DAAA - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DAAA - D-alanine aminotransferase

UniProt:	O07597	Sequences: MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGLREHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQYEAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYEAGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIKLDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQQAASIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (268)
Sequences:	8950 (5903)
Seq/√Len:	360.6

ECOLI - ILVE PABC
BACSU - DAAA ILVE1 ILVE2 PABC
HALSA - Q9HS64 Q9HNF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_A	249_T	4.213	1.00
189_T	220_D	3.911	1.00
190_V	212_I	3.116	1.00
222_T	228_E	3.055	1.00
49_E	66_I	3.025	1.00
52_F	66_I	3.005	1.00
29_G	146_L	2.977	1.00
189_T	218_K	2.844	1.00
201_N	206_M	2.593	1.00
9_L	79_E	2.537	1.00
173_V	223_P	2.433	1.00
269_A	273_E	2.347	1.00
191_R	222_T	2.339	1.00
215_N	270_A	2.284	1.00
75_K	79_E	2.283	1.00
65_S	68_D	2.276	1.00
46_E	206_M	2.247	1.00
59_G	160_E	2.143	1.00
71_W	75_K	2.078	1.00
235_I	247_V	2.055	1.00
209_L	219_L	2.053	1.00
131_I	161_A	2.028	1.00
177_G	180_S	2.002	1.00
30_I	54_S	1.994	1.00
215_N	266_Q	1.987	1.00
186_I	233_E	1.970	1.00
131_I	163_A	1.964	1.00
181_N	202_G	1.878	1.00
56_A	63_P	1.845	1.00
75_K	78_Q	1.839	1.00
206_M	210_G	1.813	1.00
249_T	252_G	1.804	1.00
265_K	269_A	1.804	1.00
43_G	207_N	1.790	1.00
45_R	70_E	1.790	1.00
132_T	251_D	1.770	1.00
266_Q	270_A	1.688	1.00
157_R	161_A	1.677	1.00
132_T	226_E	1.658	1.00
12_R	18_D	1.643	1.00
184_A	224_V	1.638	1.00
185_V	263_V	1.614	1.00
122_Q	126_Y	1.603	1.00
230_K	253_Q	1.592	1.00
37_Y	243_E	1.585	1.00
130_A	177_G	1.569	1.00
208_I	238_S	1.569	1.00
11_G	14_E	1.556	1.00
30_I	55_A	1.556	1.00
6_N	109_Q	1.554	1.00
72_D	110_T	1.554	1.00
194_P	223_P	1.552	1.00
183_Y	238_S	1.549	1.00
249_T	254_S	1.544	1.00
44_L	48_A	1.542	1.00
182_V	235_I	1.540	1.00
235_I	250_L	1.526	1.00
49_E	53_R	1.515	1.00
130_A	167_I	1.496	1.00
270_A	273_E	1.494	1.00
130_A	247_V	1.493	1.00
170_R	173_V	1.481	1.00
173_V	225_S	1.475	1.00
28_D	93_R	1.443	1.00
60_I	108_P	1.437	1.00
45_R	49_E	1.435	1.00
53_R	56_A	1.433	1.00
177_G	237_I	1.412	1.00
70_E	74_Q	1.410	1.00
129_A	164_F	1.407	1.00
34_I	41_L	1.403	1.00
46_E	210_G	1.402	1.00
190_V	217_I	1.401	1.00
128_V	164_F	1.388	1.00
184_A	232_A	1.372	1.00
184_A	191_R	1.360	1.00
205_R	221_E	1.357	1.00
36_V	77_V	1.351	1.00
186_I	231_Q	1.343	1.00
212_I	217_I	1.337	1.00
197_R	223_P	1.336	1.00
44_L	70_E	1.327	1.00
71_W	74_Q	1.317	1.00
43_G	46_E	1.314	1.00
