YHAA - BACSU - GREMLIN Contacts

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YHAA - Putative amidohydrolase YhaA

UniProt:	O07598	Sequences: MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAFIASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVPGVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLENTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGSQIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILEKEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQMGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAITYHQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	396 (355)
Sequences:	28793 (20695)
Seq/√Len:	1098.3

ECOLI - ABGA YGEY ARGE DAPE PEPT ABGB ALLC PEPD
BACSU - YHAA YTNL YXEP DAPEL YODQ FAPD AMHX YQJE PEPT PEPVL ALLC
HALSA - Q9HS25
SULSO - CBPX2 CBPX1 Q97Y12 LYSK Q97ZB7 Q97V97 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_N	136_V	3.394	1.00
196_K	257_Q	3.092	1.00
196_K	259_V	2.921	1.00
46_A	50_E	2.900	1.00
27_H	44_F	2.887	1.00
70_E	134_T	2.612	1.00
202_G	210_T	2.598	1.00
104_V	373_D	2.581	1.00
194_T	259_V	2.545	1.00
46_A	58_T	2.501	1.00
198_F	293_S	2.427	1.00
216_I	292_A	2.422	1.00
276_E	280_E	2.380	1.00
321_N	388_G	2.377	1.00
77_T	134_T	2.367	1.00
198_F	257_Q	2.350	1.00
197_V	220_I	2.347	1.00
280_E	284_K	2.345	1.00
321_N	392_T	2.302	1.00
317_S	392_T	2.280	1.00
194_T	261_I	2.270	1.00
48_Y	51_S	2.258	1.00
123_V	387_A	2.225	1.00
44_F	48_Y	2.212	1.00
77_T	136_V	2.201	1.00
246_I	259_V	2.167	1.00
68_N	134_T	2.157	1.00
196_K	295_E	2.142	1.00
49_Y	67_A	2.141	1.00
217_G	245_F	2.129	1.00
244_S	261_I	2.061	1.00
217_G	258_A	2.060	1.00
79_A	162_T	2.040	1.00
123_V	127_N	2.034	1.00
277_K	281_A	2.012	1.00
217_G	260_L	1.996	1.00
194_T	297_T	1.976	1.00
322_T	388_G	1.973	1.00
52_L	122_K	1.963	1.00
31_Y	44_F	1.954	1.00
316_V	320_K	1.941	1.00
219_Q	222_S	1.890	1.00
39_E	43_A	1.860	1.00
218_S	221_V	1.856	1.00
94_D	101_V	1.826	1.00
198_F	295_E	1.818	1.00
20_E	122_K	1.797	1.00
48_Y	52_L	1.780	1.00
151_K	155_D	1.765	1.00
220_I	283_V	1.743	1.00
315_L	389_A	1.717	1.00
24_I	48_Y	1.707	1.00
54_V	69_I	1.693	1.00
218_S	222_S	1.691	1.00
47_S	51_S	1.670	1.00
211_K	216_I	1.665	1.00
40_K	43_A	1.649	1.00
44_F	47_S	1.641	1.00
152_P	156_D	1.608	1.00
284_K	288_S	1.585	1.00
43_A	47_S	1.581	1.00
26_R	30_M	1.572	1.00
213_A	258_A	1.570	1.00
39_E	63_R	1.561	1.00
200_K	211_K	1.560	1.00
223_S	282_V	1.560	1.00
21_M	383_A	1.559	1.00
271_V	274_I	1.557	1.00
122_K	126_Q	1.554	1.00
43_A	58_T	1.547	1.00
219_Q	290_H	1.538	1.00
201_G	256_D	1.537	1.00
278_E	281_A	1.537	1.00
247_A	258_A	1.520	1.00
314_H	392_T	1.513	1.00
206_H	209_D	1.509	1.00
273_D	277_K	1.491	1.00
46_A	65_V	1.490	1.00
27_H	40_K	1.488	1.00
27_H	30_M	1.481	1.00
