GREMLIN Database
FABH2 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
UniProt: O07600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (294)
Sequences: 39003 (23561)
Seq/√Len: 1374.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_T22_D2.9151.00
134_K168_E2.6931.00
63_L166_L2.5851.00
60_V136_L2.5831.00
124_N128_T2.5211.00
61_K65_S2.4551.00
240_S243_D2.4491.00
57_I98_Y2.4341.00
121_H194_A2.4061.00
293_A305_V2.3401.00
7_T168_E2.2881.00
125_G131_L2.2581.00
132_H135_I2.2461.00
243_D304_I2.2321.00
125_G129_S2.1891.00
59_A162_A2.1881.00
127_I169_R2.1561.00
239_L304_I2.1131.00
70_T73_D2.1021.00
107_L122_L2.0841.00
227_P231_E2.0611.00
170_D174_P1.9951.00
59_A164_A1.9901.00
123_A135_I1.9801.00
297_G300_K1.9631.00
298_K302_D1.9621.00
25_K29_T1.9531.00
148_D276_E1.9441.00
169_R172_E1.9431.00
189_D294_V1.9271.00
56_C95_V1.9181.00
11_T291_D1.8641.00
290_L321_I1.8561.00
266_F271_T1.8301.00
76_M135_I1.7831.00
18_L22_D1.7581.00
267_P270_K1.7361.00
138_I164_A1.7011.00
149_Y249_P1.6961.00
78_L126_L1.6411.00
267_P271_T1.6281.00
13_A288_L1.6231.00
291_D295_K1.6231.00
168_E185_G1.6191.00
56_C79_V1.6141.00
127_I167_V1.6131.00
233_L237_A1.6081.00
231_E235_H1.6021.00
120_L290_L1.5941.00
62_N65_S1.5781.00
290_L307_L1.5761.00
9_I291_D1.5761.00
297_G302_D1.5741.00
26_I31_D1.5731.00
126_L132_H1.5621.00
79_V164_A1.5531.00
161_A281_T1.5341.00
35_V41_R1.5231.00
66_R188_G1.5031.00
133_Q172_E1.4971.00
81_T91_T1.4951.00
10_G59_A1.4951.00
60_V95_V1.4861.00
133_Q169_R1.4861.00
61_K98_Y1.4771.00
54_D98_Y1.4531.00
245_D303_Q1.4511.00
136_L166_L1.4401.00
281_T288_L1.4381.00
24_E28_D1.4331.00
22_D25_K1.4321.00
172_E182_G1.4261.00
267_P272_L1.4121.00
52_T140_G1.4051.00
261_C268_I1.4011.00
228_G232_R1.3991.00
80_A115_G1.3911.00
75_D134_K1.3911.00
125_G128_T1.3791.00
8_A66_R1.3761.00
18_L21_A1.3671.00
63_L67_Y1.3581.00
121_H125_G1.3521.00
51_F55_L1.3511.00
62_N66_R1.3481.00
119_G137_V1.3471.00
123_A137_V1.3441.00
168_E183_T1.3421.00
40_M49_H1.3341.00
126_L131_L1.3241.00
25_K28_D1.3191.00
192_Y304_I1.3151.00
159_G281_T1.3041.00
120_L167_V1.3001.00
122_L125_G1.2821.00
56_C164_A1.2751.00
293_A296_A1.2741.00
10_G62_N1.2641.00
163_G287_V1.2631.00
134_K166_L1.2631.00
78_L82_T1.2551.00
266_F270_K1.2521.00
78_L81_T1.2511.00
118_Y317_T1.2511.00
123_A167_V1.2441.00
92_A108_D1.2411.00
172_E183_T1.2401.00
6_I290_L1.2341.00
61_K99_F1.2231.00
79_V138_I1.2231.00
57_I61_K1.2211.00
306_L318_G1.2171.00
63_L164_A1.2131.00
5_K170_D1.1971.00
10_G63_L1.1891.00
25_K30_S1.1891.00
239_L243_D1.1831.00
19_T24_E1.1781.00
58_E62_N1.1771.00
147_T152_R1.1771.00
232_R236_K1.1691.00
232_R235_H1.1691.00
206_V316_Y1.1671.00
308_F318_G1.1661.00
58_E61_K1.1631.00
51_F54_D1.1561.00
266_F272_L1.1551.00
246_W293_A1.1501.00
22_D26_I1.1491.00
12_Y55_L1.1481.00
306_L320_L1.1481.00
233_L320_L1.1371.00
42_E277_H1.1211.00
117_T317_T1.1171.00
234_L239_L1.1131.00
111_A118_Y1.1121.00
234_L244_L1.1101.00
93_C313_G1.1051.00
168_E173_T1.1031.00
131_L236_K1.0991.00
239_L244_L1.0961.00
299_L302_D1.0941.00
245_D304_I1.0891.00
111_A114_A1.0851.00
228_G231_E1.0741.00
229_E318_G1.0731.00
96_Q106_A1.0681.00