76_L	112_A	1.310	1.00
129_A	248_V	1.309	1.00
210_G	214_K	1.308	1.00
266_Q	269_A	1.305	1.00
183_Y	236_F	1.299	1.00
184_A	235_I	1.286	1.00
53_R	201_N	1.281	1.00
41_L	44_L	1.279	1.00
51_F	93_R	1.270	1.00
167_I	182_V	1.264	1.00
192_T	205_R	1.258	1.00
185_V	190_V	1.255	1.00
239_S	242_A	1.234	1.00
23_G	29_G	1.220	1.00
60_I	93_R	1.217	1.00
90_Q	94_G	1.201	1.00
55_A	93_R	1.200	1.00
156_Q	160_E	1.199	1.00
234_E	261_G	1.194	1.00
46_E	49_E	1.189	1.00
54_S	143_I	1.167	1.00
225_S	228_E	1.161	1.00
191_R	220_D	1.154	1.00
170_R	198_L	1.151	1.00
72_D	112_A	1.144	1.00
41_L	73_L	1.142	1.00
217_I	263_V	1.137	1.00
74_Q	78_Q	1.128	1.00
103_E	106_L	1.124	1.00
224_V	228_E	1.124	1.00
4_L	72_D	1.123	1.00
73_L	112_A	1.106	1.00
121_E	124_Q	1.101	1.00
68_D	71_W	1.096	1.00
57_E	143_I	1.091	1.00
9_L	76_L	1.088	1.00
212_I	267_L	1.082	1.00
90_Q	93_R	1.081	1.00
154_T	168_L	1.079	1.00
30_I	51_F	1.076	1.00
183_Y	205_R	1.074	1.00
67_E	71_W	1.068	1.00
155_K	159_Y	1.065	1.00
52_F	63_P	1.065	1.00
188_G	233_E	1.049	1.00
205_R	209_L	1.046	1.00
234_E	264_T	1.044	1.00
260_P	265_K	1.040	1.00
130_A	237_I	1.039	1.00
31_Y	148_L	1.036	1.00
194_P	222_T	1.033	1.00
186_I	228_E	1.031	1.00
4_L	9_L	1.027	1.00
57_E	142_D	1.019	1.00
194_P	221_E	1.017	1.00
4_L	64_F	1.016	1.00
66_I	70_E	1.015	1.00
183_Y	209_L	1.015	1.00
76_L	114_T	1.013	1.00
48_A	70_E	1.012	1.00
195_A	205_R	0.998	1.00
157_R	160_E	0.990	1.00
172_G	227_E	0.987	1.00
191_R	224_V	0.977	1.00
193_H	224_V	0.972	1.00
237_I	247_V	0.970	1.00
167_I	229_L	0.955	1.00
92_T	111_T	0.953	1.00
174_V	182_V	0.948	1.00
186_I	191_R	0.947	1.00
52_F	56_A	0.944	1.00
134_E	157_R	0.943	1.00
268_Q	272_Q	0.940	1.00
133_D	166_A	0.940	1.00
5_V	15_A	0.937	1.00
53_R	142_D	0.936	1.00
46_E	207_N	0.935	1.00
127_G	248_V	0.929	1.00
195_A	201_N	0.924	1.00
165_E	178_T	0.918	1.00
45_R	66_I	0.911	1.00
169_L	226_E	0.906	1.00
19_L	111_T	0.898	1.00
121_E	125_A	0.890	1.00
181_N	238_S	0.890	1.00
73_L	89_I	0.889	1.00
202_G	238_S	0.888	1.00
210_G	213_E	0.882	1.00
53_R	57_E	0.880	1.00
265_K	268_Q	0.879	1.00
174_V	184_A	0.879	1.00
17_I	24_Y	0.878	1.00
5_V	111_T	0.876	1.00
185_V	234_E	0.874	1.00
49_E	52_F	0.872	1.00
212_I	219_L	0.871	1.00
59_G	156_Q	0.860	1.00
262_P	266_Q	0.854	1.00
187_N	233_E	0.853	1.00
254_S	257_S	0.851	1.00
76_L	80_N	0.850	1.00
55_A	60_I	0.850	1.00
46_E	203_I	0.849	1.00
213_E	218_K	0.848	1.00
262_P	265_K	0.848	1.00
48_A	66_I	0.844	1.00
78_Q	81_A	0.843	1.00
257_S	260_P	0.842	1.00
165_E	177_G	0.841	1.00
261_G	264_T	0.838	1.00
213_E	221_E	0.837	1.00
48_A	73_L	0.836	1.00
64_F	68_D	0.831	1.00
