GREMLIN Database
DAAA - D-alanine aminotransferase
UniProt: O07597 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (268)
Sequences: 8950 (5903)
Seq/√Len: 360.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A249_T4.2131.00
189_T220_D3.9111.00
190_V212_I3.1161.00
222_T228_E3.0551.00
49_E66_I3.0251.00
52_F66_I3.0051.00
29_G146_L2.9771.00
189_T218_K2.8441.00
201_N206_M2.5931.00
9_L79_E2.5371.00
173_V223_P2.4331.00
269_A273_E2.3471.00
191_R222_T2.3391.00
215_N270_A2.2841.00
75_K79_E2.2831.00
65_S68_D2.2761.00
46_E206_M2.2471.00
59_G160_E2.1431.00
71_W75_K2.0781.00
235_I247_V2.0551.00
209_L219_L2.0531.00
131_I161_A2.0281.00
177_G180_S2.0021.00
30_I54_S1.9941.00
215_N266_Q1.9871.00
186_I233_E1.9701.00
131_I163_A1.9641.00
181_N202_G1.8781.00
56_A63_P1.8451.00
75_K78_Q1.8391.00
206_M210_G1.8131.00
249_T252_G1.8041.00
265_K269_A1.8041.00
43_G207_N1.7901.00
45_R70_E1.7901.00
132_T251_D1.7701.00
266_Q270_A1.6881.00
157_R161_A1.6771.00
132_T226_E1.6581.00
12_R18_D1.6431.00
184_A224_V1.6381.00
185_V263_V1.6141.00
122_Q126_Y1.6031.00
230_K253_Q1.5921.00
37_Y243_E1.5851.00
130_A177_G1.5691.00
208_I238_S1.5691.00
11_G14_E1.5561.00
30_I55_A1.5561.00
6_N109_Q1.5541.00
72_D110_T1.5541.00
194_P223_P1.5521.00
183_Y238_S1.5491.00
249_T254_S1.5441.00
44_L48_A1.5421.00
182_V235_I1.5401.00
235_I250_L1.5261.00
49_E53_R1.5151.00
130_A167_I1.4961.00
270_A273_E1.4941.00
130_A247_V1.4931.00
170_R173_V1.4811.00
173_V225_S1.4751.00
28_D93_R1.4431.00
60_I108_P1.4371.00
45_R49_E1.4351.00
53_R56_A1.4331.00
177_G237_I1.4121.00
70_E74_Q1.4101.00
129_A164_F1.4071.00
34_I41_L1.4031.00
46_E210_G1.4021.00
190_V217_I1.4011.00
128_V164_F1.3881.00
184_A232_A1.3721.00
184_A191_R1.3601.00
205_R221_E1.3571.00
36_V77_V1.3511.00
186_I231_Q1.3431.00
212_I217_I1.3371.00
197_R223_P1.3361.00
44_L70_E1.3271.00
71_W74_Q1.3171.00
43_G46_E1.3141.00
76_L112_A1.3101.00
129_A248_V1.3091.00
210_G214_K1.3081.00
266_Q269_A1.3051.00
183_Y236_F1.2991.00
184_A235_I1.2861.00
53_R201_N1.2811.00
41_L44_L1.2791.00
51_F93_R1.2701.00
167_I182_V1.2641.00
192_T205_R1.2581.00
185_V190_V1.2551.00
239_S242_A1.2341.00
23_G29_G1.2201.00
60_I93_R1.2171.00
90_Q94_G1.2011.00
55_A93_R1.2001.00
156_Q160_E1.1991.00
234_E261_G1.1941.00
46_E49_E1.1891.00
54_S143_I1.1671.00
225_S228_E1.1611.00
191_R220_D1.1541.00
170_R198_L1.1511.00
72_D112_A1.1441.00
41_L73_L1.1421.00
217_I263_V1.1371.00
74_Q78_Q1.1281.00
103_E106_L1.1241.00
224_V228_E1.1241.00
4_L72_D1.1231.00
73_L112_A1.1061.00
121_E124_Q1.1011.00
68_D71_W1.0961.00
57_E143_I1.0911.00
9_L76_L1.0881.00
212_I267_L1.0821.00
90_Q93_R1.0811.00
154_T168_L1.0791.00
30_I51_F1.0761.00
183_Y205_R1.0741.00
67_E71_W1.0681.00
155_K159_Y1.0651.00
52_F63_P1.0651.00
188_G233_E1.0491.00
205_R209_L1.0461.00
234_E264_T1.0441.00
260_P265_K1.0401.00
130_A237_I1.0391.00
31_Y148_L1.0361.00
194_P222_T1.0331.00
