FABH2 - BACSU - GREMLIN Contacts

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FABH2 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2

UniProt:	O07600	Sequences: MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERRIADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWESTGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGDAAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREVYKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVEHYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (294)
Sequences:	39003 (23561)
Seq/√Len:	1374.1

ECOLI - FABH FABF FABB
BACSU - FABH2 FABH1 BCSA PKSG PKSF FABF
SULSO - Y535

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_T	22_D	2.915	1.00
134_K	168_E	2.693	1.00
63_L	166_L	2.585	1.00
60_V	136_L	2.583	1.00
124_N	128_T	2.521	1.00
61_K	65_S	2.455	1.00
240_S	243_D	2.449	1.00
57_I	98_Y	2.434	1.00
121_H	194_A	2.406	1.00
293_A	305_V	2.340	1.00
7_T	168_E	2.288	1.00
125_G	131_L	2.258	1.00
132_H	135_I	2.246	1.00
243_D	304_I	2.232	1.00
125_G	129_S	2.189	1.00
59_A	162_A	2.188	1.00
127_I	169_R	2.156	1.00
239_L	304_I	2.113	1.00
70_T	73_D	2.102	1.00
107_L	122_L	2.084	1.00
227_P	231_E	2.061	1.00
170_D	174_P	1.995	1.00
59_A	164_A	1.990	1.00
123_A	135_I	1.980	1.00
297_G	300_K	1.963	1.00
298_K	302_D	1.962	1.00
25_K	29_T	1.953	1.00
148_D	276_E	1.944	1.00
169_R	172_E	1.943	1.00
189_D	294_V	1.927	1.00
56_C	95_V	1.918	1.00
11_T	291_D	1.864	1.00
290_L	321_I	1.856	1.00
266_F	271_T	1.830	1.00
76_M	135_I	1.783	1.00
18_L	22_D	1.758	1.00
267_P	270_K	1.736	1.00
138_I	164_A	1.701	1.00
149_Y	249_P	1.696	1.00
78_L	126_L	1.641	1.00
267_P	271_T	1.628	1.00
13_A	288_L	1.623	1.00
291_D	295_K	1.623	1.00
168_E	185_G	1.619	1.00
56_C	79_V	1.614	1.00
127_I	167_V	1.613	1.00
233_L	237_A	1.608	1.00
231_E	235_H	1.602	1.00
120_L	290_L	1.594	1.00
62_N	65_S	1.578	1.00
290_L	307_L	1.576	1.00
9_I	291_D	1.576	1.00
297_G	302_D	1.574	1.00
26_I	31_D	1.573	1.00
126_L	132_H	1.562	1.00
79_V	164_A	1.553	1.00
161_A	281_T	1.534	1.00
35_V	41_R	1.523	1.00
66_R	188_G	1.503	1.00
133_Q	172_E	1.497	1.00
81_T	91_T	1.495	1.00
10_G	59_A	1.495	1.00
60_V	95_V	1.486	1.00
133_Q	169_R	1.486	1.00
61_K	98_Y	1.477	1.00
54_D	98_Y	1.453	1.00
245_D	303_Q	1.451	1.00
136_L	166_L	1.440	1.00
281_T	288_L	1.438	1.00
24_E	28_D	1.433	1.00
22_D	25_K	1.432	1.00
172_E	182_G	1.426	1.00
267_P	272_L	1.412	1.00
52_T	140_G	1.405	1.00
261_C	268_I	1.401	1.00
228_G	232_R	1.399	1.00
80_A	115_G	1.391	1.00
75_D	134_K	1.391	1.00
125_G	128_T	1.379	1.00
8_A	66_R	1.376	1.00
18_L	21_A	1.367	1.00
63_L	67_Y	1.358	1.00
121_H	125_G	1.352	1.00
51_F	55_L	1.351	1.00
62_N	66_R	1.348	1.00
119_G	137_V	1.347	1.00
123_A	137_V	1.344	1.00
168_E	183_T	1.342	1.00
40_M	49_H	1.334	1.00
126_L	131_L	1.324	1.00
25_K	28_D	1.319	1.00
192_Y	304_I	1.315	1.00
