YHFC - BACSU - GREMLIN Contacts

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YHFC - Uncharacterized membrane protein YhfC

UniProt:	O07601	Sequences: MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGALTFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFMKRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALLPIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFNVPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (247)
Sequences:	223 (175)
Seq/√Len:	11.1

BACSU - YHFC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
87_G	211_I	4.629	1.00
92_C	207_L	4.352	1.00
49_F	93_G	3.801	0.99
58_H	81_Y	3.561	0.98
87_G	215_A	3.264	0.97
87_G	188_Q	3.259	0.97
54_E	58_H	3.176	0.96
54_E	85_M	2.982	0.94
53_L	89_F	2.929	0.94
54_E	81_Y	2.844	0.93
45_T	93_G	2.739	0.91
57_V	85_M	2.737	0.91
95_Y	99_R	2.599	0.89
50_A	54_E	2.538	0.88
187_V	191_L	2.486	0.87
50_A	55_G	2.376	0.84
45_T	97_M	2.346	0.83
187_V	217_F	2.285	0.81
65_N	68_T	2.267	0.81
54_E	82_G	2.228	0.80
58_H	82_G	2.190	0.78
21_P	192_S	2.118	0.76
58_H	85_M	2.113	0.76
98_M	192_S	2.058	0.74
68_T	113_A	2.035	0.73
47_F	121_L	1.940	0.69
111_G	196_L	1.937	0.69
95_Y	211_I	1.929	0.69
221_A	225_Q	1.891	0.67
84_L	87_G	1.852	0.65
50_A	82_G	1.806	0.63
45_T	49_F	1.749	0.61
193_L	196_L	1.738	0.60
45_T	114_F	1.738	0.60
213_L	217_F	1.723	0.60
79_G	83_C	1.701	0.58
81_Y	225_Q	1.695	0.58
111_G	193_L	1.659	0.57
19_L	52_L	1.654	0.56
68_T	72_M	1.625	0.55
50_A	58_H	1.624	0.55
62_L	78_Y	1.619	0.55
183_S	240_A	1.588	0.53
222_V	225_Q	1.583	0.53
79_G	219_V	1.580	0.53
31_K	48_V	1.543	0.51
204_P	207_L	1.489	0.48
24_L	192_S	1.486	0.48
21_P	128_G	1.477	0.48
53_L	86_A	1.457	0.47
50_A	81_Y	1.445	0.46
83_C	219_V	1.434	0.46
89_F	236_E	1.431	0.46
39_F	113_A	1.430	0.45
121_L	125_L	1.425	0.45
97_M	114_F	1.410	0.45
75_P	229_I	1.406	0.44
51_Q	55_G	1.403	0.44
106_H	188_Q	1.402	0.44
53_L	58_H	1.401	0.44
120_G	192_S	1.400	0.44
98_M	102_M	1.391	0.44
11_A	96_L	1.383	0.43
49_F	142_N	1.361	0.42
111_G	250_I	1.349	0.42
91_E	94_R	1.341	0.41
127_T	185_I	1.338	0.41
166_L	171_S	1.338	0.41
113_A	116_A	1.330	0.41
28_F	254_K	1.318	0.40
29_K	176_L	1.316	0.40
86_A	218_N	1.295	0.39
44_L	188_Q	1.290	0.39
82_G	215_A	1.287	0.39
81_Y	85_M	1.282	0.39
181_R	236_E	1.280	0.38
198_A	207_L	1.268	0.38
20_L	135_I	1.260	0.38
50_A	85_M	1.258	0.37
10_L	174_W	1.233	0.36