152_P	155_D	1.472	1.00
23_E	27_H	1.469	1.00
42_A	84_F	1.458	1.00
388_G	391_I	1.457	1.00
274_I	278_E	1.454	1.00
320_K	326_Q	1.454	1.00
344_L	349_G	1.452	1.00
313_N	316_V	1.451	1.00
50_E	58_T	1.451	1.00
27_H	31_Y	1.448	1.00
95_V	98_A	1.424	1.00
79_A	138_I	1.417	1.00
45_I	84_F	1.411	1.00
231_K	278_E	1.411	1.00
318_T	392_T	1.408	1.00
55_P	70_E	1.407	1.00
388_G	392_T	1.398	1.00
94_D	98_A	1.398	1.00
381_T	384_K	1.392	1.00
21_M	119_A	1.391	1.00
19_E	23_E	1.379	1.00
76_P	163_D	1.377	1.00
223_S	285_G	1.377	1.00
79_A	165_I	1.376	1.00
47_S	50_E	1.375	1.00
69_I	125_H	1.363	1.00
46_A	56_I	1.354	1.00
197_V	217_G	1.347	1.00
48_Y	122_K	1.328	1.00
30_M	100_K	1.324	1.00
116_A	382_A	1.321	1.00
72_S	132_K	1.312	1.00
22_V	26_R	1.308	1.00
319_A	385_V	1.307	1.00
287_C	294_Y	1.306	1.00
191_D	272_R	1.305	1.00
196_K	297_T	1.297	1.00
281_A	285_G	1.291	1.00
23_E	26_R	1.288	1.00
193_F	262_G	1.287	1.00
80_L	390_A	1.276	1.00
50_E	56_I	1.273	1.00
236_Q	268_D	1.271	1.00
322_T	384_K	1.269	1.00
219_Q	289_M	1.257	1.00
195_I	260_L	1.249	1.00
157_G	160_E	1.241	1.00
377_K	381_T	1.238	1.00
184_G	188_A	1.225	1.00
316_V	331_G	1.224	1.00
277_K	280_E	1.223	1.00
43_A	46_A	1.218	1.00
380_L	384_K	1.205	1.00
276_E	298_Y	1.202	1.00
314_H	318_T	1.200	1.00
80_L	117_L	1.172	1.00
112_G	374_I	1.171	1.00
33_E	41_T	1.171	1.00
318_T	388_G	1.165	1.00
24_I	119_A	1.150	1.00
57_R	68_N	1.150	1.00
35_S	145_Y	1.150	1.00
20_E	23_E	1.149	1.00
215_L	225_Q	1.148	1.00
238_A	275_L	1.147	1.00
283_V	294_Y	1.145	1.00
127_N	387_A	1.143	1.00
214_V	245_F	1.134	1.00
125_H	128_R	1.127	1.00
197_V	216_I	1.127	1.00
92_E	371_K	1.127	1.00
31_Y	40_K	1.124	1.00
268_D	271_V	1.117	1.00
127_N	391_I	1.116	1.00
28_F	41_T	1.115	1.00
214_V	247_A	1.113	1.00
24_I	44_F	1.103	1.00
317_S	321_N	1.099	1.00
318_T	322_T	1.097	1.00
281_A	284_K	1.091	1.00
309_P	313_N	1.087	1.00
193_F	276_E	1.084	1.00
172_A	367_H	1.079	1.00
282_V	285_G	1.077	1.00
104_V	375_N	1.076	1.00
40_K	44_F	1.069	1.00
375_N	378_A	1.064	1.00
26_R	99_S	1.058	1.00
100_K	376_E	1.054	1.00
26_R	376_E	1.049	1.00
313_N	317_S	1.048	1.00
121_A	137_M	1.046	1.00
242_T	262_G	1.045	1.00
29_H	110_H	1.042	1.00
227_I	278_E	1.042	1.00
27_H	48_Y	1.038	1.00
119_A	122_K	1.038	1.00
45_I	114_T	1.036	1.00
30_M	98_A	1.033	1.00
274_I	277_K	1.032	1.00
76_P	133_G	1.028	1.00
21_M	115_A	1.027	1.00
29_H	107_A	1.017	1.00
71_G	134_T	1.017	1.00
168_T	386_L	1.014	1.00
317_S	320_K	1.013	1.00
112_G	170_L	1.012	1.00
282_V	286_I	1.011	1.00
42_A	65_V	1.009	1.00
222_S	226_H	1.006	1.00
180_L	183_P	1.005	1.00
318_T	321_N	1.003	1.00
221_V	260_L	1.002	1.00
64_G	141_H	1.001	1.00
20_E	24_I	1.001	1.00
77_T	163_D	1.000	1.00
352_F	385_V	0.993	1.00
164_V	311_E	0.989	1.00
69_I	131_L	0.989	1.00