159_G	281_T	1.304	1.00
120_L	167_V	1.300	1.00
122_L	125_G	1.282	1.00
56_C	164_A	1.275	1.00
293_A	296_A	1.274	1.00
10_G	62_N	1.264	1.00
163_G	287_V	1.263	1.00
134_K	166_L	1.263	1.00
78_L	82_T	1.255	1.00
266_F	270_K	1.252	1.00
78_L	81_T	1.251	1.00
118_Y	317_T	1.251	1.00
123_A	167_V	1.244	1.00
92_A	108_D	1.241	1.00
172_E	183_T	1.240	1.00
6_I	290_L	1.234	1.00
61_K	99_F	1.223	1.00
79_V	138_I	1.223	1.00
57_I	61_K	1.221	1.00
306_L	318_G	1.217	1.00
63_L	164_A	1.213	1.00
5_K	170_D	1.197	1.00
10_G	63_L	1.189	1.00
25_K	30_S	1.189	1.00
239_L	243_D	1.183	1.00
19_T	24_E	1.178	1.00
58_E	62_N	1.177	1.00
147_T	152_R	1.177	1.00
232_R	236_K	1.169	1.00
232_R	235_H	1.169	1.00
206_V	316_Y	1.167	1.00
308_F	318_G	1.166	1.00
58_E	61_K	1.163	1.00
51_F	54_D	1.156	1.00
266_F	272_L	1.155	1.00
246_W	293_A	1.150	1.00
22_D	26_I	1.149	1.00
12_Y	55_L	1.148	1.00
306_L	320_L	1.148	1.00
233_L	320_L	1.137	1.00
42_E	277_H	1.121	1.00
117_T	317_T	1.117	1.00
234_L	239_L	1.113	1.00
111_A	118_Y	1.112	1.00
234_L	244_L	1.110	1.00
93_C	313_G	1.105	1.00
168_E	173_T	1.103	1.00
131_L	236_K	1.099	1.00
239_L	244_L	1.096	1.00
299_L	302_D	1.094	1.00
245_D	304_I	1.089	1.00
111_A	114_A	1.085	1.00
228_G	231_E	1.074	1.00
229_E	318_G	1.073	1.00
96_Q	106_A	1.068	1.00
60_V	99_F	1.068	1.00
41_R	276_E	1.066	1.00
231_E	241_S	1.063	1.00
57_I	95_V	1.058	1.00
25_K	31_D	1.055	1.00
273_T	276_E	1.051	1.00
59_A	62_N	1.050	1.00
229_E	233_L	1.041	1.00
163_G	284_V	1.038	1.00
118_Y	315_T	1.033	1.00
124_N	191_L	1.030	1.00
274_S	278_Y	1.029	1.00
69_G	134_K	1.024	1.00
20_N	24_E	1.022	1.00
266_F	269_E	1.020	1.00
259_S	263_K	1.015	1.00
269_E	272_L	1.014	1.00
277_H	292_L	1.013	1.00
6_I	294_V	1.012	1.00
23_L	274_S	1.011	1.00
239_L	320_L	1.010	1.00
75_D	78_L	1.009	1.00
234_L	241_S	1.004	1.00
69_G	166_L	1.004	1.00
60_V	164_A	1.002	1.00
118_Y	122_L	0.997	1.00
281_T	284_V	0.994	1.00
21_A	25_K	0.994	1.00
56_C	138_I	0.994	1.00
34_I	37_R	0.992	1.00
73_D	134_K	0.984	1.00
237_A	320_L	0.983	1.00
233_L	318_G	0.983	1.00
21_A	24_E	0.981	1.00
12_Y	58_E	0.979	1.00
168_E	172_E	0.976	1.00
76_M	126_L	0.972	1.00
19_T	23_L	0.967	1.00
120_L	287_V	0.966	1.00
244_L	304_I	0.965	1.00
63_L	136_L	0.961	1.00
117_T	319_L	0.958	1.00
274_S	292_L	0.954	1.00
274_S	288_L	0.954	1.00
165_L	290_L	0.953	1.00
120_L	137_V	0.953	1.00
116_L	287_V	0.950	1.00
165_L	287_V	0.949	1.00
163_G	291_D	0.944	1.00
61_K	71_L	0.938	1.00
294_V	299_L	0.938	1.00
78_L	85_D	0.937	1.00
78_L	107_L	0.935	1.00
170_D	173_T	0.935	1.00
248_V	289_A	0.930	1.00
41_R	44_R	0.930	1.00
76_M	132_H	0.928	1.00
82_T	85_D	0.928	1.00
224_R	227_P	0.926	1.00
109_I	122_L	0.924	1.00
140_G	162_A	0.915	1.00
57_I	99_F	0.909	1.00
230_F	306_L	0.899	1.00
158_F	282_S	0.893	1.00
24_E	30_S	0.892	1.00
121_H	131_L	0.889	1.00
78_L	86_Y	0.883	1.00
122_L	126_L	0.872	1.00
