YHFE - BACSU - GREMLIN Contacts

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YHFE - Putative aminopeptidase YhfE

UniProt:	O07603	Sequences: MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVRNHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEYCQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIGVGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNNEEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQLAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTAKLLYYYVQSPMV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (327)
Sequences:	2599 (1709)
Seq/√Len:	94.5

ECOLI - SGCX FRVX YPDE
BACSU - YHFE YSDC YTOP
HALSA - Q9HPS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
151_R	155_E	4.829	1.00
17_I	30_Y	3.510	1.00
178_F	326_H	3.297	1.00
87_I	144_L	2.894	1.00
332_H	335_K	2.807	1.00
20_P	90_I	2.716	1.00
12_K	16_S	2.650	1.00
148_V	154_T	2.589	1.00
106_E	166_S	2.571	1.00
270_L	310_G	2.567	1.00
195_R	198_H	2.549	1.00
66_T	216_S	2.491	1.00
15_V	181_S	2.480	1.00
80_K	86_K	2.451	1.00
281_H	339_Y	2.428	1.00
63_R	341_V	2.331	1.00
85_L	105_I	2.291	1.00
32_E	36_K	2.221	1.00
62_H	212_H	2.215	1.00
53_T	210_T	2.190	1.00
32_E	44_R	2.167	1.00
284_D	332_H	2.165	1.00
276_Q	280_K	2.159	1.00
71_T	182_R	2.118	1.00
274_L	310_G	2.089	1.00
21_T	90_I	2.067	1.00
115_G	144_L	2.067	1.00
199_E	338_Y	2.059	1.00
177_G	328_S	2.053	1.00
85_L	165_V	2.048	1.00
331_R	335_K	2.007	1.00
81_A	151_R	1.998	1.00
274_L	340_Y	1.983	1.00
339_Y	342_Q	1.979	1.00
146_E	159_I	1.969	1.00
31_I	190_V	1.959	1.00
23_N	164_F	1.938	1.00
13_E	34_L	1.935	1.00
152_K	156_E	1.912	1.00
203_E	342_Q	1.910	1.00
33_S	36_K	1.895	1.00
197_I	213_F	1.894	1.00
152_K	155_E	1.889	1.00
76_V	165_V	1.877	1.00
13_E	30_Y	1.867	1.00
53_T	212_H	1.834	1.00
234_V	304_G	1.825	1.00
255_V	332_H	1.776	1.00
231_P	304_G	1.758	1.00
13_E	33_S	1.733	1.00
19_S	27_V	1.726	1.00
103_C	144_L	1.721	1.00
146_E	154_T	1.719	1.00
105_I	144_L	1.714	1.00
67_A	193_L	1.713	1.00
325_T	330_L	1.694	1.00
148_V	157_L	1.673	1.00
62_H	210_T	1.655	1.00
80_K	84_R	1.651	1.00
259_V	287_L	1.632	1.00
28_I	69_V	1.632	1.00
120_H	131_G	1.628	1.00
188_A	330_L	1.610	1.00
41_E	53_T	1.605	1.00
55_P	210_T	1.569	1.00
160_G	163_D	1.525	1.00
32_E	50_L	1.523	1.00
66_T	296_D	1.522	1.00
8_M	173_I	1.518	1.00
49_G	228_N	1.493	1.00
257_I	285_Y	1.489	1.00
19_S	187_K	1.488	1.00
64_M	300_A	1.477	1.00
39_K	52_A	1.472	1.00
160_G	279_E	1.470	1.00
107_T	110_G	1.467	1.00
114_T	172_E	1.464	1.00
