GREMLIN Database
YHEN - Putative polysaccharide deacetylase YheN
UniProt: O07596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (231)
Sequences: 2244 (2023)
Seq/√Len: 133.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_A261_N5.3471.00
104_D131_R4.7111.00
131_R135_E4.3191.00
107_K135_E3.9861.00
109_A264_K3.6831.00
170_Q176_K3.3001.00
117_M129_V3.2071.00
160_K164_E3.1311.00
138_A274_E3.0951.00
257_P261_N2.8981.00
227_L231_E2.5261.00
111_V260_I2.4691.00
185_G208_W2.4161.00
105_V253_V2.3851.00
166_R203_F2.3661.00
231_E262_K2.3091.00
213_M216_K2.2561.00
250_P254_N2.2511.00
102_L253_V2.1841.00
230_L259_L2.1231.00
108_S257_P2.0891.00
102_L256_L2.0481.00
262_K265_E2.0441.00
109_A257_P2.0341.00
133_E175_Y1.9801.00
117_M132_A1.9561.00
112_K137_H1.9161.00
196_R200_K1.8411.00
255_A259_L1.8371.00
148_N151_F1.8311.00
144_V164_E1.8181.00
119_S144_V1.7801.00
227_L258_V1.7791.00
101_R254_N1.7741.00
168_T172_I1.7531.00
261_N264_K1.7491.00
122_M168_T1.7261.00
100_T131_R1.7231.00
133_E173_T1.7191.00
154_T157_S1.7021.00
106_L113_A1.7001.00
88_Y271_G1.6601.00
155_P193_S1.6581.00
261_N265_E1.6251.00
130_K134_K1.6081.00
123_N168_T1.6011.00
158_P194_Q1.5931.00
163_Q167_D1.5861.00
93_D248_D1.5821.00
104_D135_E1.5741.00
87_V263_L1.5421.00
262_K266_K1.5301.00
148_N186_S1.5301.00
109_A260_I1.5261.00
148_N184_Y1.5021.00
145_T161_E1.5011.00
99_T248_D1.4971.00
151_F186_S1.4891.00
105_V256_L1.4241.00
179_L274_E1.4231.00
129_V172_I1.4151.00
105_V260_I1.4101.00
260_I270_F1.4051.00
167_D171_D1.4021.00
148_N152_Y1.3741.00
239_S242_N1.3581.00
100_T128_A1.3561.00
142_H146_H1.3341.00
122_M169_L1.3151.00
87_V244_I1.3121.00
212_S246_M1.2511.00
99_T103_L1.2491.00
122_M172_I1.2421.00
103_L137_H1.2381.00
210_I242_N1.2231.00
238_S263_L1.2201.00
144_V168_T1.2181.00
91_F256_L1.2161.00
111_V270_F1.2061.00
211_D215_W1.2011.00
85_K268_Y1.1910.99
84_D269_S1.1870.99
260_I264_K1.1870.99
256_L260_I1.1840.99
163_Q166_R1.1790.99
168_T171_D1.1630.99
95_P248_D1.1580.99
117_M139_L1.1560.99
86_T271_G1.1410.99
182_T207_D1.1380.99
86_T269_S1.1210.99
28_L31_L1.1130.99
98_V101_R1.1080.99
105_V257_P1.1080.99
93_D142_H1.1060.99
91_F102_L1.1010.99
129_V132_A1.0750.99
103_L131_R1.0660.99
112_K272_V1.0490.99
226_V255_A1.0490.99
142_H247_H1.0480.99
159_L163_Q1.0330.98
158_P197_N1.0330.98
87_V238_S1.0270.98
147_N161_E1.0260.98
132_A139_L1.0160.98
107_K131_R1.0150.98
122_M126_K1.0120.98
153_Q157_S1.0090.98
211_D216_K1.0010.98
141_L166_R0.9950.98
98_V253_V0.9890.98
32_M35_L0.9750.98
