GREMLIN Database
GLTT - Proton/sodium-glutamate symport protein
UniProt: O07605 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (392)
Sequences: 6273 (3675)
Seq/√Len: 185.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_Q150_E4.4741.00
175_K179_A3.6191.00
99_N332_Q3.1211.00
97_L232_A3.0801.00
18_L204_F3.0651.00
172_E175_K3.0481.00
78_R404_E2.9751.00
190_H193_N2.9441.00
139_I158_C2.8971.00
56_V160_T2.8591.00
60_I181_F2.7431.00
37_Q41_D2.7351.00
42_L140_V2.6611.00
281_E284_E2.6571.00
276_L297_I2.6121.00
11_Q197_K2.6081.00
22_V204_F2.6041.00
289_P406_M2.4981.00
176_P183_G2.4811.00
56_V60_I2.4441.00
284_E290_K2.4431.00
39_I205_A2.4081.00
402_K409_P2.3961.00
102_H105_T2.3821.00
57_S184_V2.3721.00
328_T331_H2.3611.00
7_G10_T2.2841.00
230_Y384_A2.2611.00
289_P401_S2.2471.00
163_F187_A2.2461.00
263_I391_T2.2141.00
227_G231_V2.1991.00
86_I244_V2.1501.00
82_Y396_A2.1071.00
134_E138_H2.0991.00
171_G174_G2.0541.00
262_E282_K2.0031.00
97_L235_F1.9881.00
21_I25_I1.9811.00
246_K249_G1.9661.00
78_R403_W1.9401.00
142_T146_Q1.9251.00
177_V180_F1.8811.00
96_A100_I1.8781.00
101_F228_L1.8701.00
13_F17_I1.8601.00
220_I224_K1.8591.00
288_C398_V1.8551.00
319_L370_G1.8501.00
235_F239_V1.8281.00
92_I96_A1.8241.00
65_G182_E1.8201.00
57_S188_M1.8191.00
233_L384_A1.8131.00
176_P179_A1.8091.00
283_M394_A1.8091.00
98_A317_L1.7981.00
15_G204_F1.7951.00
152_D155_A1.7851.00
281_E285_K1.7771.00
378_D385_R1.7661.00
177_V183_G1.7531.00
167_I187_A1.7501.00
77_F81_L1.7041.00
169_A190_H1.7031.00
50_I195_V1.6881.00
103_P321_Q1.6831.00
258_Y286_I1.6521.00
145_F148_L1.6481.00
74_K404_E1.6401.00
101_F231_V1.6221.00
288_C401_S1.6201.00
296_V397_A1.6131.00
177_V187_A1.6111.00
259_M394_A1.6071.00
248_A402_K1.6071.00
173_R186_H1.6061.00
15_G19_G1.6051.00
98_A314_I1.5691.00
326_D330_W1.5551.00
254_K257_A1.5401.00
97_L228_L1.5331.00
42_L137_L1.5201.00
319_L366_V1.4951.00
279_I394_A1.4851.00
6_F10_T1.4761.00
233_L388_V1.4691.00
232_A310_L1.4661.00
323_Y370_G1.4631.00
144_F159_F1.4621.00
245_A395_L1.4471.00
382_D386_T1.4421.00
64_A178_L1.4291.00
223_G227_G1.4231.00
22_V26_W1.4011.00
273_E348_A1.4001.00
258_Y285_K1.4001.00
263_I387_V1.3971.00
238_I242_G1.3951.00
145_F149_V1.3921.00
10_T14_V1.3831.00
48_K142_T1.3731.00
280_M293_V1.3711.00
401_S407_F1.3631.00
166_G191_V1.3581.00
180_F183_G1.3511.00
169_A194_L1.3501.00
55_V153_L1.3481.00
63_V161_V1.3461.00
138_H152_D1.3291.00
108_N324_G1.3271.00
228_L314_I1.3271.00
61_I181_F1.3181.00
56_V148_L1.3171.00