9_E	12_K	1.461	1.00
277_L	281_H	1.454	1.00
199_E	335_K	1.430	1.00
227_S	299_A	1.423	0.99
35_L	194_L	1.406	0.99
87_I	142_I	1.405	0.99
34_L	198_H	1.394	0.99
42_T	50_L	1.389	0.99
75_M	88_D	1.387	0.99
93_F	167_F	1.375	0.99
34_L	37_E	1.358	0.99
65_L	341_V	1.357	0.99
236_Y	300_A	1.347	0.99
12_K	171_V	1.344	0.99
315_G	318_A	1.337	0.99
190_V	215_I	1.336	0.99
173_I	327_K	1.325	0.99
9_E	13_E	1.324	0.99
31_I	215_I	1.318	0.99
31_I	194_L	1.314	0.99
64_M	229_I	1.308	0.99
57_R	208_P	1.308	0.99
177_G	326_H	1.307	0.99
79_I	154_T	1.301	0.99
64_M	214_L	1.298	0.99
87_I	165_V	1.297	0.99
198_H	202_T	1.292	0.99
76_V	85_L	1.292	0.99
179_I	184_L	1.292	0.99
192_L	333_T	1.288	0.99
20_P	73_G	1.285	0.99
56_G	210_T	1.271	0.99
273_H	340_Y	1.260	0.99
10_L	30_Y	1.252	0.99
275_V	285_Y	1.248	0.99
196_L	337_L	1.248	0.99
155_E	160_G	1.247	0.99
238_A	297_A	1.238	0.99
43_V	232_E	1.234	0.99
150_C	153_D	1.219	0.98
103_C	117_I	1.217	0.98
149_H	153_D	1.210	0.98
29_N	33_S	1.210	0.98
334_A	338_Y	1.205	0.98
64_M	235_E	1.200	0.98
212_H	233_T	1.197	0.98
18_P	104_Q	1.193	0.98
21_T	73_G	1.192	0.98
237_L	274_L	1.186	0.98
105_I	165_V	1.186	0.98
196_L	338_Y	1.183	0.98
28_I	44_R	1.180	0.98
74_A	98_I	1.177	0.98
15_V	171_V	1.150	0.98
297_A	309_H	1.146	0.98
78_E	86_K	1.142	0.98
129_D	132_K	1.137	0.97
188_A	325_T	1.123	0.97
273_H	277_L	1.121	0.97
108_A	163_D	1.119	0.97
10_L	194_L	1.110	0.97
196_L	334_A	1.108	0.97
219_E	319_S	1.106	0.97
153_D	156_E	1.103	0.97
85_L	146_E	1.103	0.97
64_M	233_T	1.100	0.97
275_V	287_L	1.100	0.97
41_E	55_P	1.100	0.97
35_L	52_A	1.099	0.97
89_L	95_Y	1.097	0.97
134_E	138_E	1.091	0.97
102_Y	172_E	1.083	0.97
193_L	239_V	1.081	0.97
105_I	163_D	1.078	0.96
18_P	106_E	1.073	0.96
17_I	26_E	1.065	0.96
69_V	190_V	1.062	0.96
195_R	199_E	1.058	0.96
10_L	34_L	1.043	0.96
254_S	257_I	1.042	0.96
90_I	164_F	1.039	0.96
328_S	331_R	1.034	0.96
238_A	300_A	1.033	0.96
154_T	159_I	1.032	0.96
242_G	288_D	1.032	0.96
56_G	60_S	1.032	0.96
279_E	285_Y	1.031	0.95
30_Y	34_L	1.028	0.95
283_I	336_L	1.025	0.95
271_R	275_V	1.023	0.95
214_L	229_I	1.017	0.95
102_Y	168_D	1.015	0.95
103_C	115_G	1.013	0.95
255_V	333_T	1.009	0.95
230_P	300_A	1.007	0.95
38_W	198_H	1.007	0.95
51_I	214_L	1.005	0.95
104_Q	168_D	1.005	0.95
191_A	330_L	1.002	0.95
29_N	32_E	1.000	0.95
191_A	334_A	0.994	0.94
87_I	117_I	0.985	0.94
264_G	311_L	0.980	0.94
239_V	337_L	0.980	0.94
242_G	313_G	0.973	0.94
174_T	180_K	0.972	0.94
234_V	305_H	0.970	0.94
35_L	197_I	0.969	0.94
220_E	319_S	0.967	0.94
248_Q	252_E	0.963	0.94