101_R105_V0.9730.98
192_A196_R0.9710.98
162_M198_L0.9610.98
105_V109_A0.9610.98
18_K23_A0.9540.97
111_V264_K0.9420.97
129_V139_L0.9350.97
32_M36_G0.9310.97
146_H247_H0.9250.97
258_V262_K0.9210.97
184_Y215_W0.9120.97
206_W273_L0.9000.96
92_D142_H0.8950.96
52_N55_L0.8930.96
139_L169_L0.8920.96
150_L153_Q0.8870.96
138_A179_L0.8840.96
227_L262_K0.8800.96
166_R176_K0.8790.96
122_M129_V0.8770.96
27_V30_L0.8770.96
99_T128_A0.8760.96
93_D118_L0.8640.95
155_P197_N0.8600.95
34_I37_Y0.8560.95
117_M122_M0.8550.95
95_P121_R0.8520.95
87_V270_F0.8400.95
251_A254_N0.8360.95
49_V57_D0.8330.94
133_E139_L0.8320.94
92_D181_R0.8270.94
208_W245_L0.8220.94
88_Y273_L0.8180.94
103_L135_E0.8160.94
192_A195_I0.8040.93
197_N200_K0.7990.93
127_Q130_K0.7980.93
123_N144_V0.7900.93
244_I263_L0.7890.93
141_L165_A0.7870.93
88_Y114_T0.7850.93
98_V250_P0.7810.92
116_F206_W0.7810.92
231_E266_K0.7780.92
144_V165_A0.7780.92
115_F137_H0.7770.92
165_A172_I0.7740.92
138_A273_L0.7730.92
165_A168_T0.7720.92
182_T205_Y0.7720.92
147_N150_L0.7710.92
30_L33_V0.7700.92
169_L177_T0.7640.92
103_L115_F0.7590.91
49_V52_N0.7540.91
211_D226_V0.7530.91
161_E165_A0.7520.91
116_F179_L0.7520.91
184_Y211_D0.7510.91
95_P99_T0.7500.91
33_V37_Y0.7480.91
24_V28_L0.7400.90
118_L143_G0.7370.90
81_N84_D0.7360.90
165_A169_L0.7250.89
118_L248_D0.7240.89
123_N126_K0.7200.89
48_T54_Q0.7200.89
219_N251_A0.7180.89
169_L173_T0.7180.89
28_L35_L0.7180.89
227_L255_A0.7170.89
143_G150_L0.7150.89
93_D184_Y0.7100.88
30_L37_Y0.7080.88
96_S249_L0.7060.88
246_M259_L0.7060.88
21_S28_L0.7050.88
95_P181_R0.7040.88
131_R134_K0.7010.88
24_V27_V0.7010.88
209_T242_N0.6990.87
43_K47_V0.6980.87
24_V37_Y0.6950.87
142_H245_L0.6930.87
193_S196_R0.6890.87
31_L34_I0.6890.87
48_T52_N0.6880.87
20_A23_A0.6870.87
163_Q201_D0.6860.86
24_V33_V0.6840.86
114_T138_A0.6830.86
26_C30_L0.6800.86
119_S168_T0.6790.86
107_K112_K0.6770.86
252_T256_L0.6760.86
230_L244_I0.6710.85
118_L121_R0.6690.85
50_T53_G0.6690.85
271_G275_D0.6670.85
90_T181_R0.6610.84
185_G207_D0.6610.84
159_L197_N0.6600.84
55_L58_E0.6590.84
105_V111_V0.6560.84
91_F106_L0.6540.84
27_V32_M0.6510.83
33_V36_G0.6500.83
146_H183_P0.6480.83
221_Q258_V0.6440.83
107_K110_D0.6420.83
45_K58_E0.6380.82
85_K267_G0.6370.82
166_R177_T0.6370.82
30_L35_L0.6370.82
210_I230_L0.6360.82
108_S265_E0.6320.82
157_S160_K0.6320.82
49_V54_Q0.6320.82
184_Y213_M0.6300.81
42_T50_T0.6270.81
228_Q236_S0.6250.81
35_L39_N0.6250.81
93_D146_H0.6240.81
112_K270_F0.6230.81
95_P118_L0.6220.81
167_D176_K0.6200.80
