GREMLIN Database
YHFI - Probable metallo-hydrolase YhfI
UniProt: O07607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (226)
Sequences: 9477 (7005)
Seq/√Len: 466.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_V169_A4.6931.00
142_R149_T3.5911.00
170_D205_G3.2651.00
5_V8_C3.0981.00
163_I201_E2.8761.00
2_K25_Q2.8581.00
206_E234_N2.8111.00
89_P112_I2.7121.00
25_Q30_S2.6921.00
128_T144_T2.4551.00
126_T144_T2.4201.00
121_T126_T2.3261.00
171_L208_L2.3021.00
199_A207_L2.2371.00
132_T140_A2.2061.00
173_I210_T2.1841.00
144_T149_T2.1691.00
180_A193_L2.1661.00
33_V143_I2.1181.00
29_Y53_D2.0781.00
222_R226_K2.0441.00
23_L30_S2.0151.00
89_P110_K1.9631.00
174_S190_M1.9491.00
130_L165_F1.9241.00
97_I101_Q1.9131.00
151_V166_S1.9121.00
54_A89_P1.9041.00
132_T138_C1.8761.00
42_K45_G1.8451.00
164_P167_K1.8361.00
56_V127_I1.8211.00
197_R201_E1.7801.00
168_D203_G1.6511.00
38_A42_K1.6341.00
119_P128_T1.6301.00
38_A41_S1.6261.00
31_L54_A1.6021.00
149_T169_A1.5991.00
119_P126_T1.5681.00
194_E197_R1.5411.00
56_V141_M1.5331.00
142_R151_V1.5261.00
153_T174_S1.5061.00
115_Q118_Q1.5061.00
150_V173_I1.5021.00
4_T25_Q1.4921.00
5_V208_L1.4721.00
92_G97_I1.4381.00
149_T170_D1.3951.00
160_D163_I1.3931.00
132_T153_T1.3921.00
48_P51_K1.3861.00
54_A91_Y1.3851.00
138_C154_A1.3721.00
94_D113_A1.3441.00
35_C57_L1.3391.00
166_S169_A1.3361.00
129_F141_M1.3331.00
39_V43_L1.3181.00
57_L68_I1.3161.00
29_Y123_G1.3051.00
31_L125_F1.3001.00
21_G39_V1.2961.00
8_C17_E1.2931.00
64_H211_H1.2891.00
142_R169_A1.2881.00
26_S124_P1.2831.00
199_A204_A1.2781.00
93_H139_Y1.2761.00
30_S51_K1.2691.00
133_I157_S1.2641.00
131_K137_T1.2451.00
37_S40_L1.2131.00
193_L197_R1.2101.00
196_G228_V1.2091.00
157_S194_E1.1981.00
55_V68_I1.1961.00
223_K226_K1.1951.00
219_D222_R1.1951.00
99_Q103_L1.1921.00
208_L234_N1.1911.00
97_I113_A1.1821.00
145_D148_H1.1781.00
20_S152_Y1.1671.00
167_K203_G1.1621.00
33_V56_V1.1511.00
5_V22_Y1.1431.00
176_C209_L1.1431.00
62_H66_A1.1301.00
160_D201_E1.1261.00
22_Y210_T1.1211.00
92_G96_D1.1191.00
220_N223_K1.0911.00
192_S196_G1.0891.00
114_Y120_L1.0881.00
166_S202_A1.0851.00
3_V22_Y1.0791.00
87_T110_K1.0771.00
174_S195_A1.0771.00
30_S53_D1.0691.00
197_R200_K1.0671.00
153_T156_S1.0631.00
23_L32_L1.0611.00
163_I198_I1.0601.00
37_S42_K1.0551.00
26_S29_Y1.0521.00
119_P122_A1.0491.00
127_I143_I1.0461.00
56_V120_L1.0431.00
121_T124_P1.0421.00
5_V173_I1.0281.00
135_P188_G1.0251.00
93_H96_D1.0201.00
