GREMLIN Database
YHFE - Putative aminopeptidase YhfE
UniProt: O07603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (327)
Sequences: 2599 (1709)
Seq/√Len: 94.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_R155_E4.8291.00
17_I30_Y3.5101.00
178_F326_H3.2971.00
87_I144_L2.8941.00
332_H335_K2.8071.00
20_P90_I2.7161.00
12_K16_S2.6501.00
148_V154_T2.5891.00
106_E166_S2.5711.00
270_L310_G2.5671.00
195_R198_H2.5491.00
66_T216_S2.4911.00
15_V181_S2.4801.00
80_K86_K2.4511.00
281_H339_Y2.4281.00
63_R341_V2.3311.00
85_L105_I2.2911.00
32_E36_K2.2211.00
62_H212_H2.2151.00
53_T210_T2.1901.00
32_E44_R2.1671.00
284_D332_H2.1651.00
276_Q280_K2.1591.00
71_T182_R2.1181.00
274_L310_G2.0891.00
21_T90_I2.0671.00
115_G144_L2.0671.00
199_E338_Y2.0591.00
177_G328_S2.0531.00
85_L165_V2.0481.00
331_R335_K2.0071.00
81_A151_R1.9981.00
274_L340_Y1.9831.00
339_Y342_Q1.9791.00
146_E159_I1.9691.00
31_I190_V1.9591.00
23_N164_F1.9381.00
13_E34_L1.9351.00
152_K156_E1.9121.00
203_E342_Q1.9101.00
33_S36_K1.8951.00
197_I213_F1.8941.00
152_K155_E1.8891.00
76_V165_V1.8771.00
13_E30_Y1.8671.00
53_T212_H1.8341.00
234_V304_G1.8251.00
255_V332_H1.7761.00
231_P304_G1.7581.00
13_E33_S1.7331.00
19_S27_V1.7261.00
103_C144_L1.7211.00
146_E154_T1.7191.00
105_I144_L1.7141.00
67_A193_L1.7131.00
325_T330_L1.6941.00
148_V157_L1.6731.00
62_H210_T1.6551.00
80_K84_R1.6511.00
259_V287_L1.6321.00
28_I69_V1.6321.00
120_H131_G1.6281.00
188_A330_L1.6101.00
41_E53_T1.6051.00
55_P210_T1.5691.00
160_G163_D1.5251.00
32_E50_L1.5231.00
66_T296_D1.5221.00
8_M173_I1.5181.00
49_G228_N1.4931.00
257_I285_Y1.4891.00
19_S187_K1.4881.00
64_M300_A1.4771.00
39_K52_A1.4721.00
160_G279_E1.4701.00
107_T110_G1.4671.00
114_T172_E1.4641.00
9_E12_K1.4611.00
277_L281_H1.4541.00
199_E335_K1.4301.00
227_S299_A1.4230.99
35_L194_L1.4060.99
87_I142_I1.4050.99
34_L198_H1.3940.99
42_T50_L1.3890.99
75_M88_D1.3870.99
93_F167_F1.3750.99
34_L37_E1.3580.99
65_L341_V1.3570.99
236_Y300_A1.3470.99
12_K171_V1.3440.99
315_G318_A1.3370.99
190_V215_I1.3360.99
173_I327_K1.3250.99
9_E13_E1.3240.99
31_I215_I1.3180.99
31_I194_L1.3140.99
64_M229_I1.3080.99
57_R208_P1.3080.99
177_G326_H1.3070.99
79_I154_T1.3010.99
64_M214_L1.2980.99
87_I165_V1.2970.99
198_H202_T1.2920.99
76_V85_L1.2920.99
179_I184_L1.2920.99
192_L333_T1.2880.99
20_P73_G1.2850.99
56_G210_T1.2710.99
273_H340_Y1.2600.99
10_L30_Y1.2520.99
275_V285_Y1.2480.99
196_L337_L1.2480.99
155_E160_G1.2470.99
238_A297_A1.2380.99
43_V232_E1.2340.99
150_C153_D1.2190.98
103_C117_I1.2170.98
149_H153_D1.2100.98
29_N33_S1.2100.98
334_A338_Y1.2050.98