186_I228_E1.0311.00
4_L9_L1.0271.00
57_E142_D1.0191.00
194_P221_E1.0171.00
4_L64_F1.0161.00
66_I70_E1.0151.00
183_Y209_L1.0151.00
76_L114_T1.0131.00
48_A70_E1.0121.00
195_A205_R0.9981.00
157_R160_E0.9901.00
172_G227_E0.9871.00
191_R224_V0.9771.00
193_H224_V0.9721.00
237_I247_V0.9701.00
167_I229_L0.9551.00
92_T111_T0.9531.00
174_V182_V0.9481.00
186_I191_R0.9471.00
52_F56_A0.9441.00
134_E157_R0.9431.00
268_Q272_Q0.9401.00
133_D166_A0.9401.00
5_V15_A0.9371.00
53_R142_D0.9361.00
46_E207_N0.9351.00
127_G248_V0.9291.00
195_A201_N0.9241.00
165_E178_T0.9181.00
45_R66_I0.9111.00
169_L226_E0.9061.00
19_L111_T0.8981.00
121_E125_A0.8901.00
181_N238_S0.8901.00
73_L89_I0.8891.00
202_G238_S0.8881.00
210_G213_E0.8821.00
53_R57_E0.8801.00
265_K268_Q0.8791.00
174_V184_A0.8791.00
17_I24_Y0.8781.00
5_V111_T0.8761.00
185_V234_E0.8741.00
49_E52_F0.8721.00
212_I219_L0.8711.00
59_G156_Q0.8601.00
262_P266_Q0.8541.00
187_N233_E0.8531.00
254_S257_S0.8511.00
76_L80_N0.8501.00
55_A60_I0.8501.00
46_E203_I0.8491.00
213_E218_K0.8481.00
262_P265_K0.8481.00
48_A66_I0.8441.00
78_Q81_A0.8431.00
257_S260_P0.8421.00
165_E177_G0.8411.00
261_G264_T0.8381.00
213_E221_E0.8371.00
48_A73_L0.8361.00
64_F68_D0.8311.00
52_F69_L0.8291.00
21_D94_G0.8231.00
232_A235_I0.8221.00
24_Y92_T0.8211.00
165_E180_S0.8161.00
14_E18_D0.8151.00
188_G218_K0.8081.00
135_D157_R0.8081.00
191_R228_E0.8071.00
16_S19_L0.8051.00
36_V41_L0.8051.00
55_A91_T0.8031.00
48_A52_F0.8011.00
68_D72_D0.7981.00
8_R16_S0.7971.00
25_Q113_Y0.7881.00
44_L73_L0.7871.00
263_V266_Q0.7871.00
207_N210_G0.7871.00
58_I149_L0.7861.00
9_L72_D0.7851.00
48_A69_L0.7841.00
171_D223_P0.7801.00
91_T110_T0.7741.00
23_G92_T0.7741.00
25_Q88_Y0.7711.00
214_K270_A0.7691.00
154_T178_T0.7611.00
34_I73_L0.7601.00
131_I251_D0.7581.00
35_R240_T0.7571.00
21_D98_R0.7551.00
209_L221_E0.7551.00
23_G146_L0.7521.00
176_E200_L0.7491.00
64_F72_D0.7471.00
67_E70_E0.7451.00
128_V245_I0.7451.00
154_T166_A0.7451.00
126_Y164_F0.7371.00
87_V90_Q0.7351.00
124_Q268_Q0.7351.00
182_V193_H0.7351.00
42_F207_N0.7341.00
125_A265_K0.7311.00
185_V236_F0.7301.00
69_L110_T0.7261.00
194_P197_R0.7261.00
129_A163_A0.7261.00
212_I215_N0.7231.00
25_Q92_T0.7231.00
130_A165_E0.7231.00
166_A178_T0.7221.00
209_L213_E0.7180.99
12_R20_E0.7160.99
37_Y42_F0.7160.99
230_K251_D0.7110.99
15_A19_L0.7100.99
58_I145_S0.7090.99
22_R28_D0.7090.99
183_Y192_T0.7070.99
211_L215_N0.7060.99
15_A111_T0.7030.99
90_Q146_L0.6990.99
256_G260_P0.6980.99
190_V236_F0.6950.99
80_N114_T0.6900.99
261_G265_K0.6890.99
9_L75_K0.6890.99
227_E231_Q0.6880.99
169_L174_V0.6880.99
33_V241_T0.6850.99
133_D157_R0.6820.99
72_D75_K0.6810.99
88_Y91_T0.6780.99
28_D152_V0.6780.99
35_R243_E0.6770.99
27_G147_N0.6770.99
30_I93_R0.6760.99
207_N211_L0.6730.99
253_Q256_G0.6730.99
242_A245_I0.6720.99
32_E54_S0.6700.99
156_Q159_Y0.6680.99
123_E164_F0.6620.99