114_T	168_D	0.953	0.93
174_T	324_R	0.949	0.93
118_L	317_D	0.949	0.93
58_D	210_T	0.945	0.93
312_I	333_T	0.943	0.93
241_M	318_A	0.942	0.93
35_L	215_I	0.940	0.93
298_S	301_I	0.939	0.93
8_M	171_V	0.939	0.93
25_Y	269_Q	0.934	0.92
28_I	50_L	0.933	0.92
272_K	276_Q	0.925	0.92
267_H	308_V	0.922	0.92
31_I	69_V	0.922	0.92
269_Q	308_V	0.914	0.92
61_R	209_Y	0.914	0.92
63_R	209_Y	0.913	0.92
108_A	272_K	0.907	0.91
128_K	131_G	0.906	0.91
195_R	330_L	0.905	0.91
85_L	154_T	0.902	0.91
193_L	213_F	0.899	0.91
184_L	325_T	0.897	0.91
185_D	219_E	0.895	0.91
186_D	189_S	0.894	0.91
130_A	135_R	0.888	0.90
52_A	215_I	0.887	0.90
338_Y	342_Q	0.886	0.90
98_I	117_I	0.883	0.90
20_P	164_F	0.882	0.90
180_K	324_R	0.882	0.90
192_L	334_A	0.880	0.90
48_G	217_N	0.880	0.90
71_T	183_H	0.870	0.90
42_T	52_A	0.869	0.89
25_Y	29_N	0.865	0.89
254_S	261_D	0.864	0.89
138_E	141_E	0.860	0.89
63_R	211_T	0.858	0.89
45_N	49_G	0.853	0.89
263_S	298_S	0.851	0.88
179_I	327_K	0.847	0.88
223_Y	299_A	0.843	0.88
16_S	171_V	0.842	0.88
240_D	288_D	0.840	0.88
195_R	334_A	0.836	0.88
253_Y	284_D	0.835	0.87
69_V	215_I	0.833	0.87
335_K	339_Y	0.831	0.87
237_L	337_L	0.827	0.87
67_A	186_D	0.827	0.87
199_E	334_A	0.825	0.87
113_Y	146_E	0.823	0.87
130_A	134_E	0.821	0.87
92_G	219_E	0.821	0.87
32_E	42_T	0.821	0.87
74_A	165_V	0.819	0.86
102_Y	322_F	0.813	0.86
200_I	207_L	0.811	0.86
11_I	191_A	0.810	0.86
243_A	248_Q	0.809	0.86
105_I	146_E	0.808	0.86
53_T	62_H	0.807	0.86
258_C	288_D	0.805	0.86
17_I	27_V	0.802	0.85
255_V	312_I	0.801	0.85
257_I	260_K	0.800	0.85
95_Y	98_I	0.799	0.85
218_N	223_Y	0.799	0.85
8_M	12_K	0.798	0.85
12_K	173_I	0.796	0.85
185_D	220_E	0.791	0.85
113_Y	159_I	0.790	0.84
223_Y	298_S	0.789	0.84
171_V	181_S	0.786	0.84
231_P	305_H	0.783	0.84
293_Y	318_A	0.782	0.84
275_V	279_E	0.779	0.84
88_D	260_K	0.779	0.84
99_E	142_I	0.775	0.83
11_I	184_L	0.775	0.83
303_S	307_I	0.774	0.83
68_H	219_E	0.774	0.83
54_L	197_I	0.772	0.83
248_Q	251_D	0.769	0.83
236_Y	307_I	0.767	0.83
43_V	53_T	0.766	0.83
238_A	309_H	0.763	0.82
294_G	298_S	0.758	0.82
115_G	146_E	0.756	0.82
40_V	52_A	0.755	0.82
288_D	313_G	0.755	0.82
192_L	239_V	0.751	0.81
107_T	163_D	0.751	0.81
35_L	39_K	0.751	0.81
77_K	88_D	0.750	0.81
185_D	319_S	0.749	0.81
26_E	106_E	0.742	0.81
171_V	179_I	0.741	0.80
211_T	341_V	0.739	0.80
328_S	332_H	0.737	0.80
300_A	307_I	0.736	0.80
27_V	69_V	0.735	0.80
118_L	121_Q	0.734	0.80
257_I	271_R	0.734	0.80
266_Y	311_L	0.727	0.79
57_R	210_T	0.725	0.79
39_K	42_T	0.724	0.79