52_F	69_L	0.829	1.00
21_D	94_G	0.823	1.00
232_A	235_I	0.822	1.00
24_Y	92_T	0.821	1.00
165_E	180_S	0.816	1.00
14_E	18_D	0.815	1.00
188_G	218_K	0.808	1.00
135_D	157_R	0.808	1.00
191_R	228_E	0.807	1.00
16_S	19_L	0.805	1.00
36_V	41_L	0.805	1.00
55_A	91_T	0.803	1.00
48_A	52_F	0.801	1.00
68_D	72_D	0.798	1.00
8_R	16_S	0.797	1.00
25_Q	113_Y	0.788	1.00
44_L	73_L	0.787	1.00
263_V	266_Q	0.787	1.00
207_N	210_G	0.787	1.00
58_I	149_L	0.786	1.00
9_L	72_D	0.785	1.00
48_A	69_L	0.784	1.00
171_D	223_P	0.780	1.00
91_T	110_T	0.774	1.00
23_G	92_T	0.774	1.00
25_Q	88_Y	0.771	1.00
214_K	270_A	0.769	1.00
154_T	178_T	0.761	1.00
34_I	73_L	0.760	1.00
131_I	251_D	0.758	1.00
35_R	240_T	0.757	1.00
21_D	98_R	0.755	1.00
209_L	221_E	0.755	1.00
23_G	146_L	0.752	1.00
176_E	200_L	0.749	1.00
64_F	72_D	0.747	1.00
67_E	70_E	0.745	1.00
128_V	245_I	0.745	1.00
154_T	166_A	0.745	1.00
126_Y	164_F	0.737	1.00
87_V	90_Q	0.735	1.00
124_Q	268_Q	0.735	1.00
182_V	193_H	0.735	1.00
42_F	207_N	0.734	1.00
125_A	265_K	0.731	1.00
185_V	236_F	0.730	1.00
69_L	110_T	0.726	1.00
194_P	197_R	0.726	1.00
129_A	163_A	0.726	1.00
212_I	215_N	0.723	1.00
25_Q	92_T	0.723	1.00
130_A	165_E	0.723	1.00
166_A	178_T	0.722	1.00
209_L	213_E	0.718	0.99
12_R	20_E	0.716	0.99
37_Y	42_F	0.716	0.99
230_K	251_D	0.711	0.99
15_A	19_L	0.710	0.99
58_I	145_S	0.709	0.99
22_R	28_D	0.709	0.99
183_Y	192_T	0.707	0.99
211_L	215_N	0.706	0.99
15_A	111_T	0.703	0.99
90_Q	146_L	0.699	0.99
256_G	260_P	0.698	0.99
190_V	236_F	0.695	0.99
80_N	114_T	0.690	0.99
261_G	265_K	0.689	0.99
9_L	75_K	0.689	0.99
227_E	231_Q	0.688	0.99
169_L	174_V	0.688	0.99
33_V	241_T	0.685	0.99
133_D	157_R	0.682	0.99
72_D	75_K	0.681	0.99
88_Y	91_T	0.678	0.99
28_D	152_V	0.678	0.99
35_R	243_E	0.677	0.99
27_G	147_N	0.677	0.99
30_I	93_R	0.676	0.99
207_N	211_L	0.673	0.99
253_Q	256_G	0.673	0.99
242_A	245_I	0.672	0.99
32_E	54_S	0.670	0.99
156_Q	159_Y	0.668	0.99
123_E	164_F	0.662	0.99
24_Y	111_T	0.662	0.99
155_K	165_E	0.660	0.99
5_V	10_I	0.659	0.99
227_E	230_K	0.659	0.99
172_G	226_E	0.658	0.99
33_V	239_S	0.656	0.99
124_Q	127_G	0.652	0.99
34_I	89_I	0.652	0.99
158_A	162_G	0.650	0.99
229_L	250_L	0.649	0.99
192_T	221_E	0.647	0.99
174_V	224_V	0.643	0.99
100_H	151_N	0.642	0.99
88_Y	94_G	0.642	0.99
208_I	267_L	0.642	0.99
96_A	109_Q	0.641	0.99
136_L	139_L	0.637	0.99
180_S	237_I	0.635	0.99
145_S	149_L	0.633	0.99
229_L	235_I	0.633	0.99
144_K	200_L	0.630	0.99
95_V	109_Q	0.625	0.99
214_K	274_S	0.624	0.99
211_L	270_A	0.613	0.98
243_E	272_Q	0.612	0.98
270_A	274_S	0.611	0.98
10_I	13_S	0.611	0.98
155_K	179_S	0.610	0.98