95_Y	207_L	1.231	0.36
39_F	43_A	1.228	0.36
23_G	27_W	1.226	0.36
58_H	61_V	1.189	0.34
207_L	211_I	1.177	0.34
129_L	244_A	1.173	0.34
108_W	253_A	1.172	0.34
115_G	192_S	1.169	0.34
149_L	155_V	1.166	0.33
92_C	95_Y	1.165	0.33
26_V	144_G	1.156	0.33
81_Y	215_A	1.153	0.33
9_F	175_M	1.146	0.33
15_A	213_L	1.144	0.32
16_I	23_G	1.137	0.32
115_G	189_I	1.120	0.31
95_Y	121_L	1.118	0.31
23_G	172_Y	1.115	0.31
44_L	209_Y	1.105	0.31
34_A	113_A	1.101	0.31
215_A	225_Q	1.098	0.31
7_V	60_Y	1.094	0.30
185_I	188_Q	1.090	0.30
94_R	214_H	1.072	0.29
116_A	185_I	1.072	0.29
114_F	196_L	1.070	0.29
179_I	240_A	1.069	0.29
118_H	214_H	1.066	0.29
30_R	218_N	1.066	0.29
51_Q	58_H	1.062	0.29
46_F	225_Q	1.035	0.28
83_C	218_N	1.030	0.28
114_F	118_H	1.028	0.28
94_R	118_H	1.026	0.28
30_R	103_K	1.026	0.28
28_F	74_H	1.024	0.28
45_T	190_G	1.017	0.27
45_T	129_L	1.012	0.27
216_L	219_V	1.007	0.27
244_A	248_Y	1.007	0.27
108_W	196_L	1.005	0.27
27_W	198_A	0.998	0.27
22_I	95_Y	0.997	0.27
84_L	125_L	0.991	0.26
155_V	190_G	0.980	0.26
113_A	207_L	0.980	0.26
119_G	181_R	0.979	0.26
10_L	142_N	0.977	0.26
91_E	214_H	0.972	0.26
49_F	82_G	0.972	0.26
4_Q	143_S	0.971	0.26
65_N	88_I	0.970	0.26
188_Q	194_L	0.969	0.25
35_S	208_L	0.963	0.25
84_L	88_I	0.953	0.25
94_R	192_S	0.950	0.25
39_F	116_A	0.949	0.25
110_D	113_A	0.941	0.24
10_L	138_A	0.941	0.24
33_G	77_W	0.941	0.24
38_V	143_S	0.940	0.24
8_V	194_L	0.938	0.24
126_I	141_I	0.935	0.24
126_I	138_A	0.934	0.24
129_L	150_L	0.928	0.24
218_N	236_E	0.923	0.24
20_L	182_I	0.922	0.24
225_Q	229_I	0.922	0.24
54_E	225_Q	0.918	0.24
17_A	21_P	0.913	0.23
42_G	117_G	0.913	0.23
106_H	196_L	0.904	0.23
179_I	211_I	0.903	0.23
35_S	196_L	0.902	0.23
127_T	188_Q	0.902	0.23
80_I	88_I	0.900	0.23
215_A	222_V	0.899	0.23
50_A	129_L	0.894	0.23
20_L	44_L	0.891	0.23
54_E	215_A	0.890	0.23
55_G	85_M	0.876	0.22
90_E	118_H	0.871	0.22
133_S	166_L	0.870	0.22
178_G	206_F	0.860	0.22
142_N	166_L	0.858	0.22
52_L	140_A	0.858	0.22
6_A	174_W	0.849	0.21
12_L	30_R	0.847	0.21
26_V	184_A	0.845	0.21
223_L	235_V	0.840	0.21
46_F	181_R	0.837	0.21
111_G	254_K	0.834	0.21
16_I	178_G	0.827	0.21
48_V	60_Y	0.826	0.21
193_L	250_I	0.824	0.21
37_K	110_D	0.818	0.20
21_P	45_T	0.815	0.20
126_I	203_R	0.815	0.20
75_P	188_Q	0.814	0.20
21_P	120_G	0.814	0.20
16_I	125_L	0.812	0.20
196_L	254_K	0.809	0.20
211_I	215_A	0.807	0.20
51_Q	111_G	0.803	0.20
24_L	185_I	0.801	0.20
