GREMLIN Database
YHFC - Uncharacterized membrane protein YhfC
UniProt: O07601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (247)
Sequences: 223 (175)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_G211_I4.6291.00
92_C207_L4.3521.00
49_F93_G3.8010.99
58_H81_Y3.5610.98
87_G215_A3.2640.97
87_G188_Q3.2590.97
54_E58_H3.1760.96
54_E85_M2.9820.94
53_L89_F2.9290.94
54_E81_Y2.8440.93
45_T93_G2.7390.91
57_V85_M2.7370.91
95_Y99_R2.5990.89
50_A54_E2.5380.88
187_V191_L2.4860.87
50_A55_G2.3760.84
45_T97_M2.3460.83
187_V217_F2.2850.81
65_N68_T2.2670.81
54_E82_G2.2280.80
58_H82_G2.1900.78
21_P192_S2.1180.76
58_H85_M2.1130.76
98_M192_S2.0580.74
68_T113_A2.0350.73
47_F121_L1.9400.69
111_G196_L1.9370.69
95_Y211_I1.9290.69
221_A225_Q1.8910.67
84_L87_G1.8520.65
50_A82_G1.8060.63
45_T49_F1.7490.61
193_L196_L1.7380.60
45_T114_F1.7380.60
213_L217_F1.7230.60
79_G83_C1.7010.58
81_Y225_Q1.6950.58
111_G193_L1.6590.57
19_L52_L1.6540.56
68_T72_M1.6250.55
50_A58_H1.6240.55
62_L78_Y1.6190.55
183_S240_A1.5880.53
222_V225_Q1.5830.53
79_G219_V1.5800.53
31_K48_V1.5430.51
204_P207_L1.4890.48
24_L192_S1.4860.48
21_P128_G1.4770.48
53_L86_A1.4570.47
50_A81_Y1.4450.46
83_C219_V1.4340.46
89_F236_E1.4310.46
39_F113_A1.4300.45
121_L125_L1.4250.45
97_M114_F1.4100.45
75_P229_I1.4060.44
51_Q55_G1.4030.44
106_H188_Q1.4020.44
53_L58_H1.4010.44
120_G192_S1.4000.44
98_M102_M1.3910.44
11_A96_L1.3830.43
49_F142_N1.3610.42
111_G250_I1.3490.42
91_E94_R1.3410.41
127_T185_I1.3380.41
166_L171_S1.3380.41
113_A116_A1.3300.41
28_F254_K1.3180.40
29_K176_L1.3160.40
86_A218_N1.2950.39
44_L188_Q1.2900.39
82_G215_A1.2870.39
81_Y85_M1.2820.39
181_R236_E1.2800.38
198_A207_L1.2680.38
20_L135_I1.2600.38
50_A85_M1.2580.37
10_L174_W1.2330.36
95_Y207_L1.2310.36
39_F43_A1.2280.36
23_G27_W1.2260.36
58_H61_V1.1890.34
207_L211_I1.1770.34
129_L244_A1.1730.34
108_W253_A1.1720.34
115_G192_S1.1690.34
149_L155_V1.1660.33
92_C95_Y1.1650.33
26_V144_G1.1560.33
81_Y215_A1.1530.33
9_F175_M1.1460.33
15_A213_L1.1440.32
16_I23_G1.1370.32
115_G189_I1.1200.31
95_Y121_L1.1180.31
23_G172_Y1.1150.31
44_L209_Y1.1050.31
34_A113_A1.1010.31
215_A225_Q1.0980.31
7_V60_Y1.0940.30
185_I188_Q1.0900.30
94_R214_H1.0720.29
116_A185_I1.0720.29
114_F196_L1.0700.29
179_I240_A1.0690.29
118_H214_H1.0660.29
30_R218_N1.0660.29
51_Q58_H1.0620.29
46_F225_Q1.0350.28
83_C218_N1.0300.28
114_F118_H1.0280.28
94_R118_H1.0260.28
30_R103_K1.0260.28
28_F74_H1.0240.28
45_T190_G1.0170.27
45_T129_L1.0120.27
216_L219_V1.0070.27
244_A248_Y1.0070.27
108_W196_L1.0050.27
27_W198_A0.9980.27
22_I95_Y0.9970.27
84_L125_L0.9910.26
155_V190_G0.9800.26
113_A207_L0.9800.26
