GREMLIN Database
YHAA - Putative amidohydrolase YhaA
UniProt: O07598 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (355)
Sequences: 28793 (20695)
Seq/√Len: 1098.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_N136_V3.3941.00
196_K257_Q3.0921.00
196_K259_V2.9211.00
46_A50_E2.9001.00
27_H44_F2.8871.00
70_E134_T2.6121.00
202_G210_T2.5981.00
104_V373_D2.5811.00
194_T259_V2.5451.00
46_A58_T2.5011.00
198_F293_S2.4271.00
216_I292_A2.4221.00
276_E280_E2.3801.00
321_N388_G2.3771.00
77_T134_T2.3671.00
198_F257_Q2.3501.00
197_V220_I2.3471.00
280_E284_K2.3451.00
321_N392_T2.3021.00
317_S392_T2.2801.00
194_T261_I2.2701.00
48_Y51_S2.2581.00
123_V387_A2.2251.00
44_F48_Y2.2121.00
77_T136_V2.2011.00
246_I259_V2.1671.00
68_N134_T2.1571.00
196_K295_E2.1421.00
49_Y67_A2.1411.00
217_G245_F2.1291.00
244_S261_I2.0611.00
217_G258_A2.0601.00
79_A162_T2.0401.00
123_V127_N2.0341.00
277_K281_A2.0121.00
217_G260_L1.9961.00
194_T297_T1.9761.00
322_T388_G1.9731.00
52_L122_K1.9631.00
31_Y44_F1.9541.00
316_V320_K1.9411.00
219_Q222_S1.8901.00
39_E43_A1.8601.00
218_S221_V1.8561.00
94_D101_V1.8261.00
198_F295_E1.8181.00
20_E122_K1.7971.00
48_Y52_L1.7801.00
151_K155_D1.7651.00
220_I283_V1.7431.00
315_L389_A1.7171.00
24_I48_Y1.7071.00
54_V69_I1.6931.00
218_S222_S1.6911.00
47_S51_S1.6701.00
211_K216_I1.6651.00
40_K43_A1.6491.00
44_F47_S1.6411.00
152_P156_D1.6081.00
284_K288_S1.5851.00
43_A47_S1.5811.00
26_R30_M1.5721.00
213_A258_A1.5701.00
39_E63_R1.5611.00
200_K211_K1.5601.00
223_S282_V1.5601.00
21_M383_A1.5591.00
271_V274_I1.5571.00
122_K126_Q1.5541.00
43_A58_T1.5471.00
219_Q290_H1.5381.00
201_G256_D1.5371.00
278_E281_A1.5371.00
247_A258_A1.5201.00
314_H392_T1.5131.00
206_H209_D1.5091.00
273_D277_K1.4911.00
46_A65_V1.4901.00
27_H40_K1.4881.00
27_H30_M1.4811.00
152_P155_D1.4721.00
23_E27_H1.4691.00
42_A84_F1.4581.00
388_G391_I1.4571.00
274_I278_E1.4541.00
320_K326_Q1.4541.00
344_L349_G1.4521.00
313_N316_V1.4511.00
50_E58_T1.4511.00
27_H31_Y1.4481.00
95_V98_A1.4241.00
79_A138_I1.4171.00
45_I84_F1.4111.00
231_K278_E1.4111.00
318_T392_T1.4081.00
55_P70_E1.4071.00
388_G392_T1.3981.00
94_D98_A1.3981.00
381_T384_K1.3921.00
21_M119_A1.3911.00
19_E23_E1.3791.00
76_P163_D1.3771.00
223_S285_G1.3771.00
79_A165_I1.3761.00
47_S50_E1.3751.00
69_I125_H1.3631.00
46_A56_I1.3541.00
197_V217_G1.3471.00
48_Y122_K1.3281.00
30_M100_K1.3241.00
116_A382_A1.3211.00
72_S132_K1.3121.00
22_V26_R1.3081.00
319_A385_V1.3071.00
287_C294_Y1.3061.00
191_D272_R1.3051.00
196_K297_T1.2971.00
281_A285_G1.2911.00
23_E26_R1.2881.00
193_F262_G1.2871.00
80_L390_A1.2761.00
50_E56_I1.2731.00
236_Q268_D1.2711.00
322_T384_K1.2691.00
219_Q289_M1.2571.00
195_I260_L1.2491.00
157_G160_E1.2411.00
377_K381_T1.2381.00
184_G188_A1.2251.00
316_V331_G1.2241.00
277_K280_E1.2231.00
43_A46_A1.2181.00