191_A	195_R	0.722	0.79
94_R	97_S	0.718	0.78
17_I	34_L	0.715	0.78
316_I	319_S	0.715	0.78
186_D	241_M	0.715	0.78
232_E	305_H	0.712	0.78
192_L	196_L	0.710	0.78
241_M	315_G	0.708	0.77
85_L	113_Y	0.707	0.77
118_L	143_R	0.704	0.77
237_L	310_G	0.703	0.77
107_T	113_Y	0.701	0.77
255_V	336_L	0.698	0.76
104_Q	114_T	0.698	0.76
92_G	319_S	0.698	0.76
31_I	50_L	0.696	0.76
192_L	330_L	0.695	0.76
276_Q	279_E	0.694	0.76
274_L	312_I	0.693	0.76
60_S	210_T	0.692	0.76
295_S	319_S	0.688	0.75
121_Q	124_V	0.688	0.75
92_G	294_G	0.677	0.74
15_V	182_R	0.673	0.74
155_E	279_E	0.672	0.74
108_A	276_Q	0.672	0.74
57_R	204_D	0.672	0.74
204_D	207_L	0.668	0.73
330_L	334_A	0.667	0.73
78_E	247_G	0.667	0.73
160_G	275_V	0.666	0.73
84_R	143_R	0.666	0.73
258_C	311_L	0.666	0.73
222_G	294_G	0.666	0.73
278_A	336_L	0.664	0.73
35_L	42_T	0.664	0.73
249_A	252_E	0.661	0.72
92_G	220_E	0.660	0.72
266_Y	293_Y	0.660	0.72
113_Y	148_V	0.659	0.72
30_Y	33_S	0.659	0.72
238_A	337_L	0.657	0.72
243_A	318_A	0.655	0.72
226_N	230_P	0.652	0.71
201_Q	204_D	0.650	0.71
11_I	179_I	0.650	0.71
193_L	196_L	0.650	0.71
268_Y	308_V	0.650	0.71
23_N	106_E	0.649	0.71
44_R	50_L	0.645	0.71
258_C	261_D	0.645	0.71
268_Y	272_K	0.645	0.71
173_I	177_G	0.643	0.70
279_E	282_H	0.641	0.70
200_I	211_T	0.641	0.70
121_Q	125_H	0.640	0.70
218_N	221_I	0.640	0.70
281_H	335_K	0.639	0.70
230_P	303_S	0.639	0.70
277_L	339_Y	0.637	0.70
26_E	33_S	0.635	0.69
277_L	283_I	0.632	0.69
68_H	220_E	0.632	0.69
38_W	201_Q	0.632	0.69
66_T	238_A	0.629	0.69
20_P	166_S	0.627	0.68
204_D	282_H	0.627	0.68
266_Y	271_R	0.626	0.68
100_G	321_A	0.625	0.68
40_V	54_L	0.624	0.68
74_A	87_I	0.623	0.68
196_L	341_V	0.623	0.68
25_Y	28_I	0.622	0.68
315_G	325_T	0.618	0.67
199_E	203_E	0.617	0.67
23_N	26_E	0.617	0.67
316_I	329_S	0.615	0.67
261_D	266_Y	0.614	0.67
293_Y	311_L	0.611	0.66
71_T	118_L	0.609	0.66
81_A	130_A	0.609	0.66
188_A	334_A	0.608	0.66
46_H	308_V	0.607	0.66
254_S	329_S	0.605	0.66
49_G	214_L	0.604	0.66
241_M	288_D	0.603	0.65
273_H	276_Q	0.603	0.65
240_D	295_S	0.603	0.65
65_L	337_L	0.601	0.65
146_E	157_L	0.601	0.65
301_I	309_H	0.600	0.65
258_C	290_Y	0.600	0.65
186_D	240_D	0.600	0.65
118_L	125_H	0.598	0.65
242_G	256_S	0.597	0.65
222_G	261_D	0.595	0.64
128_K	132_K	0.595	0.64
18_P	26_E	0.595	0.64
186_D	219_E	0.594	0.64
167_F	321_A	0.593	0.64
58_D	61_R	0.593	0.64
51_I	212_H	0.592	0.64
262_A	294_G	0.589	0.64
149_H	328_S	0.589	0.64
80_K	143_R	0.588	0.63
181_S	324_R	0.584	0.63
8_M	181_S	0.584	0.63
14_L	27_V	0.584	0.63