119_G181_R0.9790.26
10_L142_N0.9770.26
91_E214_H0.9720.26
49_F82_G0.9720.26
4_Q143_S0.9710.26
65_N88_I0.9700.26
188_Q194_L0.9690.25
35_S208_L0.9630.25
84_L88_I0.9530.25
94_R192_S0.9500.25
39_F116_A0.9490.25
110_D113_A0.9410.24
10_L138_A0.9410.24
33_G77_W0.9410.24
38_V143_S0.9400.24
8_V194_L0.9380.24
126_I141_I0.9350.24
126_I138_A0.9340.24
129_L150_L0.9280.24
218_N236_E0.9230.24
20_L182_I0.9220.24
225_Q229_I0.9220.24
54_E225_Q0.9180.24
17_A21_P0.9130.23
42_G117_G0.9130.23
106_H196_L0.9040.23
179_I211_I0.9030.23
35_S196_L0.9020.23
127_T188_Q0.9020.23
80_I88_I0.9000.23
215_A222_V0.8990.23
50_A129_L0.8940.23
20_L44_L0.8910.23
54_E215_A0.8900.23
55_G85_M0.8760.22
90_E118_H0.8710.22
133_S166_L0.8700.22
178_G206_F0.8600.22
142_N166_L0.8580.22
52_L140_A0.8580.22
6_A174_W0.8490.21
12_L30_R0.8470.21
26_V184_A0.8450.21
223_L235_V0.8400.21
46_F181_R0.8370.21
111_G254_K0.8340.21
16_I178_G0.8270.21
48_V60_Y0.8260.21
193_L250_I0.8240.21
37_K110_D0.8180.20
21_P45_T0.8150.20
126_I203_R0.8150.20
75_P188_Q0.8140.20
21_P120_G0.8140.20
16_I125_L0.8120.20
196_L254_K0.8090.20
211_I215_A0.8070.20
51_Q111_G0.8030.20
24_L185_I0.8010.20
12_L237_I0.7990.20
183_S212_L0.7970.20
45_T200_K0.7960.20
14_G198_A0.7880.19
40_F43_A0.7820.19
38_V123_A0.7810.19
39_F159_L0.7770.19
76_L191_L0.7730.19
22_I124_I0.7720.19
78_Y87_G0.7720.19
45_T217_F0.7690.19
240_A245_L0.7680.19
185_I245_L0.7640.19
44_L212_L0.7640.19
82_G86_A0.7630.19
108_W114_F0.7620.19
192_S232_A0.7580.19
92_C198_A0.7580.19
46_F180_E0.7560.18
205_L208_L0.7560.18
170_P227_G0.7550.18
197_Y201_N0.7470.18
119_G180_E0.7450.18
95_Y107_T0.7450.18
62_L65_N0.7440.18
102_M196_L0.7410.18
127_T177_G0.7390.18
188_Q220_P0.7360.18
184_A199_V0.7360.18
180_E218_N0.7350.18
27_W235_V0.7330.18
169_T174_W0.7300.18
134_L174_W0.7300.18
129_L172_Y0.7280.18
45_T98_M0.7260.18
128_G172_Y0.7210.17
108_W246_S0.7180.17
30_R202_R0.7150.17
146_F167_L0.7150.17
65_N174_W0.7140.17
115_G119_G0.7080.17
53_L218_N0.7070.17
108_W254_K0.7040.17
86_A181_R0.7020.17
74_H132_I0.6990.17
51_Q82_G0.6970.17
114_F132_I0.6960.17
212_L251_V0.6950.17
43_A240_A0.6930.17
104_R235_V0.6930.17
87_G122_E0.6920.17
36_L78_Y0.6910.17
4_Q216_L0.6890.17
24_L144_G0.6880.17
46_F214_H0.6860.17
76_L148_Q0.6850.17
14_G17_A0.6830.16
89_F195_V0.6790.16
212_L233_A0.6780.16
96_L211_I0.6630.16
118_H128_G0.6620.16
230_E234_A0.6570.16
194_L211_I0.6570.16
6_A123_A0.6490.16
185_I194_L0.6480.16
234_A244_A0.6480.16
145_T212_L0.6480.16
73_Q176_L0.6460.15
126_I187_V0.6380.15
58_H225_Q0.6380.15
18_F40_F0.6320.15
141_I189_I0.6310.15
77_W137_Y0.6280.15
162_I243_A0.6270.15
87_G135_I0.6250.15