64_M235_E1.2000.98
212_H233_T1.1970.98
18_P104_Q1.1930.98
21_T73_G1.1920.98
237_L274_L1.1860.98
105_I165_V1.1860.98
196_L338_Y1.1830.98
28_I44_R1.1800.98
74_A98_I1.1770.98
15_V171_V1.1500.98
297_A309_H1.1460.98
78_E86_K1.1420.98
129_D132_K1.1370.97
188_A325_T1.1230.97
273_H277_L1.1210.97
108_A163_D1.1190.97
10_L194_L1.1100.97
196_L334_A1.1080.97
219_E319_S1.1060.97
153_D156_E1.1030.97
85_L146_E1.1030.97
64_M233_T1.1000.97
275_V287_L1.1000.97
41_E55_P1.1000.97
35_L52_A1.0990.97
89_L95_Y1.0970.97
134_E138_E1.0910.97
102_Y172_E1.0830.97
193_L239_V1.0810.97
105_I163_D1.0780.96
18_P106_E1.0730.96
17_I26_E1.0650.96
69_V190_V1.0620.96
195_R199_E1.0580.96
10_L34_L1.0430.96
254_S257_I1.0420.96
90_I164_F1.0390.96
328_S331_R1.0340.96
238_A300_A1.0330.96
154_T159_I1.0320.96
242_G288_D1.0320.96
56_G60_S1.0320.96
279_E285_Y1.0310.95
30_Y34_L1.0280.95
283_I336_L1.0250.95
271_R275_V1.0230.95
214_L229_I1.0170.95
102_Y168_D1.0150.95
103_C115_G1.0130.95
255_V333_T1.0090.95
230_P300_A1.0070.95
38_W198_H1.0070.95
51_I214_L1.0050.95
104_Q168_D1.0050.95
191_A330_L1.0020.95
29_N32_E1.0000.95
191_A334_A0.9940.94
87_I117_I0.9850.94
264_G311_L0.9800.94
239_V337_L0.9800.94
242_G313_G0.9730.94
174_T180_K0.9720.94
234_V305_H0.9700.94
35_L197_I0.9690.94
220_E319_S0.9670.94
248_Q252_E0.9630.94
114_T168_D0.9530.93
174_T324_R0.9490.93
118_L317_D0.9490.93
58_D210_T0.9450.93
312_I333_T0.9430.93
241_M318_A0.9420.93
35_L215_I0.9400.93
298_S301_I0.9390.93
8_M171_V0.9390.93
25_Y269_Q0.9340.92
28_I50_L0.9330.92
272_K276_Q0.9250.92
267_H308_V0.9220.92
31_I69_V0.9220.92
269_Q308_V0.9140.92
61_R209_Y0.9140.92
63_R209_Y0.9130.92
108_A272_K0.9070.91
128_K131_G0.9060.91
195_R330_L0.9050.91
85_L154_T0.9020.91
193_L213_F0.8990.91
184_L325_T0.8970.91
185_D219_E0.8950.91
186_D189_S0.8940.91
130_A135_R0.8880.90
52_A215_I0.8870.90
338_Y342_Q0.8860.90
98_I117_I0.8830.90
20_P164_F0.8820.90
180_K324_R0.8820.90
192_L334_A0.8800.90
48_G217_N0.8800.90
71_T183_H0.8700.90
42_T52_A0.8690.89
25_Y29_N0.8650.89
254_S261_D0.8640.89
138_E141_E0.8600.89
63_R211_T0.8580.89
45_N49_G0.8530.89
263_S298_S0.8510.88
179_I327_K0.8470.88
223_Y299_A0.8430.88
16_S171_V0.8420.88
240_D288_D0.8400.88
195_R334_A0.8360.88
253_Y284_D0.8350.87
69_V215_I0.8330.87
335_K339_Y0.8310.87
237_L337_L0.8270.87
67_A186_D0.8270.87
199_E334_A0.8250.87
113_Y146_E0.8230.87
130_A134_E0.8210.87
92_G219_E0.8210.87
32_E42_T0.8210.87
74_A165_V0.8190.86
102_Y322_F0.8130.86
200_I207_L0.8110.86
11_I191_A0.8100.86
243_A248_Q0.8090.86
105_I146_E0.8080.86
53_T62_H0.8070.86
258_C288_D0.8050.86
17_I27_V0.8020.85
255_V312_I0.8010.85
