GREMLIN Database
YHFA - Uncharacterized membrane protein YhfA
UniProt: O07599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (456)
Sequences: 276 (191)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_T387_A5.3531.00
80_M280_I4.7490.99
244_L287_F3.6960.97
42_S333_L3.5840.96
16_F37_G3.5600.96
42_S55_S3.5520.96
395_S402_P3.4020.95
286_F293_G3.2730.94
181_I402_P3.0860.92
426_L441_A3.0570.91
197_M455_T2.9430.89
152_A205_A2.8980.89
148_A209_I2.8870.88
65_G166_F2.7070.85
120_L164_G2.6840.84
122_F317_P2.6600.84
154_N158_H2.6430.83
34_S75_C2.5920.82
12_L43_L2.5390.81
204_A450_I2.5290.81
14_V78_V2.5060.80
195_L199_V2.4880.79
9_V41_I2.4130.77
11_V27_R2.3510.75
136_L433_C2.3330.75
305_F314_P2.2440.72
214_K283_T2.1860.70
110_L114_L2.0970.66
189_A403_A2.0730.65
254_A279_C2.0480.64
428_P433_C2.0450.64
39_F278_I2.0320.64
21_I332_I2.0270.63
101_V138_A2.0260.63
146_P211_R2.0240.63
151_M421_L2.0060.63
20_I32_F1.9690.61
25_L301_F1.9640.61
132_G302_I1.9420.60
246_F453_L1.9380.60
46_S250_L1.9070.58
197_M201_T1.8940.58
12_L373_I1.8320.55
101_V461_M1.8070.54
164_G194_V1.7930.54
382_S414_I1.7900.53
28_K256_I1.7830.53
93_M211_R1.7800.53
381_F409_G1.7750.53
42_S170_A1.7720.53
22_L453_L1.7650.52
69_P170_A1.7640.52
78_V434_K1.7630.52
39_F43_L1.7560.52
16_F75_C1.7480.52
208_M446_I1.7410.51
169_Q444_N1.7400.51
181_I263_N1.7320.51
35_L76_F1.7320.51
30_T356_M1.7310.51
73_I436_D1.7290.51
426_L435_V1.7280.51
147_L151_M1.7110.50
131_I174_L1.7090.50
249_P315_V1.6980.49
282_F299_G1.6880.49
112_G156_F1.6860.49
27_R151_M1.6780.49
120_L146_P1.6680.48
40_I365_T1.6500.47
199_V203_T1.6480.47
359_S450_I1.6310.47
29_D320_A1.6300.47
22_L26_L1.6280.46
240_L421_L1.6150.46
384_I406_T1.6130.46
452_L456_T1.6050.45
93_M249_P1.6000.45
70_T345_V1.5960.45
260_L273_I1.5880.45
42_S69_P1.5760.44
21_I326_D1.5640.44
243_I283_T1.5610.44
73_I91_E1.5310.42
259_M374_T1.5220.42
180_G407_A1.5080.41
53_V331_S1.4850.40
17_I167_V1.4730.40
67_L317_P1.4710.40
154_N437_P1.4700.40
201_T455_T1.4620.39
211_R398_L1.4620.39
67_L135_L1.4520.39
141_R426_L1.4450.39
225_V364_A1.4380.38
303_D310_K1.4370.38
93_M435_V1.4240.38
75_C308_G1.4240.38
103_G142_A1.4190.38
297_I441_A1.4150.37
115_M129_A1.4050.37
33_I89_I1.4010.37
101_V111_I1.3990.37
43_L52_S1.3960.37
309_F313_G1.3800.36
102_R273_I1.3720.36
134_V197_M1.3660.35
92_A241_R1.3530.35
5_G27_R1.3430.35
90_N111_I1.3410.35