45_R142_T1.3111.00
41_D45_R1.3081.00
329_I333_I1.3081.00
182_E186_H1.3001.00
49_M159_F1.2811.00
253_F257_A1.2781.00
140_V158_C1.2651.00
176_P180_F1.2611.00
170_I174_G1.2531.00
289_P292_I1.2521.00
16_L207_I1.2491.00
251_S254_K1.2471.00
237_L388_V1.2431.00
244_V399_V1.2421.00
6_F14_V1.2421.00
167_I177_V1.2371.00
302_T305_L1.2371.00
292_I401_S1.2361.00
401_S405_G1.2341.00
79_T296_V1.2321.00
259_M391_T1.2321.00
30_P212_S1.2281.00
95_L332_Q1.2231.00
31_A34_T1.2211.00
194_L198_V1.2111.00
163_F184_V1.2101.00
221_S224_K1.2031.00
316_A335_L1.2031.00
131_S134_E1.1931.00
279_I297_I1.1921.00
26_W32_L1.1851.00
166_G194_L1.1811.00
50_I192_V1.1811.00
226_V377_V1.1801.00
209_V213_K1.1751.00
326_D331_H1.1731.00
224_K227_G1.1451.00
266_A386_T1.1401.00
37_Q209_V1.1381.00
188_M192_V1.1351.00
245_A250_I1.1221.00
193_N281_E1.1131.00
108_N112_A1.1091.00
162_L191_V1.1081.00
52_I156_I1.1031.00
239_V242_G1.1011.00
83_F296_V1.1011.00
146_Q149_V1.0991.00
161_V165_L1.0951.00
71_Q291_G1.0951.00
11_Q15_G1.0931.00
250_I407_F1.0911.00
175_K178_L1.0891.00
261_D285_K1.0851.00
255_F259_M1.0841.00
81_L85_I1.0761.00
21_I24_V1.0731.00
311_Y378_D1.0701.00
335_L364_I1.0701.00
170_I183_G1.0691.00
92_I336_V1.0641.00
96_A99_N1.0601.00
276_L301_Y1.0591.00
85_I89_F1.0531.00
275_V279_I1.0531.00
306_D343_S1.0511.00
57_S61_I1.0491.00
42_L46_L1.0491.00
354_F375_A1.0451.00
177_V181_F1.0441.00
86_I306_D1.0421.00
39_I198_V1.0421.00
59_L157_I1.0421.00
401_S406_M1.0391.00
198_V201_F1.0381.00
249_G402_K1.0341.00
108_N111_E1.0311.00
279_I390_L1.0311.00
283_M297_I1.0251.00
30_P33_P1.0100.99
270_S379_R1.0090.99
311_Y385_R1.0070.99
111_E114_K1.0070.99
236_F240_I1.0070.99
179_A183_G1.0060.99
288_C293_V0.9970.99
84_E88_T0.9960.99
127_Q130_K0.9930.99
75_L292_I0.9920.99
170_I187_A0.9870.99
88_T92_I0.9860.99
333_I337_L0.9840.99
308_S353_S0.9840.99
283_M288_C0.9780.99
246_K251_S0.9750.99
104_G321_Q0.9740.99
236_F310_L0.9730.99
68_N71_Q0.9660.99
179_A182_E0.9630.99
171_G175_K0.9620.99
241_F244_V0.9580.99
158_C162_L0.9570.99
94_G313_S0.9560.99
304_N393_N0.9530.99
92_I333_I0.9530.99
22_V208_G0.9500.99
226_V380_I0.9480.99
224_K321_Q0.9420.99
97_L101_F0.9400.99
257_A260_K0.9340.99
402_K405_G0.9330.99
30_P35_Y0.9260.99
45_R48_K0.9250.99
40_G206_L0.9230.99
250_I254_K0.9230.99
329_I332_Q0.9220.99
18_L22_V0.9190.99
217_G220_I0.9160.99
165_L169_A0.9130.99
162_L194_L0.9130.99
350_P382_D0.9120.99
282_K285_K0.9060.99
242_G256_L0.9050.99
32_L36_L0.9050.99
267_F383_M0.9040.99