90_Q	102_P	0.985	1.00
215_L	221_V	0.982	1.00
246_I	249_N	0.982	1.00
315_L	350_T	0.978	1.00
223_S	226_H	0.975	1.00
211_K	292_A	0.973	1.00
387_A	391_I	0.972	1.00
151_K	342_Y	0.972	1.00
100_K	103_G	0.968	1.00
250_P	253_V	0.967	1.00
278_E	282_V	0.965	1.00
384_K	388_G	0.963	1.00
165_I	347_V	0.958	1.00
383_A	387_A	0.955	1.00
194_T	251_F	0.954	1.00
54_V	67_A	0.952	1.00
26_R	100_K	0.945	1.00
112_G	379_M	0.940	1.00
75_G	133_G	0.940	1.00
217_G	221_V	0.937	1.00
284_K	287_C	0.937	1.00
78_V	164_V	0.937	1.00
251_F	261_I	0.935	1.00
280_E	296_Y	0.934	1.00
103_G	377_K	0.932	1.00
28_F	44_F	0.929	1.00
20_E	48_Y	0.924	1.00
224_L	279_I	0.924	1.00
73_E	132_K	0.923	1.00
219_Q	223_S	0.922	1.00
56_I	67_A	0.921	1.00
223_S	286_I	0.918	1.00
21_M	379_M	0.918	1.00
285_G	288_S	0.915	1.00
195_I	283_V	0.909	1.00
221_V	242_T	0.909	1.00
245_F	258_A	0.906	1.00
378_A	381_T	0.906	1.00
320_K	325_V	0.904	1.00
285_G	289_M	0.903	1.00
314_H	317_S	0.901	1.00
84_F	139_H	0.900	1.00
52_L	125_H	0.893	1.00
340_F	349_G	0.887	1.00
120_V	386_L	0.885	1.00
276_E	300_Q	0.884	1.00
183_P	313_N	0.880	1.00
136_V	162_T	0.880	1.00
198_F	256_D	0.876	1.00
314_H	389_A	0.876	1.00
312_T	350_T	0.876	1.00
55_P	68_N	0.876	1.00
42_A	46_A	0.858	1.00
36_F	142_A	0.858	1.00
123_V	384_K	0.857	1.00
214_V	258_A	0.857	1.00
310_A	313_N	0.857	1.00
66_L	136_V	0.857	1.00
215_L	218_S	0.856	1.00
374_I	379_M	0.846	1.00
312_T	316_V	0.844	1.00
195_I	220_I	0.844	1.00
122_K	125_H	0.842	1.00
120_V	387_A	0.841	1.00
121_A	125_H	0.840	1.00
356_A	378_A	0.835	1.00
123_V	383_A	0.829	1.00
167_G	351_F	0.826	1.00
191_D	276_E	0.820	1.00
49_Y	118_L	0.814	1.00
273_D	276_E	0.812	1.00
302_Y	305_V	0.810	1.00
179_I	183_P	0.810	1.00
310_A	314_H	0.802	1.00
281_A	288_S	0.800	1.00
24_I	122_K	0.800	1.00
308_H	311_E	0.799	1.00
219_Q	226_H	0.799	1.00
189_A	266_S	0.799	1.00
269_E	273_D	0.796	1.00
224_L	240_I	0.792	1.00
117_L	137_M	0.791	1.00
232_V	238_A	0.789	1.00
379_M	383_A	0.789	1.00
266_S	272_R	0.789	1.00
166_F	389_A	0.788	1.00
318_T	389_A	0.782	1.00
215_L	226_H	0.781	1.00
286_I	289_M	0.781	1.00
194_T	299_E	0.781	1.00
41_T	84_F	0.778	1.00
315_L	352_F	0.777	1.00
221_V	245_F	0.776	1.00
180_L	184_G	0.772	1.00
300_Q	303_P	0.770	1.00
57_R	66_L	0.762	1.00
54_V	125_H	0.761	1.00
351_F	355_G	0.760	1.00
242_T	260_L	0.760	1.00
27_H	47_S	0.759	1.00
89_I	97_Y	0.759	1.00
183_P	309_P	0.759	1.00
72_S	130_E	0.759	1.00
82_A	114_T	0.755	1.00
160_E	346_N	0.749	1.00
356_A	374_I	0.749	1.00
133_G	163_D	0.749	1.00
54_V	121_A	0.749	1.00
69_I	121_A	0.748	1.00
116_A	383_A	0.748	1.00
59_N	62_G	0.745	1.00
48_Y	118_L	0.744	1.00
84_F	114_T	0.743	1.00
264_A	275_L	0.742	1.00
270_N	274_I	0.742	1.00
24_I	115_A	0.740	1.00
51_S	122_K	0.739	1.00
42_A	58_T	0.736	1.00