60_V99_F1.0681.00
41_R276_E1.0661.00
231_E241_S1.0631.00
57_I95_V1.0581.00
25_K31_D1.0551.00
273_T276_E1.0511.00
59_A62_N1.0501.00
229_E233_L1.0411.00
163_G284_V1.0381.00
118_Y315_T1.0331.00
124_N191_L1.0301.00
274_S278_Y1.0291.00
69_G134_K1.0241.00
20_N24_E1.0221.00
266_F269_E1.0201.00
259_S263_K1.0151.00
269_E272_L1.0141.00
277_H292_L1.0131.00
6_I294_V1.0121.00
23_L274_S1.0111.00
239_L320_L1.0101.00
75_D78_L1.0091.00
234_L241_S1.0041.00
69_G166_L1.0041.00
60_V164_A1.0021.00
118_Y122_L0.9971.00
281_T284_V0.9941.00
21_A25_K0.9941.00
56_C138_I0.9941.00
34_I37_R0.9921.00
73_D134_K0.9841.00
237_A320_L0.9831.00
233_L318_G0.9831.00
21_A24_E0.9811.00
12_Y58_E0.9791.00
168_E172_E0.9761.00
76_M126_L0.9721.00
19_T23_L0.9671.00
120_L287_V0.9661.00
244_L304_I0.9651.00
63_L136_L0.9611.00
117_T319_L0.9581.00
274_S292_L0.9541.00
274_S288_L0.9541.00
165_L290_L0.9531.00
120_L137_V0.9531.00
116_L287_V0.9501.00
165_L287_V0.9491.00
163_G291_D0.9441.00
61_K71_L0.9381.00
294_V299_L0.9381.00
78_L85_D0.9371.00
78_L107_L0.9351.00
170_D173_T0.9351.00
248_V289_A0.9301.00
41_R44_R0.9301.00
76_M132_H0.9281.00
82_T85_D0.9281.00
224_R227_P0.9261.00
109_I122_L0.9241.00
140_G162_A0.9151.00
57_I99_F0.9091.00
230_F306_L0.8991.00
158_F282_S0.8931.00
24_E30_S0.8921.00
121_H131_L0.8891.00
78_L86_Y0.8831.00
122_L126_L0.8721.00
278_Y288_L0.8701.00
170_D190_I0.8641.00
20_N23_L0.8631.00
268_I272_L0.8581.00
26_I29_T0.8431.00
9_I294_V0.8371.00
134_K172_E0.8371.00
268_I271_T0.8341.00
67_Y166_L0.8291.00
78_L135_I0.8261.00
161_A288_L0.8211.00
298_K301_K0.8181.00
50_Q58_E0.8161.00
230_F264_T0.8141.00
60_V138_I0.8111.00
80_A119_G0.8101.00
137_V167_V0.8101.00
139_A287_V0.8101.00
33_W38_T0.8091.00
9_I20_N0.8091.00
241_S247_F0.8081.00
56_C140_G0.8061.00
225_T228_G0.8051.00
254_L258_E0.8031.00
224_R228_G0.8021.00
12_Y62_N0.7911.00
13_A163_G0.7901.00
78_L123_A0.7871.00
75_D133_Q0.7841.00
307_L321_I0.7821.00
261_C271_T0.7781.00
265_P268_I0.7771.00
71_L74_V0.7761.00
77_I82_T0.7751.00
95_V138_I0.7721.00
125_G236_K0.7711.00
28_D31_D0.7711.00
9_I188_G0.7691.00
53_S91_T0.7671.00
66_R186_N0.7671.00
214_N217_E0.7651.00
188_G294_V0.7641.00
23_L27_V0.7631.00
55_L162_A0.7611.00
27_V155_C0.7601.00
64_K71_L0.7601.00
293_A297_G0.7591.00
118_Y205_L0.7571.00
28_D298_K0.7561.00
64_K136_L0.7561.00
227_P265_P0.7511.00
23_L26_I0.7501.00
147_T154_T0.7491.00
9_I66_R0.7481.00
19_T26_I0.7481.00
19_T30_S0.7471.00
76_M105_G0.7471.00
37_R61_K0.7471.00
102_E228_G0.7461.00
230_F308_F0.7451.00
296_A300_K0.7431.00
300_K303_Q0.7391.00
194_A319_L0.7361.00
55_L142_T0.7351.00
81_T84_S0.7331.00
90_S218_V0.7331.00
184_S187_G0.7311.00
66_R294_V0.7281.00
234_L237_A0.7251.00
50_Q54_D0.7251.00
112_T312_G0.7241.00
60_V63_L0.7231.00
24_E31_D0.7211.00
56_C91_T0.7191.00
93_C106_A0.7161.00
53_S94_R0.7151.00
144_S160_D0.7121.00
183_T187_G0.7081.00
120_L319_L0.7071.00
128_T236_K0.7061.00
244_L320_L0.7051.00
16_R26_I0.7001.00
22_D31_D0.6991.00
89_P112_T0.6991.00
127_I130_G0.6981.00
136_L164_A0.6951.00
96_Q207_G0.6921.00
34_I38_T0.6921.00
120_L165_L0.6891.00
285_S289_A0.6881.00
134_K137_V0.6871.00
91_T140_G0.6871.00