50_I191_V0.9020.99
144_F151_G0.9020.99
243_I246_K0.8990.99
258_Y262_E0.8980.99
258_Y282_K0.8910.99
17_I21_I0.8910.99
30_P34_T0.8900.99
190_H194_L0.8890.99
317_L332_Q0.8890.99
22_V36_L0.8870.99
174_G183_G0.8870.99
135_T141_P0.8850.99
312_Q357_L0.8850.99
342_T360_T0.8820.99
95_L99_N0.8800.99
144_F149_V0.8750.99
134_E137_L0.8730.99
311_Y381_M0.8730.99
32_L35_Y0.8680.98
208_G212_S0.8680.98
74_K78_R0.8670.98
275_V278_R0.8660.98
239_V243_I0.8660.98
305_L393_N0.8620.98
231_V235_F0.8620.98
93_L235_F0.8620.98
147_S159_F0.8610.98
272_S389_N0.8590.98
132_V136_F0.8560.98
231_V234_A0.8560.98
128_S131_S0.8550.98
229_V381_M0.8500.98
220_I223_G0.8500.98
240_I244_V0.8500.98
163_F191_V0.8480.98
140_V143_N0.8480.98
242_G246_K0.8470.98
265_L275_V0.8470.98
262_E279_I0.8470.98
57_S181_F0.8470.98
60_I167_I0.8440.98
229_V314_I0.8410.98
193_N197_K0.8410.98
241_F245_A0.8400.98
131_S135_T0.8400.98
90_A236_F0.8360.98
226_V381_M0.8310.98
354_F371_L0.8260.98
283_M293_V0.8250.98
230_Y234_A0.8250.98
138_H141_P0.8240.98
160_T164_A0.8240.98
133_A137_L0.8230.98
61_I182_E0.8210.98
130_K138_H0.8200.98
260_K264_L0.8160.98
137_L141_P0.8140.98
185_S189_F0.8120.98
109_I112_A0.8120.98
7_G11_Q0.8080.98
358_L371_L0.8070.98
36_L208_G0.8050.97
130_K134_E0.8040.97
301_Y393_N0.8010.97
292_I296_V0.8000.97
94_G314_I0.8000.97
262_E275_V0.7950.97
255_F394_A0.7950.97
265_L278_R0.7890.97
225_L314_I0.7870.97
35_Y38_P0.7860.97
159_F163_F0.7840.97
41_D137_L0.7830.97
265_L269_T0.7820.97
31_A35_Y0.7790.97
303_F344_K0.7790.97
167_I181_F0.7770.97
60_I163_F0.7750.97
26_W36_L0.7750.97
226_V230_Y0.7750.97
70_K73_G0.7740.97
174_G178_L0.7720.97
22_V32_L0.7720.97
26_W208_G0.7720.97
315_A374_I0.7710.97
402_K407_F0.7700.97
6_F11_Q0.7690.97
36_L205_A0.7680.97
60_I160_T0.7660.97
40_G202_G0.7650.97
327_L331_H0.7640.97
135_T138_H0.7620.96
204_F208_G0.7600.96
144_F147_S0.7590.96
401_S408_N0.7580.96
97_L231_V0.7560.96
75_L400_M0.7540.96
234_A238_I0.7490.96
143_N159_F0.7470.96
43_F198_V0.7460.96
225_L381_M0.7450.96
316_A360_T0.7410.96
66_A75_L0.7390.96
12_I199_A0.7380.96
262_E278_R0.7380.96
102_H321_Q0.7340.96
270_S382_D0.7340.96
180_F184_V0.7330.96
255_F398_V0.7330.96
199_A202_G0.7320.96
43_F199_A0.7300.96
225_L311_Y0.7300.96
358_L362_G0.7290.95
45_R138_H0.7290.95
19_G208_G0.7280.95
46_L140_V0.7260.95
97_L100_I0.7260.95
124_E127_Q0.7230.95
312_Q354_F0.7210.95
108_N114_K0.7200.95
58_S185_S0.7200.95
354_F381_M0.7160.95
81_L84_E0.7160.95
323_Y369_E0.7140.95
245_A248_A0.7100.95
