GREMLIN Database
NPD - NAD-dependent protein deacetylase
UniProt: O07595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (224)
Sequences: 5813 (4067)
Seq/√Len: 271.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E237_G3.8021.00
26_S79_N3.2461.00
42_A45_M2.7451.00
107_K116_E2.6391.00
96_D180_K2.6351.00
80_E241_R2.5381.00
87_E90_K2.5351.00
22_M81_G2.5181.00
190_I236_I2.4651.00
123_T163_D2.4321.00
42_A46_E2.4311.00
234_Q239_F2.3961.00
51_D168_G2.3871.00
197_A201_F2.1611.00
206_A212_M2.1291.00
197_A200_R2.1141.00
16_V85_L2.1141.00
86_A90_K2.1111.00
24_T30_D2.0961.00
235_K238_E2.0761.00
126_C129_C2.0691.00
89_E113_H2.0541.00
81_G240_A1.9481.00
13_R183_Q1.8961.00
219_L235_K1.8611.00
133_Y160_L1.8521.00
13_R95_V1.8501.00
87_E91_Q1.8451.00
234_Q238_E1.8381.00
16_V188_L1.8041.00
77_E108_K1.7861.00
153_G156_C1.7641.00
81_G236_I1.7541.00
13_R94_Q1.7531.00
85_L97_I1.7361.00
80_E83_L1.7041.00
96_D115_Y1.6951.00
115_Y176_T1.6211.00
25_E235_K1.5921.00
131_A155_I1.5921.00
207_S229_D1.5701.00
132_R163_D1.5411.00
84_L240_A1.5371.00
217_I239_F1.5241.00
89_E111_S1.5101.00
213_K229_D1.5051.00
15_V184_A1.5031.00
50_L54_L1.5021.00
53_F127_P1.5011.00
179_E183_Q1.4961.00
111_S114_V1.4911.00
49_S52_Y1.4841.00
84_L88_L1.4541.00
129_C156_C1.4381.00
18_T106_H1.4311.00
125_A163_D1.4251.00
131_A154_D1.4141.00
186_L215_V1.4031.00
120_S123_T1.3941.00
13_R185_D1.3851.00
77_E83_L1.3761.00
222_T225_D1.3671.00
30_D33_S1.3651.00
62_P66_E1.3641.00
116_E120_S1.3591.00
35_G39_T1.3591.00
117_L199_A1.3561.00
178_Y205_D1.3551.00
84_L241_R1.3521.00
89_E112_R1.3391.00
181_L202_V1.3391.00
58_R62_P1.3351.00
73_S76_F1.3271.00
190_I240_A1.3261.00
150_G153_G1.3091.00
181_L187_L1.2931.00
216_I222_T1.2701.00
125_A132_R1.2661.00
56_Y59_L1.2651.00
18_T22_M1.2631.00
186_L213_K1.2581.00
182_D205_D1.2561.00
13_R180_K1.2511.00
232_I239_F1.2481.00
133_Y154_D1.2391.00
216_I225_D1.2341.00
28_I76_F1.2211.00
190_I217_I1.2191.00
216_I228_F1.2181.00
18_T97_I1.2161.00
115_Y180_K1.1991.00
16_V94_Q1.1971.00
83_L87_E1.1941.00
86_A109_A1.1901.00
104_G108_K1.1881.00
15_V98_F1.1731.00
123_T132_R1.1571.00
33_S39_T1.1501.00
84_L87_E1.1481.00
18_T85_L1.1271.00
53_F57_P1.1241.00
161_K169_D1.1211.00
107_K114_V1.1141.00
47_A52_Y1.1131.00
11_A186_L1.1131.00
32_R36_G1.1111.00
14_I93_K1.1051.00
104_G116_E1.0971.00
126_C156_C1.0931.00
12_Q185_D1.0891.00
213_K230_M1.0851.00
29_P40_E1.0721.00
117_L171_V1.0721.00