380_L384_K1.2051.00
276_E298_Y1.2021.00
314_H318_T1.2001.00
80_L117_L1.1721.00
112_G374_I1.1711.00
33_E41_T1.1711.00
318_T388_G1.1651.00
24_I119_A1.1501.00
57_R68_N1.1501.00
35_S145_Y1.1501.00
20_E23_E1.1491.00
215_L225_Q1.1481.00
238_A275_L1.1471.00
283_V294_Y1.1451.00
127_N387_A1.1431.00
214_V245_F1.1341.00
125_H128_R1.1271.00
197_V216_I1.1271.00
92_E371_K1.1271.00
31_Y40_K1.1241.00
268_D271_V1.1171.00
127_N391_I1.1161.00
28_F41_T1.1151.00
214_V247_A1.1131.00
24_I44_F1.1031.00
317_S321_N1.0991.00
318_T322_T1.0971.00
281_A284_K1.0911.00
309_P313_N1.0871.00
193_F276_E1.0841.00
172_A367_H1.0791.00
282_V285_G1.0771.00
104_V375_N1.0761.00
40_K44_F1.0691.00
375_N378_A1.0641.00
26_R99_S1.0581.00
100_K376_E1.0541.00
26_R376_E1.0491.00
313_N317_S1.0481.00
121_A137_M1.0461.00
242_T262_G1.0451.00
29_H110_H1.0421.00
227_I278_E1.0421.00
27_H48_Y1.0381.00
119_A122_K1.0381.00
45_I114_T1.0361.00
30_M98_A1.0331.00
274_I277_K1.0321.00
76_P133_G1.0281.00
21_M115_A1.0271.00
29_H107_A1.0171.00
71_G134_T1.0171.00
168_T386_L1.0141.00
317_S320_K1.0131.00
112_G170_L1.0121.00
282_V286_I1.0111.00
42_A65_V1.0091.00
222_S226_H1.0061.00
180_L183_P1.0051.00
318_T321_N1.0031.00
221_V260_L1.0021.00
64_G141_H1.0011.00
20_E24_I1.0011.00
77_T163_D1.0001.00
352_F385_V0.9931.00
164_V311_E0.9891.00
69_I131_L0.9891.00
90_Q102_P0.9851.00
215_L221_V0.9821.00
246_I249_N0.9821.00
315_L350_T0.9781.00
223_S226_H0.9751.00
211_K292_A0.9731.00
387_A391_I0.9721.00
151_K342_Y0.9721.00
100_K103_G0.9681.00
250_P253_V0.9671.00
278_E282_V0.9651.00
384_K388_G0.9631.00
165_I347_V0.9581.00
383_A387_A0.9551.00
194_T251_F0.9541.00
54_V67_A0.9521.00
26_R100_K0.9451.00
112_G379_M0.9401.00
75_G133_G0.9401.00
217_G221_V0.9371.00
284_K287_C0.9371.00
78_V164_V0.9371.00
251_F261_I0.9351.00
280_E296_Y0.9341.00
103_G377_K0.9321.00
28_F44_F0.9291.00
20_E48_Y0.9241.00
224_L279_I0.9241.00
73_E132_K0.9231.00
219_Q223_S0.9221.00
56_I67_A0.9211.00
223_S286_I0.9181.00
21_M379_M0.9181.00
285_G288_S0.9151.00
195_I283_V0.9091.00
221_V242_T0.9091.00
245_F258_A0.9061.00
378_A381_T0.9061.00
320_K325_V0.9041.00
285_G289_M0.9031.00
314_H317_S0.9011.00
84_F139_H0.9001.00
52_L125_H0.8931.00
340_F349_G0.8871.00
120_V386_L0.8851.00
276_E300_Q0.8841.00
183_P313_N0.8801.00
136_V162_T0.8801.00
198_F256_D0.8761.00
314_H389_A0.8761.00
312_T350_T0.8761.00
55_P68_N0.8761.00
42_A46_A0.8581.00
36_F142_A0.8581.00
123_V384_K0.8571.00
214_V258_A0.8571.00
310_A313_N0.8571.00
66_L136_V0.8571.00
215_L218_S0.8561.00
374_I379_M0.8461.00
312_T316_V0.8441.00
195_I220_I0.8441.00
122_K125_H0.8421.00
120_V387_A0.8411.00
121_A125_H0.8401.00
356_A378_A0.8351.00
123_V383_A0.8291.00
167_G351_F0.8261.00
191_D276_E0.8201.00
49_Y118_L0.8141.00
273_D276_E0.8121.00
302_Y305_V0.8101.00
179_I183_P0.8101.00
310_A314_H0.8021.00
281_A288_S0.8001.00