52_L	118_L	0.733	1.00
42_A	63_R	0.733	1.00
200_K	369_H	0.733	1.00
24_I	27_H	0.730	1.00
311_E	350_T	0.730	1.00
326_Q	329_I	0.727	1.00
272_R	276_E	0.725	1.00
316_V	330_D	0.723	1.00
96_P	99_S	0.723	1.00
101_V	104_V	0.720	1.00
25_R	105_M	0.716	1.00
354_T	382_A	0.715	1.00
99_S	105_M	0.715	1.00
240_I	264_A	0.714	1.00
127_N	130_E	0.713	1.00
166_F	311_E	0.711	1.00
150_A	154_I	0.711	1.00
80_L	120_V	0.710	1.00
45_I	139_H	0.708	1.00
216_I	290_H	0.707	1.00
211_K	291_G	0.706	1.00
342_Y	345_Q	0.705	1.00
123_V	126_Q	0.704	1.00
157_G	161_N	0.701	1.00
192_R	263_T	0.699	1.00
120_V	383_A	0.698	1.00
36_F	145_Y	0.698	1.00
202_G	254_I	0.697	1.00
322_T	325_V	0.696	1.00
78_V	390_A	0.694	1.00
197_V	260_L	0.694	1.00
301_G	304_A	0.693	1.00
75_G	134_T	0.692	1.00
246_I	261_I	0.692	1.00
286_I	290_H	0.689	1.00
30_M	99_S	0.688	1.00
93_K	98_A	0.685	1.00
377_K	380_L	0.683	1.00
145_Y	148_G	0.679	1.00
220_I	260_L	0.676	1.00
315_L	385_V	0.675	1.00
28_F	114_T	0.674	1.00
338_E	351_F	0.674	1.00
181_C	184_G	0.673	1.00
222_S	225_Q	0.673	1.00
376_E	380_L	0.671	1.00
319_A	322_T	0.671	1.00
177_G	330_D	0.670	1.00
351_F	354_T	0.670	1.00
57_R	161_N	0.670	1.00
26_R	29_H	0.667	1.00
34_L	88_P	0.665	1.00
244_S	259_V	0.664	1.00
62_G	152_P	0.663	1.00
22_V	100_K	0.662	1.00
192_R	251_F	0.662	1.00
136_V	161_N	0.661	1.00
116_A	120_V	0.659	1.00
107_A	110_H	0.657	1.00
73_E	134_T	0.655	1.00
269_E	345_Q	0.653	1.00
92_E	370_P	0.652	1.00
193_F	279_I	0.650	1.00
80_L	166_F	0.649	1.00
246_I	257_Q	0.649	1.00
103_G	375_N	0.648	1.00
39_E	58_T	0.647	1.00
82_A	112_G	0.646	1.00
298_Y	301_G	0.646	1.00
86_A	97_Y	0.644	1.00
34_L	104_V	0.640	1.00
77_T	133_G	0.639	1.00
119_A	383_A	0.638	1.00
142_A	145_Y	0.636	1.00
219_Q	286_I	0.636	1.00
54_V	137_M	0.635	1.00
25_R	115_A	0.635	1.00
115_A	119_A	0.633	1.00
24_I	28_F	0.632	1.00
269_E	303_P	0.632	1.00
65_V	139_H	0.630	1.00
34_L	37_Q	0.629	1.00
45_I	65_V	0.628	1.00
40_K	47_S	0.623	1.00
106_H	109_G	0.621	1.00
233_N	236_Q	0.620	1.00
171_W	353_F	0.617	1.00
384_K	387_A	0.617	1.00
56_I	65_V	0.616	1.00
197_V	213_A	0.616	1.00
195_I	294_Y	0.615	1.00
346_N	349_G	0.613	1.00
212_D	255_A	0.612	1.00
219_Q	225_Q	0.612	1.00
92_E	95_V	0.612	1.00
22_V	380_L	0.611	1.00
167_G	340_F	0.609	1.00
385_V	389_A	0.609	1.00
106_H	373_D	0.606	1.00
308_H	313_N	0.606	1.00
94_D	99_S	0.606	1.00
114_T	117_L	0.604	1.00
116_A	386_L	0.604	1.00
168_T	354_T	0.604	1.00
318_T	385_V	0.602	1.00
49_Y	54_V	0.602	1.00
179_I	184_G	0.601	1.00
45_I	118_L	0.599	1.00
22_V	376_E	0.598	1.00
105_M	110_H	0.597	1.00
354_T	374_I	0.596	1.00
81_R	138_I	0.595	1.00
195_I	296_Y	0.594	1.00
124_L	129_H	0.593	1.00
197_V	292_A	0.591	1.00
71_G	74_P	0.591	1.00
213_A	255_A	0.590	1.00
116_A	168_T	0.587	1.00
287_C	292_A	0.587	1.00