64_A168_S0.7080.95
71_Q74_K0.7080.95
148_L159_F0.7070.95
279_I393_N0.7060.95
228_L231_V0.7040.95
35_Y39_I0.6970.94
158_C198_V0.6970.94
232_A314_I0.6970.94
299_I303_F0.6970.94
163_F177_V0.6950.94
290_K294_S0.6940.94
74_K77_F0.6940.94
203_V350_P0.6910.94
126_E129_N0.6910.94
201_F205_A0.6890.94
148_L155_A0.6870.94
110_H113_Q0.6870.94
254_K258_Y0.6860.94
225_L374_I0.6860.94
88_T340_M0.6850.94
266_A390_L0.6830.94
11_Q201_F0.6810.94
16_L203_V0.6800.93
316_A320_A0.6800.93
188_M195_V0.6790.93
137_L140_V0.6790.93
406_M409_P0.6780.93
330_W333_I0.6780.93
339_L356_V0.6770.93
34_T212_S0.6750.93
229_V233_L0.6750.93
175_K180_F0.6730.93
308_S346_M0.6720.93
320_A325_I0.6660.93
93_L232_A0.6650.93
308_S312_Q0.6650.93
143_N147_S0.6630.93
69_G165_L0.6620.93
94_G310_L0.6620.93
86_I90_A0.6610.93
172_E179_A0.6600.92
79_T400_M0.6600.92
222_L225_L0.6590.92
237_L242_G0.6590.92
31_A212_S0.6590.92
199_A269_T0.6570.92
334_T364_I0.6570.92
32_L212_S0.6550.92
171_G178_L0.6540.92
170_I186_H0.6530.92
250_I258_Y0.6510.92
182_E185_S0.6500.92
124_E128_S0.6490.92
103_P106_G0.6450.92
346_M356_V0.6450.92
250_I408_N0.6450.92
33_P212_S0.6440.92
135_T139_I0.6430.91
83_F396_A0.6400.91
60_I184_V0.6370.91
183_G186_H0.6360.91
247_I399_V0.6350.91
106_G109_I0.6310.91
338_V363_T0.6310.91
301_Y305_L0.6270.90
186_H190_H0.6260.90
330_W334_T0.6260.90
99_N329_I0.6230.90
173_R179_A0.6220.90
332_Q336_V0.6210.90
297_I397_A0.6200.90
39_I201_F0.6200.90
305_L346_M0.6190.90
177_V184_V0.6180.90
68_N76_G0.6170.90
46_L162_L0.6140.90
225_L233_L0.6110.89
174_G187_A0.6100.89
312_Q346_M0.6080.89
83_F236_F0.6070.89
157_I323_Y0.6060.89
110_H114_K0.6050.89
136_F140_V0.6040.89
106_G224_K0.6040.89
313_S339_L0.6040.89
71_Q76_G0.6040.89
83_F393_N0.6010.89
348_A351_G0.6000.88
42_L158_C0.6000.88
365_G369_E0.5970.88
397_A401_S0.5970.88
52_I148_L0.5950.88
255_F286_I0.5950.88
147_S151_G0.5950.88
286_I398_V0.5940.88
344_K393_N0.5940.88
348_A352_T0.5940.88
399_V403_W0.5930.88
69_G76_G0.5930.88
326_D329_I0.5920.88
87_T309_V0.5920.88
289_P293_V0.5920.88
336_V339_L0.5910.88
46_L195_V0.5900.88
84_E344_K0.5890.88
370_G373_F0.5890.88
54_I157_I0.5890.88
14_V18_L0.5880.87
312_Q316_A0.5870.87
192_V267_F0.5870.87
242_G245_A0.5860.87
183_G187_A0.5850.87
334_T338_V0.5840.87
89_F92_I0.5840.87
61_I178_L0.5840.87
343_S355_V0.5830.87
19_G23_G0.5820.87
236_F306_D0.5820.87
369_E372_A0.5810.87
287_G408_N0.5810.87
102_H317_L0.5800.87
46_L198_V0.5790.87
257_A261_D0.5790.87
225_L315_A0.5790.87
22_V25_I0.5780.87