257_I260_K0.8000.85
95_Y98_I0.7990.85
218_N223_Y0.7990.85
8_M12_K0.7980.85
12_K173_I0.7960.85
185_D220_E0.7910.85
113_Y159_I0.7900.84
223_Y298_S0.7890.84
171_V181_S0.7860.84
231_P305_H0.7830.84
293_Y318_A0.7820.84
275_V279_E0.7790.84
88_D260_K0.7790.84
99_E142_I0.7750.83
11_I184_L0.7750.83
303_S307_I0.7740.83
68_H219_E0.7740.83
54_L197_I0.7720.83
248_Q251_D0.7690.83
236_Y307_I0.7670.83
43_V53_T0.7660.83
238_A309_H0.7630.82
294_G298_S0.7580.82
115_G146_E0.7560.82
40_V52_A0.7550.82
288_D313_G0.7550.82
192_L239_V0.7510.81
107_T163_D0.7510.81
35_L39_K0.7510.81
77_K88_D0.7500.81
185_D319_S0.7490.81
26_E106_E0.7420.81
171_V179_I0.7410.80
211_T341_V0.7390.80
328_S332_H0.7370.80
300_A307_I0.7360.80
27_V69_V0.7350.80
118_L121_Q0.7340.80
257_I271_R0.7340.80
266_Y311_L0.7270.79
57_R210_T0.7250.79
39_K42_T0.7240.79
191_A195_R0.7220.79
94_R97_S0.7180.78
17_I34_L0.7150.78
316_I319_S0.7150.78
186_D241_M0.7150.78
232_E305_H0.7120.78
192_L196_L0.7100.78
241_M315_G0.7080.77
85_L113_Y0.7070.77
118_L143_R0.7040.77
237_L310_G0.7030.77
107_T113_Y0.7010.77
255_V336_L0.6980.76
104_Q114_T0.6980.76
92_G319_S0.6980.76
31_I50_L0.6960.76
192_L330_L0.6950.76
276_Q279_E0.6940.76
274_L312_I0.6930.76
60_S210_T0.6920.76
295_S319_S0.6880.75
121_Q124_V0.6880.75
92_G294_G0.6770.74
15_V182_R0.6730.74
155_E279_E0.6720.74
108_A276_Q0.6720.74
57_R204_D0.6720.74
204_D207_L0.6680.73
330_L334_A0.6670.73
78_E247_G0.6670.73
160_G275_V0.6660.73
84_R143_R0.6660.73
258_C311_L0.6660.73
222_G294_G0.6660.73
278_A336_L0.6640.73
35_L42_T0.6640.73
249_A252_E0.6610.72
92_G220_E0.6600.72
266_Y293_Y0.6600.72
113_Y148_V0.6590.72
30_Y33_S0.6590.72
238_A337_L0.6570.72
243_A318_A0.6550.72
226_N230_P0.6520.71
201_Q204_D0.6500.71
11_I179_I0.6500.71
193_L196_L0.6500.71
268_Y308_V0.6500.71
23_N106_E0.6490.71
44_R50_L0.6450.71
258_C261_D0.6450.71
268_Y272_K0.6450.71
173_I177_G0.6430.70
279_E282_H0.6410.70
200_I211_T0.6410.70
121_Q125_H0.6400.70
218_N221_I0.6400.70
281_H335_K0.6390.70
230_P303_S0.6390.70
277_L339_Y0.6370.70
26_E33_S0.6350.69
277_L283_I0.6320.69
68_H220_E0.6320.69
38_W201_Q0.6320.69
66_T238_A0.6290.69
20_P166_S0.6270.68
204_D282_H0.6270.68
266_Y271_R0.6260.68
100_G321_A0.6250.68
40_V54_L0.6240.68
74_A87_I0.6230.68
196_L341_V0.6230.68
25_Y28_I0.6220.68
315_G325_T0.6180.67
199_E203_E0.6170.67
23_N26_E0.6170.67
316_I329_S0.6150.67
261_D266_Y0.6140.67
293_Y311_L0.6110.66
71_T118_L0.6090.66
81_A130_A0.6090.66
188_A334_A0.6080.66
46_H308_V0.6070.66
254_S329_S0.6050.66
49_G214_L0.6040.66
241_M288_D0.6030.65
273_H276_Q0.6030.65
240_D295_S0.6030.65