54_L127_P1.0711.00
79_N237_G1.0701.00
46_E59_L1.0651.00
188_L215_V1.0541.00
104_G122_Q1.0511.00
49_S169_D1.0501.00
127_P158_T1.0501.00
178_Y182_D1.0451.00
128_A158_T1.0421.00
174_F202_V1.0291.00
176_T179_E1.0281.00
151_N154_D1.0251.00
124_A160_L1.0031.00
50_L168_G0.9991.00
225_D231_V0.9801.00
17_L199_A0.9791.00
221_P233_H0.9781.00
48_M52_Y0.9721.00
60_F166_L0.9721.00
214_K228_F0.9711.00
71_K75_S0.9641.00
38_W48_M0.9611.00
53_F161_K0.9581.00
46_E55_S0.9551.00
86_A111_S0.9461.00
127_P159_V0.9421.00
97_I111_S0.9381.00
238_E242_S0.9381.00
104_G107_K0.9321.00
176_T180_K0.9261.00
117_L177_L0.9211.00
48_M166_L0.9051.00
125_A161_K0.9011.00
129_C158_T0.9001.00
29_P72_M0.8921.00
53_F166_L0.8921.00
80_E84_L0.8861.00
90_K112_R0.8861.00
104_G120_S0.8831.00
225_D228_F0.8781.00
81_G190_I0.8741.00
41_D44_R0.8651.00
217_I232_I0.8631.00
18_T190_I0.8581.00
238_E241_R0.8541.00
14_I186_L0.8501.00
15_V187_L0.8471.00
59_L62_P0.8401.00
137_H140_E0.8310.99
106_H111_S0.8280.99
124_A135_L0.8280.99
194_L216_I0.8190.99
13_R96_D0.8130.99
63_K67_L0.8060.99
165_V169_D0.8010.99
29_P35_G0.7990.99
49_S53_F0.7970.99
98_F199_A0.7910.99
163_D172_M0.7910.99
15_V181_L0.7860.99
11_A14_I0.7850.99
215_V230_M0.7840.99
20_A23_S0.7820.99
17_L202_V0.7780.99
108_K122_Q0.7750.99
17_L187_L0.7740.99
80_E237_G0.7710.99
134_D137_H0.7640.99
171_V198_P0.7630.99
48_M67_L0.7610.99
206_A213_K0.7600.99
174_F178_Y0.7590.99
14_I185_D0.7580.99
64_F67_L0.7560.99
234_Q242_S0.7490.99
237_G241_R0.7490.99
97_I106_H0.7430.99
33_S220_E0.7420.99
207_S227_L0.7400.99
136_P140_E0.7390.99
189_V192_T0.7380.99
173_H176_T0.7370.99
113_H176_T0.7370.99
81_G235_K0.7350.99
25_E79_N0.7290.99
85_L190_I0.7290.99
222_T228_F0.7280.99
180_K183_Q0.7270.99
137_H141_R0.7270.99
167_F196_V0.7190.99
136_P139_L0.7150.98
71_K74_G0.7070.98
220_E231_V0.7050.98
141_R154_D0.7040.98
48_M53_F0.6990.98
189_V194_L0.6980.98
125_A172_M0.6900.98
177_L202_V0.6890.98
31_F36_G0.6880.98
204_E227_L0.6820.98
198_P203_P0.6820.98
22_M106_H0.6810.98
23_S103_D0.6720.98
184_A212_M0.6720.98
137_H154_D0.6680.98
22_M190_I0.6670.98
151_N155_I0.6660.98
175_D178_Y0.6630.97
15_V202_V0.6590.97
189_V214_K0.6580.97
133_Y141_R0.6560.97
46_E52_Y0.6550.97
102_I121_I0.6530.97
188_L243_L0.6520.97
94_Q113_H0.6510.97
162_T169_D0.6480.97
16_V95_V0.6470.97
193_S196_V0.6430.97
15_V180_K0.6410.97
126_C153_G0.6410.97
56_Y60_F0.6380.97
84_L190_I0.6370.97
126_C158_T0.6370.97