12_L	237_I	0.799	0.20
183_S	212_L	0.797	0.20
45_T	200_K	0.796	0.20
14_G	198_A	0.788	0.19
40_F	43_A	0.782	0.19
38_V	123_A	0.781	0.19
39_F	159_L	0.777	0.19
76_L	191_L	0.773	0.19
22_I	124_I	0.772	0.19
78_Y	87_G	0.772	0.19
45_T	217_F	0.769	0.19
240_A	245_L	0.768	0.19
185_I	245_L	0.764	0.19
44_L	212_L	0.764	0.19
82_G	86_A	0.763	0.19
108_W	114_F	0.762	0.19
192_S	232_A	0.758	0.19
92_C	198_A	0.758	0.19
46_F	180_E	0.756	0.18
205_L	208_L	0.756	0.18
170_P	227_G	0.755	0.18
197_Y	201_N	0.747	0.18
119_G	180_E	0.745	0.18
95_Y	107_T	0.745	0.18
62_L	65_N	0.744	0.18
102_M	196_L	0.741	0.18
127_T	177_G	0.739	0.18
188_Q	220_P	0.736	0.18
184_A	199_V	0.736	0.18
180_E	218_N	0.735	0.18
27_W	235_V	0.733	0.18
169_T	174_W	0.730	0.18
134_L	174_W	0.730	0.18
129_L	172_Y	0.728	0.18
45_T	98_M	0.726	0.18
128_G	172_Y	0.721	0.17
108_W	246_S	0.718	0.17
30_R	202_R	0.715	0.17
146_F	167_L	0.715	0.17
65_N	174_W	0.714	0.17
115_G	119_G	0.708	0.17
53_L	218_N	0.707	0.17
108_W	254_K	0.704	0.17
86_A	181_R	0.702	0.17
74_H	132_I	0.699	0.17
51_Q	82_G	0.697	0.17
114_F	132_I	0.696	0.17
212_L	251_V	0.695	0.17
43_A	240_A	0.693	0.17
104_R	235_V	0.693	0.17
87_G	122_E	0.692	0.17
36_L	78_Y	0.691	0.17
4_Q	216_L	0.689	0.17
24_L	144_G	0.688	0.17
46_F	214_H	0.686	0.17
76_L	148_Q	0.685	0.17
14_G	17_A	0.683	0.16
89_F	195_V	0.679	0.16
212_L	233_A	0.678	0.16
96_L	211_I	0.663	0.16
118_H	128_G	0.662	0.16
230_E	234_A	0.657	0.16
194_L	211_I	0.657	0.16
6_A	123_A	0.649	0.16
185_I	194_L	0.648	0.16
234_A	244_A	0.648	0.16
145_T	212_L	0.648	0.16
73_Q	176_L	0.646	0.15
126_I	187_V	0.638	0.15
58_H	225_Q	0.638	0.15
18_F	40_F	0.632	0.15
141_I	189_I	0.631	0.15
77_W	137_Y	0.628	0.15
162_I	243_A	0.627	0.15
87_G	135_I	0.625	0.15
31_K	130_S	0.623	0.15
26_V	126_I	0.622	0.15
31_K	221_A	0.619	0.15
65_N	220_P	0.617	0.15
205_L	243_A	0.613	0.15
80_I	101_F	0.613	0.15
51_Q	146_F	0.613	0.15
80_I	83_C	0.610	0.15
107_T	234_A	0.608	0.15
151_V	228_I	0.607	0.15
41_I	155_V	0.606	0.15
38_V	238_I	0.605	0.14
138_A	174_W	0.604	0.14
62_L	183_S	0.603	0.14
161_P	165_Q	0.602	0.14
87_G	209_Y	0.600	0.14
71_A	96_L	0.598	0.14
49_F	83_C	0.596	0.14
17_A	103_K	0.596	0.14
48_V	63_Q	0.596	0.14
172_Y	245_L	0.594	0.14
20_L	104_R	0.594	0.14
5_E	171_S	0.592	0.14
21_P	118_H	0.592	0.14
52_L	189_I	0.592	0.14
15_A	67_M	0.592	0.14
240_A	253_A	0.591	0.14
65_N	222_V	0.588	0.14