148_L	151_N	0.610	0.98
186_I	232_A	0.608	0.98
167_I	235_I	0.607	0.98
132_T	169_L	0.599	0.98
133_D	154_T	0.598	0.98
213_E	219_L	0.597	0.98
49_E	206_M	0.597	0.98
101_Q	159_Y	0.597	0.98
243_E	271_F	0.594	0.98
235_I	255_I	0.592	0.98
17_I	21_D	0.591	0.98
30_I	58_I	0.590	0.98
52_F	65_S	0.589	0.98
128_V	237_I	0.587	0.98
184_A	229_L	0.587	0.98
175_T	199_I	0.585	0.98
228_E	231_Q	0.581	0.98
43_G	203_I	0.579	0.98
41_L	74_Q	0.579	0.98
203_I	206_M	0.578	0.98
186_I	189_T	0.577	0.98
244_I	267_L	0.576	0.98
56_A	61_S	0.574	0.98
144_K	176_E	0.574	0.98
161_A	252_G	0.573	0.97
126_Y	259_K	0.566	0.97
207_N	271_F	0.564	0.97
92_T	146_L	0.564	0.97
154_T	157_R	0.563	0.97
29_G	92_T	0.559	0.97
25_Q	90_Q	0.558	0.97
123_E	126_Y	0.558	0.97
139_L	198_L	0.558	0.97
196_N	223_P	0.555	0.97
89_I	112_A	0.554	0.97
226_E	230_K	0.554	0.97
248_V	260_P	0.553	0.97
34_I	44_L	0.552	0.97
183_Y	190_V	0.550	0.97
203_I	207_N	0.550	0.97
44_L	74_Q	0.549	0.97
127_G	245_I	0.548	0.97
64_F	110_T	0.548	0.97
42_F	240_T	0.546	0.97
195_A	221_E	0.541	0.96
248_V	255_I	0.541	0.96
188_G	217_I	0.538	0.96
190_V	263_V	0.536	0.96
85_G	114_T	0.535	0.96
89_I	114_T	0.534	0.96
208_I	244_I	0.534	0.96
76_L	79_E	0.531	0.96
24_Y	94_G	0.529	0.96
36_V	114_T	0.529	0.96
204_T	271_F	0.527	0.96
26_F	147_N	0.527	0.96
86_A	115_F	0.527	0.96
181_N	201_N	0.527	0.96
73_L	76_L	0.526	0.96
148_L	200_L	0.525	0.96
10_I	15_A	0.525	0.96
5_V	16_S	0.524	0.96
192_T	195_A	0.524	0.96
61_S	107_E	0.523	0.96
256_G	261_G	0.523	0.96
224_V	232_A	0.522	0.96
169_L	175_T	0.519	0.96
34_I	48_A	0.519	0.96
32_E	51_F	0.517	0.95
30_I	145_S	0.515	0.95
173_V	197_R	0.515	0.95
20_E	25_Q	0.515	0.95
12_R	80_N	0.513	0.95
94_G	109_Q	0.513	0.95
94_G	111_T	0.513	0.95
211_L	214_K	0.512	0.95
36_V	87_V	0.511	0.95
131_I	157_R	0.510	0.95
36_V	89_I	0.510	0.95
158_A	166_A	0.509	0.95
38_K	84_E	0.509	0.95
35_R	117_V	0.508	0.95
184_A	222_T	0.508	0.95
18_D	95_V	0.508	0.95
30_I	143_I	0.508	0.95
142_D	197_R	0.507	0.95
103_E	159_Y	0.504	0.95
244_I	264_T	0.504	0.95
50_R	200_L	0.504	0.95
31_Y	144_K	0.502	0.95
130_A	250_L	0.501	0.95
22_R	103_E	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4tm5A	2	0.9929	100	0.121	Contact Map
3daaA	2	0.9787	100	0.121	Contact Map
1iyeA	5	1	100	0.131	Contact Map
2eiyA	5	0.9965	100	0.14	Contact Map
3u0gA	5	0.9929	100	0.144	Contact Map
4chiA	2	0.9894	100	0.158	Contact Map
3dtgA	2	0.9965	100	0.168	Contact Map
4cmfA	4	0.9929	100	0.17	Contact Map
2y4rA	2	0.9397	100	0.18	Contact Map
3uzoA	2	0.9929	100	0.183	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.