77_I428_P1.3410.35
105_V206_F1.3380.34
204_A208_M1.3380.34
47_H359_S1.3370.34
250_L300_Y1.3360.34
125_S394_F1.3330.34
21_I47_H1.3320.34
67_L319_A1.3300.34
115_M154_N1.3260.34
23_F33_I1.3230.34
12_L44_W1.3150.34
135_L319_A1.3120.33
18_G254_A1.3090.33
156_F423_P1.3010.33
243_I247_L1.2930.33
86_K421_L1.2910.33
295_E362_L1.2880.32
99_S243_I1.2870.32
156_F312_F1.2870.32
214_K254_A1.2860.32
92_A138_A1.2830.32
259_M311_V1.2790.32
48_S100_L1.2790.32
11_V135_L1.2790.32
64_A72_F1.2770.32
97_F140_A1.2720.32
177_D248_I1.2690.32
20_I441_A1.2660.32
90_N323_Y1.2570.31
394_F455_T1.2560.31
65_G331_S1.2540.31
27_R300_Y1.2510.31
47_H166_F1.2500.31
57_F63_A1.2500.31
221_S224_P1.2450.31
70_T384_I1.2450.31
145_T422_V1.2380.31
341_S455_T1.2380.31
248_I265_Q1.2340.30
41_I311_V1.2290.30
77_I305_F1.2270.30
12_L258_C1.2130.30
425_A428_P1.2130.30
301_F310_K1.2050.29
322_F409_G1.2050.29
78_V324_L1.2040.29
156_F168_I1.2020.29
99_S226_L1.2020.29
248_I376_L1.1980.29
204_A331_S1.1960.29
35_L43_L1.1900.29
99_S253_L1.1890.29
134_V421_L1.1870.29
80_M142_A1.1830.29
42_S52_S1.1790.28
250_L303_D1.1780.28
293_G297_I1.1760.28
113_G246_F1.1740.28
256_I334_G1.1730.28
174_L367_L1.1680.28
200_T454_V1.1640.28
115_M431_A1.1620.28
33_I191_I1.1590.28
345_V406_T1.1560.28
80_M310_K1.1560.28
33_I422_V1.1540.28
17_I134_V1.1540.28
84_L271_A1.1530.28
253_L257_A1.1510.27
79_S305_F1.1440.27
116_F160_F1.1430.27
17_I269_A1.1380.27
77_I80_M1.1370.27
31_T384_I1.1360.27
99_S196_I1.1350.27
27_R134_V1.1350.27
187_V260_L1.1340.27
260_L330_E1.1310.27
174_L206_F1.1300.27
134_V297_I1.1270.27
21_I359_S1.1270.27
115_M158_H1.1250.27
32_F224_P1.1210.26
73_I326_D1.1150.26
441_A445_F1.1150.26
90_N385_S1.1050.26
24_M422_V1.1050.26
78_V314_P1.1040.26
110_L140_A1.1040.26
7_L208_M1.1010.26
63_A198_G1.0980.26
45_A344_I1.0950.26
248_I281_L1.0900.25
11_V138_A1.0870.25
218_H303_D1.0860.25
322_F381_F1.0860.25
167_V198_G1.0850.25
43_L47_H1.0810.25
246_F254_A1.0780.25
22_L211_R1.0740.25
22_L56_L1.0660.25
64_A68_L1.0650.25
34_S76_F1.0630.25
269_A343_G1.0610.24
220_T434_K1.0530.24
76_F281_L1.0500.24
151_M443_K1.0480.24
129_A425_A1.0470.24
28_K291_H1.0440.24
136_L264_L1.0390.24
242_S301_F1.0350.24
7_L449_A1.0320.24
357_P371_G1.0320.24
446_I450_I1.0310.24
199_V261_L1.0310.24
71_I312_F1.0290.23
366_A455_T1.0290.23
75_C89_I1.0270.23
122_F319_A1.0270.23
22_L458_A1.0270.23