323_Y367_P0.5780.87
306_D392_G0.5780.87
167_I178_L0.5770.86
93_L240_I0.5770.86
49_M191_V0.5750.86
288_C397_A0.5740.86
259_M279_I0.5740.86
190_H197_K0.5730.86
204_F215_G0.5720.86
126_E130_K0.5720.86
202_G206_L0.5720.86
170_I173_R0.5700.86
170_I190_H0.5680.86
353_S360_T0.5670.85
278_R281_E0.5660.85
280_M297_I0.5640.85
71_Q406_M0.5640.85
97_L227_G0.5630.85
77_F80_I0.5620.85
273_E301_Y0.5610.85
26_W31_A0.5600.85
95_L336_V0.5590.85
125_K128_S0.5550.84
315_A378_D0.5550.84
108_N113_Q0.5550.84
15_G223_G0.5540.84
270_S274_T0.5540.84
54_I188_M0.5530.84
15_G208_G0.5530.84
346_M353_S0.5530.84
275_V390_L0.5530.84
90_A310_L0.5510.84
292_I406_M0.5510.84
99_N317_L0.5500.84
61_I65_G0.5490.84
246_K252_I0.5490.84
66_A397_A0.5480.84
224_K228_L0.5470.83
336_V340_M0.5470.83
238_I243_I0.5470.83
178_L182_E0.5460.83
275_V301_Y0.5450.83
291_G406_M0.5430.83
167_I183_G0.5430.83
266_A382_D0.5430.83
242_G252_I0.5420.83
83_F300_G0.5410.83
327_L335_L0.5400.83
166_G170_I0.5400.83
199_A203_V0.5390.83
405_G409_P0.5390.83
216_L220_I0.5360.82
19_G207_I0.5360.82
16_L383_M0.5350.82
51_V352_T0.5350.82
266_A387_V0.5340.82
101_F224_K0.5330.82
196_M199_A0.5330.82
335_L339_L0.5330.82
89_F93_L0.5320.82
358_L368_A0.5320.82
246_K253_F0.5310.82
316_A319_L0.5280.81
8_L11_Q0.5280.81
86_I303_F0.5280.81
238_I253_F0.5280.81
91_I340_M0.5280.81
149_V152_D0.5270.81
232_A236_F0.5270.81
106_G221_S0.5250.81
75_L404_E0.5250.81
396_A399_V0.5240.81
197_K201_F0.5230.81
222_L233_L0.5230.81
307_G388_V0.5230.81
331_H334_T0.5230.81
308_S382_D0.5200.80
133_A138_H0.5200.80
283_M393_N0.5200.80
389_N393_N0.5180.80
17_I409_P0.5180.80
248_A395_L0.5170.80
379_R383_M0.5160.80
259_M263_I0.5160.80
167_I174_G0.5160.80
255_F395_L0.5140.79
227_G230_Y0.5130.79
241_F246_K0.5100.79
319_L356_V0.5100.79
255_F391_T0.5100.79
284_E293_V0.5090.79
126_E131_S0.5060.78
175_K183_G0.5060.78
52_I153_L0.5030.78
128_S134_E0.5020.78
50_I54_I0.5010.78
304_N392_G0.5010.78
26_W30_P0.5000.78
377_V381_M0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.9021 100 0.08 Contact Map
3klyA 3 0.5198 37.5 0.965 Contact Map
4czbA 2 0.6317 33.8 0.966 Contact Map
4cz8A 2 0.6434 19.5 0.97 Contact Map
3nd0A 2 0.8438 16.8 0.97 Contact Map
4eneA 2 0.8788 16.6 0.97 Contact Map
3kcuA 3 0.5105 14.3 0.971 Contact Map
3zuxA 1 0.3473 11.6 0.972 Contact Map
4n7wA 2 0.3613 8.2 0.974 Contact Map
2zy9A 2 0.2354 7.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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