278_Y	288_L	0.870	1.00
170_D	190_I	0.864	1.00
20_N	23_L	0.863	1.00
268_I	272_L	0.858	1.00
26_I	29_T	0.843	1.00
9_I	294_V	0.837	1.00
134_K	172_E	0.837	1.00
268_I	271_T	0.834	1.00
67_Y	166_L	0.829	1.00
78_L	135_I	0.826	1.00
161_A	288_L	0.821	1.00
298_K	301_K	0.818	1.00
50_Q	58_E	0.816	1.00
230_F	264_T	0.814	1.00
60_V	138_I	0.811	1.00
80_A	119_G	0.810	1.00
137_V	167_V	0.810	1.00
139_A	287_V	0.810	1.00
33_W	38_T	0.809	1.00
9_I	20_N	0.809	1.00
241_S	247_F	0.808	1.00
56_C	140_G	0.806	1.00
225_T	228_G	0.805	1.00
254_L	258_E	0.803	1.00
224_R	228_G	0.802	1.00
12_Y	62_N	0.791	1.00
13_A	163_G	0.790	1.00
78_L	123_A	0.787	1.00
75_D	133_Q	0.784	1.00
307_L	321_I	0.782	1.00
261_C	271_T	0.778	1.00
265_P	268_I	0.777	1.00
71_L	74_V	0.776	1.00
77_I	82_T	0.775	1.00
95_V	138_I	0.772	1.00
125_G	236_K	0.771	1.00
28_D	31_D	0.771	1.00
9_I	188_G	0.769	1.00
53_S	91_T	0.767	1.00
66_R	186_N	0.767	1.00
214_N	217_E	0.765	1.00
188_G	294_V	0.764	1.00
23_L	27_V	0.763	1.00
55_L	162_A	0.761	1.00
27_V	155_C	0.760	1.00
64_K	71_L	0.760	1.00
293_A	297_G	0.759	1.00
118_Y	205_L	0.757	1.00
28_D	298_K	0.756	1.00
64_K	136_L	0.756	1.00
227_P	265_P	0.751	1.00
23_L	26_I	0.750	1.00
147_T	154_T	0.749	1.00
9_I	66_R	0.748	1.00
19_T	26_I	0.748	1.00
19_T	30_S	0.747	1.00
76_M	105_G	0.747	1.00
37_R	61_K	0.747	1.00
102_E	228_G	0.746	1.00
230_F	308_F	0.745	1.00
296_A	300_K	0.743	1.00
300_K	303_Q	0.739	1.00
194_A	319_L	0.736	1.00
55_L	142_T	0.735	1.00
81_T	84_S	0.733	1.00
90_S	218_V	0.733	1.00
184_S	187_G	0.731	1.00
66_R	294_V	0.728	1.00
234_L	237_A	0.725	1.00
50_Q	54_D	0.725	1.00
112_T	312_G	0.724	1.00
60_V	63_L	0.723	1.00
24_E	31_D	0.721	1.00
56_C	91_T	0.719	1.00
93_C	106_A	0.716	1.00
53_S	94_R	0.715	1.00
144_S	160_D	0.712	1.00
183_T	187_G	0.708	1.00
120_L	319_L	0.707	1.00
128_T	236_K	0.706	1.00
244_L	320_L	0.705	1.00
16_R	26_I	0.700	1.00
22_D	31_D	0.699	1.00
89_P	112_T	0.699	1.00
127_I	130_G	0.698	1.00
136_L	164_A	0.695	1.00
96_Q	207_G	0.692	1.00
34_I	38_T	0.692	1.00
120_L	165_L	0.689	1.00
285_S	289_A	0.688	1.00
134_K	137_V	0.687	1.00
91_T	140_G	0.687	1.00
22_D	30_S	0.685	1.00
117_T	309_G	0.679	1.00
165_L	291_D	0.678	1.00
66_R	295_K	0.676	1.00
223_A	263_K	0.673	1.00
20_N	30_S	0.670	1.00
193_R	233_L	0.669	1.00
183_T	186_N	0.668	1.00
87_A	90_S	0.666	1.00
258_E	261_C	0.665	1.00
90_S	312_G	0.665	1.00
216_R	220_K	0.663	1.00
64_K	99_F	0.663	1.00
116_L	165_L	0.661	1.00
258_E	268_I	0.658	1.00
294_V	321_I	0.655	1.00
114_A	314_L	0.651	1.00
7_T	134_K	0.651	1.00
141_E	282_S	0.649	1.00
230_F	234_L	0.649	1.00
292_L	296_A	0.648	1.00
141_E	283_S	0.648	1.00
193_R	236_K	0.647	1.00
23_L	28_D	0.647	1.00
78_L	83_T	0.643	1.00
76_M	86_Y	0.643	1.00
244_L	247_F	0.639	1.00
106_A	207_G	0.638	1.00
13_A	278_Y	0.637	1.00
79_V	140_G	0.636	1.00
289_A	307_L	0.635	1.00
288_L	292_L	0.634	1.00