196_I458_A1.0250.23
170_A300_Y1.0240.23
35_L84_L1.0210.23
72_F317_P1.0210.23
27_R31_T1.0170.23
309_F317_P1.0160.23
116_F120_L1.0150.23
104_P300_Y1.0140.23
197_M394_F1.0110.23
282_F429_A1.0070.23
89_I202_T1.0050.23
215_K254_A1.0040.23
20_I291_H1.0030.23
148_A443_K1.0030.23
169_Q324_L1.0010.23
194_V198_G1.0000.23
7_L39_F1.0000.23
40_I332_I0.9990.23
44_W285_H0.9980.23
248_I390_I0.9970.22
77_I280_I0.9960.22
125_S158_H0.9930.22
103_G462_M0.9910.22
129_A158_H0.9820.22
374_T389_S0.9790.22
257_A458_A0.9790.22
25_L149_A0.9790.22
71_I154_N0.9790.22
112_G312_F0.9780.22
265_Q269_A0.9780.22
252_F272_L0.9710.22
100_L330_E0.9670.22
211_R450_I0.9640.22
73_I363_A0.9620.21
199_V457_L0.9600.21
280_I305_F0.9580.21
69_P287_F0.9510.21
428_P431_A0.9490.21
100_L286_F0.9490.21
196_I462_M0.9470.21
122_F456_T0.9410.21
33_I73_I0.9390.21
167_V330_E0.9380.21
81_S431_A0.9380.21
70_T406_T0.9370.21
249_P333_L0.9340.21
55_S170_A0.9340.21
153_M428_P0.9320.21
252_F277_A0.9320.21
39_F377_D0.9310.21
286_F457_L0.9280.20
250_L279_C0.9260.20
269_A353_S0.9240.20
257_A422_V0.9240.20
12_L331_S0.9240.20
78_V107_A0.9210.20
328_G361_E0.9190.20
344_I373_I0.9180.20
51_A196_I0.9170.20
297_I462_M0.9170.20
353_S432_I0.9150.20
233_S243_I0.9120.20
7_L355_M0.9120.20
142_A184_G0.9050.20
45_A100_L0.9040.20
36_F113_G0.9010.20
132_G136_L0.9010.20
302_I313_G0.9010.20
173_K356_M0.8990.20
108_Y286_F0.8980.20
129_A312_F0.8960.20
66_E84_L0.8900.19
173_K177_D0.8870.19
361_E427_I0.8860.19
434_K444_N0.8830.19
269_A344_I0.8830.19
58_H268_D0.8820.19
372_A416_V0.8820.19
168_I422_V0.8810.19
330_E341_S0.8780.19
9_V18_G0.8780.19
70_T326_D0.8770.19
261_L365_T0.8760.19
42_S328_G0.8720.19
166_F462_M0.8710.19
135_L138_A0.8710.19
77_I422_V0.8680.19
265_Q368_T0.8680.19
313_G317_P0.8680.19
381_F414_I0.8670.19
423_P428_P0.8660.19
8_P11_V0.8650.19
57_F167_V0.8650.19
199_V207_I0.8620.19
164_G262_F0.8610.19
19_A282_F0.8600.19
354_H446_I0.8590.19
18_G287_F0.8580.19
252_F416_V0.8580.19
190_S194_V0.8510.18
256_I449_A0.8500.18
46_S252_F0.8500.18
14_V268_D0.8500.18
93_M146_P0.8470.18
35_L232_N0.8460.18
83_L330_E0.8420.18
41_I305_F0.8410.18
248_I280_I0.8400.18
243_I299_G0.8400.18
27_R442_R0.8380.18
373_I456_T0.8370.18
21_I265_Q0.8370.18
50_S108_Y0.8360.18
6_I292_K0.8310.18
28_K295_E0.8270.18
125_S201_T0.8260.18
382_S408_L0.8260.18
251_A278_I0.8250.18
82_D85_T0.8240.18
26_L41_I0.8210.18
