YHEN - BACSU - GREMLIN Contacts

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YHEN - Putative polysaccharide deacetylase YheN

UniProt:	O07596	Sequences: MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKAKEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRLLDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLKEMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYRNSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDTMVPVHE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (231)
Sequences:	2244 (2023)
Seq/√Len:	133.1

BACSU - YHEN PDAC YLXY PDAA PDAB YXKH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_A	261_N	5.347	1.00
104_D	131_R	4.711	1.00
131_R	135_E	4.319	1.00
107_K	135_E	3.986	1.00
109_A	264_K	3.683	1.00
170_Q	176_K	3.300	1.00
117_M	129_V	3.207	1.00
160_K	164_E	3.131	1.00
138_A	274_E	3.095	1.00
257_P	261_N	2.898	1.00
227_L	231_E	2.526	1.00
111_V	260_I	2.469	1.00
185_G	208_W	2.416	1.00
105_V	253_V	2.385	1.00
166_R	203_F	2.366	1.00
231_E	262_K	2.309	1.00
213_M	216_K	2.256	1.00
250_P	254_N	2.251	1.00
102_L	253_V	2.184	1.00
230_L	259_L	2.123	1.00
108_S	257_P	2.089	1.00
102_L	256_L	2.048	1.00
262_K	265_E	2.044	1.00
109_A	257_P	2.034	1.00
133_E	175_Y	1.980	1.00
117_M	132_A	1.956	1.00
112_K	137_H	1.916	1.00
196_R	200_K	1.841	1.00
255_A	259_L	1.837	1.00
148_N	151_F	1.831	1.00
144_V	164_E	1.818	1.00
119_S	144_V	1.780	1.00
227_L	258_V	1.779	1.00
101_R	254_N	1.774	1.00
168_T	172_I	1.753	1.00
261_N	264_K	1.749	1.00
122_M	168_T	1.726	1.00
100_T	131_R	1.723	1.00
133_E	173_T	1.719	1.00
154_T	157_S	1.702	1.00
106_L	113_A	1.700	1.00
88_Y	271_G	1.660	1.00
155_P	193_S	1.658	1.00
261_N	265_E	1.625	1.00
130_K	134_K	1.608	1.00
123_N	168_T	1.601	1.00
158_P	194_Q	1.593	1.00
163_Q	167_D	1.586	1.00
93_D	248_D	1.582	1.00
104_D	135_E	1.574	1.00
87_V	263_L	1.542	1.00
262_K	266_K	1.530	1.00
148_N	186_S	1.530	1.00
109_A	260_I	1.526	1.00
148_N	184_Y	1.502	1.00
145_T	161_E	1.501	1.00
99_T	248_D	1.497	1.00
151_F	186_S	1.489	1.00
105_V	256_L	1.424	1.00
179_L	274_E	1.423	1.00
129_V	172_I	1.415	1.00
105_V	260_I	1.410	1.00
260_I	270_F	1.405	1.00
167_D	171_D	1.402	1.00
148_N	152_Y	1.374	1.00
239_S	242_N	1.358	1.00
100_T	128_A	1.356	1.00
142_H	146_H	1.334	1.00
122_M	169_L	1.315	1.00
87_V	244_I	1.312	1.00
212_S	246_M	1.251	1.00
99_T	103_L	1.249	1.00
122_M	172_I	1.242	1.00
103_L	137_H	1.238	1.00
210_I	242_N	1.223	1.00
238_S	263_L	1.220	1.00
144_V	168_T	1.218	1.00
91_F	256_L	1.216	1.00
111_V	270_F	1.206	1.00
211_D	215_W	1.201	1.00
85_K	268_Y	1.191	0.99
84_D	269_S	1.187	0.99
260_I	264_K	1.187	0.99
256_L	260_I	1.184	0.99
163_Q	166_R	1.179	0.99
168_T	171_D	1.163	0.99
95_P	248_D	1.158	0.99
117_M	139_L	1.156	0.99
86_T	271_G	1.141	0.99
182_T	207_D	1.138	0.99
86_T	269_S	1.121	0.99
28_L	31_L	1.113	0.99
98_V	101_R	1.108	0.99
105_V	257_P	1.108	0.99
93_D	142_H	1.106	0.99
91_F	102_L	1.101	0.99
129_V	132_A	1.075	0.99
103_L	131_R	1.066	0.99
112_K	272_V	1.049	0.99
226_V	255_A	1.049	0.99
142_H	247_H	1.048	0.99
159_L	163_Q	1.033	0.98