24_I122_K0.8001.00
308_H311_E0.7991.00
219_Q226_H0.7991.00
189_A266_S0.7991.00
269_E273_D0.7961.00
224_L240_I0.7921.00
117_L137_M0.7911.00
232_V238_A0.7891.00
379_M383_A0.7891.00
266_S272_R0.7891.00
166_F389_A0.7881.00
318_T389_A0.7821.00
215_L226_H0.7811.00
286_I289_M0.7811.00
194_T299_E0.7811.00
41_T84_F0.7781.00
315_L352_F0.7771.00
221_V245_F0.7761.00
180_L184_G0.7721.00
300_Q303_P0.7701.00
57_R66_L0.7621.00
54_V125_H0.7611.00
351_F355_G0.7601.00
242_T260_L0.7601.00
27_H47_S0.7591.00
89_I97_Y0.7591.00
183_P309_P0.7591.00
72_S130_E0.7591.00
82_A114_T0.7551.00
160_E346_N0.7491.00
356_A374_I0.7491.00
133_G163_D0.7491.00
54_V121_A0.7491.00
69_I121_A0.7481.00
116_A383_A0.7481.00
59_N62_G0.7451.00
48_Y118_L0.7441.00
84_F114_T0.7431.00
264_A275_L0.7421.00
270_N274_I0.7421.00
24_I115_A0.7401.00
51_S122_K0.7391.00
42_A58_T0.7361.00
52_L118_L0.7331.00
42_A63_R0.7331.00
200_K369_H0.7331.00
24_I27_H0.7301.00
311_E350_T0.7301.00
326_Q329_I0.7271.00
272_R276_E0.7251.00
316_V330_D0.7231.00
96_P99_S0.7231.00
101_V104_V0.7201.00
25_R105_M0.7161.00
354_T382_A0.7151.00
99_S105_M0.7151.00
240_I264_A0.7141.00
127_N130_E0.7131.00
166_F311_E0.7111.00
150_A154_I0.7111.00
80_L120_V0.7101.00
45_I139_H0.7081.00
216_I290_H0.7071.00
211_K291_G0.7061.00
342_Y345_Q0.7051.00
123_V126_Q0.7041.00
157_G161_N0.7011.00
192_R263_T0.6991.00
120_V383_A0.6981.00
36_F145_Y0.6981.00
202_G254_I0.6971.00
322_T325_V0.6961.00
78_V390_A0.6941.00
197_V260_L0.6941.00
301_G304_A0.6931.00
75_G134_T0.6921.00
246_I261_I0.6921.00
286_I290_H0.6891.00
30_M99_S0.6881.00
93_K98_A0.6851.00
377_K380_L0.6831.00
145_Y148_G0.6791.00
220_I260_L0.6761.00
315_L385_V0.6751.00
28_F114_T0.6741.00
338_E351_F0.6741.00
181_C184_G0.6731.00
222_S225_Q0.6731.00
376_E380_L0.6711.00
319_A322_T0.6711.00
177_G330_D0.6701.00
351_F354_T0.6701.00
57_R161_N0.6701.00
26_R29_H0.6671.00
34_L88_P0.6651.00
244_S259_V0.6641.00
62_G152_P0.6631.00
22_V100_K0.6621.00
192_R251_F0.6621.00
136_V161_N0.6611.00
116_A120_V0.6591.00
107_A110_H0.6571.00
73_E134_T0.6551.00
269_E345_Q0.6531.00
92_E370_P0.6521.00
193_F279_I0.6501.00
80_L166_F0.6491.00
246_I257_Q0.6491.00
103_G375_N0.6481.00
39_E58_T0.6471.00
82_A112_G0.6461.00
298_Y301_G0.6461.00
86_A97_Y0.6441.00
34_L104_V0.6401.00
77_T133_G0.6391.00
119_A383_A0.6381.00
142_A145_Y0.6361.00
219_Q286_I0.6361.00
54_V137_M0.6351.00
25_R115_A0.6351.00
115_A119_A0.6331.00
24_I28_F0.6321.00
269_E303_P0.6321.00
65_V139_H0.6301.00
34_L37_Q0.6291.00
45_I65_V0.6281.00
40_K47_S0.6231.00
106_H109_G0.6211.00
233_N236_Q0.6201.00
171_W353_F0.6171.00
384_K387_A0.6171.00
56_I65_V0.6161.00
197_V213_A0.6161.00
195_I294_Y0.6151.00
346_N349_G0.6131.00
212_D255_A0.6121.00
219_Q225_Q0.6121.00
92_E95_V0.6121.00
22_V380_L0.6111.00
167_G340_F0.6091.00
385_V389_A0.6091.00
106_H373_D0.6061.00