115_M312_F0.8210.18
145_T213_R0.8190.18
199_V228_G0.8170.18
149_A152_A0.8160.17
142_A315_V0.8160.17
79_S333_L0.8140.17
155_L359_S0.8120.17
102_R279_C0.8120.17
125_S154_N0.8110.17
18_G117_A0.8110.17
281_L298_T0.8060.17
409_G414_I0.8060.17
18_G228_G0.8050.17
26_L52_S0.8050.17
153_M315_V0.8040.17
16_F29_D0.8000.17
40_I271_A0.8000.17
102_R457_L0.7990.17
26_L253_L0.7990.17
25_L134_V0.7990.17
445_F449_A0.7990.17
13_Y309_F0.7980.17
202_T315_V0.7960.17
15_F217_E0.7950.17
189_A192_P0.7950.17
208_M450_I0.7940.17
128_V186_V0.7920.17
31_T89_I0.7910.17
53_V361_E0.7910.17
131_I421_L0.7910.17
49_L369_A0.7890.17
252_F297_I0.7860.17
13_Y128_V0.7860.17
309_F415_W0.7850.17
198_G367_L0.7840.17
80_M92_A0.7830.17
78_V141_R0.7800.17
156_F192_P0.7800.17
68_L194_V0.7790.17
49_L103_G0.7770.17
158_H311_V0.7750.16
80_M250_L0.7740.16
329_Y376_L0.7740.16
79_S301_F0.7730.16
257_A400_A0.7710.16
201_T431_A0.7690.16
315_V348_L0.7670.16
246_F283_T0.7670.16
23_F249_P0.7670.16
129_A154_N0.7660.16
125_S455_T0.7620.16
266_G271_A0.7610.16
89_I425_A0.7610.16
447_P451_G0.7600.16
122_F313_G0.7590.16
18_G147_L0.7590.16
92_A131_I0.7560.16
313_G437_P0.7560.16
379_S409_G0.7550.16
182_P203_T0.7520.16
420_T448_V0.7500.16
260_L402_P0.7460.16
64_A328_G0.7450.16
42_S95_S0.7450.16
298_T455_T0.7440.16
28_K462_M0.7440.16
63_A244_L0.7430.16
145_T212_E0.7420.16
79_S390_I0.7380.16
30_T429_A0.7380.16
32_F291_H0.7340.16
103_G344_I0.7340.16
200_T443_K0.7330.16
173_K269_A0.7310.15
160_F202_T0.7300.15
35_L94_I0.7300.15
113_G254_A0.7300.15
207_I285_H0.7270.15
374_T413_A0.7260.15
132_G169_Q0.7260.15
224_P243_I0.7230.15
361_E460_V0.7220.15
67_L72_F0.7220.15
212_E443_K0.7220.15
8_P421_L0.7210.15
374_T383_G0.7210.15
56_L107_A0.7200.15
155_L343_G0.7180.15
14_V75_C0.7160.15
340_G460_V0.7160.15
56_L167_V0.7140.15
374_T377_D0.7140.15
89_I345_V0.7130.15
155_L210_Q0.7130.15
430_A448_V0.7120.15
134_V332_I0.7110.15
78_V155_L0.7100.15
176_A247_L0.7090.15
258_C262_F0.7060.15
55_S98_A0.7040.15
377_D413_A0.7040.15
210_Q453_L0.7030.15
426_L459_A0.7030.15
22_L221_S0.7020.15
393_L429_A0.7010.15
375_G419_G0.7000.15
6_I184_G0.6990.15
169_Q314_P0.6990.15
5_G233_S0.6970.15
230_Q296_K0.6880.15
46_S461_M0.6880.15
414_I422_V0.6860.14
299_G402_P0.6850.14
31_T300_Y0.6850.14
53_V391_A0.6840.14
266_G318_I0.6830.14
363_A398_L0.6800.14
333_L345_V0.6790.14
394_F428_P0.6790.14
453_L461_M0.6780.14