23_L	30_S	0.633	1.00
184_S	188_G	0.632	1.00
124_N	236_K	0.631	1.00
217_E	220_K	0.631	1.00
234_L	320_L	0.630	1.00
281_T	285_S	0.626	1.00
92_A	106_A	0.623	1.00
77_I	81_T	0.616	1.00
19_T	25_K	0.616	1.00
11_T	288_L	0.613	1.00
142_T	145_K	0.612	1.00
9_I	295_K	0.611	1.00
145_K	149_Y	0.610	1.00
220_K	224_R	0.607	1.00
78_L	122_L	0.606	1.00
54_D	58_E	0.606	1.00
81_T	108_D	0.604	1.00
42_E	46_A	0.603	1.00
251_S	257_I	0.602	1.00
74_V	134_K	0.600	1.00
105_G	132_H	0.599	1.00
13_A	291_D	0.598	1.00
12_Y	59_A	0.597	1.00
43_R	46_A	0.593	1.00
18_L	26_I	0.589	1.00
5_K	190_I	0.588	1.00
101_W	136_L	0.588	1.00
156_V	282_S	0.588	1.00
215_G	218_V	0.587	1.00
163_G	288_L	0.586	1.00
23_L	31_D	0.585	1.00
244_L	306_L	0.585	1.00
242_D	270_K	0.584	1.00
239_L	301_K	0.584	1.00
11_T	20_N	0.583	1.00
182_G	185_G	0.582	1.00
56_C	60_V	0.582	1.00
22_D	292_L	0.581	1.00
223_A	227_P	0.580	1.00
185_G	188_G	0.577	1.00
274_S	289_A	0.577	1.00
254_L	273_T	0.573	1.00
20_N	26_I	0.571	1.00
117_T	286_I	0.571	1.00
258_E	262_E	0.569	1.00
192_Y	195_G	0.567	1.00
26_I	30_S	0.565	1.00
82_T	86_Y	0.564	1.00
16_R	22_D	0.564	1.00
52_T	91_T	0.563	1.00
247_F	306_L	0.561	1.00
77_I	96_Q	0.561	1.00
116_L	139_A	0.560	1.00
78_L	84_S	0.560	1.00
265_P	269_E	0.560	1.00
94_R	98_Y	0.556	1.00
19_T	31_D	0.555	1.00
230_F	305_V	0.554	1.00
206_V	232_R	0.552	1.00
215_G	219_Y	0.551	1.00
64_K	74_V	0.550	1.00
206_V	229_E	0.550	1.00
214_N	218_V	0.549	1.00
19_T	29_T	0.548	1.00
126_L	129_S	0.548	1.00
195_G	232_R	0.548	1.00
53_S	90_S	0.547	1.00
9_I	19_T	0.541	1.00
256_M	260_I	0.541	1.00
251_S	273_T	0.540	1.00
24_E	29_T	0.538	1.00
259_S	262_E	0.538	1.00
188_G	192_Y	0.538	1.00
114_A	308_F	0.536	1.00
265_P	270_K	0.536	1.00
265_P	272_L	0.535	1.00
193_R	237_A	0.532	1.00
64_K	166_L	0.531	1.00
102_E	224_R	0.528	1.00
170_D	187_G	0.527	1.00
53_S	98_Y	0.526	1.00
191_L	194_A	0.525	1.00
139_A	284_V	0.525	1.00
18_L	23_L	0.524	1.00
255_R	259_S	0.524	1.00
84_S	88_F	0.523	1.00
22_D	29_T	0.522	1.00
47_D	50_Q	0.522	1.00
78_L	109_I	0.521	1.00
5_K	173_T	0.516	1.00
79_V	92_A	0.513	1.00
257_I	260_I	0.512	1.00
77_I	101_W	0.511	1.00
169_R	174_P	0.511	1.00
246_W	303_Q	0.508	1.00
115_G	119_G	0.508	1.00
8_A	63_L	0.508	1.00
69_G	73_D	0.508	1.00
248_V	292_L	0.505	1.00
40_M	44_R	0.501	1.00
60_V	64_K	0.500	1.00
187_G	191_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rybA	2	0.9754	100	0.212	Contact Map
3gwaA	2	0.9908	100	0.219	Contact Map
1ub7A	2	0.9846	100	0.22	Contact Map
4x9kA	2	0.9908	100	0.225	Contact Map
1zowA	2	0.96	100	0.226	Contact Map
1hnjA	2	0.9754	100	0.227	Contact Map
1mzjA	2	0.9908	100	0.227	Contact Map
2x3eA	2	0.9785	100	0.231	Contact Map
3il6A	2	0.9723	100	0.232	Contact Map
3il3A	2	0.9692	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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