308_H313_N0.6061.00
94_D99_S0.6061.00
114_T117_L0.6041.00
116_A386_L0.6041.00
168_T354_T0.6041.00
318_T385_V0.6021.00
49_Y54_V0.6021.00
179_I184_G0.6011.00
45_I118_L0.5991.00
22_V376_E0.5981.00
105_M110_H0.5971.00
354_T374_I0.5961.00
81_R138_I0.5951.00
195_I296_Y0.5941.00
124_L129_H0.5931.00
197_V292_A0.5911.00
71_G74_P0.5911.00
213_A255_A0.5901.00
116_A168_T0.5871.00
287_C292_A0.5871.00
101_V106_H0.5871.00
69_I137_M0.5861.00
53_G56_I0.5851.00
300_Q305_V0.5841.00
215_L219_Q0.5841.00
220_I282_V0.5831.00
273_D300_Q0.5811.00
272_R301_G0.5811.00
153_M158_C0.5801.00
215_L222_S0.5801.00
31_Y101_V0.5781.00
165_I349_G0.5771.00
77_T162_T0.5771.00
266_S275_L0.5761.00
193_F296_Y0.5751.00
165_I343_Y0.5751.00
138_I153_M0.5741.00
117_L168_T0.5731.00
208_H233_N0.5731.00
26_R105_M0.5721.00
220_I286_I0.5711.00
216_I286_I0.5711.00
162_T347_V0.5711.00
66_L138_I0.5681.00
144_E368_H0.5651.00
195_I262_G0.5651.00
148_G302_Y0.5651.00
306_V309_P0.5611.00
216_I219_Q0.5581.00
20_E119_A0.5581.00
229_S232_V0.5551.00
31_Y41_T0.5551.00
380_L383_A0.5541.00
248_D257_Q0.5531.00
165_I340_F0.5491.00
149_G156_D0.5491.00
24_I118_L0.5471.00
232_V236_Q0.5471.00
262_G279_I0.5451.00
114_T139_H0.5451.00
68_N77_T0.5451.00
64_G153_M0.5411.00
70_E73_E0.5401.00
35_S146_Y0.5391.00
300_Q304_A0.5361.00
356_A359_E0.5361.00
50_E55_P0.5351.00
172_A356_A0.5341.00
35_S38_E0.5321.00
32_P37_Q0.5321.00
71_G128_R0.5311.00
58_T63_R0.5311.00
119_A123_V0.5301.00
86_A108_C0.5301.00
95_V373_D0.5291.00
178_T183_P0.5271.00
322_T385_V0.5271.00
277_K284_K0.5261.00
158_C161_N0.5241.00
236_Q271_V0.5231.00
129_H391_I0.5231.00
138_I343_Y0.5231.00
213_A254_I0.5221.00
28_F115_A0.5221.00
224_L242_T0.5221.00
220_I224_L0.5201.00
118_L122_K0.5191.00
61_G156_D0.5191.00
367_H372_F0.5171.00
295_E298_Y0.5161.00
112_G116_A0.5161.00
193_F298_Y0.5151.00
70_E74_P0.5151.00
171_W367_H0.5141.00
138_I165_I0.5141.00
34_L89_I0.5141.00
114_T118_L0.5131.00
89_I92_E0.5121.00
311_E314_H0.5101.00
150_A343_Y0.5091.00
34_L97_Y0.5081.00
22_V105_M0.5081.00
192_R261_I0.5081.00
264_A279_I0.5071.00
264_A270_N0.5071.00
105_M376_E0.5061.00
204_G335_M0.5061.00
88_P250_P0.5061.00
164_V348_K0.5051.00
287_C293_S0.5051.00
52_L126_Q0.5051.00
197_V283_V0.5031.00
225_Q290_H0.5011.00
20_E51_S0.5001.00
182_R333_P0.5001.00
120_V124_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ewtA 4 0.9747 100 0.246 Contact Map
3pfoA 2 0.947 100 0.263 Contact Map
1ysjA 2 0.8965 100 0.265 Contact Map
3io1A 4 0.8788 100 0.267 Contact Map
1xmbA 1 0.9192 100 0.27 Contact Map
3rzaA 2 0.8914 100 0.312 Contact Map
2pokA 2 0.9672 100 0.318 Contact Map
3ramA 4 0.9141 100 0.318 Contact Map
3gb0A 2 0.8939 100 0.321 Contact Map
1cg2A 4 0.9394 100 0.321 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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