99_S363_A0.6780.14
113_G235_Y0.6780.14
20_I348_L0.6770.14
41_I210_Q0.6770.14
278_I369_A0.6760.14
15_F141_R0.6750.14
149_A187_V0.6750.14
225_V285_H0.6750.14
41_I87_T0.6740.14
103_G218_H0.6740.14
36_F340_G0.6730.14
270_T312_F0.6730.14
379_S386_L0.6730.14
117_A147_L0.6730.14
437_P444_N0.6720.14
82_D262_F0.6720.14
266_G307_F0.6710.14
36_F238_K0.6700.14
317_P456_T0.6680.14
70_T116_F0.6660.14
348_L351_A0.6660.14
199_V215_K0.6620.14
110_L147_L0.6620.14
6_I298_T0.6610.14
158_H425_A0.6600.14
41_I55_S0.6560.14
57_F198_G0.6510.14
20_I173_K0.6500.14
14_V225_V0.6500.14
141_R258_C0.6490.14
359_S457_L0.6480.14
52_S170_A0.6460.14
83_L285_H0.6440.14
118_I149_A0.6400.14
168_I180_G0.6400.14
170_A312_F0.6390.13
375_G383_G0.6380.13
419_G447_P0.6380.13
446_I453_L0.6370.13
84_L305_F0.6360.13
283_T364_A0.6350.13
141_R254_A0.6350.13
32_F221_S0.6350.13
117_A233_S0.6340.13
102_R462_M0.6320.13
38_I175_T0.6280.13
300_Y362_L0.6270.13
129_A156_F0.6250.13
457_L462_M0.6250.13
403_A427_I0.6240.13
109_W202_T0.6240.13
393_L427_I0.6230.13
331_S335_T0.6200.13
49_L95_S0.6200.13
102_R233_S0.6190.13
36_F215_K0.6180.13
419_G448_V0.6170.13
79_S411_I0.6150.13
94_I141_R0.6150.13
73_I425_A0.6090.13
147_L209_I0.6060.13
101_V120_L0.6060.13
383_G451_G0.6060.13
328_G333_L0.6060.13
77_I203_T0.6060.13
49_L395_S0.6050.13
312_F423_P0.6050.13
13_Y387_A0.6050.13
215_K243_I0.6030.13
56_L244_L0.6010.13
80_M164_G0.6000.13
76_F113_G0.5990.13
147_L175_T0.5990.13
222_F369_A0.5990.13
258_C302_I0.5950.13
131_I372_A0.5950.13
109_W338_P0.5940.13
387_A413_A0.5920.13
346_N431_A0.5900.13
427_I442_R0.5880.12
448_V451_G0.5860.12
412_S452_L0.5860.12
87_T225_V0.5850.12
148_A454_V0.5850.12
229_E254_A0.5850.12
49_L99_S0.5840.12
223_S457_L0.5830.12
53_V181_I0.5820.12
69_P344_I0.5820.12
232_N254_A0.5790.12
29_D444_N0.5790.12
144_L459_A0.5790.12
329_Y404_I0.5780.12
346_N428_P0.5750.12
431_A437_P0.5730.12
210_Q434_K0.5720.12
423_P431_A0.5710.12
222_F254_A0.5710.12
309_F362_L0.5700.12
142_A251_A0.5700.12
16_F78_V0.5700.12
97_F224_P0.5700.12
89_I241_R0.5680.12
12_L332_I0.5680.12
313_G404_I0.5680.12
419_G451_G0.5670.12
90_N330_E0.5670.12
158_H312_F0.5670.12
122_F309_F0.5670.12
376_L382_S0.5660.12
215_K462_M0.5660.12
302_I309_F0.5650.12
35_L373_I0.5640.12
98_A141_R0.5640.12
14_V258_C0.5630.12
83_L359_S0.5630.12
394_F431_A0.5620.12
413_A462_M0.5620.12
280_I308_G0.5610.12