101_V	106_H	0.587	1.00
69_I	137_M	0.586	1.00
53_G	56_I	0.585	1.00
300_Q	305_V	0.584	1.00
215_L	219_Q	0.584	1.00
220_I	282_V	0.583	1.00
273_D	300_Q	0.581	1.00
272_R	301_G	0.581	1.00
153_M	158_C	0.580	1.00
215_L	222_S	0.580	1.00
31_Y	101_V	0.578	1.00
165_I	349_G	0.577	1.00
77_T	162_T	0.577	1.00
266_S	275_L	0.576	1.00
193_F	296_Y	0.575	1.00
165_I	343_Y	0.575	1.00
138_I	153_M	0.574	1.00
117_L	168_T	0.573	1.00
208_H	233_N	0.573	1.00
26_R	105_M	0.572	1.00
220_I	286_I	0.571	1.00
216_I	286_I	0.571	1.00
162_T	347_V	0.571	1.00
66_L	138_I	0.568	1.00
144_E	368_H	0.565	1.00
195_I	262_G	0.565	1.00
148_G	302_Y	0.565	1.00
306_V	309_P	0.561	1.00
216_I	219_Q	0.558	1.00
20_E	119_A	0.558	1.00
229_S	232_V	0.555	1.00
31_Y	41_T	0.555	1.00
380_L	383_A	0.554	1.00
248_D	257_Q	0.553	1.00
165_I	340_F	0.549	1.00
149_G	156_D	0.549	1.00
24_I	118_L	0.547	1.00
232_V	236_Q	0.547	1.00
262_G	279_I	0.545	1.00
114_T	139_H	0.545	1.00
68_N	77_T	0.545	1.00
64_G	153_M	0.541	1.00
70_E	73_E	0.540	1.00
35_S	146_Y	0.539	1.00
300_Q	304_A	0.536	1.00
356_A	359_E	0.536	1.00
50_E	55_P	0.535	1.00
172_A	356_A	0.534	1.00
35_S	38_E	0.532	1.00
32_P	37_Q	0.532	1.00
71_G	128_R	0.531	1.00
58_T	63_R	0.531	1.00
119_A	123_V	0.530	1.00
86_A	108_C	0.530	1.00
95_V	373_D	0.529	1.00
178_T	183_P	0.527	1.00
322_T	385_V	0.527	1.00
277_K	284_K	0.526	1.00
158_C	161_N	0.524	1.00
236_Q	271_V	0.523	1.00
129_H	391_I	0.523	1.00
138_I	343_Y	0.523	1.00
213_A	254_I	0.522	1.00
28_F	115_A	0.522	1.00
224_L	242_T	0.522	1.00
220_I	224_L	0.520	1.00
118_L	122_K	0.519	1.00
61_G	156_D	0.519	1.00
367_H	372_F	0.517	1.00
295_E	298_Y	0.516	1.00
112_G	116_A	0.516	1.00
193_F	298_Y	0.515	1.00
70_E	74_P	0.515	1.00
171_W	367_H	0.514	1.00
138_I	165_I	0.514	1.00
34_L	89_I	0.514	1.00
114_T	118_L	0.513	1.00
89_I	92_E	0.512	1.00
311_E	314_H	0.510	1.00
150_A	343_Y	0.509	1.00
34_L	97_Y	0.508	1.00
22_V	105_M	0.508	1.00
192_R	261_I	0.508	1.00
264_A	279_I	0.507	1.00
264_A	270_N	0.507	1.00
105_M	376_E	0.506	1.00
204_G	335_M	0.506	1.00
88_P	250_P	0.506	1.00
164_V	348_K	0.505	1.00
287_C	293_S	0.505	1.00
52_L	126_Q	0.505	1.00
197_V	283_V	0.503	1.00
225_Q	290_H	0.501	1.00
20_E	51_S	0.500	1.00
182_R	333_P	0.500	1.00
120_V	124_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ewtA	4	0.9747	100	0.246	Contact Map
3pfoA	2	0.947	100	0.263	Contact Map
1ysjA	2	0.8965	100	0.265	Contact Map
3io1A	4	0.8788	100	0.267	Contact Map
1xmbA	1	0.9192	100	0.27	Contact Map
3rzaA	2	0.8914	100	0.312	Contact Map
2pokA	2	0.9672	100	0.318	Contact Map
3ramA	4	0.9141	100	0.318	Contact Map
3gb0A	2	0.8939	100	0.321	Contact Map
1cg2A	4	0.9394	100	0.321	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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