169_L172_I0.6200.80
188_P193_S0.6200.80
259_L262_K0.6190.80
107_K137_H0.6180.80
92_D183_P0.6180.80
194_Q198_L0.6170.80
31_L35_L0.6160.80
182_T188_P0.6150.80
267_G270_F0.6150.80
198_L202_G0.6150.80
138_A272_V0.6150.80
41_S44_A0.6140.80
172_I175_Y0.6140.80
150_L161_E0.6090.79
146_H245_L0.6080.79
142_H183_P0.6060.79
54_Q57_D0.6020.78
117_M169_L0.5990.78
159_L200_K0.5980.78
120_P143_G0.5970.78
198_L205_Y0.5970.78
227_L259_L0.5970.78
27_V33_V0.5960.78
94_G99_T0.5960.78
94_G142_H0.5950.78
99_T115_F0.5930.77
141_L162_M0.5900.77
208_W215_W0.5880.77
18_K21_S0.5870.77
106_L115_F0.5870.77
92_D247_H0.5860.77
92_D146_H0.5860.77
186_S195_I0.5850.76
48_T55_L0.5850.76
209_T239_S0.5840.76
41_S52_N0.5840.76
212_S226_V0.5830.76
94_G248_D0.5760.75
99_T181_R0.5750.75
93_D247_H0.5720.75
148_N153_Q0.5720.75
94_G245_L0.5720.75
90_T243_V0.5710.75
136_G214_D0.5680.74
35_L44_A0.5630.74
228_Q231_E0.5630.74
131_R137_H0.5610.73
29_L39_N0.5610.73
43_K55_L0.5600.73
157_S161_E0.5590.73
28_L32_M0.5530.72
143_G161_E0.5520.72
31_L36_G0.5520.72
155_P159_L0.5490.72
100_T135_E0.5490.72
103_L248_D0.5470.72
97_A125_F0.5470.72
144_V161_E0.5460.71
158_P180_V0.5460.71
32_M38_S0.5450.71
121_R249_L0.5430.71
94_G181_R0.5430.71
116_F181_R0.5420.71
45_K55_L0.5410.71
220_S251_A0.5410.71
44_A53_G0.5400.71
217_Y220_S0.5360.70
27_V56_R0.5360.70
47_V57_D0.5350.70
47_V52_N0.5340.70
188_P194_Q0.5330.70
115_F214_D0.5320.70
41_S54_Q0.5320.70
156_T160_K0.5310.69
51_T55_L0.5300.69
129_V173_T0.5290.69
47_V55_L0.5280.69
33_V40_S0.5270.69
187_K195_I0.5270.69
24_V31_L0.5250.69
103_L132_A0.5240.68
212_S252_T0.5220.68
22_L28_L0.5220.68
253_V257_P0.5210.68
23_A26_C0.5210.68
255_A263_L0.5210.68
211_D214_D0.5200.68
23_A41_S0.5190.68
52_N57_D0.5190.68
47_V50_T0.5160.67
146_H208_W0.5160.67
130_K174_G0.5160.67
23_A27_V0.5130.67
33_V47_V0.5130.67
38_S49_V0.5100.66
126_K171_D0.5100.66
50_T57_D0.5090.66
22_L36_G0.5080.66
257_P260_I0.5050.66
29_L34_I0.5050.66
143_G162_M0.5030.65
100_T104_D0.5020.65
49_V56_R0.5010.65
30_L34_I0.5010.65
110_D264_K0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w3zA 1 0.7482 100 0.267 Contact Map
4m1bA 1 0.6915 100 0.28 Contact Map
2iw0A 1 0.734 100 0.285 Contact Map
2y8uA 1 0.7234 100 0.292 Contact Map
2j13A 1 0.7234 100 0.294 Contact Map
2cc0A 2 0.6738 100 0.296 Contact Map
4l1gA 1 0.7305 100 0.304 Contact Map
1ny1A 1 0.8227 100 0.305 Contact Map
2c1iA 1 0.8333 100 0.315 Contact Map
2vyoA 1 0.6986 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.