142_A412_S0.5600.12
186_V373_I0.5600.12
267_N430_A0.5590.12
78_V164_G0.5590.12
158_H377_D0.5580.12
386_L409_G0.5570.12
256_I264_L0.5570.12
252_F305_F0.5560.12
371_G376_L0.5560.12
250_L330_E0.5540.12
12_L35_L0.5540.12
91_E394_F0.5530.12
313_G452_L0.5520.12
356_M366_A0.5520.12
135_L317_P0.5520.12
28_K353_S0.5510.12
252_F256_I0.5510.12
115_M428_P0.5500.12
385_S406_T0.5490.12
86_K211_R0.5490.12
107_A449_A0.5480.12
108_Y146_P0.5470.12
201_T394_F0.5470.12
214_K264_L0.5450.12
63_A167_V0.5440.12
47_H254_A0.5430.12
271_A341_S0.5430.12
69_P333_L0.5420.12
95_S450_I0.5410.12
106_T457_L0.5410.12
132_G314_P0.5400.12
19_A76_F0.5400.12
367_L397_A0.5390.12
87_T328_G0.5380.12
73_I364_A0.5380.12
372_A453_L0.5380.12
87_T164_G0.5380.12
71_I115_M0.5370.12
424_W447_P0.5370.12
112_G433_C0.5360.12
71_I431_A0.5360.12
42_S316_I0.5350.12
421_L435_V0.5350.12
21_I241_R0.5350.12
250_L268_D0.5350.12
37_G444_N0.5340.12
341_S414_I0.5340.12
16_F20_I0.5310.11
29_D37_G0.5310.11
208_M215_K0.5300.11
23_F437_P0.5300.11
87_T389_S0.5290.11
17_I37_G0.5290.11
77_I273_I0.5290.11
80_M241_R0.5280.11
256_I391_A0.5270.11
89_I406_T0.5260.11
312_F358_M0.5240.11
103_G111_I0.5240.11
211_R273_I0.5230.11
6_I234_L0.5230.11
40_I44_W0.5230.11
142_A280_I0.5220.11
171_A275_G0.5210.11
5_G256_I0.5200.11
195_L332_I0.5190.11
50_S90_N0.5190.11
278_I370_A0.5190.11
15_F211_R0.5180.11
11_V131_I0.5180.11
198_G244_L0.5170.11
109_W112_G0.5170.11
109_W300_Y0.5150.11
5_G199_V0.5130.11
361_E391_A0.5130.11
196_I303_D0.5120.11
121_F348_L0.5110.11
31_T70_T0.5110.11
94_I290_K0.5100.11
356_M421_L0.5090.11
292_K400_A0.5090.11
256_I289_Y0.5070.11
272_L356_M0.5060.11
49_L58_H0.5060.11
97_F114_L0.5060.11
207_I244_L0.5050.11
12_L49_L0.5050.11
148_A151_M0.5040.11
303_D363_A0.5040.11
42_S136_L0.5030.11
238_K242_S0.5030.11
309_F367_L0.5030.11
411_I455_T0.5020.11
141_R434_K0.5010.11
94_I251_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8531 99.8 0.896 Contact Map
4r0cA 3 0.9179 98.8 0.942 Contact Map
4r1iA 2 0.9222 98.6 0.946 Contact Map
2kluA 1 0.1382 31.6 0.983 Contact Map
2m20A 2 0.1274 14.1 0.986 Contact Map
4j05A 3 0.4579 9.2 0.987 Contact Map
3giaA 1 0.4363 8.7 0.987 Contact Map
2ifoA 8 0.0821 8 0.987 Contact Map
3dl8E 1 0.1382 7.9 0.987 Contact Map
2kncA 1 0.1015 7.6 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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