31_K130_S0.6230.15
26_V126_I0.6220.15
31_K221_A0.6190.15
65_N220_P0.6170.15
205_L243_A0.6130.15
80_I101_F0.6130.15
51_Q146_F0.6130.15
80_I83_C0.6100.15
107_T234_A0.6080.15
151_V228_I0.6070.15
41_I155_V0.6060.15
38_V238_I0.6050.14
138_A174_W0.6040.14
62_L183_S0.6030.14
161_P165_Q0.6020.14
87_G209_Y0.6000.14
71_A96_L0.5980.14
49_F83_C0.5960.14
17_A103_K0.5960.14
48_V63_Q0.5960.14
172_Y245_L0.5940.14
20_L104_R0.5940.14
5_E171_S0.5920.14
21_P118_H0.5920.14
52_L189_I0.5920.14
15_A67_M0.5920.14
240_A253_A0.5910.14
65_N222_V0.5880.14
74_H97_M0.5870.14
49_F97_M0.5870.14
230_E239_V0.5840.14
68_T159_L0.5840.14
89_F218_N0.5810.14
86_A214_H0.5760.14
118_H191_L0.5760.14
144_G218_N0.5730.14
122_E181_R0.5720.14
66_E88_I0.5720.14
102_M110_D0.5670.14
199_V229_I0.5670.14
29_K92_C0.5660.14
34_A41_I0.5660.14
141_I146_F0.5650.14
154_D160_L0.5640.14
110_D223_L0.5610.13
78_Y128_G0.5610.13
11_A14_G0.5610.13
46_F94_R0.5600.13
34_A110_D0.5600.13
28_F112_L0.5580.13
53_L180_E0.5580.13
12_L65_N0.5570.13
8_V80_I0.5560.13
62_L75_P0.5560.13
50_A56_G0.5530.13
239_V243_A0.5530.13
112_L229_I0.5520.13
195_V214_H0.5510.13
52_L237_I0.5510.13
177_G195_V0.5500.13
22_I171_S0.5500.13
19_L159_L0.5500.13
55_G82_G0.5480.13
163_Q190_G0.5470.13
90_E117_G0.5460.13
93_G116_A0.5460.13
42_G90_E0.5460.13
39_F185_I0.5450.13
40_F78_Y0.5450.13
45_T96_L0.5430.13
37_K196_L0.5420.13
178_G250_I0.5410.13
159_L178_G0.5410.13
170_P174_W0.5400.13
81_Y221_A0.5390.13
30_R61_V0.5370.13
54_E86_A0.5370.13
77_W202_R0.5330.13
75_P127_T0.5330.13
99_R113_A0.5330.13
15_A20_L0.5320.13
180_E236_E0.5310.13
187_V194_L0.5300.13
31_K143_S0.5290.13
61_V247_V0.5250.13
224_Y228_I0.5240.13
97_M102_M0.5240.13
101_F188_Q0.5230.13
10_L131_S0.5230.13
112_L241_L0.5230.13
89_F184_A0.5220.13
202_R248_Y0.5190.13
55_G58_H0.5170.12
220_P238_I0.5160.12
82_G138_A0.5150.12
132_I240_A0.5150.12
80_I99_R0.5130.12
26_V121_L0.5130.12
49_F74_H0.5110.12
250_I254_K0.5090.12
32_Y202_R0.5080.12
121_L206_F0.5080.12
130_S133_S0.5070.12
87_G100_F0.5050.12
133_S179_I0.5040.12
108_W111_G0.5030.12
35_S108_W0.5010.12
95_Y125_L0.5000.12
93_G226_R0.5000.12
46_F52_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a63C 1 0.8643 98.5 0.876 Contact Map
4cadC 1 0.8062 95.2 0.924 Contact Map
5a63B 1 0.2597 28.8 0.961 Contact Map
4uisB 1 0.1512 23 0.963 Contact Map
2ks1B 1 0.1434 21.4 0.963 Contact Map
2jwaA 2 0.1434 20.2 0.964 Contact Map
2kegA 1 0.1163 17.7 0.964 Contact Map
2l2tA 2 0.1473 16.6 0.965 Contact Map
5a2fA 1 0 13.2 0.966 Contact Map
1iijA 1 0.124 11.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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