22_D30_S0.6851.00
117_T309_G0.6791.00
165_L291_D0.6781.00
66_R295_K0.6761.00
223_A263_K0.6731.00
20_N30_S0.6701.00
193_R233_L0.6691.00
183_T186_N0.6681.00
87_A90_S0.6661.00
258_E261_C0.6651.00
90_S312_G0.6651.00
216_R220_K0.6631.00
64_K99_F0.6631.00
116_L165_L0.6611.00
258_E268_I0.6581.00
294_V321_I0.6551.00
114_A314_L0.6511.00
7_T134_K0.6511.00
141_E282_S0.6491.00
230_F234_L0.6491.00
292_L296_A0.6481.00
141_E283_S0.6481.00
193_R236_K0.6471.00
23_L28_D0.6471.00
78_L83_T0.6431.00
76_M86_Y0.6431.00
244_L247_F0.6391.00
106_A207_G0.6381.00
13_A278_Y0.6371.00
79_V140_G0.6361.00
289_A307_L0.6351.00
288_L292_L0.6341.00
23_L30_S0.6331.00
184_S188_G0.6321.00
124_N236_K0.6311.00
217_E220_K0.6311.00
234_L320_L0.6301.00
281_T285_S0.6261.00
92_A106_A0.6231.00
77_I81_T0.6161.00
19_T25_K0.6161.00
11_T288_L0.6131.00
142_T145_K0.6121.00
9_I295_K0.6111.00
145_K149_Y0.6101.00
220_K224_R0.6071.00
78_L122_L0.6061.00
54_D58_E0.6061.00
81_T108_D0.6041.00
42_E46_A0.6031.00
251_S257_I0.6021.00
74_V134_K0.6001.00
105_G132_H0.5991.00
13_A291_D0.5981.00
12_Y59_A0.5971.00
43_R46_A0.5931.00
18_L26_I0.5891.00
5_K190_I0.5881.00
101_W136_L0.5881.00
156_V282_S0.5881.00
215_G218_V0.5871.00
163_G288_L0.5861.00
23_L31_D0.5851.00
244_L306_L0.5851.00
242_D270_K0.5841.00
239_L301_K0.5841.00
11_T20_N0.5831.00
182_G185_G0.5821.00
56_C60_V0.5821.00
22_D292_L0.5811.00
223_A227_P0.5801.00
185_G188_G0.5771.00
274_S289_A0.5771.00
254_L273_T0.5731.00
20_N26_I0.5711.00
117_T286_I0.5711.00
258_E262_E0.5691.00
192_Y195_G0.5671.00
26_I30_S0.5651.00
82_T86_Y0.5641.00
16_R22_D0.5641.00
52_T91_T0.5631.00
247_F306_L0.5611.00
77_I96_Q0.5611.00
116_L139_A0.5601.00
78_L84_S0.5601.00
265_P269_E0.5601.00
94_R98_Y0.5561.00
19_T31_D0.5551.00
230_F305_V0.5541.00
206_V232_R0.5521.00
215_G219_Y0.5511.00
64_K74_V0.5501.00
206_V229_E0.5501.00
214_N218_V0.5491.00
19_T29_T0.5481.00
126_L129_S0.5481.00
195_G232_R0.5481.00
53_S90_S0.5471.00
9_I19_T0.5411.00
256_M260_I0.5411.00
251_S273_T0.5401.00
24_E29_T0.5381.00
259_S262_E0.5381.00
188_G192_Y0.5381.00
114_A308_F0.5361.00
265_P270_K0.5361.00
265_P272_L0.5351.00
193_R237_A0.5321.00
64_K166_L0.5311.00
102_E224_R0.5281.00
170_D187_G0.5271.00
53_S98_Y0.5261.00
191_L194_A0.5251.00
139_A284_V0.5251.00
18_L23_L0.5241.00
255_R259_S0.5241.00
84_S88_F0.5231.00
22_D29_T0.5221.00
47_D50_Q0.5221.00
78_L109_I0.5211.00
5_K173_T0.5161.00
79_V92_A0.5131.00
257_I260_I0.5121.00
77_I101_W0.5111.00
169_R174_P0.5111.00
246_W303_Q0.5081.00
115_G119_G0.5081.00
8_A63_L0.5081.00
69_G73_D0.5081.00
248_V292_L0.5051.00
40_M44_R0.5011.00
60_V64_K0.5001.00
187_G191_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rybA 2 0.9754 100 0.212 Contact Map
3gwaA 2 0.9908 100 0.219 Contact Map
1ub7A 2 0.9846 100 0.22 Contact Map
4x9kA 2 0.9908 100 0.225 Contact Map
1zowA 2 0.96 100 0.226 Contact Map
1hnjA 2 0.9754 100 0.227 Contact Map
1mzjA 2 0.9908 100 0.227 Contact Map
2x3eA 2 0.9785 100 0.231 Contact Map
3il6A 2 0.9723 100 0.232 Contact Map
3il3A 2 0.9692 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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