74_H	97_M	0.587	0.14
49_F	97_M	0.587	0.14
230_E	239_V	0.584	0.14
68_T	159_L	0.584	0.14
89_F	218_N	0.581	0.14
86_A	214_H	0.576	0.14
118_H	191_L	0.576	0.14
144_G	218_N	0.573	0.14
122_E	181_R	0.572	0.14
66_E	88_I	0.572	0.14
102_M	110_D	0.567	0.14
199_V	229_I	0.567	0.14
29_K	92_C	0.566	0.14
34_A	41_I	0.566	0.14
141_I	146_F	0.565	0.14
154_D	160_L	0.564	0.14
110_D	223_L	0.561	0.13
78_Y	128_G	0.561	0.13
11_A	14_G	0.561	0.13
46_F	94_R	0.560	0.13
34_A	110_D	0.560	0.13
28_F	112_L	0.558	0.13
53_L	180_E	0.558	0.13
12_L	65_N	0.557	0.13
8_V	80_I	0.556	0.13
62_L	75_P	0.556	0.13
50_A	56_G	0.553	0.13
239_V	243_A	0.553	0.13
112_L	229_I	0.552	0.13
195_V	214_H	0.551	0.13
52_L	237_I	0.551	0.13
177_G	195_V	0.550	0.13
22_I	171_S	0.550	0.13
19_L	159_L	0.550	0.13
55_G	82_G	0.548	0.13
163_Q	190_G	0.547	0.13
90_E	117_G	0.546	0.13
93_G	116_A	0.546	0.13
42_G	90_E	0.546	0.13
39_F	185_I	0.545	0.13
40_F	78_Y	0.545	0.13
45_T	96_L	0.543	0.13
37_K	196_L	0.542	0.13
178_G	250_I	0.541	0.13
159_L	178_G	0.541	0.13
170_P	174_W	0.540	0.13
81_Y	221_A	0.539	0.13
30_R	61_V	0.537	0.13
54_E	86_A	0.537	0.13
77_W	202_R	0.533	0.13
75_P	127_T	0.533	0.13
99_R	113_A	0.533	0.13
15_A	20_L	0.532	0.13
180_E	236_E	0.531	0.13
187_V	194_L	0.530	0.13
31_K	143_S	0.529	0.13
61_V	247_V	0.525	0.13
224_Y	228_I	0.524	0.13
97_M	102_M	0.524	0.13
101_F	188_Q	0.523	0.13
10_L	131_S	0.523	0.13
112_L	241_L	0.523	0.13
89_F	184_A	0.522	0.13
202_R	248_Y	0.519	0.13
55_G	58_H	0.517	0.12
220_P	238_I	0.516	0.12
82_G	138_A	0.515	0.12
132_I	240_A	0.515	0.12
80_I	99_R	0.513	0.12
26_V	121_L	0.513	0.12
49_F	74_H	0.511	0.12
250_I	254_K	0.509	0.12
32_Y	202_R	0.508	0.12
121_L	206_F	0.508	0.12
130_S	133_S	0.507	0.12
87_G	100_F	0.505	0.12
133_S	179_I	0.504	0.12
108_W	111_G	0.503	0.12
35_S	108_W	0.501	0.12
95_Y	125_L	0.500	0.12
93_G	226_R	0.500	0.12
46_F	52_L	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5a63C	1	0.8643	98.5	0.876	Contact Map
4cadC	1	0.8062	95.2	0.924	Contact Map
5a63B	1	0.2597	28.8	0.961	Contact Map
4uisB	1	0.1512	23	0.963	Contact Map
2ks1B	1	0.1434	21.4	0.963	Contact Map
2jwaA	2	0.1434	20.2	0.964	Contact Map
2kegA	1	0.1163	17.7	0.964	Contact Map
2l2tA	2	0.1473	16.6	0.965	Contact Map
5a2fA	1	0	13.2	0.966	Contact Map
1iijA	1	0.124	11.8	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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