204_A207_L1.0121.00
171_L206_E1.0081.00
159_Q162_F1.0051.00
91_Y112_I1.0041.00
161_S164_P1.0031.00
53_D86_H0.9851.00
163_I167_K0.9811.00
58_S141_M0.9721.00
156_S162_F0.9701.00
130_L162_F0.9671.00
191_N194_E0.9581.00
3_V24_F0.9541.00
223_K227_T0.9531.00
114_Y141_M0.9531.00
6_I21_G0.9501.00
200_K228_V0.9501.00
176_C195_A0.9501.00
94_D98_E0.9451.00
35_C39_V0.9361.00
26_S125_F0.9341.00
98_E101_Q0.9301.00
116_P131_K0.9241.00
29_Y125_F0.9221.00
23_L47_V0.9181.00
29_Y124_P0.9171.00
18_A41_S0.9161.00
225_A229_F0.9151.00
200_K230_N0.9061.00
69_G73_F0.9041.00
22_Y33_V0.8961.00
157_S190_M0.8961.00
33_V58_S0.8941.00
196_G200_K0.8931.00
197_R228_V0.8911.00
220_N224_E0.8841.00
176_C192_S0.8831.00
162_F165_F0.8811.00
160_D164_P0.8801.00
24_F33_V0.8781.00
41_S45_G0.8781.00
148_H170_D0.8761.00
140_A153_T0.8731.00
33_V152_Y0.8711.00
26_S145_D0.8681.00
24_F143_I0.8661.00
128_T165_F0.8651.00
193_L227_T0.8521.00
87_T108_H0.8521.00
3_V150_V0.8491.00
3_V171_L0.8481.00
3_V173_I0.8451.00
174_S198_I0.8391.00
212_L235_I0.8361.00
22_Y173_I0.8361.00
29_Y54_A0.8331.00
32_L39_V0.8331.00
40_L44_F0.8281.00
60_Y96_D0.8251.00
94_D115_Q0.8231.00
179_Y182_Q0.8161.00
55_V71_L0.8091.00
33_V141_M0.8081.00
130_L140_A0.8011.00
49_A71_L0.8001.00
9_Y17_E0.7991.00
95_A113_A0.7941.00
32_L35_C0.7931.00
69_G103_L0.7931.00
193_L228_V0.7911.00
169_A204_A0.7901.00
29_Y122_A0.7871.00
144_T147_S0.7851.00
132_T154_A0.7831.00
42_K46_Y0.7811.00
195_A199_A0.7781.00
31_L127_I0.7761.00
60_Y95_A0.7741.00
43_L46_Y0.7691.00
179_Y192_S0.7691.00
151_V172_L0.7641.00
56_V91_Y0.7591.00
128_T142_R0.7581.00
31_L122_A0.7521.00
132_T156_S0.7501.00
157_S188_G0.7441.00
105_Y108_H0.7411.00
178_F187_A0.7381.00
196_G199_A0.7371.00
167_K201_E0.7371.00
193_L224_E0.7361.00
31_L56_V0.7271.00
169_A172_L0.7251.00
172_L199_A0.7221.00
24_F150_V0.7161.00
175_E190_M0.7141.00
95_A137_T0.7111.00
158_Y194_E0.7091.00
119_P129_F0.7071.00
18_A42_K0.7071.00
222_R233_V0.7071.00
121_T146_G0.7061.00
22_Y152_Y0.7031.00
21_G32_L0.7011.00
60_Y99_Q0.6951.00
118_Q129_F0.6941.00
191_N195_A0.6921.00
55_V88_L0.6901.00
142_R165_F0.6851.00
140_A151_V0.6851.00
127_I141_M0.6831.00
190_M198_I0.6831.00
18_A45_G0.6821.00
222_R235_I0.6801.00
60_Y65_I0.6771.00
163_I202_A0.6741.00
225_A235_I0.6731.00
153_T162_F0.6681.00
129_F139_Y0.6651.00
35_C55_V0.6621.00
105_Y111_G0.6591.00
152_Y173_I0.6591.00
130_L142_R0.6581.00
13_P37_S0.6561.00
114_Y139_Y0.6541.00
97_I111_G0.6521.00