158_P	197_N	1.033	0.98
87_V	238_S	1.027	0.98
147_N	161_E	1.026	0.98
132_A	139_L	1.016	0.98
107_K	131_R	1.015	0.98
122_M	126_K	1.012	0.98
153_Q	157_S	1.009	0.98
211_D	216_K	1.001	0.98
141_L	166_R	0.995	0.98
98_V	253_V	0.989	0.98
32_M	35_L	0.975	0.98
101_R	105_V	0.973	0.98
192_A	196_R	0.971	0.98
162_M	198_L	0.961	0.98
105_V	109_A	0.961	0.98
18_K	23_A	0.954	0.97
111_V	264_K	0.942	0.97
129_V	139_L	0.935	0.97
32_M	36_G	0.931	0.97
146_H	247_H	0.925	0.97
258_V	262_K	0.921	0.97
184_Y	215_W	0.912	0.97
206_W	273_L	0.900	0.96
92_D	142_H	0.895	0.96
52_N	55_L	0.893	0.96
139_L	169_L	0.892	0.96
150_L	153_Q	0.887	0.96
138_A	179_L	0.884	0.96
227_L	262_K	0.880	0.96
166_R	176_K	0.879	0.96
122_M	129_V	0.877	0.96
27_V	30_L	0.877	0.96
99_T	128_A	0.876	0.96
93_D	118_L	0.864	0.95
155_P	197_N	0.860	0.95
34_I	37_Y	0.856	0.95
117_M	122_M	0.855	0.95
95_P	121_R	0.852	0.95
87_V	270_F	0.840	0.95
251_A	254_N	0.836	0.95
49_V	57_D	0.833	0.94
133_E	139_L	0.832	0.94
92_D	181_R	0.827	0.94
208_W	245_L	0.822	0.94
88_Y	273_L	0.818	0.94
103_L	135_E	0.816	0.94
192_A	195_I	0.804	0.93
197_N	200_K	0.799	0.93
127_Q	130_K	0.798	0.93
123_N	144_V	0.790	0.93
244_I	263_L	0.789	0.93
141_L	165_A	0.787	0.93
88_Y	114_T	0.785	0.93
98_V	250_P	0.781	0.92
116_F	206_W	0.781	0.92
231_E	266_K	0.778	0.92
144_V	165_A	0.778	0.92
115_F	137_H	0.777	0.92
165_A	172_I	0.774	0.92
138_A	273_L	0.773	0.92
165_A	168_T	0.772	0.92
182_T	205_Y	0.772	0.92
147_N	150_L	0.771	0.92
30_L	33_V	0.770	0.92
169_L	177_T	0.764	0.92
103_L	115_F	0.759	0.91
49_V	52_N	0.754	0.91
211_D	226_V	0.753	0.91
161_E	165_A	0.752	0.91
116_F	179_L	0.752	0.91
184_Y	211_D	0.751	0.91
95_P	99_T	0.750	0.91
33_V	37_Y	0.748	0.91
24_V	28_L	0.740	0.90
118_L	143_G	0.737	0.90
81_N	84_D	0.736	0.90
165_A	169_L	0.725	0.89
118_L	248_D	0.724	0.89
123_N	126_K	0.720	0.89
48_T	54_Q	0.720	0.89
219_N	251_A	0.718	0.89
169_L	173_T	0.718	0.89
28_L	35_L	0.718	0.89
227_L	255_A	0.717	0.89
143_G	150_L	0.715	0.89
93_D	184_Y	0.710	0.88
30_L	37_Y	0.708	0.88
96_S	249_L	0.706	0.88
246_M	259_L	0.706	0.88
21_S	28_L	0.705	0.88
95_P	181_R	0.704	0.88
131_R	134_K	0.701	0.88
24_V	27_V	0.701	0.88
209_T	242_N	0.699	0.87
43_K	47_V	0.698	0.87
24_V	37_Y	0.695	0.87
142_H	245_L	0.693	0.87
193_S	196_R	0.689	0.87
31_L	34_I	0.689	0.87
48_T	52_N	0.688	0.87
20_A	23_A	0.687	0.87
163_Q	201_D	0.686	0.86
24_V	33_V	0.684	0.86
114_T	138_A	0.683	0.86
26_C	30_L	0.680	0.86
119_S	168_T	0.679	0.86
107_K	112_K	0.677	0.86
252_T	256_L	0.676	0.86
230_L	244_I	0.671	0.85
118_L	121_R	0.669	0.85
50_T	53_G	0.669	0.85
271_G	275_D	0.667	0.85
90_T	181_R	0.661	0.84
185_G	207_D	0.661	0.84
159_L	197_N	0.660	0.84
55_L	58_E	0.659	0.84
105_V	111_V	0.656	0.84
91_F	106_L	0.654	0.84
27_V	32_M	0.651	0.83
33_V	36_G	0.650	0.83
146_H	183_P	0.648	0.83
221_Q	258_V	0.644	0.83
107_K	110_D	0.642	0.83
45_K	58_E	0.638	0.82
85_K	267_G	0.637	0.82
166_R	177_T	0.637	0.82
30_L	35_L	0.637	0.82
210_I	230_L	0.636	0.82
108_S	265_E	0.632	0.82
157_S	160_K	0.632	0.82
49_V	54_Q	0.632	0.82
184_Y	213_M	0.630	0.81
42_T	50_T	0.627	0.81
