020.36
99_F236_Y0.5010.36
289_S315_K0.5000.36
25_H62_N0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.9849 100 0.237 Contact Map
1vqzA 1 0.994 100 0.256 Contact Map
2e5aA 1 0.9396 100 0.28 Contact Map
2c8mA 1 0.6979 100 0.43 Contact Map
2p0lA 1 0.7009 100 0.529 Contact Map
2p5iA 1 0.713 100 0.543 Contact Map
2qhsA 1 0.6193 100 0.588 Contact Map
1w66A 1 0.5982 100 0.62 Contact Map
3r07C 1 0.2508 99.3 0.867 Contact Map
2dxuA 2 0.6495 97.7 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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