57_R	281_H	0.582	0.63
105_I	159_I	0.582	0.63
78_E	81_A	0.580	0.62
218_N	224_G	0.579	0.62
293_Y	298_S	0.578	0.62
207_L	211_T	0.577	0.62
79_I	275_V	0.570	0.61
16_S	170_R	0.569	0.61
89_L	139_N	0.569	0.61
219_E	295_S	0.568	0.61
223_Y	294_G	0.568	0.61
72_L	323_E	0.566	0.61
197_I	314_P	0.566	0.61
151_R	154_T	0.565	0.60
93_F	124_V	0.562	0.60
107_T	158_G	0.560	0.60
107_T	159_I	0.559	0.60
181_S	184_L	0.558	0.59
202_T	282_H	0.558	0.59
214_L	236_Y	0.558	0.59
318_A	323_E	0.558	0.59
31_I	52_A	0.558	0.59
8_M	327_K	0.556	0.59
43_V	212_H	0.555	0.59
117_I	142_I	0.554	0.59
176_S	326_H	0.552	0.59
72_L	319_S	0.551	0.59
50_L	194_L	0.550	0.58
19_S	182_R	0.550	0.58
173_I	176_S	0.548	0.58
200_I	341_V	0.548	0.58
261_D	293_Y	0.544	0.58
75_M	90_I	0.543	0.57
39_K	197_I	0.541	0.57
34_L	194_L	0.540	0.57
246_D	316_I	0.540	0.57
35_L	38_W	0.539	0.57
40_V	197_I	0.535	0.56
18_P	166_S	0.535	0.56
326_H	330_L	0.535	0.56
65_L	193_L	0.534	0.56
56_G	207_L	0.534	0.56
50_L	75_M	0.533	0.56
257_I	261_D	0.532	0.56
95_Y	139_N	0.532	0.56
64_M	236_Y	0.530	0.56
286_K	329_S	0.529	0.55
28_I	48_G	0.528	0.55
255_V	258_C	0.527	0.55
66_T	270_L	0.527	0.55
184_L	330_L	0.527	0.55
36_K	42_T	0.526	0.55
259_V	271_R	0.526	0.55
51_I	229_I	0.526	0.55
10_L	195_R	0.525	0.55
40_V	55_P	0.523	0.55
178_F	324_R	0.522	0.55
74_A	167_F	0.522	0.55
254_S	286_K	0.522	0.55
63_R	237_L	0.522	0.55
225_G	228_N	0.521	0.54
265_P	298_S	0.521	0.54
227_S	230_P	0.520	0.54
23_N	90_I	0.519	0.54
27_V	183_H	0.519	0.54
77_K	87_I	0.518	0.54
277_L	340_Y	0.517	0.54
156_E	282_H	0.516	0.54
261_D	298_S	0.514	0.53
64_M	230_P	0.513	0.53
199_E	331_R	0.513	0.53
40_V	53_T	0.512	0.53
179_I	325_T	0.511	0.53
258_C	313_G	0.511	0.53
84_R	248_Q	0.510	0.53
255_V	260_K	0.510	0.53
13_E	16_S	0.508	0.53
27_V	31_I	0.508	0.53
11_I	15_V	0.507	0.52
314_P	317_D	0.506	0.52
174_T	178_F	0.505	0.52
258_C	262_A	0.502	0.52
65_L	196_L	0.501	0.52
86_K	278_A	0.501	0.52
106_E	165_V	0.500	0.51
44_R	49_G	0.500	0.51
103_C	167_F	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wwvA	4	0.9624	100	0.416	Contact Map
1y0yA	5	0.9249	100	0.433	Contact Map
2wznA	4	0.9277	100	0.435	Contact Map
2wyrA	4	0.9277	100	0.436	Contact Map
3vatA	4	0.9913	100	0.44	Contact Map
3wt4A	4	0.9451	100	0.441	Contact Map
2fvgA	1	0.8526	100	0.45	Contact Map
2gljA	6	0.9624	100	0.452	Contact Map
2glfA	4	0.9566	100	0.458	Contact Map
1y7eA	4	0.8642	100	0.464	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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