65_L337_L0.6010.65
146_E157_L0.6010.65
301_I309_H0.6000.65
258_C290_Y0.6000.65
186_D240_D0.6000.65
118_L125_H0.5980.65
242_G256_S0.5970.65
222_G261_D0.5950.64
128_K132_K0.5950.64
18_P26_E0.5950.64
186_D219_E0.5940.64
167_F321_A0.5930.64
58_D61_R0.5930.64
51_I212_H0.5920.64
262_A294_G0.5890.64
149_H328_S0.5890.64
80_K143_R0.5880.63
181_S324_R0.5840.63
8_M181_S0.5840.63
14_L27_V0.5840.63
57_R281_H0.5820.63
105_I159_I0.5820.63
78_E81_A0.5800.62
218_N224_G0.5790.62
293_Y298_S0.5780.62
207_L211_T0.5770.62
79_I275_V0.5700.61
16_S170_R0.5690.61
89_L139_N0.5690.61
219_E295_S0.5680.61
223_Y294_G0.5680.61
72_L323_E0.5660.61
197_I314_P0.5660.61
151_R154_T0.5650.60
93_F124_V0.5620.60
107_T158_G0.5600.60
107_T159_I0.5590.60
181_S184_L0.5580.59
202_T282_H0.5580.59
214_L236_Y0.5580.59
318_A323_E0.5580.59
31_I52_A0.5580.59
8_M327_K0.5560.59
43_V212_H0.5550.59
117_I142_I0.5540.59
176_S326_H0.5520.59
72_L319_S0.5510.59
50_L194_L0.5500.58
19_S182_R0.5500.58
173_I176_S0.5480.58
200_I341_V0.5480.58
261_D293_Y0.5440.58
75_M90_I0.5430.57
39_K197_I0.5410.57
34_L194_L0.5400.57
246_D316_I0.5400.57
35_L38_W0.5390.57
40_V197_I0.5350.56
18_P166_S0.5350.56
326_H330_L0.5350.56
65_L193_L0.5340.56
56_G207_L0.5340.56
50_L75_M0.5330.56
257_I261_D0.5320.56
95_Y139_N0.5320.56
64_M236_Y0.5300.56
286_K329_S0.5290.55
28_I48_G0.5280.55
255_V258_C0.5270.55
66_T270_L0.5270.55
184_L330_L0.5270.55
36_K42_T0.5260.55
259_V271_R0.5260.55
51_I229_I0.5260.55
10_L195_R0.5250.55
40_V55_P0.5230.55
178_F324_R0.5220.55
74_A167_F0.5220.55
254_S286_K0.5220.55
63_R237_L0.5220.55
225_G228_N0.5210.54
265_P298_S0.5210.54
227_S230_P0.5200.54
23_N90_I0.5190.54
27_V183_H0.5190.54
77_K87_I0.5180.54
277_L340_Y0.5170.54
156_E282_H0.5160.54
261_D298_S0.5140.53
64_M230_P0.5130.53
199_E331_R0.5130.53
40_V53_T0.5120.53
179_I325_T0.5110.53
258_C313_G0.5110.53
84_R248_Q0.5100.53
255_V260_K0.5100.53
13_E16_S0.5080.53
27_V31_I0.5080.53
11_I15_V0.5070.52
314_P317_D0.5060.52
174_T178_F0.5050.52
258_C262_A0.5020.52
65_L196_L0.5010.52
86_K278_A0.5010.52
106_E165_V0.5000.51
44_R49_G0.5000.51
103_C167_F0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9624 100 0.416 Contact Map
1y0yA 5 0.9249 100 0.433 Contact Map
2wznA 4 0.9277 100 0.435 Contact Map
2wyrA 4 0.9277 100 0.436 Contact Map
3vatA 4 0.9913 100 0.44 Contact Map
3wt4A 4 0.9451 100 0.441 Contact Map
2fvgA 1 0.8526 100 0.45 Contact Map
2gljA 6 0.9624 100 0.452 Contact Map
2glfA 4 0.9566 100 0.458 Contact Map
1y7eA 4 0.8642 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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