66_E72_M0.6360.97
220_E233_H0.6360.97
59_L63_K0.6330.97
184_A187_L0.6330.97
239_F243_L0.6320.97
86_A89_E0.6250.96
89_E106_H0.6240.96
116_E122_Q0.6230.96
161_K166_L0.6200.96
60_F64_F0.6190.96
42_A52_Y0.6170.96
104_G121_I0.6140.96
39_T44_R0.6130.96
61_W151_N0.6130.96
215_V243_L0.6130.96
52_Y59_L0.6130.96
74_G122_Q0.6110.96
24_T33_S0.6060.96
96_D113_H0.6050.96
204_E224_C0.6000.96
73_S122_Q0.5990.95
216_I231_V0.5990.95
125_A130_G0.5910.95
73_S121_I0.5890.95
102_I164_V0.5860.95
29_P33_S0.5850.95
201_F204_E0.5840.95
231_V234_Q0.5840.95
82_H100_Q0.5830.95
53_F159_V0.5820.95
162_T166_L0.5820.95
38_W167_F0.5790.95
10_E213_K0.5790.95
72_M75_S0.5780.95
52_Y63_K0.5780.95
29_P39_T0.5760.94
178_Y202_V0.5760.94
52_Y56_Y0.5760.94
14_I95_V0.5760.94
152_N159_V0.5750.94
12_Q93_K0.5740.94
47_A63_K0.5740.94
51_D55_S0.5710.94
14_I188_L0.5670.94
28_I73_S0.5670.94
57_P61_W0.5670.94
16_V88_L0.5660.94
174_F177_L0.5610.94
64_F166_L0.5610.94
215_V232_I0.5610.94
166_L169_D0.5610.94
16_V190_I0.5580.93
177_L184_A0.5550.93
187_L212_M0.5540.93
53_F61_W0.5480.93
135_L139_L0.5480.93
81_G84_L0.5480.93
11_A185_D0.5470.93
127_P161_K0.5460.93
219_L234_Q0.5460.93
189_V228_F0.5390.92
235_K239_F0.5390.92
98_F177_L0.5370.92
149_A153_G0.5350.92
189_V224_C0.5350.92
205_D209_I0.5320.92
98_F180_K0.5310.92
131_A134_D0.5310.92
24_T219_L0.5300.92
173_H178_Y0.5280.91
165_V171_V0.5270.91
149_A156_C0.5260.91
175_D179_E0.5240.91
99_T116_E0.5230.91
228_F231_V0.5230.91
23_S82_H0.5220.91
151_N156_C0.5220.91
48_M63_K0.5210.91
41_D59_L0.5210.91
81_G237_G0.5210.91
96_D114_V0.5190.91
95_V180_K0.5180.91
181_L214_K0.5140.90
204_E209_I0.5110.90
120_S163_D0.5110.90
215_V218_N0.5090.90
51_D54_L0.5090.90
72_M76_F0.5080.90
17_L97_I0.5080.90
221_P231_V0.5080.90
138_L142_E0.5080.90
148_A151_N0.5070.90
64_F121_I0.5050.90
44_R47_A0.5050.90
90_K93_K0.5050.90
232_I243_L0.5050.90
107_K111_S0.5030.89
24_T194_L0.5030.89
150_G159_V0.5020.89
217_I243_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m2kA 1 0.9514 100 0.117 Contact Map
1yc5A 1 0.9231 100 0.124 Contact Map
4iaoA 1 0.9717 100 0.127 Contact Map
3riyA 1 0.9757 100 0.13 Contact Map
4twjA 1 0.8988 100 0.133 Contact Map
3u31A 1 0.9757 100 0.135 Contact Map
2hjhA 2 0.9717 100 0.135 Contact Map
5btrA 1 0.9595 100 0.142 Contact Map
1q14A 3 0.9231 100 0.15 Contact Map
4kxqA 1 0.9595 100 0.156 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.