229_F233_V0.6511.00
153_T172_L0.6501.00
209_L233_V0.6451.00
96_D103_L0.6441.00
32_L52_L0.6421.00
118_Q128_T0.6421.00
161_S165_F0.6411.00
133_I159_Q0.6401.00
58_S152_Y0.6381.00
57_L100_F0.6371.00
68_I90_I0.6351.00
159_Q163_I0.6351.00
226_K234_N0.6320.99
174_S207_L0.6310.99
150_V171_L0.6290.99
22_Y58_S0.6280.99
177_N213_P0.6270.99
212_L216_G0.6260.99
222_R225_A0.6260.99
175_E189_H0.6250.99
124_P146_G0.6170.99
47_V51_K0.6170.99
98_E102_K0.6150.99
152_Y210_T0.6150.99
209_L212_L0.6120.99
125_F143_I0.6090.99
125_F145_D0.6080.99
226_K229_F0.6040.99
6_I23_L0.5980.99
216_G221_L0.5910.99
195_A204_A0.5900.99
104_T107_T0.5900.99
72_Q75_K0.5900.99
19_T37_S0.5880.99
72_Q88_L0.5870.99
192_S216_G0.5860.99
60_Y93_H0.5840.99
183_D186_S0.5840.99
120_L129_F0.5820.99
31_L143_I0.5800.99
19_T22_Y0.5800.99
178_F184_G0.5800.99
41_S44_F0.5790.99
54_A122_A0.5780.99
38_A43_L0.5750.99
149_T205_G0.5750.99
168_D205_G0.5730.99
114_Y129_F0.5720.99
37_S70_P0.5720.99
182_Q216_G0.5720.99
116_P139_Y0.5710.99
57_L96_D0.5700.99
40_L70_P0.5680.99
154_A211_H0.5670.99
130_L166_S0.5670.99
25_Q47_V0.5650.99
75_K86_H0.5650.99
219_D223_K0.5630.99
133_I188_G0.5620.99
196_G225_A0.5540.99
59_H64_H0.5530.99
59_H63_D0.5520.99
172_L204_A0.5490.99
37_S43_L0.5480.99
20_S210_T0.5450.99
10_G177_N0.5450.99
40_L74_A0.5440.98
224_E228_V0.5430.98
61_H134_H0.5420.98
224_E227_T0.5420.98
195_A207_L0.5410.98
179_Y228_V0.5390.98
199_A209_L0.5360.98
30_S47_V0.5340.98
226_K230_N0.5340.98
153_T175_E0.5330.98
179_Y221_L0.5320.98
9_Y16_N0.5300.98
198_I202_A0.5300.98
37_S41_S0.5280.98
110_K113_A0.5270.98
118_Q122_A0.5270.98
9_Y14_A0.5270.98
40_L43_L0.5260.98
61_H64_H0.5250.98
109_T112_I0.5240.98
156_S190_M0.5160.98
101_Q111_G0.5150.98
43_L49_A0.5130.98
209_L225_A0.5120.98
95_A98_E0.5110.98
37_S67_D0.5110.98
158_Y197_R0.5100.98
100_F103_L0.5080.98
106_K109_T0.5080.98
225_A233_V0.5070.98
176_C191_N0.5050.98
153_T198_I0.5050.98
28_D124_P0.5020.97
17_E21_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.9262 100 0.232 Contact Map
2cbnA 2 0.9795 100 0.255 Contact Map
1y44A 2 0.9795 100 0.264 Contact Map
1zkpA 2 1 100 0.289 Contact Map
3jxpA 2 0.9467 100 0.346 Contact Map
3g1pA 2 0.918 100 0.355 Contact Map
4ojvA 2 0.9754 100 0.376 Contact Map
2e7yA 2 0.9385 100 0.378 Contact Map
3md7A 2 0.9221 100 0.382 Contact Map
4qn9A 2 0.9057 100 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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