24_Y111_T0.6620.99
155_K165_E0.6600.99
5_V10_I0.6590.99
227_E230_K0.6590.99
172_G226_E0.6580.99
33_V239_S0.6560.99
124_Q127_G0.6520.99
34_I89_I0.6520.99
158_A162_G0.6500.99
229_L250_L0.6490.99
192_T221_E0.6470.99
174_V224_V0.6430.99
100_H151_N0.6420.99
88_Y94_G0.6420.99
208_I267_L0.6420.99
96_A109_Q0.6410.99
136_L139_L0.6370.99
180_S237_I0.6350.99
145_S149_L0.6330.99
229_L235_I0.6330.99
144_K200_L0.6300.99
95_V109_Q0.6250.99
214_K274_S0.6240.99
211_L270_A0.6130.98
243_E272_Q0.6120.98
270_A274_S0.6110.98
10_I13_S0.6110.98
155_K179_S0.6100.98
148_L151_N0.6100.98
186_I232_A0.6080.98
167_I235_I0.6070.98
132_T169_L0.5990.98
133_D154_T0.5980.98
213_E219_L0.5970.98
49_E206_M0.5970.98
101_Q159_Y0.5970.98
243_E271_F0.5940.98
235_I255_I0.5920.98
17_I21_D0.5910.98
30_I58_I0.5900.98
52_F65_S0.5890.98
128_V237_I0.5870.98
184_A229_L0.5870.98
175_T199_I0.5850.98
228_E231_Q0.5810.98
43_G203_I0.5790.98
41_L74_Q0.5790.98
203_I206_M0.5780.98
186_I189_T0.5770.98
244_I267_L0.5760.98
56_A61_S0.5740.98
144_K176_E0.5740.98
161_A252_G0.5730.97
126_Y259_K0.5660.97
207_N271_F0.5640.97
92_T146_L0.5640.97
154_T157_R0.5630.97
29_G92_T0.5590.97
25_Q90_Q0.5580.97
123_E126_Y0.5580.97
139_L198_L0.5580.97
196_N223_P0.5550.97
89_I112_A0.5540.97
226_E230_K0.5540.97
248_V260_P0.5530.97
34_I44_L0.5520.97
183_Y190_V0.5500.97
203_I207_N0.5500.97
44_L74_Q0.5490.97
127_G245_I0.5480.97
64_F110_T0.5480.97
42_F240_T0.5460.97
195_A221_E0.5410.96
248_V255_I0.5410.96
188_G217_I0.5380.96
190_V263_V0.5360.96
85_G114_T0.5350.96
89_I114_T0.5340.96
208_I244_I0.5340.96
76_L79_E0.5310.96
24_Y94_G0.5290.96
36_V114_T0.5290.96
204_T271_F0.5270.96
26_F147_N0.5270.96
86_A115_F0.5270.96
181_N201_N0.5270.96
73_L76_L0.5260.96
148_L200_L0.5250.96
10_I15_A0.5250.96
5_V16_S0.5240.96
192_T195_A0.5240.96
61_S107_E0.5230.96
256_G261_G0.5230.96
224_V232_A0.5220.96
169_L175_T0.5190.96
34_I48_A0.5190.96
32_E51_F0.5170.95
30_I145_S0.5150.95
173_V197_R0.5150.95
20_E25_Q0.5150.95
12_R80_N0.5130.95
94_G109_Q0.5130.95
94_G111_T0.5130.95
211_L214_K0.5120.95
36_V87_V0.5110.95
131_I157_R0.5100.95
36_V89_I0.5100.95
158_A166_A0.5090.95
38_K84_E0.5090.95
35_R117_V0.5080.95
184_A222_T0.5080.95
18_D95_V0.5080.95
30_I143_I0.5080.95
142_D197_R0.5070.95
103_E159_Y0.5040.95
244_I264_T0.5040.95
50_R200_L0.5040.95
31_Y144_K0.5020.95
130_A250_L0.5010.95
22_R103_E0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tm5A 2 0.9929 100 0.121 Contact Map
3daaA 2 0.9787 100 0.121 Contact Map
1iyeA 5 1 100 0.131 Contact Map
2eiyA 5 0.9965 100 0.14 Contact Map
3u0gA 5 0.9929 100 0.144 Contact Map
4chiA 2 0.9894 100 0.158 Contact Map
3dtgA 2 0.9965 100 0.168 Contact Map
4cmfA 4 0.9929 100 0.17 Contact Map
2y4rA 2 0.9397 100 0.18 Contact Map
3uzoA 2 0.9929 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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