228_Q	236_S	0.625	0.81
35_L	39_N	0.625	0.81
93_D	146_H	0.624	0.81
112_K	270_F	0.623	0.81
95_P	118_L	0.622	0.81
167_D	176_K	0.620	0.80
169_L	172_I	0.620	0.80
188_P	193_S	0.620	0.80
259_L	262_K	0.619	0.80
107_K	137_H	0.618	0.80
92_D	183_P	0.618	0.80
194_Q	198_L	0.617	0.80
31_L	35_L	0.616	0.80
182_T	188_P	0.615	0.80
267_G	270_F	0.615	0.80
198_L	202_G	0.615	0.80
138_A	272_V	0.615	0.80
41_S	44_A	0.614	0.80
172_I	175_Y	0.614	0.80
150_L	161_E	0.609	0.79
146_H	245_L	0.608	0.79
142_H	183_P	0.606	0.79
54_Q	57_D	0.602	0.78
117_M	169_L	0.599	0.78
159_L	200_K	0.598	0.78
120_P	143_G	0.597	0.78
198_L	205_Y	0.597	0.78
227_L	259_L	0.597	0.78
27_V	33_V	0.596	0.78
94_G	99_T	0.596	0.78
94_G	142_H	0.595	0.78
99_T	115_F	0.593	0.77
141_L	162_M	0.590	0.77
208_W	215_W	0.588	0.77
18_K	21_S	0.587	0.77
106_L	115_F	0.587	0.77
92_D	247_H	0.586	0.77
92_D	146_H	0.586	0.77
186_S	195_I	0.585	0.76
48_T	55_L	0.585	0.76
209_T	239_S	0.584	0.76
41_S	52_N	0.584	0.76
212_S	226_V	0.583	0.76
94_G	248_D	0.576	0.75
99_T	181_R	0.575	0.75
93_D	247_H	0.572	0.75
148_N	153_Q	0.572	0.75
94_G	245_L	0.572	0.75
90_T	243_V	0.571	0.75
136_G	214_D	0.568	0.74
35_L	44_A	0.563	0.74
228_Q	231_E	0.563	0.74
131_R	137_H	0.561	0.73
29_L	39_N	0.561	0.73
43_K	55_L	0.560	0.73
157_S	161_E	0.559	0.73
28_L	32_M	0.553	0.72
143_G	161_E	0.552	0.72
31_L	36_G	0.552	0.72
155_P	159_L	0.549	0.72
100_T	135_E	0.549	0.72
103_L	248_D	0.547	0.72
97_A	125_F	0.547	0.72
144_V	161_E	0.546	0.71
158_P	180_V	0.546	0.71
32_M	38_S	0.545	0.71
121_R	249_L	0.543	0.71
94_G	181_R	0.543	0.71
116_F	181_R	0.542	0.71
45_K	55_L	0.541	0.71
220_S	251_A	0.541	0.71
44_A	53_G	0.540	0.71
217_Y	220_S	0.536	0.70
27_V	56_R	0.536	0.70
47_V	57_D	0.535	0.70
47_V	52_N	0.534	0.70
188_P	194_Q	0.533	0.70
115_F	214_D	0.532	0.70
41_S	54_Q	0.532	0.70
156_T	160_K	0.531	0.69
51_T	55_L	0.530	0.69
129_V	173_T	0.529	0.69
47_V	55_L	0.528	0.69
33_V	40_S	0.527	0.69
187_K	195_I	0.527	0.69
24_V	31_L	0.525	0.69
103_L	132_A	0.524	0.68
212_S	252_T	0.522	0.68
22_L	28_L	0.522	0.68
253_V	257_P	0.521	0.68
23_A	26_C	0.521	0.68
255_A	263_L	0.521	0.68
211_D	214_D	0.520	0.68
23_A	41_S	0.519	0.68
52_N	57_D	0.519	0.68
47_V	50_T	0.516	0.67
146_H	208_W	0.516	0.67
130_K	174_G	0.516	0.67
23_A	27_V	0.513	0.67
33_V	47_V	0.513	0.67
38_S	49_V	0.510	0.66
126_K	171_D	0.510	0.66
50_T	57_D	0.509	0.66
22_L	36_G	0.508	0.66
257_P	260_I	0.505	0.66
29_L	34_I	0.505	0.66
143_G	162_M	0.503	0.65
100_T	104_D	0.502	0.65
49_V	56_R	0.501	0.65
30_L	34_I	0.501	0.65
110_D	264_K	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2w3zA	1	0.7482	100	0.267	Contact Map
4m1bA	1	0.6915	100	0.28	Contact Map
2iw0A	1	0.734	100	0.285	Contact Map
2y8uA	1	0.7234	100	0.292	Contact Map
2j13A	1	0.7234	100	0.294	Contact Map
2cc0A	2	0.6738	100	0.296	Contact Map
4l1gA	1	0.7305	100	0.304	Contact Map
1ny1A	1	0.8227	100	0.305	Contact Map
2c1iA	1	0.8333	100	0.315	Contact Map
2vyoA	1	0.6986	100	0.317	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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